Penetration and storage of particles in human skin: Perspectives and safety aspects

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 77, Issue 3, 2011, Pages 465-468

  Lademann, J ^a   Richter, H ^a   Schanzer, S ^a   Knorr, F ^a   Meinke, M ^a   Sterry, W ^a   Patzelt, A ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Drug delivery; Follicular targeting; Hair follicles; Particle; Skin barrier

Indexed keywords

COSMETIC; DRUG CARRIER; NANOPARTICLE;

ARTICLE; DERMATOLOGY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SAFETY; DRUG STORAGE; HAIR FOLLICLE; HUMAN; HUMAN TISSUE; PARTICLE SIZE; RISK ASSESSMENT; SKIN SURFACE;

ANIMALS; BIOLOGICAL TRANSPORT; COSMETICS; DRUG DELIVERY SYSTEMS; HAIR FOLLICLE; HUMANS; NANOPARTICLES; PARTICLE SIZE; PERMEABILITY; SKIN; SKIN ABSORPTION;

EID: 79952315238     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2010.10.015     Document Type: Article

References (29)

1. P. Filipe, J.N. Silva, R. Silva, J.L. Cirne de Castro, G.M. Marques, L.C. Alves, R. Santus, T. Pinheiro, Stratum corneum is an effective barrier to TiO(2) and ZnO nanoparticle percutaneous absorption, Skin Pharmacol. Physiol. 22 (2009) 266-275.
2. D. Monti, I. Brini, S. Tampucci, P. Chetoni, S. Burgalassi, D. Paganuzzi, A. Ghirardini, Skin permeation and distribution of two sunscreens: a comparison between reconstituted human skin and hairless rat skin, Skin Pharmacol. Physiol. 21 (2008) 318-325.
3. J. Lademann, H. Richter, U.F. Schaefer, U. Blume-Peytavi, A. Teichmann, N. Otberg, W. Sterry, Hair follicles - a long-term reservoir for drug delivery, Skin Pharmacol. Physiol. 19 (2006) 232-236.
4. A. Vogt, U. Blume-Peytavi, Biology of the human hair follicle. New knowledge and the clinical significance, Hautarzt 54 (2003) 692-698. (Pubitemid 36999085)
5. A. Vogt, N. Mandt, J. Lademann, H. Schaefer, U. Blume-Peytavi, Follicular targeting - a promising tool in selective dermatotherapy, J. Invest. Dermatol. Symp. Proc. 10 (2005) 252-255.
6. A. Patzelt, H. Richter, F. Knorr, U. Schäfer, C.M. Lehr, L. Dähne, W. Sterry, J. Lademann, Selective follicular targeting by modification of the particle sizes, J. Contr. Rel. (in press).
7. J. Lademann, H. Richter, A. Teichmann, N. Otberg, U. Blume-Peytavi, J. Luengo, B. Weiss, U.F. Schaefer, C.M. Lehr, R. Wepf, W. Sterry, Nanoparticles - an efficient carrier for drug delivery into the hair follicles, Eur. J. Pharm. Biopharm. 66 (2007) 159-164. (Pubitemid 46654773)
8. J. Lademann, H. Weigmann, C. Rickmeyer, H. Barthelmes, H. Schaefer, G. Mueller, W. Sterry, Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice, Skin Pharmacol. Appl. Skin Physiol. 12 (1999) 247-256. (Pubitemid 29401452)
9. J. Lademann, N. Otberg, H. Richter, H.J. Weigmann, U. Lindemann, H. Schaefer, W. Sterry, Investigation of follicular penetration of topically applied substances, Skin Pharmacol. Appl. Skin Physiol. 14 (Suppl. 1) (2001) 17-22. (Pubitemid 34299159)
10. N. Otberg, H. Richter, A. Knuttel, H. Schaefer, W. Sterry, J. Lademann, Laser spectroscopic methods for the characterization of open and closed follicles, Laser Phys. Lett. 1 (2004) 46-49.
11. R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, U. Blume-Peytavi, Penetration profile of microspheres in follicular targeting of terminal hair follicles, J. Invest. Dermatol. 123 (2004) 168-176.
12. A. Teichmann, U. Jacobi, M. Ossadnik, H. Richter, S. Koch, W. Sterry, J. Lademann, Differential stripping: determination of the amount of topically applied substances penetrated into the hair follicles, J. Invest. Dermatol. 125 (2005) 264-269.
13. J. Lademann, A. Patzelt, H. Richter, C. Antoniou, W. Sterry, F. Knorr, Determination of the cuticula thickness of human and porcine hairs and their potential influence on the penetration of nanoparticles into the hair follicles, J. Biomed. Opt. 14 (2009) 021014.
14. M. Ossadnik, H. Richter, A. Teichmann, S. Koch, U. Schafer, R. Wepf, W. Sterry, J. Lademann, Investigation of differences in follicular penetration of particle- and nonparticle-containing emulsions by laser scanning microscopy, Laser Phys. 16 (2006) 747-750. (Pubitemid 44726173)
15. N. Otberg, H. Richter, H. Schaefer, U. Blume-Peytavi, W. Sterry, J. Lademann, Variations of hair follicle size and distribution in different body sites, J. Invest. Dermatol. 122 (2004) 14-19.
16. S.E. Cross, B. Innes, M.S. Roberts, T. Tsuzuki, T.A. Robertson, P. McCormick, Human skin penetration of sunscreen nanoparticles: in-vitro assessment of a novel micronized zinc oxide formulation, Skin Pharmacol. Physiol. 20 (2007) 148-154.
17. M.S. Roberts, M.J. Roberts, T.A. Robertson, W. Sanchez, C. Thorling, Y. Zou, X. Zhao, W. Becker, A.V. Zvyagin, In vitro and in vivo imaging of xenobiotic transport in human skin and in the rat liver, J. Biophoton. 1 (2008) 478-493.
18. 2 particles, Toxicol. Sci. 115 (2010) 156-166.
19. A.V. Zvyagin, X. Zhao, A. Gierden, W. Sanchez, J.A. Ross, M.S. Roberts, Imaging of zinc oxide nanoparticle penetration in human skin in vitro and in vivo, J. Biomed. Opt. 13 (2008) 064031.
20. B. Gulson, M. McCall, M. Korsch, L. Gomez, P. Casey, Y. Oytam, A. Taylor, M. McCulloch, J. Trotter, L. Kinsley, G. Greenoak, Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin, Toxicol. Sci. 118 (2010) 140-149.
21. A. Vogt, B. Combadiere, S. Hadam, K.M. Stieler, J. Lademann, H. Schaefer, B. Autran, W. Sterry, U. Blume-Peytavi, Forty nanometer, but not 750 or 1500 nm, nanoparticles enter epidermal CD1a+ cells after transcutaneous application on human skin, J. Invest. Dermatol. 126 (2006) 1316-1322. (Pubitemid 43997914)
22. J.G. Rouse, J. Yang, J.P. Ryman-Rasmussen, A.R. Barron, N.A. Monteiro-Riviere, Effects of mechanical flexion on the penetration of fullerene amino acid-derivatized peptide nanoparticles through skin, Nano. Lett. 7 (2007) 155-160.
23. B. Baroli, M.G. Ennas, F. Loffredo, M. Isola, R. Pinna, M.A. Lopez-Quintela, Penetration of metallic nanoparticles in human full-thickness skin, J. Invest. Dermatol. 127 (2007) 1701-1712.
24. J.P. Ryman-Rasmussen, J.E. Riviere, N.A. Monteiro-Riviere, Penetration of intact skin by quantum dots with diverse physicochemical properties, Toxicol. Sci. 91 (2006) 159-165.
25. L.W. Zhang, N.A. Monteiro-Riviere, Assessment of quantum dot penetration into intact, tape-stripped, abraded and flexed rat skin, Skin Pharmacol. Physiol. 21 (2008) 166-180. (Pubitemid 351793745)
26. A. Patzelt, F. Knorr, U. Blume-Peytavi, W. Sterry, J. Lademann, Hair follicles, their disorders and their opportunities, Drug Discov. Today: Dis. Mech. 5 (2008) 173-181.
27. M. Ohyama, Hair follicle bulge: a fascinating reservoir of epithelial stem cells, J. Dermatol. Sci. 46 (2007) 81-89.
28. V.M. Meidan, M.C. Bonner, B.B. Michniak, Transfollicular drug delivery - is it a reality?, Int J. Pharm. 306 (2005) 1-14.
29. J. Lademann, F. Knorr, H. Richter, U. Blume-Peytavi, A. Vogt, C. Antoniou, W. Sterry, A. Patzelt, Hair follicles - an efficient storage and penetration pathway for topically applied substances. Summary of recent results obtained at the Center of Experimental and Applied Cutaneous Physiology, Charite - Universitatsmedizin Berlin, Germany, Skin Pharmacol. Physiol. 21 (2008) 150-155.