The connections between vascular calcification and bone health

Nephrology Dialysis Transplantation

Volumn 26, Issue 11, 2011, Pages 3429-3436

  Cannata Andia, Jorge B ^a   Roman Garcia, Pablo ^a   Hruska, Keith ^b  

^a UNIVERSITY OF OVIEDO   (Spain)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CINACALCET; DICKKOPF 1 PROTEIN; PARATHYROID HORMONE; PHOSPHATE BINDING AGENT; PHOSPHORUS; SECRETED FRIZZLED RELATED PROTEIN 2; SECRETED FRIZZLED RELATED PROTEIN 4; VITAMIN D;

AGING; BLOOD VESSEL CALCIFICATION; BONE DISEASE; BONE METABOLISM; BONE TURNOVER; CHRONIC KIDNEY DISEASE; CORONARY ARTERY CALCIFICATION; FRACTURE; HEMODIALYSIS PATIENT; HUMAN; LOW DRUG DOSE; MINERAL METABOLISM; MORTALITY; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; PATHOPHYSIOLOGY; PHENOTYPE; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SMOOTH MUSCLE FIBER; SYSTEMS BIOLOGY; VASCULAR SMOOTH MUSCLE;

BONE AND BONES; HUMANS; OSTEOPOROSIS; VASCULAR CALCIFICATION;

EID: 80155171819     PISSN: 09310509     EISSN: 14602385     Source Type: Journal    
DOI: 10.1093/ndt/gfr591     Document Type: Review

References (71)

1. Matias PJ, Ferreira C, Jorge C et al. 25-Hydroxyvitamin D3, arterial calcifications and cardiovascular risk markers in haemodialysis patients. Nephrol Dial Transplant 2009; 24: 611-618
2. Naves-Diaz M, Alvarez-Hernandez D, Passlick-Deetjen J et al. Oral active vitamin D is associated with improved survival in hemodialysis patients. Kidney Int 2008; 74: 1070-1078
3. London GM, Marchais SJ, Guerin AP et al. Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD. J Am Soc Nephrol 2008; 19: 1827-1835
4. Rodriguez-Garcia M, Gomez-Alonso C, Naves-Diaz M et al. Vascular calcifications, vertebral fractures and mortality in haemodialysis patients. Nephrol Dial Transplant 2009; 24: 239-246
5. Goodman WG, Goldin J, Kuizon BD et al. Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 2000; 342: 1478-1483
6. Goldsmith D, Ritz E, Covic A. Vascular calcification: A stiff challenge for the nephrologist: Does preventing bone disease cause arterial disease? Kidney Int 2004; 66: 1315-1333
7. London GM, Marty C, Marchais SJ et al. Arterial calcifications and bone histomorphometry in end-stage renal disease. J Am Soc Nephrol 2004; 15: 1943-1951
8. O'Neill TW, Felsenberg D, Varlow J et al. The prevalence of vertebral deformity in european men and women: The European Vertebral Osteoporosis Study. J Bone Miner Res 1996; 11: 1010-1018
9. Naves Diaz M, Diaz Lopez JB, Gomez Alonso C et al. [Study of incidence of osteoporotic fractures in a cohort of individuals older than 50 years from Asturias, Spain, after a 6 year follow-up period]. Med Clin (Barc) 2000; 115: 650-653
10. Kiel DP, Kauppila LI, Cupples LA et al. Bone loss and the progression of abdominal aortic calcification over a 25 year period: The Framingham Heart Study. Calcif Tissue Int 2001; 68: 271-276
11. Naves M, Rodriguez-Garcia M, Diaz-Lopez JB et al. Progression of vascular calcifications is associated with greater bone loss and increased bone fractures. Osteoporos Int 2008; 19: 1161-1166
12. Frye MA, Melton LJ III, Bryant SC et al. Osteoporosis and calcification of the aorta. Bone Miner 1992; 19: 185-194
13. Vogt MT, San Valentin R, Forrest KY et al. Bone mineral density and aortic calcification: The Study of Osteoporotic Fractures. J Am Geriatr Soc 1997; 45: 140-145
14. Cannata-Andia JB, Rodriguez-Garcia M, Carrillo-Lopez N et al. Vascular calcifications: Pathogenesis, management, and impact on clinical outcomes. J Am Soc Nephrol 2006; 17: S267-S273
15. Rodriguez Garcia M, Naves Diaz M, Cannata Andia JB. Bone metabolism, vascular calcifications and mortality: Associations beyond mere coincidence. J Nephrol 2005; 18: 458-463
16. Moe S, Drueke T, Cunningham J et al. Definition, evaluation, and classification of renal osteodystrophy: A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 69: 1945-1953
17. Schulz E, Arfai K, Liu X et al. Aortic calcification and the risk of osteoporosis and fractures. J Clin Endocrinol Metab 2004; 89: 4246-4253
18. Asci G, Ozkahya M, Duman S et al. The link between cardiovascular and bone disease in hemodialysis patients. Nephrol Dial Transplant Plus 2007; 22: Iv217
19. Adragao T, Herberth J, Monier-Faugere MC et al. Low bone volume- a risk factor for coronary calcifications in hemodialysis patients. Clin J Am Soc Nephrol 2009; 4: 450-455
20. Coen G, Ballanti P, Mantella D et al. Bone turnover, osteopenia and vascular calcifications in hemodialysis patients. A histomorphometric and multislice CT study. Am J Nephrol 2009; 29: 145-152
21. Barreto DV, Barreto Fde C, Carvalho AB et al. Association of changes in bone remodeling and coronary calcification in hemodialysis patients: A prospective study. Am J Kidney Dis 2008; 52: 1139-1150
22. Davies MR, Lund RJ, Hruska KA. BMP-7 is an efficacious treatment of vascular calcification in a murine model of atherosclerosis and chronic renal failure. J Am Soc Nephrol 2003; 14: 1559-1567
23. Moe SM, Chen NX. Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 2004; 95: 560-567
24. Moe SM, Chen NX. Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 2008; 19: 213-216
25. Palmer SC, Hayen A, Macaskill P et al. Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease: A systematic review and meta-analysis. JAMA 2011; 305: 1119-1127
26. Mathew S, Tustison KS, Sugatani T et al. The mechanism of phosphorus as a cardiovascular risk factor in CKD. J Am Soc Nephrol 2008; 19: 1092-1105
27. Shroff RC, Shanahan CM. The vascular biology of calcification. Semin Dial 2007; 20: 103-109
28. Reynolds JL, Joannides AJ, Skepper JN et al. Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: A potential mechanism for accelerated vascular calcification in ESRD. J Am Soc Nephrol 2004; 15: 2857-2867
29. Davies MR, Lund RJ, Mathew S et al. Low turnover osteodystrophy and vascular calcification are amenable to skeletal anabolism in an animal model of chronic kidney disease and the metabolic syndrome. J Am Soc Nephrol 2005; 16: 917-928
30. Mathew S, Lund RJ, Strebeck F et al. Reversal of the adynamic bone disorder and decreased vascular calcification in chronic kidney disease by sevelamer carbonate therapy. J Am Soc Nephrol 2007; 18: 122-130
31. Cannata-Andia JB, Naves-Diaz M. Phosphorus and survival: Key questions that need answers. J Am Soc Nephrol 2009; 20: 234-236
32. Li X, Yang HY, Giachelli CM. Role of the sodium-dependent phosphate cotransporter, Pit-1, in vascular smooth muscle cell calcification. Circ Res 2006; 98: 905-912
33. Giachelli CM. Vascular calcification mechanisms. J Am Soc Nephrol 2004; 15: 2959-2964
34. Yang H, Curinga G, Giachelli CM. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int 2004; 66: 2293-2299
35. Mathew S, Lund R, Hruska K. Mechanisms of the Inverse Relationship between vascular calcification (VC) and bone mineral density (BMD) in chronic kidney disease (CKD). J Am Soc Nephrol 2008; 20: 39A, F-FC173
36. Fang Y, Zhang Y, Mathew S et al. Early chronic kidney disease (CKD) stimulates vascular calcification (VC) and decreased bone formation rates prior to positive phosphate balance. J Am Soc Nephrol 2009; 20: 36A, TH-FC153
37. Sigrist M, Bungay P, Taal MW et al. Vascular calcification and cardiovascular function in chronic kidney disease. Nephrol Dial Transplant 2006; 21: 707-714
38. Merjanian R, Budoff M, Adler S et al. Coronary artery, aortic wall, and valvular calcification in nondialyzed individuals with type 2 diabetes and renal disease. Kidney Int 2003; 64: 263-271
39. Craver L, Marco MP, Martinez I et al. Mineral metabolism parameters throughout chronic kidney disease stages 1-5-achievement of K/ DOQI target ranges. Nephrol Dial Transplant 2007; 22: 1171-1176
40. Nasrallah MM, El-Shehaby AR, Salem MM et al. Fibroblast growth factor-23 (FGF-23) is independently correlated to aortic calcification in haemodialysis patients. Nephrol Dial Transplant 2010; 25: 2679-2685
41. Block GA, Klassen PS, Lazarus JM et al. Mineral metabolism, mortality, and morbidity in maintenance hemodialysis. J Am Soc Nephrol 2004; 15: 2208-2218
42. Inoue T, Kawashima H. 1,25-Dihydroxyvitamin D3 stimulates 45Ca21-uptake by cultured vascular smooth muscle cells derived from rat aorta. Biochem Biophys Res Commun 1988; 152: 1388-1394
43. Jono S, Nishizawa Y, Shioi A et al. 1,25-Dihydroxyvitamin D3 increases in vitro vascular calcification by modulating secretion of endogenous parathyroid hormone-related peptide. Circulation 1998; 98: 1302-1306 44. Mathew S, Lund RJ, Chaudhary LR et al. Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol 2008; 19: 1509-1519
44. Mathew S, Lund RJ, Chaudhary LR et al. Vitamin D receptor activators can protect against vascular calcification. J Am Soc Nephrol 2008; 19: 1509-1519
45. Kovesdy CP, Ahmadzadeh S, Anderson JE et al. Association of activated vitamin D treatment and mortality in chronic kidney disease. Arch Intern Med 2008; 168: 397-403
46. Shroff R, Knott C, Rees L. The virtues of vitamin D-but how much is too much? Pediatr Nephrol 2010; 25: 1607-1620
47. Shroff R, Egerton M, BridelMet al. A bimodal association of vitamin D levels and vascular disease in children on dialysis. J Am Soc Nephrol 2008; 19: 1239-1246
48. Shao JS, Cheng SL, Charlton-Kachigian N et al. Teriparatide (human parathyroid hormone (1-34)) inhibits osteogenic vascular calcification in diabetic low density lipoprotein receptor-deficient mice. J Biol Chem 2003; 278: 50195-50202
49. Vattikuti R, Towler DA. Osteogenic regulation of vascular calcification: An early perspective. Am J Physiol Endocrinol Metab 2004; 286: E686-E696
50. Graciolli FG, Neves KR, dos Reis LM et al. Phosphorus overload and PTH induce aortic expression of Runx2 in experimental uraemia. Nephrol Dial Transplant 2009; 24: 1416-1421
51. Tintut Y, Patel J, Parhami F et al. Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway. Circulation 2000; 102: 2636-2642
52. Al-Aly Z, Shao JS, Lai CF et al. Aortic Msx2-Wnt calcification cascade is regulated by TNF-alpha-dependent signals in diabetic Ldlr-/- mice. Arterioscler Thromb Vasc Biol 2007; 27: 2589-2596
53. Towler DA, Shao JS, Cheng SL et al. Osteogenic regulation of vascular calcification. Ann N Y Acad Sci 2006; 1068: 327-333
54. Lacativa PG, Farias ML. Osteoporosis and inflammation. Arq Bras Endocrinol Metabol 2010; 54: 123-132
55. Byon CH, Javed A, Dai Q et al. Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling. J Biol Chem 2008; 283: 15319-15327
56. Zebboudj AF, Shin V, Bostrom K. Matrix GLA protein and BMP-2 regulate osteoinduction in calcifying vascular cells. J Cell Biochem 2003; 90: 756-765
57. Zeadin M, Butcher M, Werstuck G et al. Effect of leptin on vascular calcification in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2009; 29: 2069-2075
58. Roman-Garcia P, Carrillo-Lopez N, Fernandez-Martin JL et al. High phosphorus diet induces vascular calcification, a related decrease in bone mass and changes in the aortic gene expression. Bone 2010; 46: 121-128
59. Surendran K, Schiavi S, Hruska KA. Wnt-dependent beta-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol 2005; 16: 2373-2384
60. Holmen SL, Giambernardi TA, Zylstra CR et al. Decreased BMD and limb deformities in mice carrying mutations in both Lrp5 and Lrp6. J Bone Miner Res 2004; 19: 2033-2040
61. Chertow GM, Burke SK, Raggi P. Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 2002; 62: 245-252
62. Qunibi W, Moustafa M, Muenz LR et al. A 1-year randomized trial of calcium acetate versus sevelamer on progression of coronary artery calcification in hemodialysis patients with comparable lipid control: The Calcium Acetate Renagel Evaluation-2 (CARE-2) study. Am J Kidney Dis 2008; 51: 952-965
63. Ferreira A, Frazao JM, Monier-Faugere MC et al. Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients. J Am Soc Nephrol 2008; 19: 405-412
64. D'Haese PC, Spasovski GB, Sikole A et al. A multicenter study on the effects of lanthanum carbonate (Fosrenol) and calcium carbonate on renal bone disease in dialysis patients. Kidney Int Suppl 2003; 85: S73-S78
65. Teng M, Wolf M, Lowrie E et al. Survival of patients undergoing hemodialysis with paricalcitol or calcitriol therapy. N Engl J Med 2003; 349: 446-456
66. Aladren Regidor MJ. Cinacalcet reduces vascular and soft tissue calcification in secondary hyperparathyroidism (SHPT) in hemodialysis patients. Clin Nephrol 2009; 71: 207-213
67. Floege J, Raggi P, Block GA et al. Study design and subject baseline characteristics in the ADVANCE Study: Effects of cinacalcet on vascular calcification in haemodialysis patients. Nephrol Dial Transplant 2010; 25: 1916-1923
68. Raggi P, Chertow G, Block G et al. A Randomized Controlled Trial To Evaluate the Effects of Cinacalcet Plus Low-Dose Vitamin D On Vascular Calcification in Hemodialysis Patients 2010. National Kidney Foundation; 2010. Spring Clinical Meetings Abstracts
69. Chonchol M, Locatelli F, Abboud HE et al. A randomized, doubleblind, placebo-controlled study to assess the efficacy and safety of cinacalcet HCl in participants with CKD not receiving dialysis. Am J Kidney Dis 2009; 53: 197-207
70. Cannata-Andia JB, Fernandez-Martin JL. Mineral metabolism: Should cinacalcet be used in patients who are not on dialysis? Nat Rev Nephrol 2009; 5: 307-308
71. Helas S, Goettsch C, SchoppetMet al. Inhibition of receptor activator of NF-kappaB ligand by denosumab attenuates vascular calcium deposition in mice. Am J Pathol 2009; 175: 473-478