Sex-specific differences in the relationship between genetic susceptibility, T cell DNA demethylation and lupus flare severity

Journal of Autoimmunity

Volumn 38, Issue 2-3, 2012, Pages

  Sawalha, Amr H ^a,b,c   Wang, Lu ^d   Nadig, Ajay ^c   Somers, Emily C ^d   McCune, W Joseph ^d   Hughes, Travis ^c   Merrill, Joan T ^c   Scofield, R Hal ^a,b,c   Strickland, Faith M ^d   Richardson, Bruce ^d,e  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

^e VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

DNA methylation; Epigenetics; Genetic risk; Genetic epigenetic interaction; Lupus; Sex disparity

Indexed keywords

KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL4; METHYL CPG BINDING PROTEIN 2;

ADULT; ALLELE; ARTICLE; AUTOSOME; CD4+ T LYMPHOCYTE; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; DNA METHYLATION; EPIGENETICS; EUROPEAN AMERICAN; FEMALE; GENE INTERACTION; GENE LOCUS; GENE SEQUENCE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE; X CHROMOSOME;

ADULT; DNA METHYLATION; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; SEX FACTORS; T-LYMPHOCYTES;

EID: 84862776683     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.11.008     Document Type: Article

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