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Volumn 71, Issue 6, 2002, Pages 508-518

Differences in sialic acid residues among bone alkaline phosphatase isoforms: A physical, biochemical, and immunological characterization

Author keywords

Biochemical markers; Glycosylation; Immunoassay; Kinetics; Osteoblasts

Indexed keywords

ALKALINE PHOSPHATASE BONE ISOENZYME; CARBOHYDRATE; CONCANAVALIN A; HOMOARGININE; ISOENZYME; LEVAMISOLE; PHENYLALANINE; SIALIC ACID; SIALIDASE; WHEAT GERM AGGLUTININ; ALKALINE PHOSPHATASE; ENZYME INHIBITOR; MONOCLONAL ANTIBODY; N ACETYLNEURAMINIC ACID;

EID: 0003238947     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00223-001-1137-4     Document Type: Article
Times cited : (48)

References (57)
  • 2
    • 0031020048 scopus 로고    scopus 로고
    • Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like growth factor-I (IGF-I) and during growth hormone therapy in adults with growth hormone deficiency
    • Magnusson P, Degerblad M, Sääf M, Larsson L, Thorén M (1997) Different responses of bone alkaline phosphatase isoforms during recombinant insulin-like growth factor-I (IGF-I) and during growth hormone therapy in adults with growth hormone deficiency. J Bone Miner Res 12:210-220
    • (1997) J Bone Miner Res , vol.12 , pp. 210-220
    • Magnusson, P.1    Degerblad, M.2    Sääf, M.3    Larsson, L.4    Thorén, M.5
  • 3
    • 0023724387 scopus 로고
    • Alkaline phosphatase is an ectoenzyme that acts on micromolar concentrations of natural substrates at physiologic pH in human osteosarcoma cells
    • Fedde KN, Lane CC, Whyte MP (1988) Alkaline phosphatase is an ectoenzyme that acts on micromolar concentrations of natural substrates at physiologic pH in human osteosarcoma cells. Arch Biochem Biophys 264:400-409
    • (1988) Arch Biochem Biophys , vol.264 , pp. 400-409
    • Fedde, K.N.1    Lane, C.C.2    Whyte, M.P.3
  • 4
    • 0030781023 scopus 로고    scopus 로고
    • Glycosyl-phosphatidylinositol anchored membrane enzymes
    • Hooper NM (1997) Glycosyl-phosphatidylinositol anchored membrane enzymes. Clin Chim Acta 266:3-12
    • (1997) Clin Chim Acta , vol.266 , pp. 3-12
    • Hooper, N.M.1
  • 5
    • 0023555024 scopus 로고
    • Levamisole and inorganic pyrophosphate inhibit β-glycerophosphate-induced mineralization of bone formed in vitro
    • Tenenbaum HC (1987) Levamisole and inorganic pyrophosphate inhibit β-glycerophosphate-induced mineralization of bone formed in vitro. Bone Miner 3:13-26
    • (1987) Bone Miner , vol.3 , pp. 13-26
    • Tenenbaum, H.C.1
  • 6
    • 0025845372 scopus 로고
    • Initiation and progression of mineralization of bone nodules formed in vitro: The role of alkaline phosphatase and organic phosphate
    • Bellows CG, Aubin JE, Heersche JNM (1991) Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate. Bone Miner 14:27-40
    • (1991) Bone Miner , vol.14 , pp. 27-40
    • Bellows, C.G.1    Aubin, J.E.2    Heersche, J.N.M.3
  • 7
    • 0032717156 scopus 로고    scopus 로고
    • Involvement of phosphodiesterase I in mineralization: Histochemical studies using antler from red deer (Cervus elaphus) as a model
    • Barling PM, Gupta DK, Lim CEL (1999) Involvement of phosphodiesterase I in mineralization: histochemical studies using antler from red deer (Cervus elaphus) as a model. Calcif Tissue Int 65:384-389
    • (1999) Calcif Tissue Int , vol.65 , pp. 384-389
    • Barling, P.M.1    Gupta, D.K.2    Lim, C.E.L.3
  • 9
    • 0017797536 scopus 로고
    • The function of carbohydrate moiety and alteration of carbohydrate composition in human alkaline phosphatase isoenzymes
    • Komoda T, Sakagishi Y (1978) The function of carbohydrate moiety and alteration of carbohydrate composition in human alkaline phosphatase isoenzymes. Biochim Biophys Acta 523:395-406
    • (1978) Biochim Biophys Acta , vol.523 , pp. 395-406
    • Komoda, T.1    Sakagishi, Y.2
  • 10
    • 0023879374 scopus 로고
    • Structural study on the carbohydrate moiety of human placental alkaline phosphatase
    • Endo T, Ohbayashi H, Hayashi Y, Ikehara Y, Kochibe N, Kobata A (1988) Structural study on the carbohydrate moiety of human placental alkaline phosphatase. J Biochem 103:182-187
    • (1988) J Biochem , vol.103 , pp. 182-187
    • Endo, T.1    Ohbayashi, H.2    Hayashi, Y.3    Ikehara, Y.4    Kochibe, N.5    Kobata, A.6
  • 11
    • 0016816173 scopus 로고
    • An estimate of the turnover rate of bone-derived plasma alkaline phosphatase in Paget's disease
    • Walton RJ, Preston CJ, Russell RGG, Kanis JA (1975) An estimate of the turnover rate of bone-derived plasma alkaline phosphatase in Paget's disease. Clin Chim Acta 63:227-229
    • (1975) Clin Chim Acta , vol.63 , pp. 227-229
    • Walton, R.J.1    Preston, C.J.2    Russell, R.G.G.3    Kanis, J.A.4
  • 12
    • 3643094131 scopus 로고
    • The behavior of infused human placental alkaline phosphatase in human subjects
    • Clubb JS, Neale FC, Posen S (1965) The behavior of infused human placental alkaline phosphatase in human subjects. J Lab Clin Med 66:493-507
    • (1965) J Lab Clin Med , vol.66 , pp. 493-507
    • Clubb, J.S.1    Neale, F.C.2    Posen, S.3
  • 13
    • 0031036060 scopus 로고    scopus 로고
    • Human tissue non-specific alkaline phosphatases: Sugar-moiety-induced enzymic and antigenic modulations and genetic aspects
    • Nosjean O, Koyama I, Goseki M, Roux B, Komoda T (1997) Human tissue non-specific alkaline phosphatases: sugar-moiety-induced enzymic and antigenic modulations and genetic aspects. Biochem J 321:297-303
    • (1997) Biochem J , vol.321 , pp. 297-303
    • Nosjean, O.1    Koyama, I.2    Goseki, M.3    Roux, B.4    Komoda, T.5
  • 14
    • 0025953793 scopus 로고
    • Sugar chain heterogeneity of bone and liver alkaline phosphatase in serum
    • Kuwana T, Sugita O, Yakata M (1991) Sugar chain heterogeneity of bone and liver alkaline phosphatase in serum. Enzyme 45:63-66
    • (1991) Enzyme , vol.45 , pp. 63-66
    • Kuwana, T.1    Sugita, O.2    Yakata, M.3
  • 15
    • 0026578459 scopus 로고
    • Determination of alkaline phosphatase isoenzymes in serum by high-performance liquid chromatography with post-column reaction detection
    • Magnusson P, Löfman O, Larsson L (1992) Determination of alkaline phosphatase isoenzymes in serum by high-performance liquid chromatography with post-column reaction detection. J Chromatogr 576:79-86
    • (1992) J Chromatogr , vol.576 , pp. 79-86
    • Magnusson, P.1    Löfman, O.2    Larsson, L.3
  • 16
    • 0027263794 scopus 로고
    • Methodological aspects on separation and reaction conditions of bone and liver alkaline phosphatase isoform analysis by high-performance liquid chromatography
    • Magnusson P, Löfman O, Larsson L (1993) Methodological aspects on separation and reaction conditions of bone and liver alkaline phosphatase isoform analysis by high-performance liquid chromatography. Anal Biochem 211:156-163
    • (1993) Anal Biochem , vol.211 , pp. 156-163
    • Magnusson, P.1    Löfman, O.2    Larsson, L.3
  • 17
    • 0028820633 scopus 로고
    • Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents
    • Magnusson P, Häger A, Larsson L (1995) Serum osteocalcin and bone and liver alkaline phosphatase isoforms in healthy children and adolescents. Pediatr Res 38:955-961
    • (1995) Pediatr Res , vol.38 , pp. 955-961
    • Magnusson, P.1    Häger, A.2    Larsson, L.3
  • 18
    • 0029583933 scopus 로고
    • Determination of bone alkaline phosphatase isoforms in serum by a new high-performance liquid chromatography assay in patients with metabolic bone disease
    • Magnusson P, Löfman O, Toss G, Larsson L (1995) Determination of bone alkaline phosphatase isoforms in serum by a new high-performance liquid chromatography assay in patients with metabolic bone disease. Acta Orthop Scand 66:203-204
    • (1995) Acta Orthop Scand , vol.66 , pp. 203-204
    • Magnusson, P.1    Löfman, O.2    Toss, G.3    Larsson, L.4
  • 19
    • 0031875137 scopus 로고    scopus 로고
    • Differences of bone alkaline phosphatase isoforms in metastatic bone disease and discrepant effects of clodronate on different skeletal sites indicated by the location of pain
    • Magnusson P, Larsson L, Englund G, Larsson B, Strang L, Selin-Sjögren L (1998) Differences of bone alkaline phosphatase isoforms in metastatic bone disease and discrepant effects of clodronate on different skeletal sites indicated by the location of pain. Clin Chem 44(suppl):1621-1628
    • (1998) Clin Chem , vol.44 , Issue.SUPPL. , pp. 1621-1628
    • Magnusson, P.1    Larsson, L.2    Englund, G.3    Larsson, B.4    Strang, L.5    Selin-Sjögren, L.6
  • 20
    • 4243468507 scopus 로고    scopus 로고
    • Bone alkaline phosphatase isoforms in Paget's disease of bone
    • abstract
    • Sharp CA, Magnusson P, Larsson L, Davie MWJ (1999) Bone alkaline phosphatase isoforms in Paget's disease of bone (abstract) J Bone Miner Res 14(suppl 266):S540
    • (1999) J Bone Miner Res , vol.14 , Issue.SUPPL. 266
    • Sharp, C.A.1    Magnusson, P.2    Larsson, L.3    Davie, M.W.J.4
  • 21
    • 0035035358 scopus 로고    scopus 로고
    • The decrease of IGF-I, IGF-binding protein-3 and bone alkaline phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac disease
    • Jansson UHG, Kristiansson B, Magnusson P, Larsson L, Albertsson-Wikland K, Bjarnason R (2001) The decrease of IGF-I, IGF-binding protein-3 and bone alkaline phosphatase isoforms during gluten challenge correlates with small intestinal inflammation in children with coeliac disease. Eur J Endocrinol 144(suppl 1):417-423
    • (2001) Eur J Endocrinol , vol.144 , Issue.SUPPL. 1 , pp. 417-423
    • Jansson, U.H.G.1    Kristiansson, B.2    Magnusson, P.3    Larsson, L.4    Albertsson-Wikland, K.5    Bjarnason, R.6
  • 22
    • 0034961668 scopus 로고    scopus 로고
    • Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms
    • Magnusson P, Sharp CA, Magnusson M, Risteli J, Davie L, Larsson L (2001) Effect of chronic renal failure on bone turnover and bone alkaline phosphatase isoforms. Kidney Int 60:257-265
    • (2001) Kidney Int , vol.60 , pp. 257-265
    • Magnusson, P.1    Sharp, C.A.2    Magnusson, M.3    Risteli, J.4    Davie, L.5    Larsson, L.6
  • 23
    • 0032712430 scopus 로고    scopus 로고
    • Isoforms of bone alkaline phosphatase: Characterization and origin in human trabecular and cortical bone
    • Magnusson P, Larsson L, Magnusson M, Davie MWJ, Sharp CA (1999) Isoforms of bone alkaline phosphatase: characterization and origin in human trabecular and cortical bone. J Bone Miner Res 14:1926-1933
    • (1999) J Bone Miner Res , vol.14 , pp. 1926-1933
    • Magnusson, P.1    Larsson, L.2    Magnusson, M.3    Davie, M.W.J.4    Sharp, C.A.5
  • 25
    • 0023358690 scopus 로고
    • Characterization of a human osteoblastic osteosarcoma cell line (SAOS-2) with high bone alkaline phosphatase activity
    • Murray E, Provvedini D, Curran D, Catherwood B, Sussman H, Manolagas S (1987) Characterization of a human osteoblastic osteosarcoma cell line (SAOS-2) with high bone alkaline phosphatase activity. J Bone Miner Res 2:231-238
    • (1987) J Bone Miner Res , vol.2 , pp. 231-238
    • Murray, E.1    Provvedini, D.2    Curran, D.3    Catherwood, B.4    Sussman, H.5    Manolagas, S.6
  • 26
    • 0024577074 scopus 로고
    • Alkaline phosphatase activity from human osteosarcoma cell line SaOS-2: An isoenzyme standard for quantifying skeletal alkaline phosphatase activity in serum
    • Farley JR, Kyeyune-Nyombi E, Tarbaux NM, Hall SL, Strong DD (1989) Alkaline phosphatase activity from human osteosarcoma cell line SaOS-2: an isoenzyme standard for quantifying skeletal alkaline phosphatase activity in serum. Clin Chem 35:223-229
    • (1989) Clin Chem , vol.35 , pp. 223-229
    • Farley, J.R.1    Kyeyune-Nyombi, E.2    Tarbaux, N.M.3    Hall, S.L.4    Strong, D.D.5
  • 27
    • 0025895597 scopus 로고
    • Skeletal alkaline phosphatase specific activity is an index of the osteoblastic phenotype in subpopulations of the human osteosarcoma cell line SaOS-2
    • Farley JR, Hall SL, Herring S, Tarbaux NM, Matsuyama JE, Wergedal JE (1991) Skeletal alkaline phosphatase specific activity is an index of the osteoblastic phenotype in subpopulations of the human osteosarcoma cell line SaOS-2. Metabolism 40:664-671
    • (1991) Metabolism , vol.40 , pp. 664-671
    • Farley, J.R.1    Hall, S.L.2    Herring, S.3    Tarbaux, N.M.4    Matsuyama, J.E.5    Wergedal, J.E.6
  • 28
    • 0031909296 scopus 로고    scopus 로고
    • Skeletal alkaline phosphatase activity is primarily released from human osteoblasts in an insoluble form, and the net release is inhibited by calcium and skeletal growth factors
    • Anh DJ, Dimai HP, Hall SL, Farley JR (1998) Skeletal alkaline phosphatase activity is primarily released from human osteoblasts in an insoluble form, and the net release is inhibited by calcium and skeletal growth factors. Calcif Tissue Int 62:332-340
    • (1998) Calcif Tissue Int , vol.62 , pp. 332-340
    • Anh, D.J.1    Dimai, H.P.2    Hall, S.L.3    Farley, J.R.4
  • 29
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 30
    • 0019887744 scopus 로고
    • Phase separation of integral membrane proteins in Triton X-114 solution
    • Bordier C (1981) Phase separation of integral membrane proteins in Triton X-114 solution. J Biol Chem 256:1604-1607
    • (1981) J Biol Chem , vol.256 , pp. 1604-1607
    • Bordier, C.1
  • 32
    • 0025036837 scopus 로고
    • Purification and characterization of glycosyl-phosphatidylinositol-specific phospholipase D
    • Huang K-S, Li S, Fung W-JC, Hulmes JD, Reik L, Pan Y-CE, Low MG (1990) Purification and characterization of glycosyl-phosphatidylinositol-specific phospholipase D. J Biol Chem 265:17738-17745
    • (1990) J Biol Chem , vol.265 , pp. 17738-17745
    • Huang, K.-S.1    Li, S.2    Fung, W.-J.C.3    Hulmes, J.D.4    Reik, L.5    Pan, Y.-C.E.6    Low, M.G.7
  • 33
    • 0025165065 scopus 로고
    • The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase
    • Hill CS, Wolfert RL (1990) The preparation of monoclonal antibodies which react preferentially with human bone alkaline phosphatase and not liver alkaline phosphatase. Clin Chim Acta 186:315-320
    • (1990) Clin Chim Acta , vol.186 , pp. 315-320
    • Hill, C.S.1    Wolfert, R.L.2
  • 35
    • 0030022003 scopus 로고    scopus 로고
    • Method for determination of bone alkaline phosphatase activity: Analytical performance and clinical usefulness in patients with metabolic and malignant bone diseases
    • Withold W, Schulte U, Reinauer H (1996) Method for determination of bone alkaline phosphatase activity: analytical performance and clinical usefulness in patients with metabolic and malignant bone diseases. Clin Chem 42:210-217
    • (1996) Clin Chem , vol.42 , pp. 210-217
    • Withold, W.1    Schulte, U.2    Reinauer, H.3
  • 36
    • 0030851285 scopus 로고    scopus 로고
    • Assessment of the performance of a capture immunoassay for the bone isoform of alkaline phosphatase in serum
    • Milligan TP, Park HR, Noonan K, Price CP (1997) Assessment of the performance of a capture immunoassay for the bone isoform of alkaline phosphatase in serum. Clin Chim Acta 263:165-175
    • (1997) Clin Chim Acta , vol.263 , pp. 165-175
    • Milligan, T.P.1    Park, H.R.2    Noonan, K.3    Price, C.P.4
  • 38
    • 0034131162 scopus 로고    scopus 로고
    • Protein glycosylation and diseases: Blood and urinary oligosaccharides as markers for diagnosis and therapeutic monitoring
    • Durand G, Seta N (2000) Protein glycosylation and diseases: blood and urinary oligosaccharides as markers for diagnosis and therapeutic monitoring. Clin Chem 46:795-805
    • (2000) Clin Chem , vol.46 , pp. 795-805
    • Durand, G.1    Seta, N.2
  • 39
    • 0034444960 scopus 로고    scopus 로고
    • Achievements and challenges of sialic acid research
    • Schauer R (2000) Achievements and challenges of sialic acid research. Glycoconjugate J 17:485-499
    • (2000) Glycoconjugate J , vol.17 , pp. 485-499
    • Schauer, R.1
  • 41
    • 0017147870 scopus 로고
    • Partial purification and some properties of human liver alkaline phosphatase
    • Komoda T, Sakagishi Y (1976) Partial purification and some properties of human liver alkaline phosphatase. Biochim Biophys Acta 438:138-152
    • (1976) Biochim Biophys Acta , vol.438 , pp. 138-152
    • Komoda, T.1    Sakagishi, Y.2
  • 44
    • 0028918706 scopus 로고
    • Biology of human alkaline phosphatases with special reference to cancer
    • Millán JL, Fishman WH (1995) Biology of human alkaline phosphatases with special reference to cancer. Crit Rev Clin Lab Sci 32:1-39
    • (1995) Crit Rev Clin Lab Sci , vol.32 , pp. 1-39
    • Millán, J.L.1    Fishman, W.H.2
  • 45
    • 0025312998 scopus 로고
    • Alkaline phosphatase isozymes: Recent progress
    • Fishman WH (1990) Alkaline phosphatase isozymes: recent progress. Clin Biochem 23:99-104
    • (1990) Clin Biochem , vol.23 , pp. 99-104
    • Fishman, W.H.1
  • 46
    • 0023976289 scopus 로고
    • Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme
    • Micanovic R, Bailey CA, Brink L, Gerber L, Pan Y-CE, Hulmes JD, Udenfriend S (1988) Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme. Proc Natl Acad Sci USA 85:1398-1402
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 1398-1402
    • Micanovic, R.1    Bailey, C.A.2    Brink, L.3    Gerber, L.4    Pan, Y.-C.E.5    Hulmes, J.D.6    Udenfriend, S.7
  • 47
    • 0023713647 scopus 로고
    • Chemical characterization of the membrane-anchoring domain of human placental alkaline phosphatase
    • Ogata S, Hayashi Y, Takami N, Ikehara Y (1988) Chemical characterization of the membrane-anchoring domain of human placental alkaline phosphatase. J Biol Chem 263:10489-10494
    • (1988) J Biol Chem , vol.263 , pp. 10489-10494
    • Ogata, S.1    Hayashi, Y.2    Takami, N.3    Ikehara, Y.4
  • 49
    • 0032483442 scopus 로고    scopus 로고
    • Genetic complexity, structure, and characterization of highly active bovine intestinal alkaline phosphatases
    • Manes T, Hoylaerts MF, Müller R, Lottspeich F, Hölke JL, Millán JL (1998) Genetic complexity, structure, and characterization of highly active bovine intestinal alkaline phosphatases. J Biol Chem 273:23353-23360
    • (1998) J Biol Chem , vol.273 , pp. 23353-23360
    • Manes, T.1    Hoylaerts, M.F.2    Müller, R.3    Lottspeich, F.4    Hölke, J.L.5    Millán, J.L.6
  • 50
    • 0035903096 scopus 로고    scopus 로고
    • Structural evidence for a functional role of human tissue nonspecific alkaline phosphatase in bone mineralization
    • Mornet E, Stura E, Lia-Baldini A-S, Stigbrand T, Menez A, Le Du M-H (2001) Structural evidence for a functional role of human tissue nonspecific alkaline phosphatase in bone mineralization. J Biol Chem 276:31171-31178
    • (2001) J Biol Chem , vol.276 , pp. 31171-31178
    • Mornet, E.1    Stura, E.2    Lia-Baldini, A.-S.3    Stigbrand, T.4    Menez, A.5    Le Du, M.-H.6
  • 52
    • 0031965447 scopus 로고    scopus 로고
    • Purification and characterization of bone-specific alkaline phosphatase from a human osteosarcoma cell line
    • Nakayama M, Gorai I, Minaguchi H, Rosenquist C, Qvist P (1998) Purification and characterization of bone-specific alkaline phosphatase from a human osteosarcoma cell line. Calcif Tissue Int 62:67-73
    • (1998) Calcif Tissue Int , vol.62 , pp. 67-73
    • Nakayama, M.1    Gorai, I.2    Minaguchi, H.3    Rosenquist, C.4    Qvist, P.5
  • 53
    • 0023662701 scopus 로고
    • Sugar-chain heterogeneity of human alkaline phosphatases: Differences between normal and tumor-associated isozymes
    • Koyama I, Miura M, Matsuzaki H, Sakagishi Y, Komoda T (1987) Sugar-chain heterogeneity of human alkaline phosphatases: differences between normal and tumor-associated isozymes. J Chromatogr 413:65-78
    • (1987) J Chromatogr , vol.413 , pp. 65-78
    • Koyama, I.1    Miura, M.2    Matsuzaki, H.3    Sakagishi, Y.4    Komoda, T.5
  • 54
    • 0029845152 scopus 로고    scopus 로고
    • Comparison of total and bone-specific alkaline phosphatase in patients with nonskeletal disorders or metabolic bone diseases
    • Woitge HW, Seibel MJ, Ziegler R (1996) Comparison of total and bone-specific alkaline phosphatase in patients with nonskeletal disorders or metabolic bone diseases. Clin Chem 42:1796-1804
    • (1996) Clin Chem , vol.42 , pp. 1796-1804
    • Woitge, H.W.1    Seibel, M.J.2    Ziegler, R.3
  • 55
    • 0030669902 scopus 로고    scopus 로고
    • Direct comparison of performance characteristics of two immunoassays for bone isoform of alkaline phosphatase in serum
    • Price CP, Milligan TP, Darte C (1997) Direct comparison of performance characteristics of two immunoassays for bone isoform of alkaline phosphatase in serum. Clin Chem 43:2052-2057
    • (1997) Clin Chem , vol.43 , pp. 2052-2057
    • Price, C.P.1    Milligan, T.P.2    Darte, C.3


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