Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents

European Journal of Medicinal Chemistry

Volumn 69, Issue , 2013, Pages 365-372

  Ribeiro, Carlos J A ^a   Kumar, S Praveen ^a   Gut, Jiri ^b   Gonçalves, Lídia M ^a   Rosenthal, Philip J ^b   Moreira, Rui ^a   Santos, Maria M M ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

4 Aminoquinoline; Antiplasmodial activity; Hybrid; Malaria; Squaramide

Indexed keywords

4 AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; SQUARIC ACID DERIVATIVE;

ANTIMALARIAL ACTIVITY; ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; CYTOTOXICITY; DRUG CONJUGATION; DRUG PENETRATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HUMAN; HUMAN CELL; HYDROGEN BOND; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; NONHUMAN; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; ROOM TEMPERATURE; STRUCTURE ACTIVITY RELATION;

4-AMINOQUINOLINE; ANTIPLASMODIAL ACTIVITY; HYBRID; MALARIA; SQUARAMIDE;

AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; CYCLOBUTANES; DOSE-RESPONSE RELATIONSHIP, DRUG; HEK293 CELLS; HUMANS; MICE; MOLECULAR STRUCTURE; NIH 3T3 CELLS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84884620898     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.08.037     Document Type: Article

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