Measuring parathyroid hormone (PTH) in patients with oxidative stress - do we need a fourth generation parathyroid hormone assay?

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Hocher, Berthold ^a   Armbruster, Franz Paul ^b   Stoeva, Stanka ^b   Reichetzeder, Christoph ^a   Grön, Hans Jürgen ^b   Lieker, Ina ^c   Khadzhynov, Dmytro ^c   Slowinski, Torsten ^c   Roth, Heinz Jürgen ^d  

^a UNIVERSITY OF POTSDAM   (Germany)

^b IMMUNDIAGNOSTIK AG   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Limbach Laboratory   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONINE SULFOXIDE; MONOCLONAL ANTIBODY; PARATHYROID HORMONE; SULFONE; TRYPTOPHAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DIALYSIS; ENZYME IMMUNOASSAY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; HUMAN; IMMUNOAFFINITY CHROMATOGRAPHY; KIDNEY FAILURE; MALE; MOLECULAR WEIGHT; OXIDATION; OXIDATIVE STRESS; PROTEIN CLEAVAGE; TANDEM MASS SPECTROMETRY; TREATMENT DURATION;

ADULT; AGED; CHROMATOGRAPHY, LIQUID; FEMALE; HUMANS; KIDNEY DISEASES; MALE; MIDDLE AGED; OXIDATION-REDUCTION; OXIDATIVE STRESS; PARATHYROID HORMONE; TANDEM MASS SPECTROMETRY;

EID: 84863687016     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040242     Document Type: Article

References (27)

1. Fraser WD, (2009) Hyperparathyroidism. Lancet 374: 145-158 doi:10.1016/S0140-6736(09)60507-9.
2. Berson SA, Yalow RS, Aurbach GD, Potts JT, (1963) IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE. Proc Natl Acad Sci USA 49: 613-617.
3. Blind E, (2008) Twenty years of progress with parathyroid hormone (PTH): from specialized and "difficult" measurement to common laboratory parameter and treatment option in osteoporosis. Clin Lab 54: 439-449.
4. Keutmann HT, Sauer MM, Hendy GN, O'Riordan LH, Potts JT Jr, (1978) Complete amino acid sequence of human parathyroid hormone. Biochemistry 17: 5723-5729.
5. Blind E, Schmidt-Gayk H, Armbruster FP, Stadler A, (1987) Measurement of intact human parathyrin by an extracting two-site immunoradiometric assay. Clin Chem 33: 1376-1381.
6. Quarles LD, Lobaugh B, Murphy G, (1992) Intact parathyroid hormone overestimates the presence and severity of parathyroid-mediated osseous abnormalities in uremia. J Clin Endocrinol Metab 75: 145-150.
7. Lepage R, Roy L, Brossard JH, Rousseau L, Dorais C, et al. (1998) A non-(1-84) circulating parathyroid hormone (PTH) fragment interferes significantly with intact PTH commercial assay measurements in uremic samples. Clin Chem 44: 805-809.
8. Brossard JH, Lepage R, Cardinal H, Roy L, Rousseau L, et al. (2000) Influence of glomerular filtration rate on non-(1-84) parathyroid hormone (PTH) detected by intact PTH assays. Clin Chem 46: 697-703.
9. Vogt W, (1995) Oxidation of methionyl residues in proteins: tools, targets, and reversal. Free Radic Biol Med 18: 93-105.
10. Galceran T, Lewis-Finch J, Martin KJ, Slatopolsky E, (1984) Absence of biological effects of oxidized parathyroid hormone-(1-34) in dogs and rats. Endocrinology 115: 2375-2378.
11. Horiuchi N, (1988) Effects of oxidation of human parathyroid hormone on its biological activity in continuously infused, thyroparathyroidectomized rats. J Bone Miner Res 3: 353-358 doi:10.1002/jbmr.5650030316.
12. Zull JE, Smith SK, Wiltshire R, (1990) Effect of methionine oxidation and deletion of amino-terminal residues on the conformation of parathyroid hormone. Circular dichroism studies. J Biol Chem 265: 5671-5676.
13. Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, et al. (1996) Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int 49: 1304-1313.
14. Tampe J, Broszio P, Manneck HE, Missbichler A, Blind E, et al. (1992) Characterization of antibodies against human N-terminal parathyroid hormone by epitope mapping. J Immunoassay 13: 1-13.
15. Rodriguez M, Felsenfeld AJ, Williams C, Pederson JA, Llach F, (1991) The effect of long-term intravenous calcitriol administration on parathyroid function in hemodialysis patients. J Am Soc Nephrol 2: 1014-1020.
16. Felsenfeld AJ, Rodriguez M, Dunlay R, Llach F, (1991) A comparison of parathyroid-gland function in haemodialysis patients with different forms of renal osteodystrophy. Nephrol Dial Transplant 6: 244-251.
17. Ramirez JA, Goodman WG, Gornbein J, Menezes C, Moulton L, et al. (1993) Direct in vivo comparison of calcium-regulated parathyroid hormone secretion in normal volunteers and patients with secondary hyperparathyroidism. J Clin Endocrinol Metab 76: 1489-1494.
18. Malberti F, Surian M, Cosci P, (1992) Effect of chronic intravenous calcitriol on parathyroid function and set point of calcium in dialysis patients with refractory secondary hyperparathyroidism. Nephrol Dial Transplant 7: 822-828.
19. Messa P, Vallone C, Mioni G, Geatti O, Turrin D, et al. (1994) Direct in vivo assessment of parathyroid hormone-calcium relationship curve in renal patients. Kidney Int 46: 1713-1720.
20. Sanchez CP, Goodman WG, Ramirez JA, Gales B, Belin TR, et al. (1995) Calcium-regulated parathyroid hormone secretion in adynamic renal osteodystrophy. Kidney Int 48: 838-843.
21. Slatopolsky E, Finch J, Clay P, Martin D, Sicard G, et al. (2000) A novel mechanism for skeletal resistance in uremia. Kidney Int 58: 753-761 doi:10.1046/j.1523-1755.2000.00222.x.
22. O'Riordan JL, Woodhead JS, Hendy GN, Parsons JA, Robinson CJ, et al. (1974) Effect of oxidation on biological and immunological activity of porcine parathyroid hormone. J Endocrinol 63: 117-124.
23. Lopez MF, Rezai T, Sarracino DA, Prakash A, Krastins B, et al. (2010) Selected reaction monitoring-mass spectrometric immunoassay responsive to parathyroid hormone and related variants. Clin Chem 56: 281-290 doi:10.1373/clinchem.2009.137323.
24. Kumar V, Barnidge DR, Chen L-S, Twentyman JM, Cradic KW, et al. (2010) Quantification of serum 1-84 parathyroid hormone in patients with hyperparathyroidism by immunocapture in situ digestion liquid chromatography-tandem mass spectrometry. Clin Chem 56: 306-313 doi:10.1373/clinchem.2009.134643.
25. Chaykovska L, Tsuprykov O, Hocher B, (2011) Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy. Clin Lab 57: 455-467.
26. Garrett G, Goldsmith DJA, (2012) Parathyroid hormone measurements, guidelines statements and clinical treatments: a real-world cautionary tale. Ann Clin Biochem 49: 4-6 doi:10.1258/acb.2011.011254.
27. Garrett G, Sardiwal S, Lamb EJ, Goldsmith DJ, (2012) PTH-A Particularly Tricky Hormone: Why Measure It at All in Kidney Patients? Clin J Am Soc Nephrol. 2012 Mar 8. [Epub ahead of print].