Essential oil of artemisia capillaris induces apoptosis in KB cells via mitochondrial stress and caspase activation mediated by MAPK-stimulated signaling pathway

Journal of Food Science

Volumn 74, Issue 9, 2009, Pages

  Cha, Jeong Dan ^a   Moon, Sang Eun ^b   Kim, Hye Young ^c   Cha, In Ho ^a   Lee, Kyung Yeol ^d  

^a Yonsei University College of Dentistry   (South Korea)

^b Kwangju Women University   (South Korea)

^c Dong Eui University   (South Korea)

^d Chonbuk National University   (South Korea)

Author keywords

Apoptosis; Artemisia capillaris; Caspases; Essential oil; MAPKs; Mitochondrial stress

Indexed keywords

ANTINEOPLASTIC AGENT; BAX PROTEIN, HUMAN; CASPASE; CYTOCHROME C; ESSENTIAL OIL; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; CASPASE INHIBITOR;

APOPTOSIS; ARTEMISIA; ARTICLE; CARCINOMA; CELL CYCLE G0 PHASE; CELL STRAIN KB; CELL SURVIVAL; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; KOREAN MEDICINE; METABOLISM; MITOCHONDRION; MOUTH TUMOR; NUCLEAR SHAPE; OSMOLARITY; SIGNAL TRANSDUCTION; DRUG EFFECTS; KB CELL LINE; MOUTH NEOPLASMS;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; ARTEMISIA; BCL-2-ASSOCIATED X PROTEIN; CARCINOMA; CASPASES; CELL NUCLEUS SHAPE; CELL SURVIVAL; CYTOCHROMES C; ENZYME ACTIVATION; G0 PHASE; HUMANS; KB CELLS; MAP KINASE SIGNALING SYSTEM; MEDICINE, KOREAN TRADITIONAL; MITOCHONDRIA; MOUTH NEOPLASMS; OILS, VOLATILE; OSMOLAR CONCENTRATION; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-BCL-2; CASPASE INHIBITORS;

ARTEMISIA; ARTEMISIA CAPILLARIS;

EID: 70449467544     PISSN: 00221147     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3841.2009.01355.x     Document Type: Article

References (47)

1. Ahmed-Choudhury J, Williams KT, Young LS, Adams DH, Afford SC. 2006. CD40 mediated human cholangiocyte apoptosis requires JAK2 dependent activation of STAT3 in addition to activation of JNK1/2 and ERK1/2. Cell Signal 18 : 456 468.
2. Allen RT, Hunter WJ 3rd., Agrawal DK. 1997. Morphological and biochemical characterization and analysis of apoptosis. J Pharmacol Toxicol Methods 37 : 215 228.
3. Aniya Y, Shimabukuro M, Shimoji M, Kohatsu M, Gyamfi MA, Miyagi C, Kunii D, Takayama F, Egashira T. 2000. Antioxidant and hepatoprotective actions of the medicinal herb Artemisia campestris from the Okinawa Islands. Biol Pharm Bull 23 : 309 312.
4. Bakiri L, Matsuo K, Wisniewska M, Wagner EF, Yaniv M. 2002. Promoter specificity and biological activity of tethered AP-1 dimers. Mol Cell Biol 22 : 4952 4964.
5. Ballif BA, Blenis J. 2001. Molecular mechanisms mediating mammalian mitogen-activated protein kinase (MAPK) kinase (MEK)-MAPK cell survival signals. Cell Growth Differ 12 : 397 408.
6. Buhagiar JA, Podesta MT, Wilson AP, Micallef MJ, Ali S. 1999. The induction of apoptosis in human melanoma, breast and ovarian cancer cell lines using an essential oil extract from the conifer Tetraclinis articulate. Anticancer Res 19 : 5435 5443.
7. Cha JD, Jeong MR, Choi HJ, Jeong SI, Moon SE, Yun SI, Kim YH, Kil BS, Song YH. 2005a. Chemical composition and antimicrobial activity of the essential oil of Artemisia lavandulaefolia. Planta Med 71 : 575 577.
8. Cha JD, Jeong MR, Jeong SI, Moon SE, Kim JY, Kil BS, Song YH. 2005b. Chemical composition and antimicrobial activity of the essential oils of Artemisia scoparia and A. capillaris. Planta Med 71 : 186 190.
9. Chen YL, Huang HC, Weng YL, Yu YJ, Lee YT. 1994. Morphological evidence for the antiatherogenic effect of scoparone in hyperlipidaemic diabetic rabbits. Cardiovasc Res 28 : 1679 1685.
10. Chen C, Yu R, Owuor ED, Kong AN. 2000. Activation of antioxidant-response element (ARE), mitogen-activated protein kinases (MAPKs) and caspases by major green tea polyphenol components during cell survival and death. Arch Pharm Res 23 : 605 612.
11. Chen YJ, Lin SC, Ka T, Kao T, Chang CS, Hong PS, Shieh TM, Chang KW. 2004. Genome-wide profiling of oral squamous cell carcinoma. J Pathol 204 : 326 332.
12. Dlugosz PJ, Billen LP, Annis MG, Zhu W, Zhang Z, Lin J, Leber B, Andrews DW. 2006. Bcl-2 changes conformation to inhibit Bax oligomerization. EMBO J 25 : 2287 2296.
13. Effiom OA, Adeyemo WL, Omitola OG, Ajayi OF, Emmanuel MM, Gbotolorun OM. 2008. Oral squamous cell carcinoma: a clinicopathologic review of 233 cases in Lagos, Nigeria. J Oral Maxillofac Surg 66 : 1595 1599.
14. Gilani AH, Yaeesh S, Jamal Q, Ghayur MN. 2005. Hepatoprotective activity of aqueousmethanol extract of Artemisia vulgaris. Phytother Res 19 : 170 172.
15. Itani WS, Ei-Banna SH, Hassan SB, Larsson RL, Bazarbachi A, Gali-Muhtasib HU. 2008. Anti colon cancer components from lebanese sage (Salvia libanotica) essential oil: mechanistic basis. Cancer Biol Ther 5 : 1765 1773.
16. Karioti A, Hadjipavlou-Litina D, Mensah ML, Fleischer TC, Skaltsa H. 2004. Composition and antioxidant activity of the essential oils of Xylopia aethiopica (Dun) A. Rich. (Annonaceae) leaves, stem bark, root bark, and fresh and dried fruits, growing in Ghana. J Agric Food Chem 52 : 8094 8098.
17. Kluck R, Bossy-Wetzel E, Green DR, Newmeyer DD. 1997. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275 : 1132 1136.
18. Koo HN, Hong SH, Jeong HJ, Lee EH, Kim NG, Choi SD, Ra RW, Kim KS, Kang BK, Kim JJ, Oh JG, Kim HM. 2002. Inhibitory effect of Artemisia capillaris on ethanol-induced cytokines (TNF-alpha, IL-1alpha) secretion in HepG2 cells. Immunopharmacol Immunotoxicol 24 : 441 453.
19. Kordali S, Cakir A, Mavi A, Kilic H, Yildirim A. 2005. Screening of chemical composition and antifungal and antioxidant activities of the essential oils from three Turkish Artemisia species. J Agric Food Chem 53 : 1408 1416.
20. Lavrik IN, Golks A, Krammer PH. 2005. Caspases: pharmacological manipulation of cell death. J Clin Invest 115 : 2665 2672.
21. Lee YM, Hsiao G, Chang JW, Sheu JR, Yen MH. 2003. Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells. Biomed Sci 10 : 518 525.
22. Lee HJ, Wang CJ, Kuo HC, Chou FP, Jean LF, Tseng TH. 2005. Induction apoptosis of luteolin in human hepatoma HepG2 cells involving mitochondria translocation of Bax/Bak and activation of JNK. Toxicol Appl Pharmacol 203 : 124 131.
23. Li X, Darzynkiewicz Z. 2000. Cleavage of Poly (ADP-ribose) polymerase measured in situ in individual cells: relationship to DNA fragmentation and cell cycle position during apoptosis. Exp Cell Res 255 : 125 132.
24. Li LY, Luo X, Wang X. 2001. Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412 : 95 9.
25. Lo WL, Kao SY, Chi LY, Wong YK, Chang RC. 2003. Outcomes of oral squamous cell carcinoma in Taiwan after surgical therapy: factors affecting survival. J Oral Maxillofac Surg 61 : 751 758.
26. Martinez D, Vermeulen M, Trevani A, Ceballos A, Sabatte J, Gamberale R, Alvarez ME, Salamone G, Tanos T, Coso OA, Geffner J. 2006. Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways. J Immunol 176 : 1163 1171.
27. McCarty MF. 2001. Current prospects for controlling cancer growth with noncytotoxic agents: nutrients, phytochemicals, herbal extracts, and available drugs. Med Hypotheses 56 : 137 154.
28. Ok YJ, Myoung H, Kim YK, Lee JH, Kim MJ, Yun PY. 2009. Apoptotic effect of CKD-602 (Camtobell) on oral squamous cell carcinoma cell lines. Oral Oncol 45 : 266 272.
29. Orrenius S. 2004. Mitochondrial regulation of apoptotic cell death. Toxicol Lett 149 : 19 23.
30. Paik SY, Koh KH, Beak SM, Paek SH, Kim JA. 2005. The essential oils from Zanthoxylum schinifolium pericarp induce apoptosis of HepG2 human hepatoma cells through increased production of reactive oxygen species. Biol Pharm Bull 28 : 802 807.
31. Pan J, Liu G, Liu H, Qiu Z, Chen L. 1998. Effects of Artemisia capillaris on blood glucose and lipid in mice. Zhong Yao Cai 21 : 408 411.
32. Pentenero M, Gandolfo S, Carrozzo M. 2005. Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature. Head Neck 27 : 1080 1091.
33. Stauble B, Boscoboinik D, Tasinato A, Azzi A. 1994. Modulation of activator protein-1 (AP-1) transcription factor and protein kinase C by hydrogen peroxide and D-alphatocopherol in vascular smooth muscle cells. Eur J Biochem 226 : 393 402.
34. Sylvestre M, Legault J, Dufour D, Pichette A. 2005. Chemical composition and anticancer activity of leaf essential oil of Myrica gale L. Phytomedicine 12 : 299 304.
35. Sylvestre M, Pichette A, Longtin A, Nagau F, Legault J. 2006. Essential oil analysis and anticancer activity of leaf essential oil of Croton flavens L. from Guadeloupe. J Ethnopharmacol 103 : 99 102.
36. Tsuruta F, Sunayama J, Mori Y, Hattori S, Shimizu S, Tsujimoto Y, Yoshioka K, Masuyama N, Gotoh Y. 2004. JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J 23 : 1889 1899.
37. van Laethem A, van Kelst S, Lippens S, Declercq W, Vandenabeele P, Janssens S, Vandenheede SR, Garmyn M, Agostinis P. 2004. Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes. FASEB J 18 : 1946 1948.
38. Whitmarsh AJ, Davis RJ. 1996. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 74 : 589 607.
39. Xu C, Shen G, Yuan X, Kim JH, Gopalkrishnan A, Keum YS, Nair S, Kong AN. 2006. ERK and JNK signaling pathways are involved in the regulation of activator protein 1 and cell death elicited by three isothiocyanates in human prostate cancer PC-3 cells. Carcinogenesis 27 : 437 445.
40. 2+-dependent endonuclease in apoptosis and its inhibition by Poly (ADP-ribose) polymerase. J Biol Chem 275 : 21302 21308.
41. Yamamoto M, Ogawa K, Morita M, Fukuda K, Komatsu Y. 1996. The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor beta 1. 23 : 552 559.
42. Yanase S, Nomura J, Matsumura Y, Nagai K, Kinoshita M, Nakanishi H, Ohnishi Y, Tokuda T, Tagawa T. 2005. Enhancement of the effect of 5-aminolevulinic acid-based photodynamic therapy by simultaneous hyperthermia. Int J Oncol 27 : 193 201.
43. Yang J, Liu X, Bhalla K, Kim CN, Ibrado AM, Cai J, Peng TI, Jones DP, Wang X. 1997. Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275 : 1129 1132.
44. Yeh CT, Yen GC. 2005. Induction of apoptosis by the anthocyanidins through regulation of Bcl-2 gene and activation of c-Jun N-terminal kinase cascade in hepatoma cells. J Agric Food Chem 53 : 1740 1749.
45. Yoshioka D, Deng T, Cavigelli M, Karin M. 1995. Antitumor promotion by phenolic antioxidants: inhibition of AP-1 activity through induction of Fra expression. Proc Natl Acad Sci USA 92 : 4972 4976.
46. Yu HH, Kim YH, Kil BS, Kim KJ, Jeong SI, You YO. 2003. Chemical composition and antibacterial activity of essential oil of Artemisia iwayomogi. Planta Med 69 : 1159 1162.
47. Zanna C, Ghelli A, Porcelli AM, Martinuzzi A, Carelli V, Rugolo M. 2005. Caspase independent death of Leber's hereditary optic neuropathy cybrids is driven by energetic failure and mediated by AIF and Endonuclease G. Apoptosis 10 : 997 1007.