Urinary phthalates and increased insulin resistance in adolescents

Pediatrics

Volumn 132, Issue 3, 2013, Pages

  Trasande, Leonardo ^a,b,c   Spanier, Adam J ^d   Sathyanarayana, Sheela ^e   Attina, Teresa M ^a   Blustein, Jan ^a,b,f  

^a NEW YORK UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY   (United States)

^c NEW YORK UNIVERSITY   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^f NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Insulin resistance; Phthalates

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; CREATININE; DI ISOBUTYL PHTHALATE; PHTHALIC ACID BENZYL BUTYL ESTER; PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER; PHTHALIC ACID DIETHYL ESTER; PHTHALIC ACID DIOCTYL ESTER; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGE; ARTICLE; BEHAVIOR; BODY MASS; CHILD; CREATININE URINE LEVEL; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DIET; FEMALE; HOMEOSTATIC MODEL ASSESSMENT OF INSULIN RESISTANCE; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLITE; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; PREVALENCE; PRIORITY JOURNAL; SCHOOL CHILD; URINE LEVEL;

EID: 84884551371     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-4022     Document Type: Article

References (44)

1. Sathyanarayana S. Phthalates and children's health. Curr Probl Pediatr Adolesc Health Care. 2008;38(2):34-49
2. Schettler T. Human exposure to phthalates via consumer products. Int J Androl. 2006;29(1):134-139, discussion 181-185
3. Fromme H, Gruber L, Schlummer M, et al. Intake of phthalates and di (2-ethylhexyl) adipate: results of the Integrated Exposure Assessment Survey based on duplicate diet samples and biomonitoring data. Environ Int. 2007;33(8):1012-1020
4. US Food and Drug Administration. FDA public health notification: PVC devices containing the plasticizer DEHP. Available at: www.fda. gov/MedicalDevices/Safety/AlertsandNotices/PublicHealthNotifications/ucm062182. htm. Accessed June 7, 2012
5. Bouma K, Schakel DJ. Migration of phthalates from PVC toys into saliva simulant by dynamic extraction. Food Addit Contam. 2002;19(6):602-610
6. US Agency for Toxic Substances & Disease Registry. Toxicological profile for di-2-ethylhexylphthalate. Available at: www.atsdr.cdc.gov/ toxprofiles/tp.asp?id=684&tid=65. Accessed August 24, 2012
7. Becker K, Seiwert M, Angerer J, et al. DEHP metabolites in urine of children and DEHP in house dust. Int J Hyg Environ Health. 2004;207(5):409-417
8. Hauser R, Calafat AM. Phthalates and human health. Occup Environ Med. 2005;62(11):806-818
9. Hatch EE, Nelson JW, Qureshi MM, et al. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ Health. 2008;7(1):27
10. Teitelbaum SL, Mervish N, Moshier EL, et al. Associations between phthalate metabolite urinary concentrations and body size measures in New York City children. Environ Res. 2012;112:186-193
11. Trasande L, Attina TM, Sathyanarayana S, et al. Race/ethnicity-specific associations of urinary phthalates with childhood body mass in a nationally representative sample. Environ Health Perspect. 2013;121(4):501-506
12. Feige JN, Gelman L, Rossi D, et al. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferatoractivated receptor g modulator that promotes adipogenesis. J Biol Chem. 2007;282(26):19152-19166
13. Lohray BB, Lohray VB, Bajji AC, et al. (2) 3-[4-[2-(Phenoxazin-10-yl) ethoxy]phenyl]-2-ethoxypropanoic acid [(2) DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity. J Med Chem. 2001;44(16):2675-2678
14. Bility MT, Thompson JT, McKee RH, et al. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol Sci. 2004;82(1):170-182
15. Hurst CH, Waxman DJ. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci. 2003;74(2):297-308
16. Grün F, Watanabe H, Zamanian Z, et al. Endocrine-disrupting organotin compounds are potent inducers of adipogenesis in vertebrates. Mol Endocrinol. 2006;20(9):2141-2155
17. Desvergne B, Feige JN, Casals-Casas C. PPAR-mediated activity of phthalates: a link to the obesity epidemic? Mol Cell Endocrinol. 2009;304(1-2):43-48
18. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult US males. Environ Health Perspect. 2007;115(6):876-882
19. James-Todd T, Stahlhut R, Meeker JD, et al. Urinary phthalate metabolite concentrations and diabetes among women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008. Environ Health Perspect. 2012;120(9):1307-1313
20. Vehik K, Dabelea D. The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes Metab Res Rev. 2011;27(1):3-13
21. Dabelea D, Bell RA, D'Agostino RB Jr, et al; Writing Group for the SEARCH for Diabetes in Youth Study Group. Incidence of diabetes in youth in the United States. JAMA. 2007;297(24):2716-2724
22. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419
23. Wallace TM, Levy JC, Matthews DR. Use and abuse of HOMA modeling. Diabetes Care. 2004;27(6):1487-1495
24. Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG. Prevalence and determinants of insulin resistance among US adolescents: a population-based study. Diabetes Care. 2006;29(11):2427-2432
25. Silva MJ, Barr DB, Reidy JA, et al. Urinary levels of seven phthalate metabolites in the US population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect. 2004;112(3):331-338
26. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. Urinary creatinine concentrations in the US population: implications for urinary biologic monitoring measurements. Environ Health Perspect. 2005;113(2):192-200
27. Ogden CL, Kuczmarski RJ, Flegal KM, et al. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics. 2002;109(1):45-60
28. Weitzman M, Cook S, Auinger P, et al. Tobacco smoke exposure is associated with the metabolic syndrome in adolescents. Circulation. 2005;112(6):862-869
29. US Centers for Disease Control and Prevention. Overview of NHANES survey design and weights. Available at: www.cdc.gov/nchs/tutorials/dietary/ SurveyOrientation/SurveyDesign/intro.htm. Accessed April 4, 2012
30. Korn EL, Graubard BI. Analysis of large health surveys: accounting for the sampling design. J R Stat Soc Ser A Stat Soc. 1995;158(2):263-295
31. Rubin DB. Multiple Imputation for Nonresponse in Surveys. New York, NY: John Wiley & Sons, Inc.; 1987
32. Graham JW, Olchowski AE, Gilreath TD. How many imputations are really needed? Some practical clarifications of multiple imputation theory. Prev Sci. 2007;8(3):206-213
33. Rusyn I, Peters JM, Cunningham ML. Modes of action and species-specific effects of di-(2-ethylhexyl) phthalate in the liver. Crit Rev Toxicol. 2006;36(5):459-479
34. Trasande L, Attina TM, Blustein J. Association between urinary bisphenol A concentration and obesity prevalence in children and adolescents. JAMA. 2012;308(11):1113-1121
35. Frederiksen H, Sørensen K, Mouritsen A, et al. High urinary phthalate concentration associated with delayed pubarche in girls. Int J Androl. 2012;35(3):216-226
36. Frederiksen H, Skakkebaek NE, Andersson A-M. Metabolism of phthalates in humans. Mol Nutr Food Res. 2007;51(7):899-911
37. Silva MJ, Kato K, Gray EL, Wolf C, Needham LL, Calafat AM. Urinary metabolites of di-noctyl phthalate in rats. Toxicology. 2005;210(2-3):123-133
38. Hoppin JA, Brock JW, Davis BJ, Baird DD. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect. 2002;110(5):515-518
39. Mes J, Coffin DE, Campbell DS. Di-n-butyland di-2-ethylhexyl phthalate in human adipose tissue. Bull Environ Contam Toxicol. 1974;12(6):721-725
40. Hauser R, Meeker JD, Park S, Silva MJ, Calafat AM. Temporal variability of urinary phthalate metabolite levels in men of reproductive age. Environ Health Perspect. 2004;112(17):1734-1740
41. Fleiss JL, Shrout PE. The effects of measurement errors on some multivariate procedures. Am J Public Health. 1977;67(12):1188-1191
42. Cao X-L. Phthalate esters in foods: sources, occurrence, and analytical methods. Compr Rev Food Sci Food Saf. 2010;9(1):21-43
43. Rudel RA, Gray JM, Engel CL, et al. Food packaging and bisphenol A and bis (2-ethyhexyl) phthalate exposure: findings from a dietary intervention. Environ Health Perspect. 2011;119(7):914-920
44. Colacino JA, Harris TR, Schecter A. Dietary intake is associated with phthalate body burden in a nationally representative sample. Environ Health Perspect. 2010;118(7):998-1003