Associations between phthalate metabolite urinary concentrations and body size measures in New York City children

Environmental Research

Volumn 112, Issue , 2012, Pages 186-193

  Teitelbaum, Susan L ^a   Mervish, Nancy ^a   L Moshier, Erin ^a   Vangeepuram, Nita ^a   Galvez, Maida P ^a   Calafat, Antonia M ^b   Silva, Manori J ^b   L Brenner, Barbara ^a   Wolff, Mary S ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

Author keywords

Body mass index; Children; Obesity; Phthalates; Waist circumference

Indexed keywords

BUTYLTIN DERIVATIVE; DRUG METABOLITE; MONO(2 ETHYL 5 CARBOXYPENTYL); MONO(2 ETHYL 5 HYDROXYHEXYL)PHTHALATE; MONO(2 ETHYL 5 OXOHEXYL); MONOETHYL; PHTHALIC ACID; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; UNCLASSIFIED DRUG;

BODY MASS; BODY SIZE; CHILD HEALTH; CONCENTRATION (COMPOSITION); DOSE-RESPONSE RELATIONSHIP; METABOLITE; OBESITY; PHTHALATE; URINE; WEIGHT;

AFRICAN AMERICAN; AGE; ANTHROPOMETRY; ARTICLE; BODY MASS; BODY SIZE; CHILD; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GEOMETRY; HISPANIC; HUMAN; MAJOR CLINICAL STUDY; MALE; MOLECULAR WEIGHT; OBESITY; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SCHOOL CHILD; SEX; UNITED STATES; URINALYSIS; WAIST CIRCUMFERENCE;

AFRICAN AMERICANS; BODY SIZE; CHILD; COHORT STUDIES; DATA INTERPRETATION, STATISTICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; FOLLOW-UP STUDIES; HISPANIC AMERICANS; HUMANS; MALE; NEW YORK CITY; PHTHALIC ACIDS; PROSPECTIVE STUDIES;

NEW YORK [NEW YORK (STT)]; NEW YORK [UNITED STATES]; UNITED STATES;

EID: 84856216471     PISSN: 00139351     EISSN: 10960953     Source Type: Journal    
DOI: 10.1016/j.envres.2011.12.006     Document Type: Article

References (48)

1. Ainsworth B.E., Haskell W.L., Whitt M.C., Irwin M.L., Swartz A.M., Strath S.J., O'Brien W.L., Bassett D.R., Schmitz K.H., Emplaincourt P.O., Jacobs D.R., Leon A.S. Compendium of physical activities: an update of activity codes and MET intensities. Med. Sci. Sports Exerc. 2000, 32:S498-S504.
2. Bility M.T., Thompson J.T., McKee R.H., David R.M., Butala J.H., Vanden Heuvel J.P., Peters J.M. Activation of mouse and human peroxisome proliferator-activated receptors (PPARs) by phthalate monoesters. Toxicol. Sci. 2004, 82:170-182.
3. Black J.L., Macinko J. The changing distribution and determinants of obesity in the neighborhoods of New York City, 2003-2007. Am. J. Epidemiol. 2010, 171:765-775.
4. Boas M., Frederiksen H., Feldt-Rasmussen U., Skakkebaek N.E., Hegedus L., Hilsted L., Juul A., Main K.M. 2010. Childhood exposure to phthalates-associations with thyroid function, Insulin-like Growth Factor I (IGF-I) and growth. Environ. Health Perspect..
5. Boberg J., Metzdorff S., Wortziger R., Axelstad M., Brokken L., Vinggaard A.M., Dalgaard M., Nellemann C. Impact of diisobutyl phthalate and other PPAR agonists on steroidogenesis and plasma insulin and leptin levels in fetal rats. Toxicology 2008, 250:75-81.
6. Botelho G.G., Golin M., Bufalo A.C., Morais R.N., Dalsenter P.R., Martino-Andrade A.J. Reproductive effects of di(2-ethylhexyl)phthalate in immature male rats and its relation to cholesterol, testosterone, and thyroxin levels. Arch. Environ. Contam. Toxicol. 2009, 57:777-784.
7. Carrieri M., Trevisan A., Bartolucci G.B. Adjustment to concentration-dilution of spot urine samples: correlation between specific gravity and creatinine. Int. Arch. Occup. Environ. Health 2001, 74:63-67.
8. Casals-Casas C., Feige J.N., Desvergne B. Interference of pollutants with PPARs: endocrine disruption meets metabolism. Int. J. Obes. (London) 2008, 32(Suppl 6):S53-S61.
9. Centers for Disease Control and Prevention, 2005. National Center for Health Statistics: The Third National Health and Nutrition Examination Survey (NHANES III 1988-94). Reference Manuals and Reports, Bethesda, MD.
10. Centers for Disease Control and Prevention, 2009. Fourth National Report on Human Exposure to Environmental Chemicals. http://www.cdc.gov/exposurereport/.
11. Centers for Disease Control and Prevention, 2010. National Center for Health Statistics. http://www.cdc.gov/nchs.
12. Dostal L.A., Jenkins W.L., Schwetz B.A. Hepatic peroxisome proliferation and hypolipidemic effects of di(2-ethylhexyl)phthalate in neonatal and adult rats. Toxicol. Appl. Pharmacol. 1987, 87:81-90.
13. Engel S.M., Berkowitz G.S., Barr D.B., Teitelbaum S.L., Siskind J., Meisel S.J., Wetmur J.G., Wolff M.S. Prenatal organophosphate metabolite and organochlorine levels and performance on the Brazelton Neonatal Behavioral Assessment Scale in a multiethnic pregnancy cohort. Am. J. Epidemiol. 2007, 165:1397-1404.
14. Feige J.N., Gelman L., Rossi D., Zoete V., Metivier R., Tudor C., Anghel S.I., Grosdidier A., Lathion C., Engelborghs Y., Michielin O., Wahli W., Desvergne B. The endocrine disruptor monoethyl-hexyl-phthalate is a selective peroxisome proliferator-activated receptor gamma modulator that promotes adipogenesis. J. Biol. Chem. 2007, 282:19152-19166.
15. Freedman D.S., Kahn H.S., Mei Z., Grummer-Strawn L.M., Dietz W.H., Srinivasan S.R., Berenson G.S. Relation of body mass index and waist-to-height ratio to cardiovascular disease risk factors in children and adolescents: the Bogalusa heart study. Am. J. Clin. Nutr. 2007, 86:33-40.
16. Goran M.I., Gower B.A. Relation between visceral fat and disease risk in children and adolescents. Am. J. Clin. Nutr. 1999, 70:149S-156S.
17. Hatch E.E., Nelson J.W., Qureshi M.M., Weinberg J., Moore L.L., Singer M., Webster T.F. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ. Health 2008, 7:27.
18. Hauser R., Calafat A.M. Phthalates and human health. Occup. Environ. Med. 2005, 62:806-818.
19. Hines E.P., Calafat A.M., Silva M.J., Mendola P., Fenton S.E. Concentrations of phthalate metabolites in milk, urine, saliva, and serum of lactating North Carolina women. Environ. Health Perspect. 2009, 117:86-92.
20. Hotchkiss A.K., Rider C.V., Blystone C.R., Wilson V.S., Hartig P.C., Ankley G.T., Foster P.M., Gray C.L., Gray L.E. Fifteen years after "Wingspread"-environmental endocrine disrupters and human and wildlife health: where we are today and where we need to go. Toxicol. Sci. 2008, 105:235-259.
21. Hurst C.H., Waxman D.J. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol. Sci. 2003, 74:297-308.
22. Janssen I., Heymsfield S.B., Allison D.B., Kotler D.P., Ross R. Body mass index and waist circumference independently contribute to the prediction of nonabdominal, abdominal subcutaneous, and visceral fat. Am. J. Clin. Nutr. 2002, 75:683-688.
23. Kato K., Silva M.J., Needham L.L., Calafat A.M. Determination of 16 phthalate metabolites in urine using automated sample preparation and on-line preconcentration/high-performance liquid chromatography/tandem mass spectrometry. Anal. Chem. 2005, 77:2985-2991.
24. Koo J.W., Parham F., Kohn M.C., Masten S.A., Brock J.W., Needham L.L., Portier C.J. The association between biomarker-based exposure estimates for phthalates and demographic factors in a human reference population. Environ. Health Perspect. 2002, 110:405-410.
25. Lorber M., Gibb H., Grant L., Pinto J., Pleil J., Cleverly D Assessment of inhalation exposures and potential health risks to the general population that resulted from the collapse of the World Trade Center towers. Risk Anal. 2007, 27:1203-1221.
26. Maffeis C., Corciulo N., Livieri C., Rabbone I., Trifiro G., Falorni A., Guerraggio L., Peverelli P., Cuccarolo G., Bergamaschi G., Di P.M., Grezzani A. Waist circumference as a predictor of cardiovascular and metabolic risk factors in obese girls. Eur. J. Clin. Nutr. 2003, 57:566-572.
27. Mayes J.S., Watson G.H. Direct effects of sex steroid hormones on adipose tissues and obesity. Obes. Rev. 2004, 5:197-216.
28. McDowell M.A., Fryar C.D., Hirsch R., Ogden C.L. 2005. Anthropometric reference data for children and adults: U.S. population, 1999-2002. Adv. Data1-5.
29. McLachlan J.A. Functional toxicology: a new approach to detect biologically active xenobiotics. Environ. Health Perspect. 1993, 101:386-387.
30. Meeker J.D., Calafat A.M., Hauser R. Di(2-ethylhexyl) phthalate metabolites may alter thyroid hormone levels in men. Environ. Health Perspect. 2007, 115:1029-1034.
31. National Academy of Sciences Phthalates and Cumulative Risk Assessment The Task Ahead 2008, National Academy Press, Washington, DC.
32. Newbold R.R., Padilla-Banks E., Jefferson W.N., Heindel J.J. Effects of endocrine disruptors on obesity. Int. J. Androl. 2008, 31:201-208.
33. Ogden C.L., Carroll M.D., Flegal K.M. High body mass index for age among US children and adolescents, 2003-2006. JAMA 2008, 299:2401-2405.
34. Olson E., Van Wye G., Kerker B., Thorpe L., Frieden T. Take Care East Harlem 2006, NYC Community Health Profiles. second ed.
35. Pan G., Hanaoka T., Yoshimura M., Zhang S., Wang P., Tsukino H., Inoue K., Nakazawa H., Tsugane S., Takahashi K. Decreased serum free testosterone in workers exposed to high levels of di-n-butyl phthalate (DBP) and di-2-ethylhexyl phthalate (DEHP): a cross-sectional study in China. Environ. Health Perspect. 2006, 114:1643-1648.
36. Parks L.G., Ostby J.S., Lambright C.R., Abbott B.D., Klinefelter G.R., Barlow N.J., Gray L.E. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal testosterone synthesis during sexual differentiation in the male rat. Toxicol. Sci. 2000, 58:339-349.
37. Pasquali R. Obesity and androgens: facts and perspectives. Fertil. Steril. 2006, 85:1319-1340.
38. Skinner A.M., Addison G.M., Price D.A. Changes in the urinary excretion of creatinine, albumin and N-acetyl-beta-D-glucosaminidase with increasing age and maturity in healthy schoolchildren. Eur. J. Pediatr. 1996, 155:596-602.
39. Snodgrass W. Physiological and biochemical differences between children and adults as determinants of toxic exposure to environmental pollutants. Similarities and Differences between Children and Adults: Implications for Risk Assessment 1992, 35-42. International Life Sciences Institute, Washington, DC. P. Guzelian, C. Henry, S. Olin (Eds.).
40. Stahlhut R.W., van W.E., Dye T.D., Cook S., Swan S.H. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ. Health Perspect. 2007, 115:876-882.
41. Teitelbaum S.L., Britton J.A., Calafat A.M., Ye X., Silva M.J., Reidy J.A., Galvez M.P., Brenner B.L., Wolff M.S. Temporal variability in urinary concentrations of phthalate metabolites, phytoestrogens and phenols among minority children in the United States. Environ Res 2008, 106:257-269.
42. The European Parliament and the Council of the European Union D12, 2010. Directive 2005/84/EC. The European Parliament and the Council of the European Union, December 14, 2005.
43. US Consumer Product Safety Commission, 2010. Consumer Product Safety Improvement Act of 2008, H.R. 4040, 110th Congress, August 14, 2008. US Consumer Product Safety Commission.
44. US Department of Health and Human Service The Practical Guide-Identification, Evaluation and Treatment of Overweight and Obesity in Adults. 00-4084 2000, National Institutes of Health, Bethesda, MD.
45. US Food and Drug Administration Phthalates and cosmetic Products 2010, US Department of Health and Human Services.
46. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 2000, 21:697-738.
47. Willett W. Nutritional Epidemiology 1998, Oxford University Press, New York, NY. 2nd ed.
48. Wolff M.S., Engel S.M., Berkowitz G.S., Ye X., Silva M.J., Zhu C., Wetmur J., Calafat A.M. Prenatal phenol and phthalate exposures and birth outcomes. Environ. Health Perspect. 2008, 116:1092-1097.