Differential Requirement for CCR4 in the Maintenance but Not Establishment of the Invariant Vγ5+ Dendritic Epidermal T-Cell Pool

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Nakamura, Kyoko ^a   White, Andrea J ^a   Parnell, Sonia M ^a   Lane, Peter J ^a   Jenkinson, Eric J ^a   Jenkinson, William E ^a   Anderson, Graham ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE REGULATOR PROTEIN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR7; G PROTEIN COUPLED RECEPTOR;

ALPHA BETA T LYMPHOCYTE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL HOMING; CELL MATURATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GAMMA DELTA T LYMPHOCYTE; LYMPHOCYTE COUNT; LYMPHOCYTE MIGRATION; MOUSE; NEWBORN; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; T LYMPHOCYTE; THYMOCYTE; VGAMMA5+ DENDRITIC EPIDERMAL T CELL;

ANIMALS; ANIMALS, NEWBORN; CELL DIFFERENTIATION; EPIDERMIS; LYMPHOID PROGENITOR CELLS; MICE; MICE, KNOCKOUT; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, CCR4; RECEPTORS, CCR7; SIGNAL TRANSDUCTION; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 84884195271     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074019     Document Type: Article

References (41)

1. Nikolich-Zugich J, Slifka MK, Messaoudi I, (2004) The many important facets of T-cell repertoire diversity. Nat Rev Immunol 4: 123-132.
2. Pardoll DM, Fowlkes BJ, Bluestone JA, Kruisbeek A, Maloy WL, et al. (1987) Differential expression of two distinct T-cell receptors during thymocyte development. Nature 326: 79-81.
3. Bluestone JA, Pardoll D, Sharrow SO, Fowlkes BJ, (1987) Characterization of murine thymocytes with CD3-associated T-cell receptor structures. Nature 326: 82-84.
4. Havran WL, Allison JP, (1988) Developmentally ordered appearance of thymocytes expressing different T-cell antigen receptors. Nature 335: 443-445.
5. Macleod AS, Havran WL, (2011) Functions of skin-resident gammadelta T cells. Cell Mol Life Sci 68: 2399-2408.
6. Calderon L, Boehm T, (2011) Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus. Proc Natl Acad Sci U S A 108: 7517-7522.
7. Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Forster R, (2010) CC chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood 115: 1906-1912.
8. Zlotoff DA, Sambandam A, Logan TD, Bell JJ, Schwarz BA, et al. (2010) CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus. Blood 115: 1897-1905.
9. Plotkin J, Prockop SE, Lepique A, Petrie HT, (2003) Critical role for CXCR4 signaling in progenitor localization and T cell differentiation in the postnatal thymus. J Immunol 171: 4521-4527.
10. Misslitz A, Pabst O, Hintzen G, Ohl L, Kremmer E, et al. (2004) Thymic T cell development and progenitor localization depend on CCR7. J Exp Med 200: 481-491.
11. Benz C, Heinzel K, Bleul CC, (2004) Homing of immature thymocytes to the subcapsular microenvironment within the thymus is not an absolute requirement for T cell development. Eur J Immunol 34: 3652-3663.
12. Liu C, Saito F, Liu Z, Lei Y, Uehara S, et al. (2006) Coordination between CCR7- and CCR9-mediated chemokine signals in prevascular fetal thymus colonization. Blood 108: 2531-2539.
13. Ueno T, Saito F, Gray DH, Kuse S, Hieshima K, et al. (2004) CCR7 signals are essential for cortex-medulla migration of developing thymocytes. J Exp Med 200: 493-505.
14. Ueno T, Hara K, Willis MS, Malin MA, Hopken UE, et al. (2002) Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus. Immunity 16: 205-218.
15. Laan M, Kisand K, Kont V, Moll K, Tserel L, et al. (2009) Autoimmune regulator deficiency results in decreased expression of CCR4 and CCR7 ligands and in delayed migration of CD4+ thymocytes. J Immunol 183: 7682-7691.
16. Lei Y, Ripen AM, Ishimaru N, Ohigashi I, Nagasawa T, et al. (2011) Aire-dependent production of XCL1 mediates medullary accumulation of thymic dendritic cells and contributes to regulatory T cell development. J Exp Med 208: 383-394.
17. Roberts NA, White AJ, Jenkinson WE, Turchinovich G, Nakamura K, et al. (2012) Rank signaling links the development of invariant gammadelta T cell progenitors and Aire(+) medullary epithelium. Immunity 36: 427-437.
18. Barbee SD, Woodward MJ, Turchinovich G, Mention JJ, Lewis JM, et al. (2011) Skint-1 is a highly specific, unique selecting component for epidermal T cells. Proc Natl Acad Sci U S A 108: 3330-3335.
19. Jiang X, Campbell JJ, Kupper TS, (2010) Embryonic trafficking of gammadelta T cells to skin is dependent on E/P selectin ligands and CCR4. Proc Natl Acad Sci U S A 107: 7443-7448.
20. Chantry D, Romagnani P, Raport CJ, Wood CL, Epp A, et al. (1999) Macrophage-derived chemokine is localized to thymic medullary epithelial cells and is a chemoattractant for CD3(+), CD4(+), CD8(low) thymocytes. Blood 94: 1890-1898.
21. Tanabe S, Lu Z, Luo Y, Quackenbush EJ, Berman MA, et al. (1997) Identification of a new mouse beta-chemokine, thymus-derived chemotactic agent 4, with activity on T lymphocytes and mesangial cells. J Immunol 159: 5671-5679.
22. Campbell JJ, Pan J, Butcher EC, (1999) Cutting edge: developmental switches in chemokine responses during T cell maturation. J Immunol 163: 2353-2357.
23. Suzuki G, Sawa H, Kobayashi Y, Nakata Y, Nakagawa K, et al. (1999) Pertussis toxin-sensitive signal controls the trafficking of thymocytes across the corticomedullary junction in the thymus. J Immunol 162: 5981-5985.
24. Ramsey C, Winqvist O, Puhakka L, Halonen M, Moro A, et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11: 397-409.
25. Chvatchko Y, Hoogewerf AJ, Meyer A, Alouani S, Juillard P, et al. (2000) A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med 191: 1755-1764.
26. Pahuja A, Maki RA, Hevezi PA, Chen A, Verge GM, et al. (2006) Experimental autoimmune encephalomyelitis develops in CC chemokine receptor 7-deficient mice with altered T-cell responses. Scand J Immunol 64: 361-369.
27. Van Vliet E, Melis M, Van Ewijk W, (1984) Monoclonal antibodies to stromal cell types of the mouse thymus. Eur J Immunol 14: 524-529.
28. Farr A, Nelson A, Truex J, Hosier S, (1991) Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium. J Histochem Cytochem 39: 645-653.
29. Jenkinson W, Jenkinson E, Anderson G (2008) Preparation of 2-dGuo-treated thymus organ cultures. J Vis Exp.
30. Nitta T, Nitta S, Lei Y, Lipp M, Takahama Y, (2009) CCR7-mediated migration of developing thymocytes to the medulla is essential for negative selection to tissue-restricted antigens. Proc Natl Acad Sci U S A 106: 17129-17133.
31. Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, et al. (2002) Projection of an immunological self shadow within the thymus by the aire protein. Science 298: 1395-1401.
32. Cowan JE, Parnell SM, Nakamura K, Caamano JH, Lane PJ, et al. (2013) The thymic medulla is required for Foxp3+ regulatory but not conventional CD4+ thymocyte development. J Exp Med 210: 675-681.
33. Aschenbrenner K, D'Cruz LM, Vollmann EH, Hinterberger M, Emmerich J, et al. (2007) Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol 8: 351-358.
34. Taniguchi RT, DeVoss JJ, Moon JJ, Sidney J, Sette A, et al. (2012) Detection of an autoreactive T-cell population within the polyclonal repertoire that undergoes distinct autoimmune regulator (Aire)-mediated selection. Proc Natl Acad Sci U S A 109: 7847-7852.
35. Anderson MS, Venanzi ES, Chen Z, Berzins SP, Benoist C, et al. (2005) The cellular mechanism of Aire control of T cell tolerance. Immunity 23: 227-239.
36. Alferink J, Lieberam I, Reindl W, Behrens A, Weiss S, et al. (2003) Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen. J Exp Med 197: 585-599.
37. Lieberam I, Forster I, (1999) The murine beta-chemokine TARC is expressed by subsets of dendritic cells and attracts primed CD4+ T cells. Eur J Immunol 29: 2684-2694.
38. Lkhagvasuren E, Sakata M, Ohigashi I, Takahama Y, (2013) Lymphotoxin beta Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells. J Immunol 190: 5110-5117.
39. Proietto AI, Lahoud MH, Wu L, (2008) Distinct functional capacities of mouse thymic and splenic dendritic cell populations. Immunol Cell Biol 86: 700-708.
40. Hu S, Xiong N, (2013) Programmed downregulation of CCR6 is important for establishment of epidermal gammadeltaT cells by regulating their thymic egress and epidermal location. J Immunol 190: 3267-3275.
41. Jin Y, Xia M, Sun A, Saylor CM, Xiong N, (2010) CCR10 is important for the development of skin-specific gammadeltaT cells by regulating their migration and location. J Immunol 185: 5723-5731.