메뉴 건너뛰기




Volumn 9, Issue 10, 2013, Pages 1255-1263

Reconstructed skin models as emerging tools for drug absorption studies

Author keywords

Disease models; in vitro; Reconstructed skin models; Skin absorption testing; Transdermal drug delivery

Indexed keywords

BENZOIC ACID; CAFFEINE; DIGOXIN; FLUFENAMIC ACID; NICOTINE; TESTOSTERONE;

EID: 84884253454     PISSN: 17425255     EISSN: 17447607     Source Type: Journal    
DOI: 10.1517/17425255.2013.816284     Document Type: Review
Times cited : (49)

References (69)
  • 1
    • 0034950707 scopus 로고    scopus 로고
    • Pesticides as a cause of occupational skin diseases in farmers
    • Spiewak R. Pesticides as a cause of occupational skin diseases in farmers. Ann Agric Environ Med 2001;8(1):1-5
    • (2001) Ann Agric Environ Med , vol.8 , Issue.1 , pp. 1-5
    • Spiewak, R.1
  • 3
    • 0016545625 scopus 로고
    • Drug permeation through human skin: Theory andinvitro experimental measurement
    • Michaels AS, Chandrasekaran SK, Shaw JE. Drug permeation through human skin: Theory andinvitro experimental measurement. AIChE J 1975;21(5):985-96
    • (1975) AIChE J , vol.21 , Issue.5 , pp. 985-996
    • Michaels, A.S.1    Chandrasekaran, S.K.2    Shaw, J.E.3
  • 4
    • 84864288846 scopus 로고    scopus 로고
    • The structure and function of the stratum corneum
    • Menon GK, Cleary GW, Lane ME. The structure and function of the stratum corneum. Int J Pharm 2012;435(1):3-9
    • (2012) Int J Pharm , vol.435 , Issue.1 , pp. 3-9
    • Menon, G.K.1    Cleary, G.W.2    Lane, M.E.3
  • 5
    • 1542268930 scopus 로고    scopus 로고
    • Lipid vesicles and other colloids as drug carriers on the skin
    • Cevc G. Lipid vesicles and other colloids as drug carriers on the skin. Adv Drug Deliv Rev 2004;56(5):675-711
    • (2004) Adv Drug Deliv Rev , vol.56 , Issue.5 , pp. 675-711
    • Cevc, G.1
  • 6
    • 0031898536 scopus 로고    scopus 로고
    • Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: A high-resolution confocal laser scanning microscopy study using highly deformable vesicles (transfersomes
    • Schätzlein A, Cevc G. Non-uniform cellular packing of the stratum corneum and permeability barrier function of intact skin: A high-resolution confocal laser scanning microscopy study using highly deformable vesicles (Transfersomes). Br J Dermatol 1998;138(4):583-92
    • (1998) Br J Dermatol , vol.138 , Issue.4 , pp. 583-592
    • Schätzlein, A.1    Cevc, G.2
  • 7
    • 79952315238 scopus 로고    scopus 로고
    • Penetration and storage of particles in human skin: Perspectives and safety aspects
    • Lademann J, Richter H, Schanzer S, et al. Penetration and storage of particles in human skin: Perspectives and safety aspects. Eur J Pharm Biopharm 2011;77(3):465-8
    • (2011) Eur J Pharm Biopharm , vol.77 , Issue.3 , pp. 465-468
    • Lademann, J.1    Richter, H.2    Schanzer, S.3
  • 8
    • 79951949743 scopus 로고    scopus 로고
    • Selective follicular targeting by modification of the particle sizes
    • Patzelt A, Richter H, Knorr F, et al. Selective follicular targeting by modification of the particle sizes. J Control Release 2011;150(1):45-8
    • (2011) J Control Release , vol.150 , Issue.1 , pp. 45-48
    • Patzelt, A.1    Richter, H.2    Knorr, F.3
  • 9
    • 0026606514 scopus 로고
    • Predicting skin permeability
    • Potts RO, Guy RH. Predicting skin permeability. Pharm Res 1992;9(5):663-9
    • (1992) Pharm Res , vol.9 , Issue.5 , pp. 663-669
    • Potts, R.O.1    Guy, R.H.2
  • 10
    • 0034098046 scopus 로고    scopus 로고
    • The 500 Dalton rule for the skin penetration of chemical compounds and drugs
    • Bos JD, Meinardi MM. The 500 Dalton rule for the skin penetration of chemical compounds and drugs. Exp Dermatol 2000;9(3):165-9
    • (2000) Exp Dermatol , vol.9 , Issue.3 , pp. 165-169
    • Bos, J.D.1    Meinardi, M.M.2
  • 11
    • 31544460650 scopus 로고    scopus 로고
    • In vitro studies-how good are they at replacing in vivo studies for measurement of skin absorption?
    • Williams FM. In vitro studies-how good are they at replacing in vivo studies for measurement of skin absorption? Environ Toxicol Pharmacol 2006;21(2):199-203
    • (2006) Environ Toxicol Pharmacol , vol.21 , Issue.2 , pp. 199-203
    • Williams, F.M.1
  • 12
    • 35349002202 scopus 로고    scopus 로고
    • Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models
    • Godin B, Touitou E. Transdermal skin delivery: Predictions for humans from in vivo, ex vivo and animal models. Adv Drug Deliv Rev 2007;59(11):1152-61
    • (2007) Adv Drug Deliv Rev , vol.59 , Issue.11 , pp. 1152-1161
    • Godin, B.1    Touitou, E.2
  • 13
    • 84862849691 scopus 로고    scopus 로고
    • The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study
    • Ng SF, Rouse JJ, Sanderson FD, Eccleston GM. The relevance of polymeric synthetic membranes in topical formulation assessment and drug diffusion study. Arch Pharm Res 2012;35(4):579-93
    • (2012) Arch Pharm Res , vol.35 , Issue.4 , pp. 579-593
    • Ng, S.F.1    Rouse, J.J.2    Sanderson, F.D.3    Eccleston, G.M.4
  • 14
  • 15
    • 33746307222 scopus 로고    scopus 로고
    • Guidance document for the conduct of skin absorption studies
    • OECD OECD, Paris, France
    • OECD. Guidance document for the conduct of skin absorption studies. Series on testing assessment No. 28. OECD, Paris, France; 2003
    • (2003) Series On Testing Assessment No , vol.28
  • 16
    • 53949103329 scopus 로고    scopus 로고
    • Reconstructed epidermis and full-thickness skin for absorption testing: Influence of the vehicles used on steroid permeation
    • Schäfer-Korting M, Mahmoud A, Lombardi Borgia S, et al. Reconstructed epidermis and full-thickness skin for absorption testing: Influence of the vehicles used on steroid permeation. Altern Lab Anim 2008;36(4):441-52
    • (2008) Altern Lab Anim , vol.36 , Issue.4 , pp. 441-452
    • Schäfer-Korting, M.1    Mahmoud, A.2    Lombardi Borgia, S.3
  • 17
    • 69049107780 scopus 로고    scopus 로고
    • Use of excised human skin to assess the bioequivalence of topical products
    • Franz TJ, Lehman PA, Raney SG. Use of excised human skin to assess the bioequivalence of topical products. Skin Pharmacol Physiol 2009;22(5):276-86
    • (2009) Skin Pharmacol Physiol , vol.22 , Issue.5 , pp. 276-286
    • Franz, T.J.1    Lehman, P.A.2    Raney, S.G.3
  • 19
    • 0014446409 scopus 로고
    • Percutaneous penetration of steroids in man
    • Feldmann RJ, Maibach HI. Percutaneous penetration of steroids in man. J Invest Dermatol 1969;52(1):89-94
    • (1969) J Invest Dermatol , vol.52 , Issue.1 , pp. 89-94
    • Feldmann, R.J.1    Maibach, H.I.2
  • 20
    • 33751503464 scopus 로고    scopus 로고
    • Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments
    • Netzlaff F, Schaefer UF, Lehr CM, et al. Comparison of bovine udder skin with human and porcine skin in percutaneous permeation experiments. Altern Lab Anim 2006;34(5):499-513
    • (2006) Altern Lab Anim , vol.34 , Issue.5 , pp. 499-513
    • Netzlaff, F.1    Schaefer, U.F.2    Lehr, C.M.3
  • 22
    • 20444449143 scopus 로고    scopus 로고
    • Reconstructed epidermis versus human and animal skin in skin absorption studies
    • Schreiber S, Mahmoud A, Vuia A, et al. Reconstructed epidermis versus human and animal skin in skin absorption studies. Toxicol In Vitro 2005;19(6):813-22
    • (2005) Toxicol In Vitro , vol.19 , Issue.6 , pp. 813-822
    • Schreiber, S.1    Mahmoud, A.2    Vuia, A.3
  • 23
    • 77955577355 scopus 로고    scopus 로고
    • Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: Unraveling the peeling skin disease
    • Oji V, Eckl KM, Aufenvenne K, et al. Loss of corneodesmosin leads to severe skin barrier defect, pruritus, and atopy: Unraveling the peeling skin disease. Am J Hum Genet 2010;87(2):274-81
    • (2010) Am J Hum Genet , vol.87 , Issue.2 , pp. 274-281
    • Oji, V.1    Eckl, K.M.2    Aufenvenne, K.3
  • 24
    • 28244474457 scopus 로고    scopus 로고
    • Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy
    • Lombardi Borgia S, Regehly M, Sivaramakrishnan R, et al. Lipid nanoparticles for skin penetration enhancement-correlation to drug localization within the particle matrix as determined by fluorescence and parelectric spectroscopy. J Control Release 2005;110(1):151-63
    • (2005) J Control Release , vol.110 , Issue.1 , pp. 151-163
    • Lombardi Borgia, S.1    Regehly, M.2    Sivaramakrishnan, R.3
  • 25
    • 67650649428 scopus 로고    scopus 로고
    • Use of various models for in vitro percutaneous absorption studies of ultraviolet filters
    • Huong SP, Bun H, Fourneron JD, et al. Use of various models for in vitro percutaneous absorption studies of ultraviolet filters. Skin Res Technol 2009;15(3):253-61
    • (2009) Skin Res Technol , vol.15 , Issue.3 , pp. 253-261
    • Huong, S.P.1    Bun, H.2    Fourneron, J.D.3
  • 26
    • 69549107433 scopus 로고    scopus 로고
    • Experimental models in predicting topical antifungal efficacy: Practical aspects and challenges
    • Lai J, Maibach HI. Experimental models in predicting topical antifungal efficacy: Practical aspects and challenges. Skin Pharmacol Physiol 2009;22(5):231-9
    • (2009) Skin Pharmacol Physiol , vol.22 , Issue.5 , pp. 231-239
    • Lai, J.1    Maibach, H.I.2
  • 27
    • 33746311297 scopus 로고    scopus 로고
    • Reconstructed human epidermis for skin absorption testing: Results of the German prevalidation study
    • Schäfer-Korting M, Bock U, Gamer A, et al. Reconstructed human epidermis for skin absorption testing: Results of the German prevalidation study. Altern Lab Ani 2006;34(3):283-94
    • (2006) Altern Lab Ani , vol.34 , Issue.3 , pp. 283-294
    • Schäfer-Korting, M.1    Bock, U.2    Gamer, A.3
  • 28
    • 0031939545 scopus 로고    scopus 로고
    • Human cadaver skin viability for in vitro percutaneous absorption: Storage and detrimental effects of heat-separation and freezing
    • Wester RC, Christoffel J, Hartway T, et al. Human cadaver skin viability for in vitro percutaneous absorption: Storage and detrimental effects of heat-separation and freezing. Pharm Res 1998;15(1):82-4
    • (1998) Pharm Res , vol.15 , Issue.1 , pp. 82-84
    • Wester, R.C.1    Christoffel, J.2    Hartway, T.3
  • 29
    • 45549105564 scopus 로고    scopus 로고
    • The use of reconstructed human epidermis for skin absorption testing: Results of the validation study
    • Schäfer-Korting M, Bock U, Diembeck W, et al. The use of reconstructed human epidermis for skin absorption testing: Results of the validation study. Altern Lab Ani 2008;36(2):161-87
    • (2008) Altern Lab Ani , vol.36 , Issue.2 , pp. 161-187
    • Schäfer-Korting, M.1    Bock, U.2    Diembeck, W.3
  • 30
    • 0036166247 scopus 로고    scopus 로고
    • In vitro permeability and binding of hydrocarbons in pig ear and human abdominal skin
    • Singh S, Zhao K, Singh J. In vitro permeability and binding of hydrocarbons in pig ear and human abdominal skin. Drug Chem Toxicol 2002;25(1):83-92
    • (2002) Drug Chem Toxicol , vol.25 , Issue.1 , pp. 83-92
    • Singh, S.1    Zhao, K.2    Singh, J.3
  • 31
    • 58149191280 scopus 로고    scopus 로고
    • Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review
    • Barbero AM, Frasch HF. Pig and guinea pig skin as surrogates for human in vitro penetration studies: A quantitative review. Toxicol In Vitro 2009;23(1):1-13
    • (2009) Toxicol In Vitro , vol.23 , Issue.1 , pp. 1-13
    • Barbero, A.M.1    Frasch, H.F.2
  • 32
    • 0025141213 scopus 로고
    • Shed snake skin and hairless mouse skin as model membranes for human skin during permeation studies
    • Rigg PC, Barry BW. Shed snake skin and hairless mouse skin as model membranes for human skin during permeation studies. J Invest Dermatol 1990;94(2):235-40
    • (1990) J Invest Dermatol , vol.94 , Issue.2 , pp. 235-240
    • Rigg, P.C.1    Barry, B.W.2
  • 33
    • 0024998531 scopus 로고
    • Comparisons of in vitro nitroglycerin (TNG) flux across yucatan pig, hairless mouse, and human skins
    • Roberts ME, Mueller KR. Comparisons of in vitro nitroglycerin (TNG) flux across yucatan pig, hairless mouse, and human skins. Pharm Res 1990;7(6):673-6
    • (1990) Pharm Res , vol.7 , Issue.6 , pp. 673-676
    • Roberts, M.E.1    Mueller, K.R.2
  • 34
    • 77957178122 scopus 로고
    • A comparative study of the rates of in vitro percutaneous absorption of eight chemicals using rat and human skin
    • Barber ED, Teetsel NM, Kolberg KF, Guest D. A comparative study of the rates of in vitro percutaneous absorption of eight chemicals using rat and human skin. Fundam Appl Toxicol 1992;19(4):493-7
    • (1992) Fundam Appl Toxicol , vol.19 , Issue.4 , pp. 493-497
    • Barber, E.D.1    Teetsel, N.M.2    Kolberg, K.F.3    Guest, D.4
  • 35
    • 0027385961 scopus 로고
    • The isolated perfused bovine udder as an in vitro model of percutaneous drug absorption. Skin viability and percutaneous absorption of dexamethasone, benzoyl peroxide, and etofenamate
    • Kietzmann M, Loscher W, Arens D, et al. The isolated perfused bovine udder as an in vitro model of percutaneous drug absorption. Skin viability and percutaneous absorption of dexamethasone, benzoyl peroxide, and etofenamate. J Pharmacol Toxicol Methods 1993;30(2):75-84
    • (1993) J Pharmacol Toxicol Methods , vol.30 , Issue.2 , pp. 75-84
    • Kietzmann, M.1    Loscher, W.2    Arens, D.3
  • 36
    • 65449139553 scopus 로고    scopus 로고
    • Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering
    • Auxenfans C, Fradette J, Lequeux C, et al. Evolution of three dimensional skin equivalent models reconstructed in vitro by tissue engineering. Eur J Dermatol 2009;19(2):107-13
    • (2009) Eur J Dermatol , vol.19 , Issue.2 , pp. 107-113
    • Auxenfans, C.1    Fradette, J.2    Lequeux, C.3
  • 37
    • 79956212332 scopus 로고    scopus 로고
    • Three-dimensional skin models as tools for transdermal drug delivery: Challenges and limitations
    • Van Gele M, Geusens B, Brochez L, et al. Three-dimensional skin models as tools for transdermal drug delivery: Challenges and limitations. Expert Opin Drug Deliv 2011;8(6):705-20
    • (2011) Expert Opin Drug Deliv , vol.8 , Issue.6 , pp. 705-720
    • Van Gele, M.1    Geusens, B.2    Brochez, L.3
  • 38
    • 84872418188 scopus 로고    scopus 로고
    • In vitro 3D full-thickness skin-equivalent tissue model using silk and collagen biomaterials
    • Bellas E, Seiberg M, Garlick J, Kaplan DL. In vitro 3D full-thickness skin-equivalent tissue model using silk and collagen biomaterials. Macromol Biosci 2012;12(12):1627-36
    • (2012) Macromol Biosci , vol.12 , Issue.12 , pp. 1627-1636
    • Bellas, E.1    Seiberg, M.2    Garlick, J.3    Kaplan, D.L.4
  • 39
    • 38649123305 scopus 로고    scopus 로고
    • The ecvam international validation study on in vitro tests for acute skin irritation: Report on the validity of the episkin and epiderm assays and on the skin integrity function test
    • Spielmann H, Hoffmann S, Liebsch M, et al. The ECVAM international validation study on in vitro tests for acute skin irritation: Report on the validity of the EPISKIN and EpiDerm assays and on the Skin Integrity Function Test. Altern Lab Ani 2007;35(6):559-601
    • (2007) Altern Lab Ani , vol.35 , Issue.6 , pp. 559-601
    • Spielmann, H.1    Hoffmann, S.2    Liebsch, M.3
  • 40
    • 72049101914 scopus 로고    scopus 로고
    • The Phenion full-thickness skin model for percutaneous absorption testing
    • Ackermann K, Borgia SL, Korting HC, et al. The Phenion full-thickness skin model for percutaneous absorption testing. Skin Pharmacol Physiol 2009;23(2):105-12
    • (2009) Skin Pharmacol Physiol , vol.23 , Issue.2 , pp. 105-112
    • Ackermann, K.1    Borgia, S.L.2    Korting, H.C.3
  • 41
    • 33444456243 scopus 로고    scopus 로고
    • OECD guideline for the testing of chemicals No 431
    • OECD OECD; Paris, France
    • OECD. OECD guideline for the testing of chemicals, No. 431, In vitro skin corrosion; human skin model test. OECD; Paris, France: 2004. p. 8
    • (2004) Vitro Skin Corrosion; Human Skin Model Test , pp. 8
  • 42
    • 84884237063 scopus 로고    scopus 로고
    • OECD guideline for testing of chemicals no. 432
    • OECD OECD, Paris, France
    • OECD. OECD guideline for testing of chemicals, No.432, In vitro 3T3 NRU phototoxicity test. OECD, Paris, France; 2004
    • (2004) Vitro 3t3 Nru Phototoxicity Test
  • 43
    • 0033762246 scopus 로고    scopus 로고
    • Evaluation of a human bio-engineered skin equivalent for drug permeation studies
    • Asbill C, Kim N, El-Kattan A, et al. Evaluation of a human bio-engineered skin equivalent for drug permeation studies. Pharm Res 2000;17(9):1092-7
    • (2000) Pharm Res , vol.17 , Issue.9 , pp. 1092-1097
    • Asbill, C.1    Kim, N.2    El-Kattan, A.3
  • 45
    • 0028923171 scopus 로고
    • Characterization of stratum corneum structure in reconstructed epidermis by X-ray diffraction
    • Bouwstra JA, Gooris GS, Weerheim A, et al. Characterization of stratum corneum structure in reconstructed epidermis by X-ray diffraction. J Lipid Res 1995;36(3):496-504
    • (1995) J Lipid Res , vol.36 , Issue.3 , pp. 496-504
    • Bouwstra, J.A.1    Gooris, G.S.2    Weerheim, A.3
  • 46
    • 84872186168 scopus 로고    scopus 로고
    • Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents
    • Thakoersing VS, van Smeden J, Mulder AA, et al. Increased presence of monounsaturated fatty acids in the stratum corneum of human skin equivalents. J Invest Dermatol 2013;133(1):59-67
    • (2013) J Invest Dermatol , vol.133 , Issue.1 , pp. 59-67
    • Thakoersing, V.S.1    Van Smeden, J.2    Mulder, A.A.3
  • 47
    • 84855371944 scopus 로고    scopus 로고
    • Unraveling barrier properties of three different in-house human skin equivalents
    • Thakoersing VS, Gooris GS, Mulder A, et al. Unraveling barrier properties of three different in-house human skin equivalents. Tissue Eng Part C Methods 2012;18(1):1-11
    • (2012) Tissue Eng Part C Methods , vol.18 , Issue.1 , pp. 1-11
    • Thakoersing, V.S.1    Gooris, G.S.2    Mulder, A.3
  • 48
    • 84929601832 scopus 로고    scopus 로고
    • Mechanical forces on cells
    • In: Dorf RC Editor CRC Press Taylor and Francis Group, Boca Raton, Florida, USA
    • Shiu YT. Mechanical forces on cells. In: Dorf RC, editor. Tissue engineering and artifical organs. CRC Press Taylor and Francis Group, Boca Raton, Florida, USA; 2006
    • (2006) Tissue Engineering And Artifical Organs
    • Shiu, Y.T.1
  • 49
    • 77954038080 scopus 로고    scopus 로고
    • Reconstituting organ-level lung functions on a chip
    • Huh D, Matthews BD, Mammoto A, et al. Reconstituting organ-level lung functions on a chip. Science 2010;328(5986):1662-8
    • (2010) Science , vol.328 , Issue.5986 , pp. 1662-1668
    • Huh, D.1    Matthews, B.D.2    Mammoto, A.3
  • 50
    • 84861800932 scopus 로고    scopus 로고
    • A review of the responses of two- and three-dimensional engineered tissues to electric fields
    • Hronik-Tupaj M, Kaplan DL. A review of the responses of two- and three-dimensional engineered tissues to electric fields. Tissue Eng Part B Rev 2012;18(3):167-80
    • (2012) Tissue Eng Part B Rev , vol.18 , Issue.3 , pp. 167-180
    • Hronik-Tupaj, M.1    Kaplan, D.L.2
  • 51
    • 0012796190 scopus 로고    scopus 로고
    • How structural networks influence cellular information processing networks
    • Ingber DE. Tensegrity II. How structural networks influence cellular information processing networks. J Cell Sci 2003;116(PT8):1397-408
    • (2003) J Cell Sci , vol.116 , Issue.PART 8 , pp. 1397-1408
    • Ingber, D.E.1    Tensegrity, I.I.2
  • 52
    • 0036311836 scopus 로고    scopus 로고
    • Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage
    • Davisson T, Kunig S, Chen A, et al. Static and dynamic compression modulate matrix metabolism in tissue engineered cartilage. J Orthop Res 2002;20(4):842-8
    • (2002) J Orthop Res , vol.20 , Issue.4 , pp. 842-848
    • Davisson, T.1    Kunig, S.2    Chen, A.3
  • 53
    • 77953940743 scopus 로고    scopus 로고
    • Modest but increased penetration through damaged skin: An overview of the in vivo human model
    • Gattu S, Maibach HI. Modest but increased penetration through damaged skin: An overview of the in vivo human model. Skin Pharmacol Physiol 2011;24(1):2-9
    • (2011) Skin Pharmacol Physiol , vol.24 , Issue.1 , pp. 2-9
    • Gattu, S.1    Maibach, H.I.2
  • 54
    • 82455181520 scopus 로고    scopus 로고
    • Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on flg knock-down
    • Küchler S, Henkes D, Eckl KM, et al. Hallmarks of atopic skin mimicked in vitro by means of a skin disease model based on FLG knock-down. Altern Lab Ani 2011;39(5):471-80
    • (2011) Altern Lab Ani , vol.39 , Issue.5 , pp. 471-480
    • Küchler, S.1    Henkes, D.2    Eckl, K.M.3
  • 55
    • 77955716350 scopus 로고    scopus 로고
    • Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model
    • Mildner M, Jin J, Eckhart L, et al. Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model. J Invest Dermatol 2010;130(9):2286-94
    • (2010) J Invest Dermatol , vol.130 , Issue.9 , pp. 2286-2294
    • Mildner, M.1    Jin, J.2    Eckhart, L.3
  • 56
    • 84856901014 scopus 로고    scopus 로고
    • One remarkable molecule: Filaggrin
    • Brown SJ, McLean WH. One remarkable molecule: Filaggrin. J Invest Dermatol 2012;132(3 PT2):751-62
    • (2012) J Invest Dermatol , vol.132 , Issue.3 PART 2 , pp. 751-762
    • Brown, S.J.1    McLean, W.H.2
  • 57
    • 33645399288 scopus 로고    scopus 로고
    • Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis
    • Palmer CN, Irvine AD, Terron-Kwiatkowski A, et al. Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat Genet 2006;38(4):441-6
    • (2006) Nat Genet , vol.38 , Issue.4 , pp. 441-446
    • Palmer, C.N.1    Irvine, A.D.2    Terron-Kwiatkowski, A.3
  • 58
    • 84862865908 scopus 로고    scopus 로고
    • Percutaneous absorption in diseased skin: An overview
    • Chiang A, Tudela E, Maibach HI. Percutaneous absorption in diseased skin: An overview. J Appl Toxicol 2012;32(8):537-63
    • (2012) J Appl Toxicol , vol.32 , Issue.8 , pp. 537-563
    • Chiang, A.1    Tudela, E.2    Maibach, H.I.3
  • 59
    • 2142816577 scopus 로고    scopus 로고
    • Novel lipid mixtures based on synthetic ceramides reproduce the unique stratum corneum lipid organization
    • de Jager MW, Gooris GS, Dolbnya IP, et al. Novel lipid mixtures based on synthetic ceramides reproduce the unique stratum corneum lipid organization. J Lipid Res 2004;45(5):923-32
    • (2004) J Lipid Res , vol.45 , Issue.5 , pp. 923-932
    • De Jager, M.W.1    Gooris, G.S.2    Dolbnya, I.P.3
  • 60
    • 30844463224 scopus 로고    scopus 로고
    • Lipid mixtures prepared with well-defined synthetic ceramides closely mimic the unique stratum corneum lipid phase behavior
    • de Jager MW, Gooris GS, Ponec M, Bouwstra JA. Lipid mixtures prepared with well-defined synthetic ceramides closely mimic the unique stratum corneum lipid phase behavior. J Lipid Res 2005;46(12):2649-56
    • (2005) J Lipid Res , vol.46 , Issue.12 , pp. 2649-2656
    • De Jager, M.W.1    Gooris, G.S.2    Ponec, M.3    Bouwstra, J.A.4
  • 61
    • 0038082964 scopus 로고    scopus 로고
    • Comparison of effects of different ointment bases on the penetration of ketoprofen through heat-separated human epidermis and artificial lipid barriers
    • Jaeckle E, Schaefer UF, Loth H. Comparison of effects of different ointment bases on the penetration of ketoprofen through heat-separated human epidermis and artificial lipid barriers. J Pharm Sci 2003;92(7):1396-406
    • (2003) J Pharm Sci , vol.92 , Issue.7 , pp. 1396-1406
    • Jaeckle, E.1    Schaefer, U.F.2    Loth, H.3
  • 62
    • 80052523243 scopus 로고    scopus 로고
    • Lipophilic penetration enhancers and their impact to the bilayer structure of stratum corneum lipid model membranes: Neutron diffraction studies based on the example oleic acid
    • Engelbrecht TN, Schroeter A, Hauss T, Neubert RH. Lipophilic penetration enhancers and their impact to the bilayer structure of stratum corneum lipid model membranes: Neutron diffraction studies based on the example oleic acid. Biochim Biophys Acta 2011;1808(12):2798-806
    • (2011) Biochim Biophys Acta , vol.12 , pp. 2798-2806
    • Engelbrecht, T.N.1    Schroeter, A.2    Hauss, T.3    Neubert, R.H.4
  • 63
    • 84861097338 scopus 로고    scopus 로고
    • Characterization of lipid model membranes designed for studying impact of ceramide species on drug diffusion and penetration
    • Ochalek M, Heissler S, Wohlrab J, Neubert RH. Characterization of lipid model membranes designed for studying impact of ceramide species on drug diffusion and penetration. Eur J Pharm Biopharm 2012;81(1):113-20
    • (2012) Eur J Pharm Biopharm , vol.81 , Issue.1 , pp. 113-120
    • Ochalek, M.1    Heissler, S.2    Wohlrab, J.3    Neubert, R.H.4
  • 64
    • 78651233478 scopus 로고    scopus 로고
    • Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes
    • Janusova B, Zbytovska J, Lorenc P, et al. Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes. Biochim Biophys Acta 2011;1811(3):129-37
    • (2011) Biochim Biophys Acta , vol.3 , pp. 129-137
    • Janusova, B.1    Zbytovska, J.2    Lorenc, P.3
  • 65
    • 72949123240 scopus 로고    scopus 로고
    • Mathematical model to predict skin concentration of drugs: Toward utilization of silicone membrane to predict skin concentration of drugs as an animal testing alternative
    • Sugibayashi K, Todo H, Oshizaka T, Owada Y. Mathematical model to predict skin concentration of drugs: Toward utilization of silicone membrane to predict skin concentration of drugs as an animal testing alternative. Pharm Res 2010;27(1):134-42
    • (2010) Pharm Res , vol.27 , Issue.1 , pp. 134-142
    • Sugibayashi, K.1    Todo, H.2    Oshizaka, T.3    Owada, Y.4
  • 66
    • 0033018306 scopus 로고    scopus 로고
    • Percutaneous absorption of salicylic acid in man after topical administration of three different formulations
    • Schwarb FP, Gabard B, Rufli T, Surber C. Percutaneous absorption of salicylic acid in man after topical administration of three different formulations. Dermatology 1999;198(1):44-51
    • (1999) Dermatology , vol.198 , Issue.1 , pp. 44-51
    • Schwarb, F.P.1    Gabard, B.2    Rufli, T.3    Surber, C.4
  • 67
    • 0034605979 scopus 로고    scopus 로고
    • Ionisation and the effect of absorption enhancers on transport of salicylic acid through silastic rubber and human skin
    • Smith JC, Irwin WJ. Ionisation and the effect of absorption enhancers on transport of salicylic acid through silastic rubber and human skin. Int J Pharm 2000;210(1-2):69-82
    • (2000) Int J Pharm , vol.210 , Issue.1-2 , pp. 69-82
    • Smith, J.C.1    Irwin, W.J.2
  • 68
    • 0024504052 scopus 로고
    • Transdermal drug transport and metabolism I comparison of in vitro and in vivo results
    • Guzek DB, Kennedy AH, McNeill SC, et al. Transdermal drug transport and metabolism. I. Comparison of in vitro and in vivo results. Pharm Res 1989;6(1):33-9
    • (1989) Pharm Res , vol.6 , Issue.1 , pp. 33-39
    • Guzek, D.B.1    Kennedy, A.H.2    McNeill, S.C.3
  • 69
    • 84878313855 scopus 로고    scopus 로고
    • Esterase activity in excised and reconstructed human skin - Biotransformation of prednicarbate and the model dye fluorescein diacetate
    • Bätz FM, Klipper W, Korting HC, et al. Esterase activity in excised and reconstructed human skin - Biotransformation of prednicarbate and the model dye fluorescein diacetate. Eur J Pharm Biopharm 2013;84(2):374-85
    • (2013) Eur J Pharm Biopharm , vol.84 , Issue.2 , pp. 374-385
    • Bätz, F.M.1    Klipper, W.2    Korting, H.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.