Associations of serum alkaline phosphatase with metabolic syndrome and mortality

American Journal of Medicine

Volumn 124, Issue 6, 2011, Pages

  Krishnamurthy, Vidya Raj ^a,b   Baird, Bradley C ^b   Wei, Guo ^b   Greene, Tom ^a,b   Raphael, Kalani ^a,b   Beddhu, Srinivasan ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

All cause mortality; Metabolic syndrome; Serum alkaline phosphatase

Indexed keywords

ALKALINE PHOSPHATASE;

ADULT; ALKALINE PHOSPHATASE BLOOD LEVEL; ARTICLE; DEMOGRAPHY; DISEASE ASSOCIATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MORTALITY; PREVALENCE; PRIORITY JOURNAL;

ADULT; AGED; ALKALINE PHOSPHATASE; BIOLOGICAL MARKERS; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; METABOLIC SYNDROME X; MIDDLE AGED; MORTALITY; MULTIVARIATE ANALYSIS; NUTRITION SURVEYS; ODDS RATIO; PREVALENCE; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; RISK FACTORS; UNITED STATES;

EID: 79957503249     PISSN: 00029343     EISSN: 15557162     Source Type: Journal    
DOI: 10.1016/j.amjmed.2010.11.030     Document Type: Article

References (28)

1. D.S. Pratt, and M.M. Kaplan Evaluation of abnormal liver-enzyme results in asymptomatic patients N Engl J Med 342 17 2000 1266 1271 (Pubitemid 30235957)
2. J.K. Limdi, and G.M. Hyde Evaluation of abnormal liver function tests Postgrad Med J 79 932 2003 307 312 (Pubitemid 36819456)
3. M. Tonelli, G. Curhan, and M. Pfeffer Relation between alkaline phosphatase, serum phosphate, and all-cause or cardiovascular mortality Circulation 120 18 2009 1784 1792
4. S. Beddhu, X. Ma, B. Baird, A.K. Cheung, and T. Greene Serum alkaline phosphatase and mortality in African Americans with chronic kidney disease Clin J Am Soc Nephrol 4 11 2009 1805 1810
5. M.J. Blayney, R.L. Pisoni, and J.L. Bragg-Gresham High alkaline phosphatase levels in hemodialysis patients are associated with higher risk of hospitalization and death Kidney Int 75 5 2008 655 663
6. K. Kalantar-Zadeh, M.L. Brennan, and S.L. Hazen Serum myeloperoxidase and mortality in maintenance hemodialysis patients Am J Kidney Dis 48 1 2006 59 68
7. G.H. Lee, D. Benner, D.L. Regidor, and K. Kalantar-Zadeh Impact of kidney bone disease and its management on survival of patients on dialysis J Ren Nutr 17 1 2007 38 44 (Pubitemid 46014446)
8. D.L. Regidor, C.P. Kovesdy, and R. Mehrotra Serum alkaline phosphatase predicts mortality among maintenance hemodialysis patients J Am Soc Nephrol 19 11 2008 2193 2203
9. T.E. Clancy, T.P. Sengupta, J. Paulus, F. Ahmed, M.S. Duh, and M.H. Kulke Alkaline phosphatase predicts survival in patients with metastatic neuroendocrine tumors Dig Dis Sci 51 5 2006 877 884 (Pubitemid 44030808)
10. D. Robinson, G. Sandblom, and R. Johansson Prediction of survival of metastatic prostate cancer based on early serial measurements of prostate specific antigen and alkaline phosphatase J Urol 179 1 2008 117 122 discussion 122-123
11. P.N. Lara Jr, C.M. Tangen, S.J. Conlon, R.C. Flanigan, and E.D. Crawford Predictors of survival of advanced renal cell carcinoma: long-term results from Southwest Oncology Group Trial S8949 J Urol 181 2 2009 512 516 discussion 516-517
12. M.J. Blayney, R.L. Pisoni, and J.L. Bragg-Gresham High alkaline phosphatase levels in hemodialysis patients are associated with higher risk of hospitalization and death Kidney Int 74 5 2008 655 663
13. A.J. Hanley, K. Williams, A. Festa, L.E. Wagenknecht, R.B. D'Agostino Jr, and S.M. Haffner Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study Diabetes 54 11 2005 3140 3147 (Pubitemid 43334367)
14. National Center for Health Statistics Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988-1994 1995 National Center for Health Statistics Hyattsville, MD
15. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Executive Summary of the Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA 285 19 2001 2486 2497
16. Plan and operation of the Third National Health and Nutrition Examination Survey, 1988-94 Series 1: programs and collection procedures Vital Health Stat 1 32 1994 1 407
17. E.S. Ford, W.H. Giles, and W.H. Dietz Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey JAMA 287 3 2002 356 359 (Pubitemid 34251969)
18. R. Dhingra, L. Sullivan, and P.F. Jacques Soft drink consumption and risk of developing cardiometabolic risk factors and the metabolic syndrome in middle-aged adults in the community Circulation 116 5 2007 480 488 (Pubitemid 47450256)
19. D.M. Zelle, E. Corpeleijn, and R.M. van Ree Markers of the hepatic component of the metabolic syndrome as predictors of mortality in renal transplant recipients Am J Transplant 10 1 2010 106 114
20. M.W. Pantsari, and S.A. Harrison Nonalcoholic fatty liver disease presenting with an isolated elevated alkaline phosphatase J Clin Gastroenterol 40 7 2006 633 635 (Pubitemid 44259772)
21. N. Bucay, I. Sarosi, and C.R. Dunstan Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification Genes Dev 12 9 1998 1260 1268 (Pubitemid 28213402)
22. K.M. Utzschneider, and S.E. Kahn Review: the role of insulin resistance in nonalcoholic fatty liver disease J Clin Endocrinol Metab 91 12 2006 4753 4761 (Pubitemid 44917301)
23. A. Kerner, O. Avizohar, and R. Sella Association between elevated liver enzymes and C-reactive protein: possible hepatic contribution to systemic inflammation in the metabolic syndrome Arterioscler Thromb Vasc Biol 25 1 2005 193 197 (Pubitemid 40054275)
24. G. Jean, J.C. Terrat, and T. Vanel Daily oral 25-hydroxycholecalciferol supplementation for vitamin D deficiency in haemodialysis patients: effects on mineral metabolism and bone markers Nephrol Dial Transplant 23 11 2008 3670 3676
25. G.P. Fadini, P. Pauletto, A. Avogaro, and M. Rattazzi The good and the bad in the link between insulin resistance and vascular calcification Atherosclerosis 193 2 2007 241 244 (Pubitemid 47058124)
26. K.A. Lomashvili, P. Garg, S. Narisawa, J.L. Millan, and W.C. O'Neill Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification Kidney Int 73 9 2008 1024 1030 (Pubitemid 351543906)
27. M.K. Sigrist, M.W. Taal, P. Bungay, and C.W. McIntyre Progressive vascular calcification over 2 years is associated with arterial stiffening and increased mortality in patients with stages 4 and 5 chronic kidney disease Clin J Am Soc Nephrol 2 6 2007 1241 1248
28. S.R. Cole, and M.A. Hernan Fallibility in estimating direct effects Int J Epidemiol 31 1 2002 163 165 (Pubitemid 34284920)