Urinary metabolites of di-n-octyl phthalate in rats

Toxicology

Volumn 210, Issue 2-3, 2005, Pages 123-133

  Silva, Manori J ^a   Kato, Kayoko ^a   Gray, Earl L ^b   Wolf, Cynthia ^b   Needham, Larry L ^a   Calafat, Antonia M ^a  

^a NATIONAL CENTER FOR ENVIRONMENTAL HEALTH   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Di n octyl phthalate; Mono (7 carboxy n heptyl) phthalate; Mono (7 hydroxy n octyl) phthalate; Mono (7 oxo n octyl) phthalate; Mono 3 carboxypropyl phthalate; Mono n octyl phthalate; Oxidative metabolism; Phthalates

Indexed keywords

PHTHALIC ACID DERIVATIVE; PHTHALIC ACID DIOCTYL ESTER;

ANIMAL EXPERIMENT; ARTICLE; CHROMATOGRAPHY; FEMALE; LIVER MICROSOME; MASS SPECTROMETRY; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; STANDARD; STATISTICAL SIGNIFICANCE; TOXICOKINETICS; TOXIN SYNTHESIS; URINARY EXCRETION;

EID: 17144389332     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.01.012     Document Type: Article

References (18)

1. P.W. Albro, and B. Moore Identification of the metabolites of simple phthalate diesters in rat urine J. Chromatogr. 94 1974 209 218
2. P.W. Albro, R. Thomas, and L. Fishbein Metabolism of diethylhexyl phthalate by rats. Isolation and characterization of the urinary metabolites J. Chromatogr. 76 1973 321 330
3. P.W. Albro, I. Tondeur, D. Marbury, S. Jordan, J. Schroeder, and J.T. Corbett Polar metabolites of di-(2-ethylhexyl)phthalate in the rat Biochim. Biophys. Acta 760 1983 283 292
4. ATSDR, 2002. Toxicological Profile for Di-(2-ethylhexyl)phthalate (DEHP). Agency for Toxic Substances and Disease Registry, Atlanta, GA. Available: http://www.atsdr.cdc.gov/toxprofiles/tp9.html (accessed 26 July 2004).
5. ATSDR, 1997. Toxicological Profile for Di-n-octyl phthalate (DNOP). Agency for Toxic Substances and Disease Registry, Atlanta, GA. Available: http://www.atsdr.cdc.gov/toxprofiles/tp95.html (accessed 26 July 2004).
6. D.B. Barr, M.J. Silva, K. Kato, J.A. Reidy, N.A. Malek, D. Hurtz, M. Sadowski, L.L. Needham, and A.M. Calafat Assessing human exposure to phthalates using monoesters and their oxidized metabolites as biomarkers Environ. Health Perspect. 111 2003 1148 1151
7. CERHR, 2000. NTP-CERHR Expert Panel Report on Di-n-octyl phthalate. National Toxicology Program, U.S. Department of Health and Human Services, Research Triangle Park, NC. Available: http://cerhr.niehs.nih.gov/news/index. html (accessed 19 September 2003).
8. R.M. David, R.H. McKee, J.H. Butala, R.A. Barter, and M. Kayser Esters of aromatic mono-, di-, and tricarboxylic acids, aromatic diacids, and di-, tri-, or polyalcohols E. Bingham B. Cohrssen C.H. Powell Patty's Toxicology, vol. 6, 5th ed. 2001 Wiley New York 635 932
9. C.A. Harris, P. Henttu, M.G. Parker, and J.P. Sumpter The estrogenic activity of phthalate esters in vitro Environ. Health Perspect. 105 1997 802 811
10. K. Kato, M.J. Silva, J.A. Reidy, D. Hurtz, N.A. Malek, L.L. Needham, H. Nakazawa, D.B. Barr, and A.M. Calafat Mono-(2-ethyl-5-hydroxyhexyl) phthalate and mono-(2-ethyl-5-oxohexyl) phthalate as biomarkers for human exposure assessment to di-(2-ethylhexyl) phthalate Environ. Health Perspect. 112 2004 327 330
11. R. Kavlock, K. Boekelheide, R. Chapin, M. Cunningham, E. Faustman, P. Foster, M. Golub, R. Henderson, I. Hinberg, R. Little, J. Seed, K. Shea, S. Tabacova, R. Tyl, P. Williams, and T. Zacharewski NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-(2-ethylhexyl) phthalate Reprod. Toxicol. 16 2002 529 653
12. R. Kavlock, K. Boekelheide, R. Chapin, M. Cunningham, E. Faustman, P. Foster, M. Golub, R. Henderson, I. Hinberg, R. Little, J. Seed, K. Shea, S. Tabacova, R. Tyl, P. Williams, and T. Zacharewski NTP Center for the Evaluation of Risks to Human Reproduction: phthalates expert panel report on the reproductive and developmental toxicity of di-n-octyl phthalate Reprod. Toxicol. 16 2002 721 734
13. H.M. Koch, B. Rossbach, H. Drexler, and J. Angerer Internal exposure of the general population to DEHP and other phthalates - determination of secondary and primary phthalate monoester metabolites in urine Environ. Res. 93 2003 177 185
14. R. Poon, P. Lecavalier, R. Mueller, V.E. Valli, B.G. Procter, and I. Chu Subchronic oral toxicity of di-n-octyl phthalate and di-(2-ethylhexyl) phthalate in the rat Food Chem. Toxicol. 35 1997 225 239
15. M.J. Silva, D.B. Barr, J.A. Reidy, K. Kato, N.A. Malek, C.C. Hodge, D. Hurtz, A.M. Calafat, L.L. Needham, and J.W. Brock Glucuronidation patterns of common urinary and serum monoester phthalate metabolites Arch. Toxicol. 77 2003 561 567
16. M.J. Silva, A.R. Slakman, J.A. Reidy, J.L. Preau, A.R. Herbert, E. Samandar, L.L. Needham, and A.M. Calafat Analysis of human urine for fifteen phthalate metabolites using automated solid-phase extraction J. Chromatogr. B 805 2004 161 167
17. C.A. Staples, D.R. Peterson, T.F. Parkerton, and W.J. Adams The environmental fate of phthalate esters: a literature review Chemosphere 35 1997 667 749
18. T.R. Zacharewski, M.D. Meek, J.H. Clemons, Z.F. Wu, M.R. Fielden, and J.B. Matthews Examination of the in vitro and in vivo estrogenic activities of eight commercial phthalate esters Toxicol. Sci. 46 1998 282 293