Serum alkaline phosphatase and phosphate and risk of mortality and hospitalization

Clinical Journal of the American Society of Nephrology

Volumn 5, Issue 6, 2010, Pages 1064-1071

  Abramowitz, Matthew ^a   Muntner, Paul ^b   Coco, Maria ^a   Southern, William ^a   Lotwin, Irwin ^a   Hostetter, Thomas H ^a   Melamed, Michal L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; PHOSPHATE; BIOLOGICAL MARKER;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; DIABETES MELLITUS; ETHNICITY; FEMALE; GLOMERULUS FILTRATION RATE; HOSPITALIZATION; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHOSPHATE BLOOD LEVEL; RISK FACTOR; AGED; BLOOD; CARDIOVASCULAR DISEASES; CHI SQUARE DISTRIBUTION; COMPLICATION; EPIDEMIOLOGY; KIDNEY FAILURE, CHRONIC; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; RISK ASSESSMENT; STATISTICS AND NUMERICAL DATA; TIME; UNITED STATES; UPREGULATION; URBAN POPULATION;

ADULT; AGED; ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CHI-SQUARE DISTRIBUTION; FEMALE; GLOMERULAR FILTRATION RATE; HOSPITALIZATION; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; NEW YORK CITY; PHOSPHATES; PROPORTIONAL HAZARDS MODELS; RENAL DIALYSIS; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; UP-REGULATION; URBAN POPULATION;

EID: 77953298199     PISSN: 15559041     EISSN: 1555905X     Source Type: Journal    
DOI: 10.2215/CJN.08621209     Document Type: Article

References (37)

1. Foley RN, Parfrey PS, Sarnak MJ: Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis 32: S112-S119, 1998 (Pubitemid 28527268)
2. Giachelli CM, Speer MY, Li X, Rajachar RM, Yang H: Regulation of vascular calcification: Roles of phosphate and osteopontin. Circ Res 96: 717-722, 2005
3. Steitz SA, Speer MY, Curinga G, Yang HY, Haynes P, Aebersold R, Schinke T, Karsenty G, Giachelli CM: Smooth muscle cell phenotypic transition associated with calcification: Upregulation of Cbfa1 and downregulation of smooth muscle lineage markers. Circ Res 89: 1147-1154, 2001 (Pubitemid 34627872)
4. Lomashvili K, Garg P, O'Neill WC: Chemical and hormonal determinants of vascular calcification in vitro. Kidney Int 69: 1464-1470, 2006
5. Block GA, Hulbert-Shearon TE, Levin NW, Port FK: Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study. Am J Kidney Dis 31: 607-617, 1998 (Pubitemid 28158000)
6. Block GA, Klassen PS, Lazarus JM, Ofsthun N, Lowrie EG, Chertow GM: Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 15: 2208-2218, 2004
7. Ganesh SK, Stack AG, Levin NW, Hulbert-Shearon T, Port FK: Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients. J Am Soc Nephrol 12: 2131-2138, 2001 (Pubitemid 32880350)
8. Melamed ML, Eustace JA, Plantinga L, Jaar BG, Fink NE, Coresh J, Klag MJ, Powe NR: Changes in serum calcium, phosphate, and PTH and the risk of death in incident dialysis patients: A longitudinal study. Kidney Int 70: 351-357, 2006
9. Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB Sr, Gaziano JM, Vasan RS: Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 167: 879-885, 2007
10. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G: Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112: 2627-2633, 2005
11. Regidor DL, Kovesdy CP, Mehrotra R, Rambod M, Jing J, McAllister CJ, Van Wyck D, Kopple JD, Kalantar-Zadeh K: Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients. J Am Soc Nephrol 19: 2193-2203, 2008
12. Blayney MJ, Pisoni RL, Bragg-Gresham JL, Bommer J, Piera L, Saito A, Akiba T, Keen ML, Young EW, Port FK: High alkaline phosphatase levels in hemodialysis patients are associated with higher risk of hospitalization and death. Kidney Int 74: 655-663, 2008
13. Tonelli M, Curhan G, Pfeffer M, Sacks F, Thadhani R, Melamed ML, Wiebe N, Muntner P: Relation between alkaline phosphatase, serum phosphate, and all-cause or cardiovascular mortality. Circulation 120: 1784-1792, 2009
14. Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA: Serum phosphorus levels associate with coronary atherosclerosis in young adults. J Am Soc Nephrol 20: 397-404, 2009
15. Shantouf R, Kovesdy CP, Kim Y, Ahmadi N, Luna A, Luna C, Rambod M, Nissenson AR, Budoff MJ, Kalantar-Zadeh K: Association of serum alkaline phosphatase with coronary artery calcification in maintenance hemodialysis patients. Clin J Am Soc Nephrol 4: 1106-1114, 2009
16. O'Neill WC, Sigrist MK, McIntyre CW: Plasma pyrophosphate and vascular calcification in chronic kidney disease. Nephrol Dial Transplant 25: 187-191, 2010
17. Blacher J, Guerin AP, Pannier B, Marchais SJ, London GM: Arterial calcifications, arterial stiffness, and cardiovascular risk in end-stage renal disease. Hypertension 38: 938-942, 2001 (Pubitemid 34258697)
18. Detrano R, Guerci AD, Carr JJ, Bild DE, Burke G, Folsom AR, Liu K, Shea S, Szklo M, Bluemke DA, O'Leary DH, Tracy R, Watson K, Wong ND, Kronmal RA: Coronary calcium as a predictor of coronary events in four racial or ethnic groups. N Engl J Med 358: 1336-1345, 2008
19. Bagger YZ, Tanko LB, Alexandersen P, Qin G, Christiansen C: Radiographic measure of aorta calcification is a site-specific predictor of bone loss and fracture risk at the hip. J Intern Med 259: 598-605, 2006
20. Hak AE, Pols HA, van Hemert AM, Hofman A, Witteman JC: Progression of aortic calcification is associated with metacarpal bone loss during menopause: A population-based longitudinal study. Arterioscler Thromb Vasc Biol 20: 1926-1931, 2000
21. Schulz E, Arfai K, Liu X, Sayre J, Gilsanz V: Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 89: 4246-4253, 2004
22. Southern WN, Berger MA, Bellin EY, Hailpern SM, Arnsten JH: Hospitalist care and length of stay in patients requiring complex discharge planning and close clinical monitoring. Arch Intern Med 167: 1869-1874, 2007
23. Levey AS, Greene T, Kusek JW, Beck GJ: A simplified equation to predict glomerular filtration rate from serum creatinine [Abstract]. J Am Soc Nephrol 11: 155A, 2000
24. Cowper DC, Kubal JD, Maynard C, Hynes DM: A primer and comparative review of major US mortality databases. Ann Epidemiol 12: 462-468, 2002
25. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF III, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, Coresh J: A new equation to estimate glomerular filtration rate. Ann Intern Med 150: 604-612, 2009
26. Royston P: Multiple imputation of missing values. Stata J 4: 227-241, 2004
27. van Buuren S, Boshuizen HC, Knook DL: Multiple imputation of missing blood pressure covariates in survival analysis. Stat Med 18: 681-694, 1999
28. Narisawa S, Harmey D, Yadav MC, O'Neill WC, Hoylaerts MF, Millan JL: Novel inhibitors of alkaline phosphatase suppress vascular smooth muscle cell calcification. J Bone Miner Res 22: 1700-1710, 2007
29. Iba K, Takada J, Yamashita T: The serum level of bone-specific alkaline phosphatase activity is associated with aortic calcification in osteoporosis patients. J Bone Miner Metab 22: 594-596, 2004
30. Plantinga LC, Fink NE, Melamed ML, Briggs WA, Powe NR, Jaar BG: Serum phosphate levels and risk of infection in incident dialysis patients. Clin J Am Soc Nephrol 3: 1398-1406, 2008
31. Horowitz MC, Bothwell AL, Hesslein DG, Pflugh DL, Schatz DG: B cells and osteoblast and osteoclast development. Immunol Rev 208: 141-153, 2005
32. Jollis JG, Ancukiewicz M, DeLong ER, Pryor DB, Muhlbaier LH, Mark DB: Discordance of databases designed for claims payment versus clinical information systems. Implications for outcomes research. Ann Intern Med 119: 844-850, 1993 (Pubitemid 24012651)
33. Dominici F, Peng RD, Bell ML, Pham L, McDermott A, Zeger SL, Samet JM: Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 295: 1127-1134, 2006
34. Chavers BM, Solid CA, Gilbertson DT, Collins AJ: Infection-related hospitalization rates in pediatric versus adult patients with end-stage renal disease in the United States. J Am Soc Nephrol 18: 952-959, 2007
35. Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA: Risk of pelvic fractures in older women following pelvic irradiation. JAMA 294: 2587-2593, 2005
36. Brauer CA, Coca-Perraillon M, Cutler DM, Rosen AB: Incidence and mortality of hip fractures in the United States. JAMA 302: 1573-1579, 2009
37. Parikh S, Mogun H, Avorn J, Solomon DH: Osteoporosis medication use in nursing home patients with fractures in 1 US state. Arch Intern Med 168: 1111-1115, 2008