Cardiac Contractility Modulation Electrical Signals Normalize Activity, Expression, and Phosphorylation of the Na+-Ca2+ Exchanger in Heart Failure

Journal of Cardiac Failure

Volumn 15, Issue 1, 2009, Pages 48-56

  Gupta, Ramesh C ^a   Mishra, Sudhish ^a   Wang, Mengjun ^a   Jiang, Alice ^a   Rastogi, Sharad ^a   Rousso, Benny ^b   Mika, Yuval ^b   Sabbah, Hani N ^a  

^a HENRY FORD HEART AND VASCULAR INSTITUTE   (United States)

^b IMPULSE Dynamics   (United States)

Author keywords

Animal models; Congestive heart failure; Contractility; Gene expression; Protein expression; Protein phosphorylation; Sodium calcium exchanger; Ventricular performance

Indexed keywords

CALCIUM; FRIEND OF GATA 2 PROTEIN; MESSENGER RNA; REGULATOR PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC CONTRACTILITY MODULATION THERAPY; CONTROLLED STUDY; DEVICE THERAPY; DOG; GENE EXPRESSION; HEART FAILURE; HEART LEFT VENTRICLE; HEART LEFT VENTRICLE FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; CARDIAC PACING, ARTIFICIAL; DOGS; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION; HEART FAILURE; MYOCARDIAL CONTRACTION; PACEMAKER, ARTIFICIAL; PHOSPHORYLATION; RNA, MESSENGER; SARCOLEMMA; SIGNAL TRANSDUCTION; SODIUM-CALCIUM EXCHANGER; TRANSCRIPTION FACTORS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR FUNCTION, LEFT;

EID: 58749107732     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2008.08.011     Document Type: Article

References (54)

1. Hjalmarson A., Goldstein S., Fagerberg B., et al. Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: the Metoprolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group. JAMA 283 (2000) 1295-1302
2. Pitt B., Zannad F., Remme W.J., et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 341 (1999) 709-717
3. Investigators. Effect of Enalapril on survival in patient with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 325 (1991) 293-302
4. Morita H., Suzuki G., Haddad W., et al. Long- term effects of non-excitatory cardiac contractility modulation electric signals on the progression of heart failure in dogs. Eur J Heart Fail 6 (2004) 145-150
5. Packer M. Vasodilator and inotropic drugs for the treatment of chronic heart failure: distinguishing hype from hope. J Am Coll Cardiol 12 (1988) 1299-1317
6. Packer M., Carver J.R., Rodeheffer R.J., et al. Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med 325 (1991) 1468-1475
7. Auricchio A., Stellbrink C., Block M., et al. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. The Pacing Therapies for Congestive Heart Failure Study Group. The Guidant Congestive Heart Failure Research Group. Circulation 99 (1999) 2993-3001
8. Auricchio A., Stellbrink C., Sack S., et al. The Pacing Therapies for Congestive Heart Failure (PATH-CHF) study: rationale, design, and endpoints of a prospective randomized multicenter study. Am J Cardiol 83 (1999) 130D-135D
9. Blanc J.J., Etienne Y., Gilard M., et al. Evaluation of different ventricular pacing sites in patients with severe heart failure: results of an acute hemodynamic study. Circulation 96 (1997) 3273-3277
10. Gras D., Mabo P., Tang T., et al. Multisite pacing as a supplemental treatment of congestive heart failure: preliminary results of the Medtronic Inc. InSync Study. Pacing Clin Electrophysiol 21 (1998) 2249-2255
11. Kass D.A., Chen C.H., Curry C., et al. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 99 (1999) 1567-1573
12. Saxon L.A., Boehmer J.P., Hummel J., et al. Biventricular pacing in patients with congestive heart failure: two prospective randomized trials. The VIGOR CHF and VENTAK CHF. Investigators. Am J Cardiol 83 (1999) 120D-123D
13. Lawo T., Borggrefe M., Butter C., et al. Electrical signals applied during the absolute refractory period: an investigational treatment for advanced heart failure in patients with normal QRS duration. J Am Coll Cardiol 46 (2005) 2229-2236
14. Morita H., Suzuki G., Haddad W., et al. Cardiac contractility modulation with nonexcitatory electric signals improves left ventricular function in dogs with chronic heart failure. J Card Fail 9 (2003) 69-75
15. Pappone C., Augello G., Rosanio S., et al. First human chronic experience with cardiac contractility modulation by nonexcitatory electrical currents for treating systolic heart failure: mid-term safety and efficacy results from a multicenter study. J Cardiovasc Electrophysiol 15 (2004) 418-427
16. Pappone C., Rosanio S., Burkhoff D., et al. Cardiac contractility modulation by electric currents applied during the refractory period in patients with heart failure secondary to ischemic or idiopathic dilated cardiomyopathy. Am J Cardiol 90 (2002) 1307-1313
17. Sabbah H.N., Gupta R.C., Rastogi S., et al. Treating heart failure with cardiac contractility modulation electrical signals. Curr Heart Fail Rep 3 (2006) 21-24
18. Sabbah H.N., Haddad W., Mika Y., et al. Cardiac contractility modulation with the impulse dynamics signal: studies in dogs with chronic heart failure. Heart Fail Rev 6 (2001) 45-53
19. Dhalla N.S., Dixon I.M., Rupp H., et al. Experimental congestive heart failure due to myocardial infarction: sarcolemmal receptors and cation transporters. Basic Res Cardiol 86 Suppl 3 (1991) 13-23
20. Haghighi K., Gregory K.N., and Kranias E.G. Sarcoplasmic reticulum Ca-ATPase- phospholamban interactions and dilated cardiomyopathy. Biochem Biophys Res Commun 322 (2004) 1214-1222
21. Hasenfuss G. Alterations of calcium-regulatory proteins in heart failure. Cardiovasc Res 37 (1998) 279-289
22. Houser S.R., Piacentino III V., and Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol 32 (2000) 1595-1607
23. Hasenfuss G., Schillinger W., Lehnart S.E., et al. Relationship between Na+-Ca2+-exchanger protein levels and diastolic function of failing human myocardium. Circulation 99 (1999) 641-648
24. IA H., and O'Rourke B. Enhanced Ca(2+)-activated Na(+)-Ca(2+) exchange activity in canine pacing-induced heart failure. Circ Res 87 (2000) 690-698
25. Pogwizd S.M. Increased Na(+)-Ca(2+) exchanger in the failing heart. Circ Res 87 (2000) 641-643
26. Pogwizd S.M., Qi M., Yuan W., et al. Upregulation of Na(+)/Ca(2+) exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 85 (1999) 1009-1019
27. Wei S.K., Ruknudin A., Hanlon S.U., et al. Protein kinase A hyperphosphorylation increases basal current but decreases beta- adrenergic responsiveness of the sarcolemmal Na+-Ca2+ exchanger in failing pig myocytes. Circ Res 92 (2003) 897-903
28. Hatem S.N., Sham J.S., and Morad M. Enhanced Na(+)-Ca2+ exchange activity in cardiomyopathic Syrian hamster. Circ Res 74 (1994) 253-261
29. Cheng G., Hagen T.P., Dawson M.L., et al. The role of GATA, CArG, E-box, and a novel element in the regulation of cardiac expression of the Na+-Ca2+ exchanger gene. J Biol Chem 274 (1999) 12819-12826
30. Pikkarainen S., Tokola H., Kerkela R., et al. GATA transcription factors in the developing and adult heart. Cardiovasc Res 63 (2004) 196-207
31. Hirai M., Ono K., Morimoto T., et al. FOG-2 competes with GATA-4 for transcriptional coactivator p300 and represses hypertrophic responses in cardiac myocytes. J Biol Chem 279 (2004) 37640-37650
32. Lu J.R., McKinsey T.A., Xu H., et al. FOG-2, a heart- and brain-enriched cofactor for GATA transcription factors. Mol Cell Biol 19 (1999) 4495-4502
33. Svensson E.C., Tufts R.L., Polk C.E., et al. Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 in cardiomyocytes. Proc Natl Acad Sci U S A 96 (1999) 956-961
34. Molkentin J.D. The zinc finger-containing transcription factors GATA-4, -5, and - 6. Ubiquitously expressed regulators of tissue-specific gene expression. J Biol Chem 275 (2000) 38949-38952
35. Sabbah H.N., Stein P.D., Kono T., et al. A canine model of chronic heart failure produced by multiple sequential coronary microembolizations. Am J Physiol 260 (1991) H1379-H1384
36. Lee S.W., Wallick E.T., Schwartz A., et al. Influence of protein kinase phosphorylation on isolated sarcolemmal membranes. J Mol Cell Cardiol 17 (1985) 1085-1093
37. Mansier P., Charlemagne D., Rossi B., et al. Isolation of impermeable inside-out vesicles from an enriched sarcolemma fraction of rat heart. J Biol Chem 258 (1983) 6628-6635
38. Schoenmakers T.J., and Flik G. Sodium-extruding and calcium-extruding sodium/calcium exchangers display similar calcium affinities. J Exp Biol 168 (1992) 151-159
39. Gupta R.C., Mishra S., Mishima T., et al. Reduced sarcoplasmic reticulum Ca(2+)-uptake and expression of phospholamban in left ventricular myocardium of dogs with heart failure. J Mol Cell Cardiol 31 (1999) 1381-1389
40. Gupta R.C., Mishra S., Yang X.P., et al. Reduced inhibitor 1 and 2 activity is associated with increased protein phosphatase type 1 activity in left ventricular myocardium of one-kidney, one-clip hypertensive rats. Mol Cell Biochem 269 (2005) 49-57
41. Mishra S., Gupta R.C., Tiwari N., et al. Molecular mechanisms of reduced sarcoplasmic reticulum Ca(2+) uptake in human failing left ventricular myocardium. J Heart Lung Transplant 21 (2002) 366-373
42. Imai M., Rastogi S., Gupta R.C., et al. Therapy with cardiac contractility modulation electrical signals improves left ventricular function and remodeling in dogs with chronic heart failure. J Am Coll Cardiol 49 (2007) 2120-2128
43. Flesch M., Schwinger R.H., Schiffer F., et al. Evidence for functional relevance of an enhanced expression of the Na(+)- Ca2+ exchanger in failing human myocardium. Circulation 94 (1996) 992-1002
44. Studer R., Reinecke H., Bilger J., et al. Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure. Circ Res 75 (1994) 443-453
45. Mattiello J.A., Margulies K.B., Jeevanandam V., et al. Contribution of reverse-mode sodium-calcium exchange to contractions in failing human left ventricular myocytes. Cardiovasc Res 37 (1998) 424-431
46. Weber C.R., Piacentino III V., Houser S.R., et al. Dynamic regulation of sodium/calcium exchange function in human heart failure. Circulation 108 (2003) 2224-2229
47. Shao Q., Ren B., Elimban V., et al. Modification of sarcolemmal Na+-K+-ATPase and Na+/Ca2+ exchanger expression in heart failure by blockade of renin-angiotensin system. Am J Physiol Heart Circ Physiol 288 (2005) H2637-H2646
48. Dixon I.M., Hata T., and Dhalla N.S. Sarcolemmal calcium transport in congestive heart failure due to myocardial infarction in rats. Am J Physiol 262 (1992) H1387-H1394
49. Wagner J.A., Weisman H.F., Snowman A.M., et al. Alterations in calcium antagonist receptors and sodium-calcium exchange in cardiomyopathic hamster tissues. Circ Res 65 (1989) 205-214
50. Baartscheer A., Schumacher C.A., Belterman C.N., et al. [Na+]i and the driving force of the Na+/Ca2+-exchanger in heart failure. Cardiovasc Res 57 (2003) 986-995
51. Weisser-Thomas J., Piacentino III V., et al. Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes. Cardiovasc Res 57 (2003) 974-985
52. O'Rourke B., Kass D.A., Tomaselli G.F., et al. Mechanisms of altered excitation-contraction coupling in canine tachycardia- induced heart failure, I: experimental studies. Circ Res 84 (1999) 562-570
53. Wei S.K., Ruknudin A.M., Shou M., et al. Muscarinic modulation of the sodium-calcium exchanger in heart failure. Circulation 115 (2007) 1225-1233
54. Diedrichs H., Chi M., Boelck B., et al. Increased regulatory activity of the calcineurin/NFAT pathway in human heart failure. Eur J Heart Fail 6 (2004) 3-9