Bioconjugation strategies for label-free optical microcavity sensors

IEEE Journal on Selected Topics in Quantum Electronics

Volumn 20, Issue 2, 2014, Pages

  Hunt, Heather K ^a   Armani, Andrea M ^b  

^a UNIVERSITY OF MISSOURI   (United States)

^b University of Southern California   (United States)

Author keywords

biological techniques; Biophotonics; biosensors; nanobiotechnology; optical resonators

Indexed keywords

ACTIVE MOLECULES; BIO PHOTONICS; BIOLOGICAL TECHNIQUES; BIOMIMETIC CHEMISTRY; GRAFTING TECHNIQUES; OPTICAL MICROCAVITIES; PHYSICAL INTERACTIONS; PROTEIN ADSORPTION;

BIOLOGICAL MATERIALS; BIOMATERIALS; BIOMIMETICS; BIOMOLECULES; BIOSENSORS; CELL ADHESION; MICROCAVITIES; NANOBIOTECHNOLOGY; OPTICAL RESONATORS; PHOTONICS; SENSORS; SURFACE CHEMISTRY; TOOLS; WHISPERING GALLERY MODES;

CHEMICAL ANALYSIS;

EID: 84884574804     PISSN: 1077260X     EISSN: None     Source Type: Journal    
DOI: 10.1109/JSTQE.2013.2272916     Document Type: Article

References (107)

1. M. S. Luchansky and R. C. Bailey, "High-Q optical sensors for chemical and biological analysis," Anal. Chem., vol. 84, pp. 793-821, Jan. 2012.
2. H. K. Hunt and A. M. Armani, "Label-free biological and chemical sensors," Nanoscale, vol. 2, pp. 1544-1559, 2010.
3. M. S. Hanay, S. Kelber, A. K. Naik, D. Chi, S. Hentz, E. C. Bullard, E. Colinet, L. Duraffourg, and M. L. Roukes, "Single-protein nanomechanical mass spectrometry in real time," Nature Nanotechnol., vol. 7, pp. 602-608, Sep. 2012.
4. J. L. Arlett, E. B. Myers, andM. L. Roukes, "Comparative advantages of mechanical biosensors," Nature Nanotechnol., vol. 6, pp. 203-215, Apr. 2011.
5. P. Xie, Q. H. Xiong, Y. Fang, Q. Qing, and C. M. Lieber, "Local electrical potential detection of DNA by nanowire-nanopore sensors," Nature Nanotechnol., vol. 7, pp. 119-125, Feb. 2012.
6. H. J. Wu, J. Henzie, W. C. Lin, C. Rhodes, Z. Li, E. Sartorel, J. Thorner, P. D. Yang, and J. T. Groves, "Membrane-protein binding measured with solution-phase plasmonic nanocube sensors," Nature Methods, vol. 9, pp. 1189-1191, Dec. 2012.
7. B. Ilic, Y. Yang, and H. G. Craighead, "Virus detection using nanoelectromechanical devices," Appl. Phys. Lett., vol. 85, pp. 2604-2606, Sep. 2004.
8. Z. D. Harms, K. B. Mogensen, P. S. Nunes, K. M. Zhou, B. W. Hildenbrand, I. Mitra, Z. N. Tan, A. Zlotnick, J. P. Kutter, and S. C. Jacobson, "Nanofluidic devices with two pores in series for resistive-pulse sensing of single virus capsids," Anal. Chem., vol. 83, pp. 9573-9578, Dec. 2011.
9. A. Gupta, D. Akin, and R. Bashir, "Single virus particle mass detection using microresonators with nanoscale thickness," Appl. Phys. Lett., vol. 84, pp. 1976-1978, Mar. 2004.
10. G. G. Daaboul, C. A. Lopez, A. Yurt, B. B. Goldberg, J. H. Connor, and M. S. Unlu, "Label-free optical biosensors for virus detection and characterization," IEEE J. Sel. Topics Quantum Electron., vol. 18, no. 4, pp. 1422-1433, Jul./Aug. 2012.
11. T. P. Burg, M. Godin, S. M. Knudsen, W. Shen, G. Carlson, J. S. Foster, K. Babcock, and S. R. Manalis, "Weighing of biomolecules, single cells and single nanoparticles in fluid," Nature, vol. 446, pp. 1066-1069, 2007. (Pubitemid 46676057)
12. F. Vollmer and S. Arnold, "Whispering-gallery-mode biosensing: Labelfree detection down to single molecules," Nature Methods, vol. 5, pp. 591-596, Jul. 2008. (Pubitemid 351911861)
13. R. Roberts and J. Szostak, "RNA-peptide fusions for the in vitro selection of peptides and proteins," Proc. Nat. Acad. Sci. U.S.A., vol. 94, pp. 12297-12302, 1997. (Pubitemid 27492522)
14. S. S. Iqbal, M. W. Mayo, J. G. Bruno, B. V. Bronk, C. A. Batt, and J. P. Chambers, "A review of molecular recognition technologies for detection of biological threat agents," Biosens. Bioelectron., vol. 15, pp. 549-578, Dec. 2000.
15. C. C. Goodnow, C. G. Vinuesa, K. L. Randall, F. Mackay, and R. Brink, "Control systems and decision making for antibody production," Nature Immunol., vol. 11, pp. 681-688, Aug. 2010.
16. J. Lofblom, J. Feldwisch, V. Tolmachev, J. Carlsson, S. Stahl, and F. Y. Frejd, "Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications," FEBS Lett., vol. 584, pp. 2670-2680, Jun. 2010.
17. T. J. Hou, J. M. Wang, Y. Y. Li, and W. Wang, "Assessing the performance of the MM/PBSA and MM/GBSA methods-Part 1: The accuracy of binding free energy calculations based on molecular dynamics simulations," J. Chem. Inf. Model., vol. 51, pp. 69-82, Jan. 2011.
18. P. Kozma, A. Hamori, S. Kurunczi, K. Cottier, and R. Horvath, "Grating coupled optical waveguide interferometer for label-free biosensing," Sens. Actuators B, Chem., vol. 155, pp. 446-450, Jul. 2011.
19. A. Nitkowski, A. Baeumner, and M. Lipson, "On-chip spectrophotometry for bioanalysis using microring resonators," Biomed.Opt. Exp., vol. 2, pp. 271-277, Feb. 2011.
20. C. E. Soteropulos, H. K. Hunt, and A. M. Armani, "Determination of binding kinetics using whispering gallery mode microcavities," Appl. Phys. Lett., vol. 99, no. 10, p. 103703, Sep. 2011.
21. K. E. Zinoviev, A. B. Gonzalez-Guerrero, C. Dominguez, and L. M. Lechuga, "Integrated bimodal waveguide interferometric biosensor for label-free analysis," J. Lightw. Technol., vol. 29, no. 13, pp. 1926-1930, Jul. 2011.
22. X. D. Fan, I. M. White, S. I. Shopova, H. Y. Zhu, J. D. Suter, and Y. Z. Sun, "Sensitive optical biosensors for unlabeled targets: A review," Anal. Chim. Acta, vol. 620, pp. 8-26, Jul. 14, 2008.
23. M. L. Gorodetsky, A. A. Savchenkov, and V. S. Ilchenko, "Ultimate Q of optical microsphere resonators," Opt. Lett., vol. 21, pp. 453-455, Apr. 1, 1996. (Pubitemid 126572763)
24. D. W. Vernooy, V. S. Ilchenko, H. Mabuchi, E. W. Streed, and H. J. Kimble, "High-Q measurements of fused-silica microspheres in the near infrared," Opt. Lett., vol. 23, pp. 247-249, Feb. 15, 1998. (Pubitemid 128587550)
25. X. Zhang, H.-S. Choi, and A. M. Armani, "Ultimate quality factor of silica microtoroid resonant cavities," Appl. Phys. Lett., vol. 96, no. 15, p. 153304, 2010.
26. D. K. Armani, T. J. Kippenberg, S. M. Spillane, and K. J. Vahala, "Ultrahigh-Q toroidmicrocavity on a chip," Nature, vol. 421, pp. 925-928, Feb. 27, 2003.
27. T. Grossmann, S. Klinkhammer, M. Hauser, D. Floess, T. Beck, C. Vannahme, T. Mappes, U. Lemmer, and H. Kalt, "Strongly confined, low-threshold laser modes in organic semiconductor microgoblets," Opt. Exp., vol. 19, pp. 10009-10016, May 2011.
28. Y. Okawachi, K. Saha, J. S. Levy,Y. H.Wen, M. Lipson, andA. L.Gaeta, "Octave-spanning frequency comb generation in a silicon nitride chip," Opt. Lett., vol. 36, pp. 3398-3400, Sep. 2011.
29. H. Lee, T. Chen, J. Li, K. Y. Yang, S. Jeon, O. Painter, and K. J. Vahala Painter, "Chemically etched ultrahigh-Q wedge-resonator on a silicon chip," Nature Photon., vol. 6, pp. 369-373, Jun. 2012.
30. M. Chistiakova and A. M. Armani, "Cascaded Raman microlaser in air and buffer," Opt. Lett., vol. 37, pp. 4068-4070, 2012.
31. V. R. Almeida, C. A. Barrios, R. R. Panepucci, and M. Lipson, "Alloptical control of light on a silicon chip," Nature, vol. 431, pp. 1081-1084, Oct. 2004. (Pubitemid 39480684)
32. P. Del'Haye, A. Schliesser, O. Arcizet, T. Wilken, R. Holzwarth, and T. J. Kippenberg, "Optical frequency comb generation from a monolithic microresonator," Nature, vol. 450, pp. 1214-1217, Dec. 20, 2007.
33. A. L. Washburn, M. S. Luchansky, A. L. Bowman, and R. C. Bailey, "Quantitative, label-free detection of five protein biomarkers using multiplexed arrays of silicon photonic microring resonators," Anal. Chem., vol. 82, pp. 69-72, 2010.
34. C. Shi, S. Mehrabani, and A. M. Armani, "Leveraging bimodal kinetics to improve detection specificity," Opt. Lett., vol. 37, pp. 1643-1645, May 2012.
35. K. A. Wilson, C. A. Finch, P. Anderson, F. Vollmer, and J. J. Hickman, "Whispering gallerymode biosensor quantification of fibronectin adsorption kinetics onto alkylsilane monolayers and interpretation of resultant cellular response," Biomaterials, vol. 33, pp. 225-236, 2012.
36. M. I. Cheema, S. Mehrabani, Y.-A. Peter, A. M. Armani, and A. G. Kirk, "Simultaneous measurement of quality factor and wavelength shift by phase shift microcavity ring down spectroscopy," Opt. Exp., vol. 20, pp. 9090-9098, 2012.
37. J. L. Guesdon, T. Ternynck, and S. Avrameas, "Use of avidin-biotin interaction in immunoenzymatic techniques," J. Histochem. Cytochem., vol. 27, pp. 1131-1139, 1979. (Pubitemid 9246245)
38. J. V. Ravetch and J. P.Kinet, "Fc-receptors," Annu. Rev. Immunol., vol. 9, pp. 457-492, 1991.
39. V. T. Moy, E. L. Florin, and H. E. Gaub, "Intermolecular forces and energies between ligands and receptors," Science, vol. 266, pp. 257-259, Oct. 1994. (Pubitemid 24343509)
40. R. G. Chapman, E. Ostuni, M. N. Liang, G. Meluleni, E. Kim, L. Yan, G. Pier, H. S. Warren, and G. M. Whitesides, E. Ostuni, M. N. Liang, G. Meluleni, E. Kim, L. Yan et al., "Polymeric thin films that resist the adsorption of proteins and the adhesion of bacteria," Langmuir, vol. 17, pp. 1225-1233, Feb. 2001. (Pubitemid 32252615)
41. R. G. Chapman, E. Ostuni, L. Yan, and G. M. Whitesides, "Preparation of mixed self-assembled monolayers (SAMs) that resist adsorption of proteins using the reaction of amines with a SAM that presents interchain carboxylic anhydride groups," Langmuir, vol. 16, pp. 6927-6936, Aug. 2000.
42. A. Halperin, "Polymer brushes that resist adsorption of model proteins: Design parameters," Langmuir, vol. 15, pp. 2525-2533, Mar. 1999.
43. E. Ostuni, R. G. Chapman, M. N. Liang, G. Meluleni, G. Pier, D. E. Ingber, and G. M. Whitesides, "Self-assembled monolayers that resist the adsorption of proteins and the adhesion of bacterial and mammalian cells," Langmuir, vol. 17, pp. 6336-6343, Oct. 2001. (Pubitemid 35330713)
44. W. Senaratne, L. Andruzzi, and C. K. Ober, "Self-assembled monolayers and polymer brushes in biotechnology: Current applications and future perspectives," Biomacromolecules, vol. 6, pp. 2427-2448, Sep./Oct. 2005. (Pubitemid 41397904)
45. H. Therien-Aubin, L. Chen, and C. K. Ober, "Fouling-resistant polymer brush coatings," Polymer, vol. 52, pp. 5419-5425, Nov. 2011.
46. R. Barbey, L. Lavanant, D. Paripovic, N. Scḧuwer, C. Sugnaux, S. Tugulu, and H. A. Klok, "Polymer brushes via surface-initiated controlled radical polymerization: Synthesis, characterization, properties, and applications," Chem. Rev., vol. 109, pp. 5437-5527, 2009.
47. A. Halperin, "Polymer brushes that resist adsorption of model proteins: Design parameters," Langmuir, vol. 15, pp. 2525-2533, Mar. 1, 1999.
48. B. Zhao and W. J. Brittain, "Polymer brushes: Surface-immobilized macromolecules," Progr. Polymer Sci., vol. 25, pp. 677-710, 2000.
49. R. E. Holmlin, X. X. Chen, R. G. Chapman, S. Takayama, and G. M. Whitesides, "Zwitterionic SAMs that resist nonspecific adsorption of protein from aqueous buffer," Langmuir, vol. 17, pp. 2841-2850, May 2001. (Pubitemid 35330542)
50. X. S. Jiang, D. Y. Li,X.Xu,Y. B.Ying,Y. B. Li, Z. Z.Ye, and J. P.Wang, "Immunosensors for detection of pesticide residues," Biosens. Bioelectron., vol. 23, pp. 1577-1587, Jun. 15, 2008.
51. M. Y.Wei and L. H. Guo, "Advances in the determination of environmental pollutants by immunosensors," Progr. Chem., vol. 21, pp. 492-502, Mar. 2009.
52. R. S. Cantor, "Lipid composition and the lateral pressure profile in bilayers," Biophys. J., vol. 76, pp. 2625-2639, May 1999. (Pubitemid 29264622)
53. E. T. Castellana and P. S. Cremer, "Solid supported lipid bilayers: From biophysical studies to sensor design," Surface Sci. Reports, vol. 61, pp. 429-444, Nov. 2006. (Pubitemid 44634133)
54. D. Falconnet, G. Csucs, H. M. Grandin, and M. Textor, "Surface engineering approaches to micropattern surfaces for cell-based assays," Biomaterials, vol. 27, pp. 3044-3063, Jun. 2006. (Pubitemid 43247579)
55. W. M. Gelbart and A. BenShaul, "The "new" science of "complex fluids"," J. Phys. Chem., vol. 100, pp. 13169-13189, Aug. 1996.
56. R. Goetz, G. Gompper, and R. Lipowsky, "Mobility and elasticity of self-assembled membranes," Phys. Rev. Lett., vol. 82, pp. 221-224, Jan. 1999. (Pubitemid 129661990)
57. C. A. Keller and B. Kasemo, "Surface specific kinetics of lipid vesicle adsorption measured with a quartz crystal microbalance," Biophys. J., vol. 75, pp. 1397-1402, Sep. 1998. (Pubitemid 28397608)
58. H. Lang, C. Duschl, and H. Vogel, "A new class of thiolipids for the attachment of lipid bilayers on gold surfaces," Langmuir, vol. 10, pp. 197-210, Jan. 1994.
59. B. D. Ratner and S. J. Bryant, "Biomaterials: Where we have been and where we are going," Annu. Rev. Biomed. Eng., vol. 6, pp. 41-75, 2004. (Pubitemid 39209492)
60. R. R. Rye, G. C. Nelson, and M. T. Dugger, "Mechanistic aspects of alkylchlorosilane coupling reactions," Langmuir, vol. 13, pp. 2965-2972, May 28, 1997. (Pubitemid 127604408)
61. M. J. Stevens, "Thoughts on the structure of alkylsilane monolayers," Langmuir, vol. 15, pp. 2773-2778, Mar. 1999.
62. J. Parvole, G. Laruelle, C. Guimon, J. Francois, and L. Billon, "Initiatorgrafted silica particles for controlled free radical polymerization: Influence of the initiator structure on the grafting density," Macromolecular Rapid Commun., vol. 24, pp. 1074-1078, 2003.
63. A.Walcarius, M. Etienne, and B. Lebeau, "Rate of access to the binding sites in organically modified silicates-Part 2: Ordered mesoporous silicas grafted with amine or thiol groups," Chem.Mater., vol. 15, pp. 2161-2173, May 2003.
64. T. Porstmann and S. T. Kiessig, "Enzyme immunoassay techniques. An overview," J. Immunol. Methods, vol. 150, pp. 5-21, 1992.
65. T. P. Sullivan and W. T. S. Huck, "Reactions on monolayers: Organic synthesis in two dimensions," Eur. J. Organic Chem., vol. 2003, pp. 17-29, 2003.
66. P. R. Edwards, A. Gill, D. V. Pollard-Knight, M. Hoare, P. E. Buckle, P. A. Lowe, and R. J. Leatherbarrow, "Kinetics of protein-protein interactions at the surface of an optical biosensor," Anal. Biochem., vol. 231, pp. 210-217, 1995.
67. T. Wu, K. Efimenko, P. Vlcek, V. Subr, and J. Genzer, "Formation and properties of anchored polymers with a gradual variation of grafting densities on flat substrates," Macromolecules, vol. 36, pp. 2448-2453, Apr. 2003.
68. R. R. Bhat, M. R. Tomlinson, T. Wu, and J. Genzer, "Surface-grafted polymer gradients: Formation, characterization, and applications," in Surface-Initiated Polymerization II, vol. 198, R. Jordan, Ed. Berlin, Germany: Springer-Verlag, 2006, pp. 51-124.
69. S. J. Sofia, V. Premnath, and E. W. Merrill, "Poly(ethylene oxide) grafted to silicon surfaces: Grafting density and protein adsorption," Macromolecules, vol. 31, pp. 5059-5070, Jul. 1998. (Pubitemid 128565524)
70. H. K. Hunt, C. Soteropulos, and A. M. Armani, "Bioconjugation strategies for microtoroidal optical resonators," Sensors, vol. 10, pp. 9317-9336, Oct. 2010.
71. A. Arafat, M. Giesbers, M. Rosso, E. J. R. Sudḧolter, K. Schröen, R. G. White et al., "Covalent biofunctionalization of silicon nitride surfaces," Langmuir, vol. 23, pp. 6233-6244, 2007. (Pubitemid 46868695)
72. R. K. Manova, S. P. Pujari, C. A. Weijers, H. Zuilhof, and T. A. v. Beek, "Copper-free click biofunctionalization of silicon nitride surfaces via strain-promoted alkyne-azide cycloaddition reactions," Langmuir, vol. 28, pp. 8651-8663, 2012.
73. D. Caballero, E. Martinez, J. Bausells, A. Errachid, and J. Samitier, "Impedimetric immunosensor for human serum albumin detection on a direct aldehyde-functionalized silicon nitride surface," Anal. Chim. Acta., vol. 720, pp. 43-48, 2012.
74. N. Patel, M. C. Davies, M. Hartshorne, R. J. Heaton, C. J. Roberts, S. J. B. Tendler, and P. M. Williams, "Immobilization of protein molecules onto homogeneous and mixed carboxylate-terminated selfassembled monolayers," Langmuir, vol. 13, pp. 6485-6490, Nov. 1997. (Pubitemid 127592064)
75. E. Huang, F. M. Zhou, and L. Deng, "Studies of surface coverage and orientation of DNA molecules immobilized onto preformed alkanethiol self-assembled monolayers," Langmuir, vol. 16, pp. 3272-3280, Apr. 2000. (Pubitemid 30581121)
76. B. W. Biggs, H. K. Hunt, and A. M. Armani, "Selective patterning of Si-based biosensor surfaces using isotropic silicon etchants," J. Colloid Interface Sci., vol. 369, pp. 477-481, Mar. 2012.
77. H. K. Hunt and A. M. Armani, "Recycling microcavity optical biosensors," Opt. Lett., vol. 36, pp. 1092-1094, Apr. 2011.
78. J. P. Cloarec, N. Deligianis, J. R. Martin, I. Lawrence, E. Souteyrand, C. Polychronakos, and M. F. Lawrence, "Immobilization of homooligonucleotide probe layers onto Si/SiO2 substrates: Characterization by electrochemical impedance measurements and radiolabelling," Biosens. Bioelectron., vol. 17, pp. 405-412, May 2002. (Pubitemid 34219139)
79. T. Bocking, K. A. Killan, K. Gaus, and J. J. Gooding, "Single-step DNA immobilization on antifouling self-assembled monolayers covalently bound to silicon (111)," Langmuir, vol. 22, pp. 3494-3496, Apr. 2006. (Pubitemid 43672516)
80. K. Hernandez and R. Fernandez-Lafuente, "Control of protein immobilization: Coupling immobilization and site-directed mutagenesis to improve biocatalyst or biosensor performance," Enzyme Microbial Technol., vol. 48, pp. 107-122, Feb. 2011.
81. H. C. Kolb, M. G. Finn, and K. B. Sharpless, "Click chemistry: Diverse chemical function from a few good reactions," Angew. Chem. Int. Ed. Engl., vol. 40, pp. 2004-2021, 2001.
82. P.Wu, A. K. Feldman, A. K. Nugent, C. J. Hawker, A. Scheel, B. Voit, J. Pyun, J. M. J. Frechet, K. B. Sharpless, and V. V. Fokin, "Efficiency and fidelity in a click-chemistry route to triazole dendrimers by the copper(I)-catalyzed ligation of azides and alkynes," Angew. Chem. Int. Ed. Engl., vol. 43, pp. 3928-3932, 2004. (Pubitemid 39257472)
83. F. Himo, T. Lovell, R. Hilgraf, V. V. Rostovtsev, L. Noodleman, K. B. Sharpless, and V. V. Fokin, "Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates," J. Amer. Chem. Soc., vol. 127, pp. 210-216, Jan. 2005. (Pubitemid 40094384)
84. S. Narayan, J. Muldoon, M. G. Finn, V. V. Fokin, H. C. Kolb, and K. B. Sharpless, ""On water": Unique reactivity of organic compounds in aqueous suspension," Angew. Chem. Int. Ed. Engl., vol. 44, pp. 3275-3279, 2005. (Pubitemid 40778352)
85. B. P. Duckworth, J. H. Xu, T. A. Taton, A. Guo, and M. D. Distefano, "Site-specific, covalent attachment of proteins to a solid surface," Bioconjugate Chem., vol. 17, pp. 967-974, Jul. 2006. (Pubitemid 44162615)
86. X. L. Sun, C. L. Stabler, C. S. Cazalis, and E. L. Chaikof, "Carbohydrate and protein immobilization onto solid surfaces by sequential Diels-Alder and azide-alkyne cycloadditions," Bioconjugate Chem., vol. 17, pp. 52-57, Jan./Feb. 2006. (Pubitemid 43157584)
87. S. Ciampi, T. Bocking, K. A. Kilian, M. James, J. B. Harper, and J. J. Gooding, "Functionalization of acetylene-terminated monolayers on Si(100) surfaces: A click chemistry approach," Langmuir, vol. 23, pp. 9320-9329, Aug. 2007. (Pubitemid 47383520)
88. P. V. Chang, J. A. Prescher, E. M. Sletten, J. M. Baskin, I. A. Miller, N. J. Agard, A. Lo, and C. R. Bertozzi, "Copper-free click chemistry in living animals," Proc. Nat. Acad. Sci., vol. 107, pp. 1821-1826, Jan. 14, 2010.
89. J.-Y. Byeon, F. T. Limpoco, and R. C. Bailey, "Efficient bioconjugation of protein capture agenst to biosensor surfaces using aniline-catalyzed hydrazone ligation," Langmuir, vol. 26, pp. 15430-15435, 2010.
90. J. F. Nagle and S. Tristram-Nagle, "Structure of lipid bilayers," Biochim. Biophys. Acta-Rev. Biomembranes, vol. 1469, pp. 159-195, Nov. 2000.
91. A. V. Samsonov, I. Mihalyov, and F. S. Cohen, "Characterization of cholesterol-sphingomyelin domains and their dynamics in bilayer membranes," Biophys. J., vol. 81, pp. 1486-1500, Sep. 2001. (Pubitemid 32783589)
92. J. Salafsky, J. T. Groves, and S. G. Boxer, "Architecture and function of membrane proteins in planar supported bilayers: A study with photosynthetic reaction centers," Biochemistry, vol. 35, pp. 14773-14781, Nov. 1996. (Pubitemid 26423810)
93. E. Reimhult, F. Hook, and B. Kasemo, "Intact vesicle adsorption and supported biomembrane formation from vesicles in solution: Influence of surface chemistry, vesicle size, temperature, and osmotic pressure," Langmuir, vol. 19, pp. 1681-1691, Mar. 2003.
94. L. M. Freeman, S. Li, Y. Dayani, H. S. Choi, N. Malmstadt, and A. M. Armani, "Excitation of Cy5 in self-assembled lipid bilayers using optical microresonators," Appl. Phys. Lett., vol. 98, no. 15, p. 143703, Apr. 2011.
95. L. M. Freeman and A. M. Armani, "Photobleaching of Cy5 conjugated lipid bilayers determined with optical microresonators," IEEE J. Select. Topics Quantum Electron., vol. 18, no. 3, pp. 1160-1165, May/Jun. 2012.
96. T. L. Clare, B. H. Clare, B. M. Nichols, N. L. Abbott, and R. J. Hamers, "Functional monolayers for improved resistance to protein adsorption: Oligo(ethylene glycol)-modified silicon and diamond surfaces," Langmuir, vol. 21, pp. 6344-6355, Jul. 2005. (Pubitemid 41006449)
97. D. Leckband, S. Sheth, and A. Halperin, "Grafted poly(ethylene oxide) brushes as nonfouling surface coatings," J. Biomater. Sci.-Polymer Ed., vol. 10, pp. 1125-1147, 1999.
98. C. Zhao, L. Y. Li, M. M. Guo, and J. Zheng, "Functional polymer thin films designed for antifouling materials and biosensors," Chem. Papers, vol. 66, pp. 323-339, Jun. 2012.
99. S. F. Chen, L. Y. Li, C. Zhao, and J. Zheng, "Surface hydration: Principles and applications toward low-fouling/nonfouling biomaterials," Polymer, vol. 51, pp. 5283-5293, Oct. 2010.
100. E. Ostuni, R. G. Chapman, R. E. Holmlin, S. Takayama, and G. M. Whitesides, "A survey of structure-property relationships of surfaces that resist the adsorption of protein," Langmuir, vol. 17, pp. 5605-5620, 2001. (Pubitemid 35330800)
101. S. F. Chen,Z. Q.Cao, and S. Y. Jiang, "Ultra-lowfouling peptide surfaces derived from natural amino acids," Biomaterials, vol. 30, pp. 5892-5896, Oct. 2009.
102. C. E. Soteropulos, K. M. Zurick, M. T. Bernards, and H. K. Hunt, "Tailoring the protein adsorption properties of whispering gallery mode optical biosensors," Langmuir, vol. 28, pp. 15743-15750, Nov. 06, 2012.
103. A. Gaulton, L. J. Bellis, A. P. Bento, J. Chambers, M. Davies, A. Hersey, Y. Light, S. McGlinchey, D. Michalovich, B. Al-Lazikani, and J. P. Overington, "ChEMBL: A large-scale bioactivity database for drug discovery," Nucleic Acids Res., vol. 40, pp. D1100-D1107, Jan. 2012.
104. A. B. Iliuk, L. H. Hu, and W. A. Tao, "Aptamer in bioanalytical applications," Anal. Chem., vol. 83, pp. 4440-4452, Jun. 2011.
105. R. Liu, J. Barrick, J. Szostak, and R. Roberts, "Optimized synthesis of RNA-protein fusions for in vitro protein selection," Methods Enzymology, vol. 318, pp. 268-293, 2000. (Pubitemid 30421654)
106. D. S.Wilson, A. D. Keefe, and J. W. Szostak, "The use of mRNA display to select high-affinity protein-binding peptides," Proc. Nat. Acad. Sci. U.S.A., vol. 98, pp. 3750-3755, Mar. 2001. (Pubitemid 32249843)
107. E. D. Lobo, R. J. Hansen, and J. P. Balthasar, "Antibody pharmacokinetics and pharmacodynamics," J. Pharmaceutical Sci., vol. 93, pp. 2645-2668, Nov. 2004. (Pubitemid 39506617)