PI3Kγ inhibition alleviates symptoms and increases axon number in experimental autoimmune encephalomyelitis mice

Neuroscience

Volumn 253, Issue , 2013, Pages 89-99

  Li, H ^a   Park, D ^a   Abdul Muneer, P M ^a   Xu, B ^a   Wang, H ^a   Xing, B ^a   Wu, D ^b   Li, S ^a  

^a TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Axon; EAE; Functional recovery; Multiple sclerosis; Myelination; PI3 kinase

Indexed keywords

5 [(2,2 DIFLUORO 1,3 BENZODIOXOL 5 YL)METHYLIDENE] 2,4 THIAZOLIDINEDIONE; CD3 ANTIGEN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; SEROTONIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL COUNT; CELL MIGRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DISEASE COURSE; DRUG DOSE COMPARISON; ENZYME INHIBITION; IN VIVO STUDY; INFLAMMATION; LEUKOCYTE; LUMBAR SPINAL CORD; MOUSE; MULTIPLE SCLEROSIS; MYELINATION; NERVE FIBER; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYMPTOM; SYSTEMIC THERAPY;

AXON; DIMETHYL SULFOXIDE; DMSO; EAE; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FUNCTIONAL RECOVERY; GPCR; GTP-BINDING PROTEIN-COUPLED RECEPTOR; KNOCKOUT; KO; LFB; LUXOL FAST BLUE; MBP; MOG; MS; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEIN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; MYELINATION; NEUROFILAMENT; NF; PBS; PHOSPHATE-BUFFERED SALINE; PHOSPHATIDYLINOSITOL-3 4 5-TRISPHOSPHATE; PHOSPHATIDYLINOSITOL-4 5-BISPHOSPHATE; PHOSPHOINOSITIDE 3-KINASE Γ; PI(3 4 5)P3; PI(4 5)P2; PI3 KINASE Γ; PI3KΓ;

ANIMALS; ANTIGENS, CD3; AXONS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DIOXOLES; DISEASE MODELS, ANIMAL; ECTODYSPLASINS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELIN SHEATH; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; NEUROFILAMENT PROTEINS; PEPTIDE FRAGMENTS; SEROTONIN; SEVERITY OF ILLNESS INDEX; SPINAL CORD; THIAZOLIDINEDIONES; TIME FACTORS;

EID: 84884536143     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2013.08.051     Document Type: Article

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