High levels of circulating epinephrine trigger apical cardiodepression in a β 2-adrenergic receptor/Gi-dependent manner: A new model of takotsubo cardiomyopathy

Circulation

Volumn 126, Issue 6, 2012, Pages 697-706

  Paur, Helen ^a   Wright, Peter T ^a   Sikkel, Markus B ^a   Tranter, Matthew H ^a   Mansfield, Catherine ^a   O'Gara, Peter ^a   Stuckey, Daniel J ^a   Nikolaev, Viacheslav O ^b   Diakonov, Ivan ^a   Pannell, Laura ^a   Gong, Haibin ^c   Sun, Hong ^d   Peters, Nicholas S ^a   Petrou, Mario ^d   Zheng, Zhaolun ^f   Gorelik, Julia ^a   Lyon, Alexander R ^a,e   Harding, Sian E ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^c Xuzhou Cardiovascular Disease Institute   (China)

^d XUZHOU MEDICAL UNIVERSITY   (China)

^e ROYAL BROMPTON HOSPITAL   (United Kingdom)

^f UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

acute heart failure; catecholamines; receptors, adrenergic, beta; Takotsubo syndrome

Indexed keywords

ADRENALIN; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; LEVOSIMENDAN; NORADRENALIN; PERTUSSIS TOXIN; PROPRANOLOL;

ACUTE HEART FAILURE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG MEGADOSE; HEART CONTRACTION; HEART MUSCLE CELL; HEART PROTECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INOTROPISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TAKOTSUBO CARDIOMYOPATHY;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EPINEPHRINE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; HUMANS; MALE; MYOCYTES, CARDIAC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA-2; SIGNAL TRANSDUCTION; TAKOTSUBO CARDIOMYOPATHY;

EID: 84864691520     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.111591     Document Type: Article

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