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Volumn 39, Issue 2, 2011, Pages 688-693

Inflammation: A role for NR4A orphan nuclear receptors?

Author keywords

Acute inflammation; Angiogenesis; Chronic inflammation; Cytokine; Macrophage polarization; Nuclear receptor

Indexed keywords

DEXAMETHASONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH FACTOR; MERCAPTOPURINE; METHOTREXATE; NUCLEAR RECEPTOR NR4A3; NUCLEAR RECEPTOR NUR77; NUCLEAR RECEPTOR RELATED FACTOR 1; PROSTAGLANDIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

EID: 79953180610     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0390688     Document Type: Review
Times cited : (138)

References (50)
  • 1
    • 0348222661 scopus 로고    scopus 로고
    • Adenosine: An endogenous regulator of innate immunity
    • Hasko, G. and Cronstein, B. N. (2004) Adenosine: an endogenous regulator of innate immunity. Trends Immunol. 25, 33-39
    • (2004) Trends Immunol. , vol.25 , pp. 33-39
    • Hasko, G.1    Cronstein, B.N.2
  • 2
    • 0037265240 scopus 로고    scopus 로고
    • Alternative activation of macrophages
    • Gordon, S. (2003) Alternative activation of macrophages. Nat. Rev. Immunol. 3, 23-35
    • (2003) Nat. Rev. Immunol. , vol.3 , pp. 23-35
    • Gordon, S.1
  • 3
    • 73249125200 scopus 로고    scopus 로고
    • Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis
    • Bartok, B. and Firestein, G. S. (2010) Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol. Rev. 233, 233-255
    • (2010) Immunol. Rev. , vol.233 , pp. 233-255
    • Bartok, B.1    Firestein, G.S.2
  • 4
    • 0034545158 scopus 로고    scopus 로고
    • The pathogenesis and prevention of joint damage in rheumatoid arthritis: Advances from synovial biopsy and tissue analysis
    • DOI 10.1002/1529-0131(200012)43:12<2619::AID-ANR1>3.0.CO;2-V
    • Tak, P.P. and Bresnihan, B. (2000) The pathogenesis and prevention of joint damage in rheumatoid arthritis: advances from synovial biopsy and tissue analysis. Arthritis Rheum. 43, 2619-2633 (Pubitemid 32001727)
    • (2000) Arthritis and Rheumatism , vol.43 , Issue.12 , pp. 2619-2633
    • Tak, P.P.1    Bresnihan, B.2
  • 5
    • 0032091809 scopus 로고    scopus 로고
    • Review: Angiogenesis: Implications for rheumatoid arthritis
    • Koch, A.E. (1998) Review: angiogenesis: implications for rheumatoid arthritis. Arthritis Rheum. 41, 951-962
    • (1998) Arthritis Rheum. , vol.41 , pp. 951-962
    • Koch, A.E.1
  • 6
    • 34249720998 scopus 로고    scopus 로고
    • Cytokines in the pathogenesis of rheumatoid arthritis
    • McInnes, I.B. and Schett, G. (2007) Cytokines in the pathogenesis of rheumatoid arthritis. Nat. Rev. Immunol. 7, 429-442
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 429-442
    • McInnes, I.B.1    Schett, G.2
  • 7
    • 55849095891 scopus 로고    scopus 로고
    • Evidence that cytokines play a role in rheumatoid arthritis
    • Brennan, F.M. and McInnes, I.B. (2008) Evidence that cytokines play a role in rheumatoid arthritis. J. Clin. Invest. 118, 3537-3545
    • (2008) J. Clin. Invest. , vol.118 , pp. 3537-3545
    • Brennan, F.M.1    McInnes, I.B.2
  • 8
  • 9
    • 33646684974 scopus 로고    scopus 로고
    • Cardiovascular disease in rheumatoid arthritis
    • Kaplan, M.J. (2006) Cardiovascular disease in rheumatoid arthritis. Curr. Opin. Rheumatol. 18, 289-297
    • (2006) Curr. Opin. Rheumatol. , vol.18 , pp. 289-297
    • Kaplan, M.J.1
  • 10
    • 14244258610 scopus 로고    scopus 로고
    • Psoriasis pathophysiology: Current concepts of pathogenesis
    • Krueger, J.G. and Bowcock, A. (2005) Psoriasis pathophysiology: current concepts of pathogenesis. Ann. Rheum. Dis. 64 (Suppl. 2), ii30-ii36
    • (2005) Ann. Rheum. Dis. , vol.64 , Issue.SUPPL. 2
    • Krueger, J.G.1    Bowcock, A.2
  • 11
    • 0029150307 scopus 로고
    • Intralesional T-lymphocyte activation as a mediator of psoriatic epidermal hyperplasia
    • Bata-Csorgo, Z., Hammerberg, C., Voorhees, J.J. and Cooper, K.D. (1995) Intralesional T-lymphocyte activation as a mediator of psoriatic epidermal hyperplasia. J. Invest. Dermatol. 105, 89S-94S
    • (1995) J. Invest. Dermatol. , vol.105
    • Bata-Csorgo, Z.1    Hammerberg, C.2    Voorhees, J.J.3    Cooper, K.D.4
  • 12
    • 0030716227 scopus 로고    scopus 로고
    • Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin
    • Wrone-Smith, T., Mitra, R.S., Thompson, C.B., Jasty, R., Castle, V.P. and Nickoloff, B.J. (1997) Keratinocytes derived from psoriatic plaques are resistant to apoptosis compared with normal skin. Am. J. Pathol. 151, 1321-1329
    • (1997) Am. J. Pathol. , vol.151 , pp. 1321-1329
    • Wrone-Smith, T.1    Mitra, R.S.2    Thompson, C.B.3    Jasty, R.4    Castle, V.P.5    Nickoloff, B.J.6
  • 13
    • 5644304287 scopus 로고    scopus 로고
    • Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate
    • DOI 10.1002/art.20518
    • Kane, D., Gogarty, M., O'Leary, J., Silva, I., Bermingham, N., Bresnihan, B. and FitzGerald, O. (2004) Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 50, 3286-3295 (Pubitemid 39372006)
    • (2004) Arthritis and Rheumatism , vol.50 , Issue.10 , pp. 3286-3295
    • Kane, D.1    Gogarty, M.2    O'Leary, J.3    Silva, I.4    Bermingham, N.5    Bresnihan, B.6    FitzGerald, O.7
  • 16
    • 47949094965 scopus 로고    scopus 로고
    • Integration of metabolism and inflammation by lipid-activated nuclear receptors
    • Bensinger, S.J. and Tontonoz, P. (2008) Integration of metabolism and inflammation by lipid-activated nuclear receptors. Nature 454, 470-477
    • (2008) Nature , vol.454 , pp. 470-477
    • Bensinger, S.J.1    Tontonoz, P.2
  • 17
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer, N. and Tontonoz, P. (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 116, 607-614
    • (2006) J. Clin. Invest. , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 18
    • 0037126018 scopus 로고    scopus 로고
    • Protective function of transcription factor TR3 orphan receptor in atherogenesis: Decreased lesion formation in carotid artery ligation model in TR3 transgenic mice
    • Arkenbout, E.K., de Waard, V., van Bragt, M., van Achterberg, T.A., Grimbergen, J.M., Pichon, B., Pannekoek, H. and de Vries, C.J. (2002) Protective function of transcription factor TR3 orphan receptor in atherogenesis: decreased lesion formation in carotid artery ligation model in TR3 transgenic mice. Circulation 106, 1530-1535
    • (2002) Circulation , vol.106 , pp. 1530-1535
    • Arkenbout, E.K.1    De Waard, V.2    Van Bragt, M.3    Van Achterberg, T.A.4    Grimbergen, J.M.5    Pichon, B.6    Pannekoek, H.7    De Vries, C.J.8
  • 22
    • 77956650878 scopus 로고    scopus 로고
    • NR4A orphan nuclear receptors in cardiovascular biology
    • Zhao, Y. and Bruemmer, D. (2009) NR4A orphan nuclear receptors in cardiovascular biology. Drug Discovery Today Dis. Mech. 6, e43-e48
    • (2009) Drug Discovery Today Dis. Mech. , vol.6
    • Zhao, Y.1    Bruemmer, D.2
  • 23
    • 46149104979 scopus 로고    scopus 로고
    • Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines
    • Doi, Y., Oki, S., Ozawa, T., Hohjoh, H., Miyake, S. and Yamamura, T. (2008) Orphan nuclear receptor NR4A2 expressed in T cells from multiple sclerosis mediates production of inflammatory cytokines. Proc. Natl. Acad. Sci. U.S.A. 105, 8381-8386
    • (2008) Proc. Natl. Acad. Sci. U.S.A. , vol.105 , pp. 8381-8386
    • Doi, Y.1    Oki, S.2    Ozawa, T.3    Hohjoh, H.4    Miyake, S.5    Yamamura, T.6
  • 25
    • 33645411885 scopus 로고    scopus 로고
    • Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77
    • Pei, L., Castrillo, A. and Tontonoz, P. (2006) Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol. Endocrinol. 20, 786-794
    • (2006) Mol. Endocrinol. , vol.20 , pp. 786-794
    • Pei, L.1    Castrillo, A.2    Tontonoz, P.3
  • 26
    • 0035052486 scopus 로고    scopus 로고
    • Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis
    • DOI 10.1002/1529-0131(200104)44:4<782::AID-ANR134>3.0.CO;2-H
    • Murphy, E.P., McEvoy, A., Conneely, O.M., Bresnihan, B. and FitzGerald, O. (2001) Involvement of the nuclear orphan receptor NURR1 in the regulation of corticotropin-releasing hormone expression and actions in human inflammatory arthritis. Arthritis Rheum. 44, 782-793 (Pubitemid 32319770)
    • (2001) Arthritis and Rheumatism , vol.44 , Issue.4 , pp. 782-793
    • Murphy, E.P.1    McEvoy, A.2    Conneely, O.M.3    Bresnihan, B.4    Fitzgerald, O.5
  • 27
    • 23844468795 scopus 로고    scopus 로고
    • Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli
    • Pei, L., Castrillo, A., Chen, M., Hoffmann, A. and Tontonoz, P. (2005) Induction of NR4A orphan nuclear receptor expression in macrophages in response to inflammatory stimuli. J. Biol. Chem. 280, 29256-29262
    • (2005) J. Biol. Chem. , vol.280 , pp. 29256-29262
    • Pei, L.1    Castrillo, A.2    Chen, M.3    Hoffmann, A.4    Tontonoz, P.5
  • 28
    • 70349443394 scopus 로고    scopus 로고
    • Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis
    • Aherne, C.M., McMorrow, J., Kane, D., FitzGerald, O., Mix, K.S. and Murphy, E.P. (2009) Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol. Immunol. 46, 3345-3357
    • (2009) Mol. Immunol. , vol.46 , pp. 3345-3357
    • Aherne, C.M.1    McMorrow, J.2    Kane, D.3    FitzGerald, O.4    Mix, K.S.5    Murphy, E.P.6
  • 29
    • 0042591275 scopus 로고    scopus 로고
    • Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1
    • Ordentlich, P., Yan, Y., Zhou, S. and Heyman, R.A. (2003) Identification of the antineoplastic agent 6-mercaptopurine as an activator of the orphan nuclear hormone receptor Nurr1. J. Biol. Chem. 278, 24791-24799
    • (2003) J. Biol. Chem. , vol.278 , pp. 24791-24799
    • Ordentlich, P.1    Yan, Y.2    Zhou, S.3    Heyman, R.A.4
  • 31
    • 0028909238 scopus 로고
    • Long-term methotrexate therapy in psoriatic arthritis: Clinical and radiological outcome
    • Abu-Shakra, M., Gladman, D.D., Thorne, J.C., Long, J., Gough, J. and Farewell, V.T. (1995) Long-term methotrexate therapy in psoriatic arthritis: clinical and radiological outcome. J. Rheumatol. 22, 241-245
    • (1995) J. Rheumatol. , vol.22 , pp. 241-245
    • Abu-Shakra, M.1    Gladman, D.D.2    Thorne, J.C.3    Long, J.4    Gough, J.5    Farewell, V.T.6
  • 32
    • 0031887318 scopus 로고    scopus 로고
    • Longterm prospective study of methotrexate in rheumatoid arthritis: Conclusion after 132 months of therapy
    • Weinblatt, M.E., Maier, A.L., Fraser, P.A. and Coblyn, J.S. (1998) Long-term prospective study of methotrexate in rheumatoid arthritis: conclusion after 132 months of therapy. J. Rheumatol. 25, 238-242 (Pubitemid 28088249)
    • (1998) Journal of Rheumatology , vol.25 , Issue.2 , pp. 238-242
    • Weinblatt, M.E.1    Maier, A.L.2    Fraser, P.A.3    Coblyn, J.S.4
  • 33
    • 0029896521 scopus 로고    scopus 로고
    • Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation
    • DOI 10.1002/art.1780390608
    • Boyle, D.L., Sajjadi, F.G. and Firestein, G.S. (1996) Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum. 39, 923-930 (Pubitemid 26182059)
    • (1996) Arthritis and Rheumatism , vol.39 , Issue.6 , pp. 923-930
    • Boyle, D.L.1    Sajjadi, F.G.2    Firestein, G.S.3
  • 34
    • 0031790420 scopus 로고    scopus 로고
    • Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes
    • DOI 10.1002/1529-0131(199811)41:11<2032::AID-ART19>3.0.CO;2-J
    • Seitz, M., Zwicker, M. and Loetscher, P. (1998) Effects of methotrexate on differentiation of monocytes and production of cytokine inhibitors by monocytes. Arthritis Rheum. 41, 2032-2038 (Pubitemid 28506694)
    • (1998) Arthritis and Rheumatism , vol.41 , Issue.11 , pp. 2032-2038
    • Seitz, M.1    Zwicker, M.2    Loetscher, P.3
  • 35
    • 77749277178 scopus 로고    scopus 로고
    • Methotrexate: How does it really work?
    • Chan, E.S. and Cronstein, B.N. (2010) Methotrexate: how does it really work? Nat. Rev. Rheumatol. 6, 175-178
    • (2010) Nat. Rev. Rheumatol. , vol.6 , pp. 175-178
    • Chan, E.S.1    Cronstein, B.N.2
  • 36
    • 17844388561 scopus 로고    scopus 로고
    • Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1
    • Desai, A., Victor-Vega, C., Gadangi, S., Montesinos, M.C., Chu, C.C. and Cronstein, B.N. (2005) Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1. Mol. Pharmacol. 67, 1406-1413
    • (2005) Mol. Pharmacol. , vol.67 , pp. 1406-1413
    • Desai, A.1    Victor-Vega, C.2    Gadangi, S.3    Montesinos, M.C.4    Chu, C.C.5    Cronstein, B.N.6
  • 38
    • 0037207972 scopus 로고    scopus 로고
    • 3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68
    • DOI 10.1002/art.10712
    • Montesinos, M.C., Desai, A., Delano, D., Chen, J.F., Fink, J.S., Jacobson, M.A. and Cronstein, B.N. (2003) Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Arthritis Rheum. 48, 240-247 (Pubitemid 36091669)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.1 , pp. 240-247
    • Montesinos, M.C.1    Desai, A.2    Delano, D.3    Chen, J.-F.4    Fink, J.S.5    Jacobson, M.A.6    Cronstein, B.N.7
  • 40
    • 47249153519 scopus 로고    scopus 로고
    • Role of cytokines in rheumatoid arthritis: An education in pathophysiology and therapeutics
    • Feldmann, M. and Maini, S.R. (2008) Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics. Immunol. Rev. 223, 7-19
    • (2008) Immunol. Rev. , vol.223 , pp. 7-19
    • Feldmann, M.1    Maini, S.R.2
  • 41
    • 57749180869 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis: A systematic review and meta-analysis of dosage regimens
    • Zintzaras, E., Dahabreh, I.J., Giannouli, S., Voulgarelis, M. and Moutsopoulos, H.M. (2008) Infliximab and methotrexate in the treatment of rheumatoid arthritis: a systematic review and meta-analysis of dosage regimens. Clin. Ther. 30, 1939-1955
    • (2008) Clin. Ther. , vol.30 , pp. 1939-1955
    • Zintzaras, E.1    Dahabreh, I.J.2    Giannouli, S.3    Voulgarelis, M.4    Moutsopoulos, H.M.5
  • 42
    • 40649117711 scopus 로고    scopus 로고
    • Treatment of psoriatic arthritis and rheumatoid arthritis with disease modifying drugs - Comparison of drugs and adverse reactions
    • Helliwell, P.S. and Taylor, W.J. (2008) Treatment of psoriatic arthritis and rheumatoid arthritis with disease modifying drugs: comparison of drugs and adverse reactions. J. Rheumatol. 35, 472-476 (Pubitemid 351374424)
    • (2008) Journal of Rheumatology , vol.35 , Issue.3 , pp. 472-476
    • Helliwell, P.S.1    Taylor, W.J.2
  • 43
    • 34248166702 scopus 로고    scopus 로고
    • Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage
    • Mix, K.S., Attur, M.G., Al-Mussawir, H., Abramson, S.B., Brinckerhoff, C.E. and Murphy, E.P. (2007) Transcriptional repression of matrix metalloproteinase gene expression by the orphan nuclear receptor NURR1 in cartilage. J. Biol. Chem. 282, 9492-9504
    • (2007) J. Biol. Chem. , vol.282 , pp. 9492-9504
    • Mix, K.S.1    Attur, M.G.2    Al-Mussawir, H.3    Abramson, S.B.4    Brinckerhoff, C.E.5    Murphy, E.P.6
  • 44
    • 66049110306 scopus 로고    scopus 로고
    • The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases
    • Hamilton, J.A. and Tak, P.P. (2009) The dynamics of macrophage lineage populations in inflammatory and autoimmune diseases. Arthritis Rheum. 60, 1210-1221
    • (2009) Arthritis Rheum. , vol.60 , pp. 1210-1221
    • Hamilton, J.A.1    Tak, P.P.2
  • 45
    • 77952240075 scopus 로고    scopus 로고
    • Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation
    • Bonta, P.I., Pols, T.W., van Tiel, C.M., Vos, M., Arkenbout, E.K., Rohlena, J., Koch, K.T., de Maat, M.P., Tanck, M.W., de Winter, R.J. et al. (2010) Nuclear receptor Nurr1 is expressed in and is associated with human restenosis and inhibits vascular lesion formation in mice involving inhibition of smooth muscle cell proliferation and inflammation. Circulation 121, 2023-2032
    • (2010) Circulation , vol.121 , pp. 2023-2032
    • Bonta, P.I.1    Pols, T.W.2    Van Tiel, C.M.3    Vos, M.4    Arkenbout, E.K.5    Rohlena, J.6    Koch, K.T.7    De Maat, M.P.8    Tanck, M.W.9    De Winter, R.J.10
  • 46
    • 63049083734 scopus 로고    scopus 로고
    • A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death
    • Saijo, K., Winner, B., Carson, C.T., Collier, J.G., Boyer, L., Rosenfeld, M.G., Gage, F.H. and Glass, C.K. (2009) A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137, 47-59
    • (2009) Cell , vol.137 , pp. 47-59
    • Saijo, K.1    Winner, B.2    Carson, C.T.3    Collier, J.G.4    Boyer, L.5    Rosenfeld, M.G.6    Gage, F.H.7    Glass, C.K.8
  • 47
    • 28544446111 scopus 로고    scopus 로고
    • Monocyte and macrophage heterogeneity
    • Gordon, S. and Taylor, P.R. (2005) Monocyte and macrophage heterogeneity. Nat. Rev. Immunol. 5, 953-964
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 953-964
    • Gordon, S.1    Taylor, P.R.2
  • 48
    • 0036839143 scopus 로고    scopus 로고
    • Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
    • DOI 10.1016/S1471-4906(02)02302-5, PII S1471490602023025
    • Mantovani, A., Sozzani, S., Locati, M., Allavena, P. and Sica, A. (2002) Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23, 549-555 (Pubitemid 35223554)
    • (2002) Trends in Immunology , vol.23 , Issue.11 , pp. 549-555
    • Mantovani, A.1    Sozzani, S.2    Locati, M.3    Allavena, P.4    Sica, A.5
  • 49
    • 0036679853 scopus 로고    scopus 로고
    • GM-CSF in inflammation and autoimmunity
    • Hamilton, J.A. (2002) GM-CSF in inflammation and autoimmunity. Trends Immunol. 23, 403-408
    • (2002) Trends Immunol. , vol.23 , pp. 403-408
    • Hamilton, J.A.1
  • 50
    • 75549087056 scopus 로고    scopus 로고
    • Disease-associated functions of IL-33: The new kid in the IL-1 family
    • Liew, F.Y., Pitman, N.I. and McInnes, I.B. (2010) Disease-associated functions of IL-33: the new kid in the IL-1 family. Nat. Rev. Immunol. 10, 103-110
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 103-110
    • Liew, F.Y.1    Pitman, N.I.2    McInnes, I.B.3


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