Cardiac contractility modulation therapy in advanced systolic heart failure

Nature Reviews Cardiology

Volumn 10, Issue 10, 2013, Pages 584-598

  Lyon, Alexander R ^a   Samara, Michael A ^b,c,d   Feldman, David S ^b,c,d  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

^b MINNEAPOLIS HEART INSTITUTE FOUNDATION   (United States)

^c GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^d MOREHOUSE SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOLAMBAN;

CARDIAC RESYNCHRONIZATION THERAPY; DEVICE THERAPY; EXERCISE TOLERANCE; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CONTRACTILITY; HOSPITALIZATION; HUMAN; INOTROPISM; MORTALITY; NONHUMAN; PATIENT SAFETY; PHOSPHORYLATION; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SYSTOLIC HEART FAILURE;

ACTION POTENTIALS; ANIMALS; ELECTRIC STIMULATION THERAPY; HEART FAILURE, SYSTOLIC; HEART VENTRICLES; HUMANS; PAPILLARY MUSCLES; RECOVERY OF FUNCTION; STROKE VOLUME; SYSTOLE; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 84884595883     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2013.114     Document Type: Review

References (70)

1. Swedberg, K. et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet 376, 875-885 (2010).
2. Wood, E. H., Heppner, R. L. & Weidmann, S. Inotropic effects of electric currents. Circ. Res. 24, 409-445 (1969).
3. Aiba, T. et al. Electrophysiological consequences of dyssynchronous heart failure and its restoration by resynchronization therapy. Circulation 119, 1220-1230 (2009).
4. Birks, E. J. et al. Left ventricular assist device and drug therapy for the reversal of heart failure. N. Engl. J. Med. 355, 1873-1884 (2006). (Pubitemid 44664645)
5. Kawase, Y. et al. Reversal of cardiac dysfunction after long-yerm expression of SERCA2a by gene transfer in a pre-clinical model of heart failure. J. Am. Coll. Cardiol. 51, 1112-1119 (2008). (Pubitemid 351374774)
6. Terracciano, C. M. N. et al. Clinical recovery from end-stage heart failure using left-ventricular assist device and pharmacological therapy correlates with increased sarcoplasmic reticulum calcium content but not with regression of cellular hypertrophy. Circulation 109, 2263-2265 (2004). (Pubitemid 38656863)
7. O'Connor, C. M. et al. Continuous intravenous dobutamine is associated with an increased risk of death in patients with advanced heart failure: insights from the Flolan International Randomized Survival Trial (FIRST). Am. Heart J. 138, 78-86 (1999). (Pubitemid 29331125)
8. Packer, M. et al. Effect of oral milrinone on mortality in severe chronic heart failure. N. Engl. J. Med. 325, 1468-1475 (1991).
9. del Monte, F. et al. Improvement in survival and cardiac metabolism after gene transfer of sarcoplasmic reticulum Ca2+-ATPase in a rat model of heart failure. Circulation 104, 1424-1429 (2001). (Pubitemid 32880157)
10. Burniston, J. G. et al. Relative toxicity of cardiotonic agents: some induce more cardiac and skeletal myocyte apoptosis and necrosis in vivo than others. Cardiovasc. Toxicol. 5, 355-364 (2005). (Pubitemid 43021258)
11. Mohri, S. et al. Electric currents applied during refractory period enhance contractility and systolic calcium in the ferret heart. Am. J. Physiol. Heart Circ. Physiol. 284, H1119-H1123 (2003). (Pubitemid 36348573)
12. Brunckhorst, C. B., Shemer, I., Mika, Y., BenHaim, S. A. & Burkhoff, D. Cardiac contractility modulation by non-excitatory currents: Studies in isolated cardiac muscle. Eur. J. Heart Fail. 8, 7-15 (2006). (Pubitemid 43012095)
13. Winter, J., Brack, K. E. & Ng, G. A. The acute inotropic effects of cardiac contractility modulation (CCM) are associated with action potential duration shortening and mediated by βadrenoceptor signalling. J. Mol. Cell. Cardiol. 51, 252-262 (2011).
14. Cannell, M. B. & Kong, C. H. T. Local control in cardiac EC coupling. J. Mol. Cell. Cardiol. 52, 298-303 (2012).
15. Marks, A. R. Calcium cycling proteins and heart failure: mechanisms and therapeutics. J. Clin. Invest. 123, 46-52 (2013).
16. Eisner, D., Bode, E., Venetucci, L. & Trafford, A. Calcium flux balance in the heart. J. Mol. Cell. Cardiol. 58, 110-117 (2013).
17. Zhao, Z. et al. Revisiting the ionic mechanisms of early afterdepolarizations in cardiomyocytes: predominant by Ca waves or Ca currents? Am. J. Physiol. Heart Circ. Physiol. 302, H1636-H1644 (2012).
18. Xie, L. H. & Weiss, J. N. Arrhythmogenic consequences of intracellular calcium waves. Am. J. Physiol. Heart Circ. Physiol. 297, H997-H1002 (2009).
19. Chaudhri, B., del Monte, F., Hajjar, R.J. & Harding, S. E. Contractile effects of adenovirally-mediated increases in SERCA2a activity: a comparison between rat and rabbit ventricular myocytes. Mol. Cell. Biochem. 251, 103-109 (2003). (Pubitemid 37220716)
20. Erickson, J. R., He, B. J., Grumbach, I. M. & Anderson, M. E. CaMKII in the cardiovascular system: sensing redox states. Physiol. Rev. 91, 889-915 (2011).
21. Kho, C. et al. SUMO1-dependent modulation of SERCA2a in heart failure. Nature 477, 601-605 (2011).
22. Imai, M. et al. Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. J. Am. Coll. Cardiol. 49, 2120-2128 (2007). (Pubitemid 46771049)
23. Meyer, C. et al. Augmentation of left ventricular contractility by cardiac sympathetic neural stimulation. Circulation 121, 1286-1294 (2010).
24. Lohse, M. J., Engelhardt, S. & Eschenhagen, T. What is the role of beta-adrenergic signalling in heart failure? Circ. Res. 93, 896-906 (2003). (Pubitemid 37433227)
25. Mohri, S. et al. Cardiac contractility modulation by electric currents applied during the refractory period. Am. J. Physiol. Heart Circ. Physiol. 282, H1642-H1647 (2002). (Pubitemid 34654830)
26. Gupta, R. C. et al. Ca2+-binding proteins in dogs with heart failure: effects of cardiac contractility modulation electrical signals. Clin. Transl. Sci. 2, 211-215 (2009).
27. Gupta, R. C. et al. Cardiac contractility modulation electrical signals normalize activity, expression, and phosphorylation of the Na+-Ca2+ exchanger in heart failure. J. Card. Fail. 15, 48-56 (2009).
28. Butter, C. et al. Enhanced inotropic state of the failing left ventricle by cardiac contractility modulation electrical signals is not associated with increased myocardial oxygen consumption. J. Card. Fail. 13, 137-142 (2007). (Pubitemid 46467396)
29. Sakata, S. et al. Restoration of mechanical and energetic function in failing aortic-banded rat hearts by gene transfer of calcium cycling proteins. J. Mol. Cell. Cardiol. 42, 852-861 (2007). (Pubitemid 46527593)
30. Morita, H. et al. Long-term effects of non-excitatory cardiac contractility modulation electric signals on the progression of heart failure in dogs. Eur. J. Heart Fail. 6, 145-150 (2004). (Pubitemid 38249357)
31. Butter, C. et al. Cardiac contractility modulation electrical signals improve myocardial gene expression in patients with heart failure. J. Am. Coll. Cardiol. 51, 1784-1789 (2008). (Pubitemid 351608495)
32. Kumarswamy, R. et al. SERCA2a gene therapy restores microRNA1 expression in heart failure via an Akt/FoxO3A-dependent pathway. Eur. Heart J. 33, 1067-1075 (2012).
33. Lyon, A. R. et al. SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure. Circ. Arrhythm. Electrophysiol. 4, 362-372 (2011).
34. Lyon, A. R. et al. Plasticity of surface structures and β2-adrenergic receptor localization in failing ventricular cardiomyocytes during recovery from heart failure. Circ. Heart Fail. 5, 357-365 (2012).
35. Pleger, S. T. et al. Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation 115, 2506-2515 (2007). (Pubitemid 46763224)
36. Pleger, S. T. et al. Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model. Sci. Transl. Med. 3, 92ra64 (2011).
37. Rastogi, S. et al. Effects of chronic therapy with cardiac contractility modulation electrical signals on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure. Cardiology 110, 230-237 (2008). (Pubitemid 351919788)
38. Pappone, C. et al. Cardiac contractility modulation by electric currents applied during the refractory period in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am. J. Cardiol. 90, 1307-1313 (2002). (Pubitemid 35449475)
39. Nelson, G. S. et al. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation 102, 3053-3059 (2000).
40. Askenazi, J., Alexander, J. H., Koenigsberg, D. I., Belic, N. & Lesch, M. Alteration of left ventricular performance by left bundle branch block simulated with atrioventricular sequential pacing. Am. J. Cardiol. 53, 99-104 (1984). (Pubitemid 14217515)
41. Lawo, T. et al. Electrical signals applied during the absolute refractory period: an investigational treatment for advanced heart failure in patients with normal QRS duration. J. Am. Coll. Cardiol. 46, 2229-2236 (2005).
42. Pappone, C. et al. First human chronic Experience with cardiac contractility modulation by nonexcitatory electrical currents for treating systolic heart failure. J. Cardiovasc. Electrophysiol. 15, 418-427 (2004). (Pubitemid 38510099)
43. Stix, G. et al. Chronic electrical stimulation during the absolute refractory period of the myocardium improves severe heart failure. Eur. Heart J. 25, 650-655 (2004). (Pubitemid 38579493)
44. Yu, C. M. et al. Impact of cardiac contractility modulation on left ventricular global and regional function and remodeling. JACC Cardiovasc. Imaging 2, 1341-1349 (2009).
45. Zhang, Q. et al. Comparison of left ventricular reverse remodeling induced by cardiac contractility modulation and cardiac resynchronization therapy in heart failure patients with different QRS durations. Int. J. Cardiol. 167, 889-893 (2013).
46. Neelagaru, S. B. et al. Nonexcitatory, cardiac contractility modulation electrical impulses: feasibility study for advanced heart failure in patients with normal QRS duration. Heart Rhythm 3, 1140-1147 (2006). (Pubitemid 44464160)
47. Abraham, W. T. et al. Cardiac resynchronization in chronic heart failure. N. Engl. J. Med. 346, 1845-1853 (2002). (Pubitemid 34603028)
48. Borggrefe, M. M. et al. Randomized, double blind study of non-excitatory, cardiac contractility modulation electrical impulses for symptomatic heart failure. Eur. Heart J. 29, 1019-1028 (2008). (Pubitemid 351844673)
49. Cazeau, S. et al. Effects of Multisite Biventricular Pacing in Patients with Heart Failure and Intraventricular Conduction Delay. N. Engl. J. Med. 344, 873-880 (2001). (Pubitemid 32224395)
50. Kadish, A. et al. A randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. Am. Heart J. 161, 329-337 (2011).
51. Higgins, S. L. et al. Cardiac resynchronization therapy for the treatment of heart failure in patients with intraventricular conduction delay and malignant ventricular tachyarrhythmias. J. Am. Coll. Cardiol. 42, 1454-1459 (2003). (Pubitemid 37267289)
52. Myers, J. et al. The ventilatory anaerobic threshold in heart failure: a multicenter evaluation of reliability. J. Card. Fail. 16, 76-83 (2010).
53. Poggio, R., Arazi, H. C., Giorgi, M. & Miriuka, S. G. Prediction of severe cardiovascular events by VE/VCO2 slope versus peak VO2 in systolic heart failure: A meta-analysis of the published literature. Am. Heart J. 160, 1004-1014 (2010).
54. Burkhoff, D. Does contractility modulation have a role in the treatment of heart failure? Curr. Heart Fail. Rep. 8, 260-265 (2011).
55. Kwong, J. S. W., Sanderson, J. E. & Yu, C.M. Cardiac contractility modulation for heart failure: a meta-analysis of randomized controlled trials. Pacing Clin. Electrophysiol. 35, 1111-1118 (2012).
56. Cleland, J. G. F. et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N. Engl. J. Med. 352, 1539-1549 (2005). (Pubitemid 40517094)
57. Schau, T., Seifert, M., Meyhöfer, J., Neuss, M. & Butter, C. Long-term outcome of cardiac contractility modulation in patients with severe congestive heart failure. Europace 13, 1436-1444 (2011).
58. Levy, W. C. et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation 113, 1424-1433 (2006). (Pubitemid 43739439)
59. Auricchio, A. et al. Clinical efficacy of cardiac resynchronization therapy using left ventricular pacing in heart failure patients stratified by severity of ventricular conduction delay. J. Am. Coll. Cardiol. 42, 2109-2116 (2003). (Pubitemid 37549894)
60. Abraham, W. T. et al. Subgroup analysis of a randomized controlled trial evaluating the safety and efficacy of cardiac contractility modulation in advanced heart failure. J. Card. Fail. 17, 710-717 (2011).
61. US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01381172 (2012).
62. Dupont, E. et al. Altered connexin expression in human congestive heart failure. J. Mol. Cell. Cardiol. 33, 359-371 (2001). (Pubitemid 32537933)
63. The SOLVD Investigators. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions. N. Engl. J. Med. 327, 685-691 (1992).
64. Butter, C., Meyhöfer, J., Seifert, M., Neuss, M. & Minden, H.H. First use of cardiac contractility modulation (CCM) in a patient failing CRT therapy: Clinical and technical aspects of combined therapies. Eur. J. Heart Fail. 9, 955-958 (2007). (Pubitemid 47332313)
65. Nagele, H., Behrens, S. & Eisermann, C. Cardiac contractility modulation in non-responders to cardiac resynchronization therapy. Europace 10, 1375-1380 (2008).
66. Bogaard, M. D. et al. Baseline left ventricular dP/dtmax rather than the acute improvement in dP/dtmax predicts clinical outcome in patients with cardiac resynchronization therapy. Eur. J. Heart Fail. 13, 1126-1132 (2011).
67. Yu, C. M. et al. Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy. Circulation 112, 1580-1586 (2005).
68. Blumenthal, J. A. et al. Effects of exercise training on depressive symptoms in patients with chronic heart failure: The HF-ACTION randomized trial. JAMA 308, 465-474 (2012).
69. Anker, S. D. et al. Ferric carboxymaltose in patients with heart failure and iron deficiency. N. Engl. J. Med. 361, 2436-2448 (2009).
70. Paur, H. et al. High levels of circulating epinephrine trigger apical cardiodepression in a β2-adrenergic receptor/Gi-dependent manner/clinical perspective. Circulation 126, 697-706 (2012).