Notch signaling induces EMT in OSCC cell lines in a hypoxic environment

Oncology Letters

Volumn 6, Issue 5, 2013, Pages 1201-1206

  Ishida, Takayuki ^a   Hijioka, Hiroshi ^a   Kume, Kenichi ^a   Miyawaki, Akihiko ^b   Nakamura, Norifumi ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

^b UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

EMT; Hypoxia; Notch; Oral squamous cell carcinoma

Indexed keywords

GAMMA SECRETASE INHIBITOR; MESSENGER RNA; NOTCH RECEPTOR; UVOMORULIN;

ARTICLE; CELL INVASION; CELL MOTILITY; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOHISTOCHEMISTRY; MOUTH SQUAMOUS CELL CARCINOMA; POLYMERASE CHAIN REACTION; WOUND HEALING;

EID: 84884486436     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2013.1549     Document Type: Article

References (40)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin 58: 71-96, 2008.
2. Kademani D, Bell RB, Bagheri S, Holmgren E, Dierks E, Potter B and Homer L: Prognostic factors in intraoral squamous cell carcinoma: the influence of histologic grade. J Oral Maxillofac Surg 63: 1599-1605, 2005.
3. Weinberg RA: Twisted epithelial-mesenchymal transition blocks senescence. Nat Cell Biol 10: 1021-1023, 2008.
4. Yang MH, Wu MZ, Chiou SH, et al: Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 10: 295-305, 2008.
5. Cannito S, Novo E, Compagnone A, et al: Redox mechanisms switch on hypoxia-dependent epithelial-mesenchymal transition in cancer cells. Carcinogenesis 29: 2267-2278, 2008.
6. Leong KG, Niessen K, Kulic I, et al: Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin. J Exp Med 204: 2935-2948, 2007.
7. Miele L: Notch signaling. Clin Cancer Res 12: 1074-1079, 2006.
8. Wang Z, Zhang Y, Li Y, Banerjee S, Liao J and Sarkar FH: Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells. Mol Cancer Ther5: 483-493, 2006.
9. Chen, J, Imanaka N, Chen J and Griffin JD: Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion. Br JCancer102: 351-360, 2009.
10. Pietras A, von Stedingk K, Lindgren D, Påhlman S and AxelsonH: JAG2 induction in hypoxic tumor cells alters Notch signaling and enhances endothelial cell tube formation. Mol Cancer Res9: 626-636, 2011.
11. Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ and PowellMB: Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest 118: 3660, 2008.
12. Jiang YG, Luo Y, He DL, et al: Role of Wnt/beta-catenin signaling pathway in epithelial-mesenchymal transition of human prostate cancer induced by hypoxia-inducible factor-1alpha. Int J Urol 14: 1034-1039, 2007.
13. Chambers AF, Groom AC and MacDonald IC: Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer2: 563-572, 2002.
14. Ansieau, S, Bastid J, Doreau AS, et al: Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 14: 79-89, 2008.
15. Gavert N, Conacci-Sorrell M, Gast D, et al: L1, a novel target of beta-catenin signaling, transforms cells and is expressed at the invasive front of colon cancers. J Cell Biol 168: 633-642, 2005.
16. Hlubek F, Spaderna S, Jung A, et al: β-catenin activates a coordinated expression of the proinvasive factors laminin-5 γ2 chain and MT1-MMP in colorectal carcinomas. Int J cancer 108: 321-326, 2004.
17. Brizel DM, Scully SP, Harrelson JM, et al: Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56: 941-943, 1996.
18. Hockel M, Schlenger K, Aral B and Mitze M: Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 56: 4509-4515, 1996.
19. Fyles A, Milosevic M, Wong R, et al: Oxygenation predicts radiation response and survival in patients with cervix cancer. Radiother Oncol 48: 149-156, 1998.
20. Hill RP, Marie-Egyptienne DT and Hedley DW: Cancer stem cells, hypoxia and metastasis. Semin Radiat Oncol 19: 106-111, 2009.
21. Howard JD, Lu B and Chung CH: Therapeutic targets in head and neck squamous cell carcinoma: Identification, evaluation, and clinical translation. Oral Oncol 48: 10-17, 2011.
22. Agrawal N, Frederick MJ, Pickering CR, et al: Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154-1157, 2011.
23. Stransky N, Egloff AM, Tward AD, et al: The mutational landscape of head and neck squamous cell carcinoma. Science333: 1157-1160, 2011.
24. Hijioka H, Setoguchi T, Miyawaki, et al: Upregulation of Notch pathway molecules in oral squamous cell carcinoma. Int JOncol36: 817-822, 2010.
25. Weijzen S, Rizzo P, Braid M, et al: Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells. Nat Med 8: 979-986, 2002.
26. Santagata S, Demichelis F, Riva A, et al: JAGGED1 expression is associated with prostate cancer metastasis and recurrence. Cancer Res 64: 6854-6857, 2004.
27. Dickson BC, Mulligan AM, Zhang H, et al: High-level JAG1 mRNA and protein predict poor outcome in breast cancer. Mod Pathol 20: 685-693, 2007.
28. Lin JT, Chen MK, Yeh KT, et al: Association of high levels of Jagged-1 and Notch-1 expression with poor prognosis in head and neck cancer. Ann Surg Oncol 17: 2976-2983, 2010.
29. Zhang TH, Liu HC, Zhu LJ, et al: Activation of Notch signaling in human tongue carcinoma. J Oral Pathol Med 40: 37-45, 2011.
30. Zavadil J, Cermak L, Soto-Nieves N and Böttinger EP: Integration of TGF-beta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J 23: 1155-1165, 2004.
31. Sahlgren C, Gustafsson MV, Jin S, Poellinger L and Lendahl U: Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc Natl Acad Sci USA 105: 6392-6397, 2008.
32. Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW and Semenza GL: Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer 88: 2606-2618, 2000.
33. Harris AL: Hypoxia-a key regulatory factor in tumour growth. Nat Rev Cancer 2: 38-47, 2002.
34. Schindl M, Schoppmann SF, Samonigg H, et al: Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res 8: 1831-1837, 2002.
35. Gupta GP and Massagué J: Cancer metastasis: building a framework. Cell 127: 679-695, 2006.
36. Perl AK, Wilgenbus P, Dahl U, Semb H and Christofori G: A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392: 190-193, 1998.
37. Moody SE, Perez D, Pan TC, et al: The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8: 197-209, 2005.
38. Erler JT, Bennewith KL, Nicolau M, et al: Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440: 1222-1226, 2006.
39. Pouysségur J, Dayan F and Mazure NM: Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441: 437-443, 2006.
40. Timmerman LA, Grego-Bessa J, Raya A, et al: Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 18: 99-115, 2004.