Tumor necrosis factor inhibition modulates thrombospondin-1 expression in human inflammatory joint disease through altered nr4a2 activity

American Journal of Pathology

Volumn 183, Issue 4, 2013, Pages 1243-1257

  McMorrow, Jason P ^a   Crean, Daniel ^a   Gogarty, Martina ^a   Smyth, Aisling ^a   Connolly, Mary ^a,b   Cummins, Eoin ^a   Veale, Douglas ^a,b   Fearon, Ursula ^a,b   Tak, Paul P ^c   Fitzgerald, Oliver ^a,b   Murphy, Evelyn P ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MESSENGER RNA; NUCLEAR RECEPTOR RELATED FACTOR 1; THROMBOSPONDIN 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR ETS 2; TUMOR NECROSIS FACTOR;

ADULT; AGED; ARTICLE; BIOINFORMATICS; CELL HYPOXIA; CELL IMMORTALIZATION; CHRONIC INFLAMMATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA BINDING; FIBROBLAST; GENE DELETION; GENE REPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RHEUMATOID ARTHRITIS; SYNOVIOCYTE; SYNOVIUM; THERAPY EFFECT; TISSUE DISTRIBUTION; TRANSCRIPTION REGULATION; TREATMENT RESPONSE;

ADULT; AGED; AGED, 80 AND OVER; ANGIOGENESIS INDUCING AGENTS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; DNA; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; JOINTS; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 4, GROUP A, MEMBER 2; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SYNOVIAL MEMBRANE; THROMBOSPONDIN 1; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84884568692     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2013.06.029     Document Type: Article

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