Complex HLA-DR and -DQ interactions confer risk of narcolepsy-cataplexy in three ethnic groups

American Journal of Human Genetics

Volumn 68, Issue 3, 2001, Pages 686-699

  Mignot, Emmanuel ^a   Lin, Ling ^a   Rogers, William ^a   Honda, Yutaka ^c   Qiu, Xiaohong ^a   Lin, Xiaoyan ^a   Okun, Michele ^a   Hohjoh, Hirohiko ^d,e   Miki, Tetsuro ^f   Hsu, Susan H ^g   Leffell, Mary S ^h   Grumet, F Carl ^a   Fernandez Vina, Marcelo ⁱ   Risch, Neil ^b  

^a STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF TOKYO   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e TOKYO METROPOLITAN MATSUZAWA HOSPITAL   (Japan)

^f EHIME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g Musser Blood Center   (United States)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

ⁱ UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DQ ANTIGEN; HLA DR ANTIGEN; OREXIN;

ARTICLE; CATAPLEXY; CONTROLLED STUDY; DISEASE PREDISPOSITION; ETHNIC GROUP; HAPLOTYPE; HLA TYPING; HUMAN; MAJOR CLINICAL STUDY; NARCOLEPSY; PRIORITY JOURNAL; RISK ASSESSMENT; SLEEP DISORDER;

EID: 0035091595     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/318799     Document Type: Article

References (31)

1. Susceptibility to multiple sclerosis mediated by HLA-DRB1 is influenced by a second gene telomeric of the TNF cluster
2. Autoimmune hypothesis in narcolepsy
3. Narcolepsy in orexin knockout mice: Molecular genetics of sleep regulation
4. HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy
5. Alleles at four HLA class II loci determined by oligonucleotide hybridization and their associations in five ethnic groups
6. Multiple sclerosis: A modifying influence of HLA class I genes in an HLA class II associated autoimmune disease
7. Genetics of type 1 diabetes mellitus
8. Significant association of a single nucleotide polymorphism in the tumor necrosis factor-alpha (TNF-alpha) gene promoter with human narcolepsy
9. A genetic study of narcolepsy and excessive sleepiness in 308 families with a narcolepsy or hypersomnia proband
10. Genetic aspects of narcolepsy
11. SSOP-ELISA, HLA-DRB typing using an in-house ELISA-based oligoprobe assay
12. The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
13. DQ microsatellite association studies in three ethnic groups
14. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
15. DQ (rather than DR) gene marks susceptibility to narcolepsy
16. Immunological features of narcolepsy in Japan
17. Human histocompatibility leukocyte antigen (HLA) haplotype frequencies estimated from the data on HLA class I, II, and III antigens in 111 Japanese narcoleptics
18. Genetic and familial aspects of narcolepsy
19. HLA DQB1 * 0602 is associated with cataplexy in 509 narcoleptic patients
20. Extensive HLA class II studies in 58 non-DRB1 * 15 (DR2) narcoleptic patients with cataplexy
21. DQB1 * 0602 and DQA1 * 0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans
22. Narcolepsy and immunity
23. Linkage of human narcolepsy with HLA association to chromosome 4p13-q21
24. Hypocretin (orexin) deficiency in human narcolepsy
25. HLA-DQB1 * 0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups: US Modafinil in Narcolepsy Multicenter Study Group
26. A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
27. Assessing the role of HLA-linked and unlinked determinants of disease
28. Reduced number of hypocretin neurons in human narcolepsy
29. The mode of inheritance of the HLA-linked gene predisposing to narcolepsy
30. In vivo evidence for the contribution of human histocompatibility leukocyte antigen (HLA)-DQ molecules to the development of diabetes
31. Different contribution of HLA-DR and -DQ genes in susceptibility and resistance to insulin-dependent diabetes mellitus (IDDM)