Passive transfer of narcolepsy: Anti-TRIB2 autoantibody positive patient IgG causes hypothalamic orexin neuron loss and sleep attacks in mice

Journal of Autoimmunity

Volumn 45, Issue , 2013, Pages 24-30

  Katzav, Aviva ^a,b   Arango, Maria T ^b,c   Kivity, Shaye ^b   Tanaka, Susumu ^d   Givaty, Gili ^a,b   Agmon Levin, Nancy ^b   Honda, Makoto ^d   Anaya, Juan Manuel ^c   Chapman, Joab ^a,b   Shoenfeld, Yehuda ^b  

^a SHEBA MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c UNIVERSIDAD DEL ROSARIO   (Colombia)

^d TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

Author keywords

Anti Tribbles homolog 2 (TRIB2) antibodies; Behavioral deficits; Narcolepsy; Orexin; Passive transfer

Indexed keywords

AUTOANTIBODY; BIOLOGICAL MARKER; HLA ANTIBODY; IMMUNOGLOBULIN G; NEURON SPECIFIC NUCLEAR PROTEIN; OREXIN; SYNAPTOPHYSIN; TRIB2 AUTOANTIBODY; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; BRAIN REGION; CATAPLEXY; COGNITIVE DEFECT; CONTROLLED STUDY; DAYTIME SOMNOLENCE; HUMAN; HYPERACTIVITY; HYPOTHALAMUS; IMMOBILIZATION; LONG TERM MEMORY; MOUSE; NARCOLEPSY; NONHUMAN; NORMAL HUMAN; PASSIVE TRANSPORT; PATHOGENESIS; PRIORITY JOURNAL; RECOGNITION; SLEEP;

ANTI-TRIBBLES HOMOLOG 2 (TRIB2) ANTIBODIES; BEHAVIORAL DEFICITS; NARCOLEPSY; OREXIN; PASSIVE TRANSFER;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; CATAPLEXY; CELL DEATH; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOTHALAMUS; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C3H; NARCOLEPSY; NEURONS; NEUROPEPTIDES; PATTERN RECOGNITION, PHYSIOLOGICAL;

EID: 84884287135     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.06.010     Document Type: Article

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