Bone alkaline phosphatase in CKD-mineral bone disorder

American Journal of Kidney Diseases

Volumn 62, Issue 4, 2013, Pages 810-822

  Sardiwal, Sunita ^a   Magnusson, Per ^b   Goldsmith, David J A ^c   Lamb, Edmund J ^a  

^a KENT AND CANTERBURY HOSPITAL   (United Kingdom)

^b LINKÖPING UNIVERSITY   (Sweden)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

bone alkaline phosphatase; bone disease; dialysis; Kidney disease; parathyroid hormone; vascular calcification

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; BIOLOGICAL MARKER; CALCIUM PHOSPHATE; CINACALCET; COLLAGEN TYPE 1; FIBROBLAST GROWTH FACTOR 23; GLYCEROL 2 PHOSPHATE; INORGANIC PYROPHOSPHATASE; OSTEOCALCIN; OSTEOPONTIN; PARATHYROID HORMONE; PHOSPHATE; VITAMIN D;

ADIPOGENESIS; ARTERY CALCIFICATION; ARTICLE; BLOOD SAMPLING; BLOOD VESSEL CALCIFICATION; BONE BIOPSY; BONE DISEASE; BONE TURNOVER; CARDIOVASCULAR DISEASE; CARDIOVASCULAR MORTALITY; CARDIOVASCULAR RISK; CHRONIC KIDNEY DISEASE; CORONARY ARTERY CALCIFICATION; DIAGNOSTIC ACCURACY; GRAFT RECIPIENT; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; HYPERPHOSPHATEMIA; KIDNEY FAILURE; LIPID STORAGE; MESENCHYMAL STEM CELL; MORPHOMETRICS; NONHUMAN; OSTEOBLAST; OSTEOLYSIS; OUTCOME ASSESSMENT; PATHOPHYSIOLOGY; PATIENT CARE; SECONDARY HYPERPARATHYROIDISM; TUNICA MEDIA;

EID: 84884530206     PISSN: 02726386     EISSN: 15236838     Source Type: Journal    
DOI: 10.1053/j.ajkd.2013.02.366     Document Type: Review

References (130)

1. M.J. Sarnak, A.S. Levey Cardiovascular disease and chronic renal disease: a new paradigm Am J Kidney Dis 35 4 suppl 1 2000 S117 S131
2. A.S. Go, G.M. Chertow, D. Fan Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization N Engl J Med 351 13 2004 1296 1305
3. S.M. Moe, T. Drueke, N. Lameire Chronic kidney disease-mineral-bone disorder: a new paradigm Adv Chronic Kidney Dis 14 1 2007 3 12
4. R.N. Moorthi, S.M. Moe CKD-mineral and bone disorder: core curriculum 2011 Am J Kidney Dis 58 6 2011 1022 1036
5. G. Garrett, S. Sardiwal, E.J. Lamb PTH - a particularly tricky hormone: why measure it at all in kidney patients? Clin J Am Soc Nephrol 8 2 2013 299 312
6. A.M. Alem, D.J. Sherrard, D.L. Gillen Increased risk of hip fracture among patients with end-stage renal disease Kidney Int 58 1 2000 396 399
7. M.D. Danese, J. Kim, Q.V. Doan PTH and the risks for hip, vertebral, and pelvic fractures among patients on dialysis Am J Kidney Dis 47 1 2006 149 156
8. A. Mittalhenkle, D.L. Gillen, C.O. Stehman-Breen Increased risk of mortality associated with hip fracture in the dialysis population Am J Kidney Dis 44 4 2004 672 679
9. Kidney Disease: Improving Global Outcomes KDIGO clinical practice guideline for the diagnosis, evaluation, prevention, and treatment of Chronic Kidney Disease-Mineral and Bone Disorder (CKD-MBD) Kidney Int Suppl 113 2009 S1 S130
10. H.H. Malluche, H.W. Mawad, M.C. Monier-Faugere Renal osteodystrophy in the first decade of the new millennium: analysis of 630 bone biopsies in black and white patients J Bone Miner Res 26 6 2011 1368 1376
11. S.M. Sprague Renal bone disease Curr Opin Endocrinol Diabetes Obes 17 6 2010 535 539
12. F.C. Barreto, D.V. Barreto, R.M. Moyses K/DOQI-recommended intact PTH levels do not prevent low-turnover bone disease in hemodialysis patients Kidney Int 73 6 2008 771 777
13. A. Gal-Moscovici, M.M. Popovtzer New worldwide trends in presentation of renal osteodystrophy and its relationship to parathyroid hormone levels Clin Nephrol 63 4 2005 284 289
14. C. Moore, J. Yee, H. Malluche Relationship between bone histology and markers of bone and mineral metabolism in African-American hemodialysis patients Clin J Am Soc Nephrol 4 9 2009 1484 1493
15. M. Rodriguez, V. Lorenzo Parathyroid hormone, a uremic toxin Semin Dial 22 4 2009 363 368
16. T.K. Teal, M. Reed, P.E. Stevens Stability of parathyroid hormone ex vivo in haemodialysis patients Ann Clin Biochem 40 pt 2 2003 191 193
17. J.H. Brossard, R. Lepage, H. Cardinal Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays Clin Chem 46 5 2000 697 703
18. R. Lepage, L. Roy, J.H. Brossard A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples Clin Chem 44 4 1998 805 809
19. J.H. Brossard, M. Cloutier, L. Roy Accumulation of a non-(1-84) molecular form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the interpretation of PTH values J Clin Endocrinol Metab 81 11 1996 3923 3929
20. T. Cantor, Z. Yang, N. Caraiani Lack of comparability of intact parathyroid hormone measurements among commercial assays for end-stage renal disease patients: implication for treatment decisions Clin Chem 52 9 2006 1771 1776
21. C.M. Sturgeon, S.M. Sprague, W. Metcalfe Variation in parathyroid hormone immunoassay results - a critical governance issue in the management of chronic kidney disease Nephrol Dial Transplant 26 11 2011 3440 3445
22. E.J. Lamb, S. Vickery, A.R. Ellis Parathyroid hormone, kidney disease, evidence and guidelines Ann Clin Biochem 44 pt 1 2007 1 4
23. A. Almond, A.R. Ellis, S.W. Walker Current parathyroid hormone immunoassays do not adequately meet the needs of patients with chronic kidney disease Ann Clin Biochem 49 pt 1 2012 63 67
24. C. Gardham, P.E. Stevens, M.P. Delaney Variability of parathyroid hormone and other markers of bone mineral metabolism in patients receiving hemodialysis Clin J Am Soc Nephrol 5 7 2010 1261 1267
25. B. Hocher, F.P. Armbruster, S. Stoeva Measuring parathyroid hormone (PTH) in patients with oxidative stress - do we need a fourth generation parathyroid hormone assay? PLoS One 7 7 2012 e40242
26. D. Martin, D.F. Tucker, P. Gorman The human placental alkaline phosphatase gene and related sequences map to chromosome 2 band q37 Ann Hum Genet 51 pt 2 1987 145 152
27. M. Smith, M.J. Weiss, C.A. Griffin Regional assignment of the gene for human liver/bone/kidney alkaline phosphatase to chromosome 1p36.1-p34 Genomics 2 2 1988 139 143
28. H. Harris The human alkaline phosphatases: what we know and what we don't know Clin Chim Acta 186 2 1990 133 150
29. C. Halling Linder, S. Narisawa, J.L. Millan Glycosylation differences contribute to distinct catalytic properties among bone alkaline phosphatase isoforms Bone 45 5 2009 987 993
30. P. Magnusson, J.R. Farley Differences in sialic acid residues among bone alkaline phosphatase isoforms: a physical, biochemical, and immunological characterization Calcif Tissue Int 71 6 2002 508 518
31. O. Nosjean, I. Koyama, M. Goseki Human tissue non-specific alkaline phosphatases: sugar-moiety-induced enzymic and antigenic modulations and genetic aspects Biochem J 321 pt 2 1997 297 303
32. P. Magnusson, M. Degerblad, M. Saaf Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like growth factor-I (IGF-I) and during growth hormone therapy in adults with growth hormone deficiency J Bone Miner Res 12 2 1997 210 220
33. L. Tibi, S.C. Chhabra, V.M. Sweeting Multiple forms of alkaline phosphatase in plasma of hemodialysis patients Clin Chem 37 6 1991 815 820
34. M.E. De Broe, V. Bosteels, R.J. Wieme Letter: Increased intestinal alkaline phosphatase in serum of patients on maintenance haemodialysis Lancet 1 7860 1974 753 754
35. M.E. De Broe, H.V. Van Multiple forms of alkaline phosphatase in plasma of hemodialysis patients Clin Chem 37 6 1991 783 784
36. K.N. Fedde, C.C. Lane, M.P. Whyte Alkaline phosphatase is an ectoenzyme that acts on micromolar concentrations of natural substrates at physiologic pH in human osteosarcoma (SAOS-2) cells Arch Biochem Biophys 264 2 1988 400 409
37. N.M. Hooper Glycosyl-phosphatidylinositol anchored membrane enzymes Clin Chim Acta 266 1 1997 3 12
38. T.C. Phan, J. Xu, M.H. Zheng Interaction between osteoblast and osteoclast: impact in bone disease Histol Histopathol 19 4 2004 1325 1344
39. H.C. Anderson, J.B. Sipe, L. Hessle Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice Am J Pathol 164 3 2004 841 847
40. D.J. Anh, H.P. Dimai, S.L. Hall Skeletal alkaline phosphatase activity is primarily released from human osteoblasts in an insoluble form, and the net release is inhibited by calcium and skeletal growth factors Calcif Tissue Int 62 4 1998 332 340
41. D.J. Anh, A. Eden, J.R. Farley Quantitation of soluble and skeletal alkaline phosphatase, and insoluble alkaline phosphatase anchor-hydrolase activities in human serum Clin Chim Acta 311 2 2001 137 148
42. M.P. Whyte Physiological role of alkaline phosphatase explored in hypophosphatasia Ann N Y Acad Sci 1192 2010 190 200
43. C. Wennberg, L. Hessle, P. Lundberg Functional characterization of osteoblasts and osteoclasts from alkaline phosphatase knockout mice J Bone Miner Res 15 10 2000 1879 1888
44. K.A. Johnson, L. Hessle, S. Vaingankar Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1 Am J Physiol Regul Integr Comp Physiol 279 4 2000 R1365 R1377
45. E. Mornet, E. Stura, A.S. Lia-Baldini Structural evidence for a functional role of human tissue nonspecific alkaline phosphatase in bone mineralization J Biol Chem 276 33 2001 31171 31178
46. F. Vittur, N. Stagni, L. Moro Alkaline phosphatase binds to collagen; a hypothesis on the mechanism of extravesicular mineralization in epiphyseal cartilage Experientia 40 8 1984 836 837
47. S. Yamada, M. Inaba, M. Kurajoh Utility of serum tartrate-resistant acid phosphatase (TRACP5b) as a bone resorption marker in patients with chronic kidney disease: independence from renal dysfunction Clin Endocrinol (Oxf) 69 2 2008 189 196
48. C. Bieglmayer, G. Prager, B. Niederle Kinetic analyses of parathyroid hormone clearance as measured by three rapid immunoassays during parathyroidectomy Clin Chem 48 10 2002 1731 1738
49. G.W. Maier, M.E. Kreis, W. Renn Parathyroid hormone after adenectomy for primary hyperparathyroidism A study of peptide hormone elimination kinetics in humans J Clin Endocrinol Metab 83 11 1998 3852 3856
50. S. Posen, H.S. Grunstein Turnover rate of skeletal alkaline phosphatase in humans Clin Chem 28 1 1982 153 154
51. M.P. Whyte, R. Valdes Jr, L.M. Ryan Infantile hypophosphatasia: enzyme replacement therapy by intravenous infusion of alkaline phosphatase-rich plasma from patients with Paget bone disease J Pediatr 101 3 1982 379 386
52. P. Magnusson, C.A. Sharp, M. Magnusson Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms Kidney Int 60 1 2001 257 265
53. P. Magnusson, O. Lofman, L. Larsson Methodological aspects on separation and reaction conditions of bone and liver alkaline phosphatase isoform analysis by high-performance liquid chromatography Anal Biochem 211 1 1993 156 163
54. P. Magnusson, L. Larsson, M. Magnusson Isoforms of bone alkaline phosphatase: characterization and origin in human trabecular and cortical bone J Bone Miner Res 14 11 1999 1926 1933
55. P. Magnusson, C.A. Sharp, J.R. Farley Different distributions of human bone alkaline phosphatase isoforms in serum and bone tissue extracts Clin Chim Acta 325 1-2 2002 59 70
56. P. Magnusson, A. Hager, L. Larsson Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents Pediatr Res 38 6 1995 955 961
57. P. Magnusson, O. Lofman, L. Larsson Determination of alkaline phosphatase isoenzymes in serum by high-performance liquid chromatography with post-column reaction detection J Chromatogr 576 1 1992 79 86
58. P. Magnusson, M.W. Davie, C.A. Sharp Circulating and tissue-derived isoforms of bone alkaline phosphatase in Paget's disease of bone Scand J Clin Lab Invest 70 2 2010 128 135
59. P. Magnusson, L. Larsson, G. Englund Differences of bone alkaline phosphatase isoforms in metastatic bone disease and discrepant effects of clodronate on different skeletal sites indicated by the location of pain Clin Chem 44 8, pt 1 1998 1621 1628
60. M. Haarhaus, H.J. Arnqvist, P. Magnusson Calcifying human aortic smooth muscle cells express different bone alkaline phosphatase isoforms, including the novel B1x isoform J Vasc Res 50 2 2013 167 174
61. M. Haarhaus, A. Fernstrom, M. Magnusson Clinical significance of bone alkaline phosphatase isoforms, including the novel B1x isoform, in mild to moderate chronic kidney disease Nephrol Dial Transplant 24 11 2009 3382 3389
62. D. Swolin-Eide, S. Hansson, L. Larsson The novel bone alkaline phosphatase B1x isoform in children with kidney disease Pediatr Nephrol 21 11 2006 1723 1729
63. V. Van Hoof, M.E. De Broe Interpretation and clinical significance of alkaline phosphatase isoenzyme patterns Crit Rev Clin Lab Sci 31 3 1994 197 293
64. D.W. Moss, L.G. Whitby A simplified heat-inactivation method for investigating alkaline phosphatase isoenzymes in serum Clin Chim Acta 61 1 1975 63 71
65. S.B. Rosalki, A.Y. Foo Two new methods for separating and quantifying bone and liver alkaline phosphatase isoenzymes in plasma Clin Chem 30 7 1984 1182 1186
66. J. Griffiths, J. Black Separation and identification of alkaline phosphatase isoenzymes and isoforms in serum of healthy persons by isoelectric focusing Clin Chem 33 12 1987 2171 2177
67. D.L. Broyles, R.G. Nielsen, E.M. Bussett Analytical and clinical performance characteristics of Tandem-MP Ostase, a new immunoassay for serum bone alkaline phosphatase Clin Chem 44 10 1998 2139 2147
68. B. Gomez Jr, S. Ardakani, J. Ju Monoclonal antibody assay for measuring bone-specific alkaline phosphatase activity in serum Clin Chem 41 11 1995 1560 1566
69. C.S. Hill, R.L. Wolfert The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase Clin Chim Acta 186 2 1990 315 320
70. K. Panigrahi, P.D. Delmas, F. Singer Characteristics of a two-site immunoradiometric assay for human skeletal alkaline phosphatase in serum Clin Chem 40 5 1994 822 828
71. P. Magnusson, L. Arlestig, E. Paus Monoclonal antibodies against tissue-nonspecific alkaline phosphatase Report of the ISOBM TD9 workshop Tumour Biol 23 4 2002 228 248
72. A.R. Bervoets, G.B. Spasovski, G.J. Behets Useful biochemical markers for diagnosing renal osteodystrophy in predialysis end-stage renal failure patients Am J Kidney Dis 41 5 2003 997 1007
73. G. Coen, P. Ballanti, E. Bonucci Bone markers in the diagnosis of low turnover osteodystrophy in haemodialysis patients Nephrol Dial Transplant 13 9 1998 2294 2302
74. M.M. Couttenye, P.C. D'Haese, H.V. Van Low serum levels of alkaline phosphatase of bone origin: a good marker of adynamic bone disease in haemodialysis patients Nephrol Dial Transplant 11 6 1996 1065 1072
75. S. Fletcher, R.G. Jones, H.C. Rayner Assessment of renal osteodystrophy in dialysis patients: use of bone alkaline phosphatase, bone mineral density and parathyroid ultrasound in comparison with bone histology Nephron 75 4 1997 412 419
76. C. Jarava, J.R. Armas, M. Salgueira Bone alkaline phosphatase isoenzyme in renal osteodystrophy Nephrol Dial Transplant 11 suppl 3 1996 43 46
77. G. Lehmann, U. Ott, D. Kaemmerer Bone histomorphometry and biochemical markers of bone turnover in patients with chronic kidney disease stages 3-5 Clin Nephrol 70 4 2008 296 305
78. P. Urena, M. Hruby, A. Ferreira Plasma total versus bone alkaline phosphatase as markers of bone turnover in hemodialysis patients J Am Soc Nephrol 7 3 1996 506 512
79. Malluche H, Bellorin-Font E, Rojas E, et al. Predictive value of biomarkers for bone turnover in ESKD [abstract]. Presented at American Society of Nephrology Renal Week; November 16-21, 2010; Denver, CO.
80. G.A. Block, K.J. Martin, A.L. de Francisco Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis N Engl J Med 350 15 2004 1516 1525
81. V. Belozeroff, W.G. Goodman, L. Ren Cinacalcet lowers serum alkaline phosphatase in maintenance hemodialysis patients Clin J Am Soc Nephrol 4 3 2009 673 679
82. J. Bonet, B. Bayes, P. Fernandez-Crespo Cinacalcet may reduce arterial stiffness in patients with chronic renal disease and secondary hyperparathyroidism - results of a small-scale, prospective, observational study Clin Nephrol 75 3 2011 181 187
83. M. Ketteler, K.J. Martin, M. Wolf Paricalcitol versus cinacalcet plus low-dose vitamin D therapy for the treatment of secondary hyperparathyroidism in patients receiving haemodialysis: results of the IMPACT SHPT Study Nephrol Dial Transplant 27 8 2012 3270 3278
84. M. Ueda, M. Inaba, S. Okuno Serum BAP as the clinically useful marker for predicting BMD reduction in diabetic hemodialysis patients with low PTH Life Sci 77 10 2005 1130 1139
85. Y. Tsuruta, K. Okano, K. Kikuchi Effects of cinacalcet on bone mineral density and bone markers in hemodialysis patients with secondary hyperparathyroidism Clin Exp Nephrol 17 1 2013 120 126
86. J.C. Park, C.P. Kovesdy, U. Duong Association of serum alkaline phosphatase and bone mineral density in maintenance hemodialysis patients Hemodial Int 14 2 2010 182 192
87. S. Sardiwal, C. Gardham, A.E. Coleman Bone-specific alkaline phosphatase concentrations are less variable than those of parathyroid hormone in stable hemodialysis patients Kidney Int 82 1 2012 100 105
88. N.X. Chen, S.M. Moe Vascular calcification: pathophysiology and risk factors Curr Hypertens Rep 14 3 2012 228 237
89. A. Covic, M. Kanbay, L. Voroneanu Vascular calcification in chronic kidney disease Clin Sci (Lond) 119 3 2010 111 121
90. G. Coen Calcimimetics, parathyroid hormone, and vascular calcification in chronic kidney disease Kidney Int 74 10 2008 1229 1231
91. J.B. Cannata-Andia, P. Roman-Garcia, K. Hruska The connections between vascular calcification and bone health Nephrol Dial Transplant 26 11 2011 3429 3436
92. G.A. Block Prevalence and clinical consequences of elevated Ca x P product in hemodialysis patients Clin Nephrol 54 4 2000 318 324
93. J. Braun, M. Oldendorf, W. Moshage Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients Am J Kidney Dis 27 3 1996 394 401
94. M. Noordzij, E.M. Cranenburg, L.F. Engelsman Progression of aortic calcification is associated with disorders of mineral metabolism and mortality in chronic dialysis patients Nephrol Dial Transplant 26 5 2011 1662 1669
95. G.M. London, A.P. Guerin, S.J. Marchais Arterial media calcification in end-stage renal disease: impact on all-cause and cardiovascular mortality Nephrol Dial Transplant 18 9 2003 1731 1740
96. S.M. Moe, K.D. O'Neill, D. Duan Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins Kidney Int 61 2 2002 638 647
97. K. Bostrom, K.E. Watson, S. Horn Bone morphogenetic protein expression in human atherosclerotic lesions J Clin Invest 91 4 1993 1800 1809
98. L.A. Fitzpatrick, A. Severson, W.D. Edwards Diffuse calcification in human coronary arteries Association of osteopontin with atherosclerosis J Clin Invest 94 4 1994 1597 1604
99. C.M. Shanahan, N.R. Cary, J.C. Metcalfe High expression of genes for calcification-regulating proteins in human atherosclerotic plaques J Clin Invest 93 6 1994 2393 2402
100. C.M. Giachelli, N. Bae, M. Almeida Osteopontin is elevated during neointima formation in rat arteries and is a novel component of human atherosclerotic plaques J Clin Invest 92 4 1993 1686 1696
101. K. Lomashvili, P. Garg, W.C. O'Neill Chemical and hormonal determinants of vascular calcification in vitro Kidney Int 69 8 2006 1464 1470
102. S.M. Moe, N.X. Chen Pathophysiology of vascular calcification in chronic kidney disease Circ Res 95 6 2004 560 567
103. J.M. Chillon, A. Mozar, I. Six Pathophysiological mechanisms and consequences of cardiovascular calcifications: role of uremic toxicity Ann Pharm Fr 67 4 2009 234 240
104. K.A. Lomashvili, S. Cobbs, R.A. Hennigar Phosphate-induced vascular calcification: role of pyrophosphate and osteopontin J Am Soc Nephrol 15 6 2004 1392 1401
105. K.A. Lomashvili, P. Garg, S. Narisawa Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification Kidney Int 73 9 2008 1024 1030
106. W.C. O'Neill, K.A. Lomashvili, H.H. Malluche Treatment with pyrophosphate inhibits uremic vascular calcification Kidney Int 79 5 2011 512 517
107. B.L. Riser, F.C. Barreto, R. Rezg Daily peritoneal administration of sodium pyrophosphate in a dialysis solution prevents the development of vascular calcification in a mouse model of uraemia Nephrol Dial Transplant 26 10 2011 3349 3357
108. R.A. Terkeltaub Inorganic pyrophosphate generation and disposition in pathophysiology Am J Physiol Cell Physiol 281 1 2001 C1 C11
109. S. Narisawa, D. Harmey, M.C. Yadav Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification J Bone Miner Res 22 11 2007 1700 1710
110. A.T. Ali, C.B. Penny, J.E. Paiker Alkaline phosphatase is involved in the control of adipogenesis in the murine preadipocyte cell line, 3T3-L1 Clin Chim Acta 354 1-2 2005 101 109
111. A.T. Ali, C.B. Penny, J.E. Paiker The effect of alkaline phosphatase inhibitors on intracellular lipid accumulation in preadipocytes isolated from human mammary tissue Ann Clin Biochem 43 pt 3 2006 207 213
112. W.S. Ryu, S.H. Lee, C.K. Kim Increased serum alkaline phosphatase as a predictor of long-term mortality after stroke Neurology 75 22 2010 1995 2002
113. M. Tonelli, G. Curhan, M. Pfeffer Relation between alkaline phosphatase, serum phosphate, and all-cause or cardiovascular mortality Circulation 120 18 2009 1784 1792
114. V.R. Krishnamurthy, B.C. Baird, G. Wei Associations of serum alkaline phosphatase with metabolic syndrome and mortality Am J Med 124 6 2011 566 567
115. M. Abramowitz, P. Muntner, M. Coco Serum alkaline phosphatase and phosphate and risk of mortality and hospitalization Clin J Am Soc Nephrol 5 6 2010 1064 1071
116. B.M. Cheung, K.L. Ong, L.Y. Wong Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004 Int J Cardiol 135 2 2009 156 161
117. M.J. Blayney, R.L. Pisoni, J.L. Bragg-Gresham High alkaline phosphatase levels in hemodialysis patients are associated with higher risk of hospitalization and death Kidney Int 74 5 2008 655 663
118. K. Kalantar-Zadeh, N. Kuwae, D.L. Regidor Survival predictability of time-varying indicators of bone disease in maintenance hemodialysis patients Kidney Int 70 4 2006 771 780
119. D.L. Regidor, C.P. Kovesdy, R. Mehrotra Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients J Am Soc Nephrol 19 11 2008 2193 2203
120. C.P. Kovesdy, V. Ureche, J.L. Lu Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD Nephrol Dial Transplant 25 9 2010 3003 3011
121. M.Z. Molnar, C.P. Kovesdy, I. Mucsi Association of pre-kidney transplant markers of mineral and bone disorder with post-transplant outcomes Clin J Am Soc Nephrol 7 11 2012 1859 1871
122. C. Drechsler, M. Verduijn, S. Pilz Bone alkaline phosphatase and mortality in dialysis patients Clin J Am Soc Nephrol 6 7 2011 1752 1759
123. I. Kobayashi, K. Shidara, S. Okuno Higher serum bone alkaline phosphatase as a predictor of mortality in male hemodialysis patients Life Sci 90 5-6 2012 212 218
124. E. Ritz, H.H. Malluche, B. Krempien Pathogenesis of renal osteodystrophy: roles of phosphate and skeletal resistance to PTH Adv Exp Med Biol 103 1978 423 436
125. R. Bhuriya, S. Li, S.C. Chen Plasma parathyroid hormone level and prevalent cardiovascular disease in CKD stages 3 and 4: an analysis from the Kidney Early Evaluation Program (KEEP) Am J Kidney Dis 53 4 suppl 4 2009 S3 S10
126. C. Vulpio, M. Bossola, D. Speranza Influence of blood sampling site on intact parathyroid hormone concentrations in hemodialysis patients Clin Chem 56 3 2010 489 490
127. G.M. Chertow, G.A. Block, R. Correa-Rotter Effect of cinacalcet on cardiovascular disease in patients undergoing dialysis N Engl J Med 367 26 2012 2482 2494
128. T.B. Drueke, M.H. Lafage-Proust Sclerostin: just one more player in renal bone disease? Clin J Am Soc Nephrol 6 4 2011 700 703
129. S. Thambiah, R. Roplekar, P. Manghat Circulating sclerostin and Dickkopf-1 (DKK1) in predialysis chronic kidney disease (CKD): relationship with bone density and arterial stiffness Calcif Tissue Int 90 6 2012 473 480
130. M. Fukagawa, T. Nii-Kono, J.J. Kazama Role of fibroblast growth factor 23 in health and in chronic kidney disease Curr Opin Nephrol Hypertens 14 4 2005 325 329