Urinary phthalate metabolite concentrations and diabetes among women in the national health and nutrition examination survey (NHANES) 2001-2008

Environmental Health Perspectives

Volumn 120, Issue 9, 2012, Pages 1307-1313

  James Todd, Tamarra ^a   Stahlhut, Richard ^b   Meeker, John D ^c   Powell, Sheena Gail ^a   Hauser, Russ ^d   Huang, Tianyi ^a   Rich Edwards, Janet ^a,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Di(2 ethylhexyl) phthalate; Diabetes; Mono (3 carboxypropyl) phthalate; Mono isobutyl phthalate; Mono n butyl phthalate; Monobenzyl phthalate; Monoethyl phthalate; Women

Indexed keywords

HEMOGLOBIN A1C; MONO 3 CARBOXYPROPYL PHTHALATE; MONO ISOBUTYL PHTHALATE; MONO N BUTYL PHTHALATE; MONOBENZYL PHTHALATE; PHTHALIC ACID; PHTHALIC ACID 2 ETHYLHEXYL MONOESTER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BODY MASS; CREATININE URINE LEVEL; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DIABETES MELLITUS; DIET; DISEASE ASSOCIATION; EXPOSURE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HEALTH SURVEY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INSULIN RESISTANCE; PRIORITY JOURNAL; SOCIOECONOMICS; TANDEM MASS SPECTROMETRY;

ADULT; AGED; CROSS-SECTIONAL STUDIES; DIABETES MELLITUS; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; FEMALE; HUMANS; LOGISTIC MODELS; MIDDLE AGED; NUTRITION SURVEYS; PHTHALIC ACIDS; RISK FACTORS; UNITED STATES; YOUNG ADULT;

EID: 84930479869     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1104717     Document Type: Article

References (46)

1. Ali MK, Bullard KM, Beckles GL, Stevens MR, Barker L, Narayan KM, et al. 2011. Household income and cardiovascular disease risks in U.S. children and young adults: analyses from NHANES 1999-2008. Diabetes Care 34(9):1998-2004.
2. Baillie-Hamilton PF. 2002. Chemical toxins: a hypothesis to explain the global obesity epidemic. J Altern Complement Med 8(2):185-192.
3. Barr DB, Wilder LC, Caudill SP, Gonzalez AJ, Needham LL, Pirkle JL. 2005. Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect 113:192-200.
4. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, et al. 2000. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 23(1):57-63.
5. Burgette LF, Reiter JP, Miranda ML. 2011. Exploratory quantile regression with many covariates: an application to adverse birth outcomes. Epidemiology 22(6):859-866.
6. Casals-Casas C, Feige JN, Desvergne B. 2008. Interference of pollutants with PPARs: endocrine disruption meets metabolism. Int J Obes (Lond) 32(suppl 6):S53-S61.
7. CDC (Centers for Disease Control and Prevention). 2011a. Data and Trends. Age-Adjusted Percentage of Civilian, Noninstitutionalized Population with Diagnosed Diabetes, by Sex, United States, 1980-2010. Available: http://www.cdc.gov/diabetes/statistics/prev/national/figbysex.htm [accessed 15 February 2012].
8. CDC (Centers for Disease Control and Prevention). 2011b. National Health and Nutrition Examination Survey. Available: http://www.cdc.gov/nchs/nhanes.htm [accessed 3 October 2011].
9. CDC (Centers for Disease Control and Prevention). 2011c. The Fourth National Report on Human Exposure to Environmental Chemicals, 2009. Available: http://www.cdc.gov/exposurereport/ [accessed 3 October 2011].
10. CDC (Centers for Disease Control and Prevention). 2011d. Task 3a: How to Identify Outliers and Evaluate Their Impact Using SAS. Available: http://www.cdc.gov/nchs/tutorials/nhanes/Preparing/CleanRecode/Task3.htm [accessed 3 October 2011].
11. CDC (Centers for Disease Control and Prevention). 2011e. NHANES Analyses Course. Available: http://www.cdc.gov/nchs/tutorials/NHANES/NHANESAnalyses/logisticregression/logistic_regression_intro.htm [accessed 3 October 2011].
12. Colditz GA, Willett WC, Rotnitzky A, Manson JE. 1995. Weight gain as a risk factor for clinical diabetes mellitus in women. Ann Intern Med 122(7):481-486.
13. Crinnion WJ. 2010. Toxic effects of the easily avoidable phthalates and parabens. Altern Med Rev 15(3):190-196.
14. Danaei G, Friedman AB, Oza S, Murray CJ, Ezzati M. 2009. Diabetes prevalence and diagnosis in US states: analysis of health surveys. Popul Health Metr 7:16.
15. Desvergne B, Feige JN, Casals-Casas C. 2009. PPAR-mediated activity of phthalates: A link to the obesity epidemic? Mol Cell Endocrinol 304(1-2):43-48.
16. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, et al. 1999. Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 22(5):818-822.
17. Feige JN, Gerber A, Casals-Casas C, Yang Q, Winkler C, Bedu E, et al. 2010. The pollutant diethylhexyl phthalate regulates hepatic energy metabolism via species-specific PPARalpha-dependent mechanisms. Environ Health Perspect 118:234-241.
18. Flegal KM, Carroll MD, Ogden CL, Curtin LR. 2010. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 303(3):235-241.
19. Fromme H, Bolte G, Koch HM, Angerer J, Boehmer S, Drexler H, et al. 2007. Occurrence and daily variation of phthalate metabolites in the urine of an adult population. Int J Hyg Environ Health 210(1):21-33.
20. Gayathri NS, Dhanya CR, Indu AR, Kurup PA. 2004. Changes in some hormones by low doses of di (2-ethyl hexyl) phthalate (DEHP), a commonly used plasticizer in PVC blood storage bags & medical tubing. Indian J Med Res 119(4):139-144.
21. Grun F, Blumberg B. 2007. Perturbed nuclear receptor signaling by environmental obesogens as emerging factors in the obesity crisis. Rev Endocr Metab Disord 8(2):161-171.
22. Harris MI. 1995. Classification, diagnostic criteria, and screening for diabetes. In: Diabetes in America. Publication No. 95-1468. Bethesda, MD:National Institute of Diabetes and Digestive and Kidney Diseases, 15-36.
23. Hatch EE, Nelson JW, Qureshi MM, Weinberg J, Moore LL, Singer M, et al. 2008. Association of urinary phthalate metabolite concentrations with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999-2002. Environ Health 7:27; doi:10.1186/1476-069X-7-27 [Online 3 June 2008].
24. Hauser R, Calafat AM. 2005. Phthalates and human health. Occup Environ Med 62(11):806-818.
25. Hauser R, Duty S, Godfrey-Bailey L, Calafat AM. 2004. Medications as a source of human exposure to phthalates. Environ Health Perspect 112:751-753
26. Hermans MP, Levy JC, Morris RJ, Turner RC. 1999. Comparison of insulin sensitivity tests across a range of glucose tolerance from normal to diabetes. Diabetologia 42(6):678-687.
27. Hoppin JA, Brock JW, Davis BJ, Baird DD. 2002. Reproducibility of urinary phthalate metabolites in first morning urine samples. Environ Health Perspect 110:515-518.
28. Hurst CH, Waxman DJ. 2003. Activation of PPARalpha and PPARgamma by environmental phthalate monoesters. Toxicol Sci 74(2):297-308.
29. Kelley KE, Hernandez-Diaz S, Chaplin EL, Hauser R, Mitchell AA. 2012. Identification of phthalates in medications and dietary supplement formulations in the United States and Canada. Environ Health Perspect 120:379-384.
30. Korn EL, Graubard BI. 1991. Epidemiologic studies utilizing surveys: accounting for the sampling design. Am J Public Health 81(9):1166-1173.
31. Lapinskas PJ, Brown S, Leesnitzer LM, Blanchard S, Swanson C, Cattley RC, et al. 2005. Role of PPARalpha in mediating the effects of phthalates and metabolites in the liver. Toxicology 207(1):149-163.
32. Latini G. 2005. Monitoring phthalate exposure in humans. Clin Chim Acta 361(1-2):20-29.
33. Latini G, Marcovecchio ML, Del Vecchio A, Gallo F, Bertino E, Chiarelli F. 2009. Influence of environment on insulin sensitivity. Environ Int 35(6):987-993.
34. Mokdad AH, Ford ES, Bowman BA, Nelson DE, Engelgau MM, Vinicor F, et al. 2000. Diabetes trends in the U.S.: 1990-1998. Diabetes Care 23(9):1278-1283.
35. Newbold RR. 2010. Impact of environmental endocrine disrupting chemicals on the development of obesity. Hormones (Athens) 9(3):206-217.
36. Peck JD, Sweeney AM, Symanski E, Gardiner J, Silva MJ, Calafat AM, et al. 2010. Intra- and inter-individual variability of urinary phthalate metabolite concentrations in Hmong women of reproductive age. J Expo Sci Environ Epidemiol 20(1):90-100.
37. Rengarajan S, Parthasarathy C, Anitha M, Balasubramanian K. 2007. Diethylhexyl phthalate impairs insulin binding and glucose oxidation in Chang liver cells. Toxicol In Vitro 21(1):99-102.
38. Romero-Franco M, Hernandez-Ramirez RU, Calafat AM, Cebrian ME, Needham LL, Teitelbaum S, et al. 2011. Personal care product use and urinary levels of phthalate metabolites in Mexican women. Environ Int 37(5):867-871.
39. SAS Institute Inc. 2011. The QUANTREG Procedure (Experimental). Available: http://support.sas.com/rnd/app/papers/quantreg.pdf [accessed 1 Februrary 2012].
40. Silva MJ, Barr DB, Reidy JA, Malek NA, Hodge CC, Caudill SP, et al. 2004. Urinary levels of seven phthalate metabolites in the U.S. population from the National Health and Nutrition Examination Survey (NHANES) 1999-2000. Environ Health Perspect 112:331-338.
41. Stahlhut RW, van Wijngaarden E, Dye TD, Cook S, Swan SH. 2007. Concentrations of urinary phthalate metabolites are associated with increased waist circumference and insulin resistance in adult U.S. males. Environ Health Perspect 115:876-882.
42. Svensson K, Hernandez-Ramirez RU, Burguete-Garcia A, Cebrian ME, Calafat AM, Needham LL, et al. 2011. Phthalate exposure associated with self-reported diabetes among Mexican women. Environ Res 111(6):792-796.
43. Swan SH. 2008. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ Res 108(2):177-184.
44. Thayer KA, Heindel JJ, Bucher JR, Gallo MA. 2012. Role of environmental chemicals in diabetes and obesity: a National Toxicology Program workshop report. Environ Health Perspect 120:779-789.
45. Tordjman K, Standley KN, Bernal-Mizrachi C, Leone TC, Coleman T, Kelly DP, et al. 2002. PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells. J Lipid Res 43(6):936-943.
46. Tsatsoulis A, Wyckoff J, Brown FM, eds. 2009. Diabetes in Women: Pathphysiology and Therapy. New York:Humana Press/Springer Science+Business Media.