Clinical, polysomnographic and laboratory characteristics of narcolepsy-cataplexy in a sample of children and adolescents

Sleep Medicine

Volumn 12, Issue 1, 2011, Pages 24-27

  Peraita Adrados, Rosa ^a   García Peñas, Juan J ^b   Ruiz Falcó, Luz ^b   Gutiérrez Solana, Luis ^b   López Esteban, Pilar ^b   Vicario, José L ^c   Miano, Silvia ^d   Aparicio Meix, Manuel ^e   Martinez Sopena, María José ^f  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^b HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

^c Histocompatibility Blood Centre of the Community of Madrid ^*  (Spain)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

^e HOSPITAL RAMÓN Y CAJAL   (Spain)

^f HOSPITAL CLÍNICO UNIVERSITARIO DE VALLADOLID   (Spain)

Author keywords

Adolescent; Childhood; Diagnosis; POCS; Sporadic narcolepsy cataplexy; Treatment

Indexed keywords

ANTIDEPRESSANT AGENT; CLOMIPRAMINE; FLUOXETINE; HLA DQ1 ANTIGEN; HLA DQB1 ANTIGEN; HLA DR2 ANTIGEN; METFORMIN; METHYLPHENIDATE; MODAFINIL; ORAL CONTRACEPTIVE AGENT; OREXIN A; OXYBATE SODIUM; VENLAFAXINE;

ACADEMIC ACHIEVEMENT; ADOLESCENT; ARTICLE; BODY MASS; BRUXISM; CATAPLEXY; CEREBROSPINAL FLUID LEVEL; CHILD; CLINICAL ARTICLE; DEPRESSION; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EATING DISORDER; EMOTIONAL DISORDER; EMPTY SELLA SYNDROME; EPWORTH SLEEPINESS SCALE; FEMALE; HUMAN; HYPERANDROGENISM; HYPNAGOGIC HALLUCINATION; INSULIN RESISTANCE; MALE; NARCOLEPSY; NEUROIMAGING; NEUROLOGIC EXAMINATION; NIGHT SLEEP; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY POLYCYSTIC DISEASE; PARASOMNIA; PHYSICAL EXAMINATION; POLYSOMNOGRAPHY; PRECOCIOUS PUBERTY; PRESCHOOL CHILD; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; RATING SCALE; SCHOOL CHILD; ULLANLINNA NARCOLEPSY SCALE; WEIGHT GAIN;

ADOLESCENT; BRAIN; CHILD; EATING DISORDERS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; NARCOLEPSY; POLYSOMNOGRAPHY;

EID: 78650290253     PISSN: 13899457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.sleep.2010.02.017     Document Type: Article

References (36)

1. American Academy of Sleep Medicine. International classification of sleep disorders. 2nd ed. Diagnostic and coding manual. Westchester, IL: American Academy of Sleep Medicine;2005.
2. Overeem S., Mignot E., van Dijk J.G., Lammers G.J. Narcolepsy: clinical features, new pathophysiologic insights, and future perspectives. J Clin Neurophysiol 2001, 18(2):78-105.
3. Lecendreux M., Dauvilliers Y., Arnulf I., Franco P. Narcolepsy with cataplexy in the child: clinical evaluation and therapeutical management. Rev Neurol (Paris) 2008, 164(8-9):646-657.
4. Plazzi G., Parmeggiani A., Mignot E., Lin L., Scano M.C., Posar A., et al. Narcolepsy-cataplexy associated with precocious puberty. Neurology 2006, 66(10):1577-1579.
5. Plazzi G., Serra L., Ferri R. Nocturnal aspects of narcolepsy with cataplexy. Sleep Med Rev 2008, 2:109-128.
6. Nevsimalova S. Narcolepsy in childhood. Sleep Med Rev 2009, 13(2):169-180.
7. Mignot E., Lin X., Arrigoni J., Macaubas C., Olive F., Hallmayer J., et al. DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans. Sleep 1994, 17(8 Suppl.):S60-S67.
8. Nishino S., Ripley B., Overeem S., Nevsimalova S., Lammers G.J., Vankova J., et al. Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy. Ann Neurol 2001, 50(3):381-388.
9. Mignot E., Lammers G.J., Ripley B., Okun M., Nevsimalova S., Overeem S., et al. The role of cerebrospinal fluid hypocretin measurement in the diagnosis of narcolepsy and other hypersomnias. Arch Neurol 2002, 59(10):1553-1562.
10. Kanbayashi T., Inoue Y., Chiba S., Aizawa R., Saito Y., Tsukamoto H., et al. CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res 2002, 11(1):91-93.
11. Krahn L.E., Pankratz V.S., Oliver L., Boeve B.F., Silber M.H. Hypocretin (orexin) levels in cerebrospinal fluid of patients with narcolepsy: relationship to cataplexy and HLA DQB1*0602 status. Sleep 2002, 25(7):733-736.
12. Guilleminault C., Pelayo R. Narcolepsy in children: a practical guide to its diagnosis, treatment and follow-up. Paediatr Drugs 2000, 2(1):1-9.
13. Macleod S., Ferrie C., Zuberi S.M. Symptoms of narcolepsy in children misinterpreted as epilepsy. Epileptic Disord 2005, 7(1):13-17.
14. Nevšímalová S., Buskova J., Kemlink D., Sonka K., Skibova J. Does age at onset of narcolepsy influence the course and severity of the disease?. Sleep Med 2009, 19(9):967-972.
15. Peterson P.C., Husain A.M. Pediatric narcolepsy. Brain and Development 2008, 30(10):609-623.
16. Kubota H., Kanbayashi T., Tanabe Y., Ito M., Takanashi J., Kohno Y., et al. Decreased cerebrospinal fluid hypocretin-1 levels near the onset of narcolepsy in 2 prepubertal children. Sleep 2003, 26(5):555-557.
17. Rechtschaffen A., Kales A. A manual of standardized terminology, techniques and scoring system for sleep stages in human subjects. Public Health Service Publication No. 204 1968, US Government Printing Office, Washington, DC.
18. Melendres M.C., Lutz J.M., Rubin E.D., Marcus C.L. Daytime sleepiness and hyperactivity in children with suspected sleep-disordered breathing. Pediatrics 2004, 114(3):768-775.
19. Hublin C., Kaprio J., Partinen M., Koskenvuo M., Heikkila K. The Ullanlinna narcolepsy scale: validation of a measure of symptoms of the narcoleptic syndrome. J Sleep Res. 1994, 3:52-59.
20. Anic-Labat S., Guilleminault C., Kraemer H.C., Meehand J., Arrigoni J., Mignot E. Validation of a cataplexy questionnaire in 983 sleep disorder patients. Sleep 1999, 22(1):77-87.
21. Pelin Z., Guilleminault C., Risch N., Grumet F.C., Mignot E. HLA-DQB1*0602 homozygosity increases relative risk for narcolepsy but not disease severity in two ethnic groups, US Modafinil in Narcolepsy Multicenter Study Group. Tissue Antigens 1998, 51(1):96-100.
22. Peraita-Adrados R., Ezpeleta D., Balas A., Vicario J.L. Narcolepsy Cataplexy syndrome associated with DRB1*0806-DQB1*0602 haplotype in a Caucasian patient. Sleep Res Online 1999, 2(2):29-31.
23. Knutson K.L., Spiegel K., Penev P., Van Cauter E. The metabolic consequences of sleep deprivation. Sleep Med Rev 2007, 11:163-178.
24. Taheri S., Lin L., Austin D., Young T., Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med 2004, 1:e62.
25. Poli F., Plazzi G., Di Dalmazi G., Ribichini D., Vicennati V., et al. Body mass index-independent metabolic alterations in narcolepsy with cataplexy. Sleep 2009, 32(11):1491-1497.
26. Dahl R.E., Holttum J., Trubnick L. A clinical picture of child and adolescent narcolepsy. J Am Acad Child Adolesc Psychiatry 1994, 33:834-841.
27. Kotagal S., Krahn L.E., Slocumb N. A putative link between childhood narcolepsy and obesity. Sleep Med 2004, 5:147-150.
28. Ferguson A.V., Samson W.K. The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic functions. Front Neuroendocrinol 2003, 24:141-150.
29. Russell S.H., Small C.J., Dakin C.L., et al. Effects of orexins on the hypothalamic-pituitary-adrenal system. J Neuroendocrinol 2000, 12:1174-1178.
30. Schuld A., Hebebrand J., Geller F., Pollmächer T. Increased body-mass index in patients with narcolepsy. Lancet 2000, 355(9211):1274-1275.
31. Kok S., Roelfsema F., Overeem S., Lammers G.J., et al. Altered setting of the pituitary-thyroid ensemble in hypocretin-deficient narcoleptic men. Am J Physiol Endocrinol Metab 2005, 5:E892-E899.
32. Pöllmacher T., Dalal M., Schul A. Immunoendocrine abnormalities in narcolepsy. Sleep Med Clin 2007, 2:293-302.
33. Roberts H.J. Hyperinsulinism, narcolepsy and obesity - an important clinical triad. Clin Res 1962, 10:234.
34. Honda Y., Doi Y., Ninomiya R., Ninomiya C. Increased frequency of non-insulin-dependent diabetes mellitus among narcoleptic patients. Sleep 1986, 9(1 Pt 2):254-259.
35. Peraita-Adrados R., Hor H., Vicario J.L., Pfister C., Lammers G., Tafti M. Familial narcolepsy, obesity and type 2 diabetes with hypocretin deficiency. J Sleep Res 2008, 17(Suppl. 1):O49.
36. Vgontzas A.N., Legro R.S., Bixler E.O., Grayev A., Kales A., Chrousos G.P. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab 2001, 86(2):517-520.