Environmental exposure, estrogen and two X chromosomes are required for disease development in an epigenetic model of lupus

Journal of Autoimmunity

Volumn 38, Issue 2-3, 2012, Pages

  Strickland, Faith M ^a   Hewagama, Anura ^a   Lu, Qianjian ^b   Wu, Ailing ^a   Hinderer, Robert ^a   Webb, Ryan ^c   Johnson, Kent ^a   Sawalha, Amr H ^c   Delaney, Colin ^a   Yung, Raymond ^a,d   Richardson, Bruce C ^a,d  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^d VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

Author keywords

Extracellular receptor kinase (ERK); Mouse; Systemic lupus erythematosus (SLE)

Indexed keywords

CD40 LIGAND; CD70 ANTIGEN; DNA METHYLTRANSFERASE 1; DOUBLE STRANDED DNA ANTIBODY; DOXYCYCLINE; ESTRADIOL; IMMUNOGLOBULIN G; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; MITOGEN ACTIVATED PROTEIN KINASE; PLACEBO;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DISEASE MODEL; DISEASE PREDISPOSITION; DNA DEMETHYLATION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GLOMERULUS; HISTOPATHOLOGY; INTRACELLULAR SIGNALING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SEX DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE; X CHROMOSOME;

ANIMALS; ANTIBODIES, ANTINUCLEAR; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENESIS, GENETIC; ESTROGENS; FEMALE; GENE EXPRESSION; GENE-ENVIRONMENT INTERACTION; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SEX FACTORS; X CHROMOSOME;

EID: 84858753280     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2011.11.001     Document Type: Article

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