Protein nitration, PARP activation and NAD+ depletion may play a critical role in the pathogenesis of cyclophosphamide-induced hemorrhagic cystitis in the rat

Cancer Chemotherapy and Pharmacology

Volumn 64, Issue 2, 2009, Pages 279-285

  Abraham, Premila ^a   Rabi, Suganthy ^a  

^a CHRISTIAN MEDICAL COLLEGE   (India)

Author keywords

Cyclophosphamide; Hemorrhagic cystitis; NAD depletion; PARP activation

Indexed keywords

3 NITROTYROSINE; CYCLOPHOSPHAMIDE; MALONALDEHYDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRITE; PEROXYNITRITE; PLACEBO; SUPEROXIDE DISMUTASE; THIOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER BIOPSY; CELL DEATH; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; HEMATURIA; HEMORRHAGIC CYSTITIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY; NITRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, ALKYLATING; ANTIOXIDANTS; CYCLOPHOSPHAMIDE; CYSTITIS; HEMORRHAGE; IMMUNOENZYME TECHNIQUES; MALE; MALONDIALDEHYDE; NAD; NITRIC OXIDE; OXIDATIVE STRESS; PEROXYNITROUS ACID; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; TYROSINE; URINARY BLADDER;

EID: 67349163258     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0868-6     Document Type: Article

References (32)

1. AL Levine PJ Richie 1989 Urological complications of cyclophosphamide J Urol 41 1063 1069
2. NJ West 1997 Prevention and treatment of hemorrhagic cystitis Pharmacotherapy 4 696 706 (Pubitemid 27318963)
3. N Brock J Pohl J Stekar 1981 Studies on the urotoxicity of oxazaphosphorine cytostatics and it prevention. 1. Experimental studies on the urotoxicity of alkylating compounds Eur J Cancer 7 595 601
4. A Korkmaz S Oter S Sadir 2005 Peroxynitrite may be involved in bladder damage caused by cyclophosphamide in rats J Urol 173 1793 1796 (Pubitemid 40524834)
5. BE Linares-Fernández AB Alfieri 2007 Cyclophosphamide induced cystitis: role of nitric oxide synthase, cyclooxygenase-1 and 2, and NK (1) receptors J Urol 177 1531 1536 (Pubitemid 46435995)
6. R Radi JS Beckman KM Bush 1991 Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide Arch Biochem Biophys 288 481
7. C Szabo B Zingarelli M O'Connor 1996 DNA strand breakage, activation of poly (ADP-ribose) synthase and cellular energy depletion are involved in the cytotoxicity of macrophages, and smooth muscle cell exposed to peroxynitrite Proc Natl Acad Sci 93 1753 1758 (Pubitemid 26079829)
8. R Radi 2004 Nitric oxide, oxidants, and protein tyrosine nitration Proc Nat Acad Sci USA 101 4003 4008 (Pubitemid 38405874)
9. LA MacMillan-Crow JP Crow JD Kerby 1996 Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts Proc Natl Acad Sci USA 93 11853 11858 (Pubitemid 26347213)
10. + depletion Biochem Biophys Res Commun 199 1270 1277
11. J Zhang VL Dawson TM Dawson 1994 Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity Science 263 687 689 (Pubitemid 24076297)
12. J Zhang A Pieper SH Snyder 1995 Poly (ADP-ribose) synthetase activation: an early indicator of neurotoxic DNA damage J Neurochem 65 1411 1414
13. FR Althaus C Richter 1987 ADP-ribosylation of proteins: enzymology and biological significance Mol Biol Biochem Biophys 37 1 237
14. Radi R, Denicola A, Alvarez B et al (2000) In: Ignarro L (ed) Nitric oxide. Academic Press, San Diego, pp 57-82
15. A Ahluwalia CA Maggi P Santicioli 1994 Characterization of the capsaicin sensitive component of cyclophosphamide-induced inflammation in the rat urinary bladder Br J Pharmacol 111 1017 1022 (Pubitemid 24148764)
16. S Cuzzocrea B Zingarelli M O'Connor 1997 Role of peroxynitrite and activation of poly (ADP-ribose) synthase in the vascular failure induced by zymosan-activated plasma Br J Pharmacol 122 493 503 (Pubitemid 27429724)
17. JH Kupper L van Gool M Muller 1996 Detection of poly (ADP-ribose) polymerase and its reaction product by immunohistochemistry Histochem J 28 391 395 (Pubitemid 26226130)
18. H Ohkawa N Ohishi K Yagi 1979 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 351 358 (Pubitemid 9194347)
19. J Sedlak RH Lindsay 1968 Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman's reagent Anal Biochem 25 192 205
20. N Ohkuma S Matsuo M Tutsui 1982 Superoxide dismutase in the epidermis (author's transl) Nippon Hifuka Gakkai Zasshi 92 583 590
21. KV Sastry RP Moudgal J Mohan 2002 Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy Anal Biochem 306 79 82 (Pubitemid 34722019)
22. H Matsumura S Miyachi 1980 Cycling assay for nicotinamide adenine dinucleotides Methods Enzymol 69 465 470
23. S Oter A Korkmaz E Ostaz 2004 Inducible nitric oxide synthase inhibition in cyclophosphamide induced hemorrhagic cystitis Urol Res 32 185
24. T Topal Y Oztas A Korkmaz 2005 Melatonin ameliorates bladder damage induced by cyclophosphamide in rats J Pineal Res 38 272 277 (Pubitemid 41475439)
25. JS Stamler 1992 S nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds Proc Natl Acad Sci USA 89 444 448
26. C Cosi H Suzuki D Milani 1992 Poly (ADP-ribose) polymerase: early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cells J Neurosci Res 39 38 46
27. B Zingarelli M O'Conner H Wong 1996 Peroxynitrite mediated DNA strand breakage activates polyadenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial lipopolysaccharide J Immunol 156 350 358 (Pubitemid 26006983)
28. C Nosseri S Coppola L Ghibelli 1992 Possible involvement of poly (ADP-ribosyl) polymerase in triggering stress-induced apoptosis Exp Cell Res 212 367 373 (Pubitemid 124002953)
29. A Korkmaz T Topal S Oter 2007 Pathophysiological aspects of cyclophosphamide and isofamide induced hemorrhagic cystitis; implications of reactive oxygen species as well as PARP activation Cell Biol Toxicol 23 303 312 (Pubitemid 46919119)
30. CA de la Lastra I Villegas S Sánchez-Fidalgo 2007 Poly (ADP-ribose) polymerase inhibitors: new pharmacological functions and potential clinical implications Curr Pharm Res 13 933 962 (Pubitemid 46628291)
31. A Korkmaz B Kurt I Yildirim S Basal T Topal S Sadir S Oter 2008 Effects of poly(ADP-ribose) polymerase inhibition caused by cyclophosphamide in rats Exp Biol Med (Maywood) 233 338 343
32. L Viralag C Szabo 2002 The therapeutic potential of poly (ADP-Ribose) polymerase inhibitors Pharmacol Rev 54 375