Leptin Induces IL-6 Expression through OBRl Receptor Signaling Pathway in Human Synovial Fibroblasts

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Yang, Wei Hung ^a,b,c,d   Liu, Shan Chi ^d   Tsai, Chun Hao ^c,e   Fong, Yi Chin ^c,e   Wang, Shoou Jyi ^f   Chang, Yung Sen ^a   Tang, Chih Hsin ^c,g,h  

^a Taichung Hospital   (Taiwan)

^b NATIONAL TAICHUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^f Chang Hua Hospital   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

^h ASIA UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR OBR ISOFORM; LEPTIN RECEPTOR OBRI ISOFORM; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P110; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FIBROBLAST; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; OSTEOARTHRITIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; SYNOVIAL FIBROBLAST; SYNOVIOCYTE; UPREGULATION;

CELLS, CULTURED; FIBROBLASTS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; INTERLEUKIN-6; LEPTIN; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, LEPTIN; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SYNOVIAL MEMBRANE; TRANSFECTION;

EID: 84884683366     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075551     Document Type: Article

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