GPR3 Stimulates Aβ Production via Interactions with APP and β-Arrestin2

PLoS ONE

Volumn 8, Issue 9, 2013, Pages

  Nelson, Christopher D ^a   Sheng, Morgan ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA ARRESTIN 2; G PROTEIN COUPLED RECEPTOR; GAMMA SECRETASE; PROSTAGLANDIN E RECEPTOR 2; PROTEIN GPR3; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOCYTOSIS; INTERNALIZATION; MOLECULAR PATHOLOGY; NEUROPATHOLOGY; NONHUMAN; PROTEIN BINDING; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; RAT; RECEPTOR BINDING;

AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ARRESTINS; CELL LINE; DINOPROSTONE; GENE EXPRESSION; HUMANS; INTRACELLULAR SPACE; MUTATION; PROTEIN BINDING; PROTEIN TRANSPORT; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PROSTAGLANDIN E, EP2 SUBTYPE;

EID: 84884193435     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074680     Document Type: Article

References (43)

1. Alzheimer's Association (2012) 2012 Alzheimer's disease facts and figures. Alzheimer's and Dementia: The Journal of the Alzheimer's Association 8: 131-168.
2. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA, (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60: 1119-1122.
3. Qiu C, Kivipelto M, von Strauss E, (2009) Epidemiology of Alzheimer's disease: occurrence, determinants, and strategies toward intervention. Dialogues Clin Neurosci 11: 111-128.
4. Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, et al. (2012) A mutation in APP protects against Alzheimer's disease and age-related cognitive decline. Nature 488: 96-99.
5. Cruchaga C, Haller G, Chakraverty S, Mayo K, Vallania FL, et al. (2012) Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. PLoS One 7: e31039.
6. Hardy J, Crook R (2010) APP mutations table. Alzheimer Research Forum. Available: http://www.alzforum.org/res/com/mut/app/table1.asp. Accessed 2013 Apr 15.
7. Cruts M, Theuns J, Van Broeckhoven C, (2012) Locus-specific mutation databases for neurodegenerative brain diseases. Hum Mutat 33: 1340-1344.
8. Citron M, Teplow DB, Selkoe DJ, (1995) Generation of amyloid beta protein from its precursor is sequence specific. Neuron 14: 661-670.
9. Haass C, Lemere CA, Capell A, Citron M, Seubert P, et al. (1995) The Swedish mutation causes early-onset Alzheimer's disease by beta-secretase cleavage within the secretory pathway. Nat Med 1: 1291-1296.
10. Mullan M, Crawford F, Axelman K, Houlden H, Lilius L, et al. (1992) A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1: 345-347.
11. Golde TE, Petrucelli L, Lewis J, (2010) Targeting Abeta and tau in Alzheimer's disease, an early interim report. Exp Neurol 223: 252-266.
12. Karran E, Mercken M, De Strooper B, (2011) The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 10: 698-712.
13. Selkoe DJ, (2011) Resolving controversies on the path to Alzheimer's therapeutics. Nat Med 17: 1060-1065.
14. Thathiah A, Spittaels K, Hoffmann M, Staes M, Cohen A, et al. (2009) The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons. Science 323: 946-951.
15. Iismaa TP, Kiefer J, Liu ML, Baker E, Sutherland GR, et al. (1994) Isolation and chromosomal localization of a novel human G-protein-coupled receptor (GPR3) expressed predominantly in the central nervous system. Genomics 24: 391-394.
16. Mehlmann LM, Saeki Y, Tanaka S, Brennan TJ, Evsikov AV, et al. (2004) The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes. Science 306: 1947-1950.
17. Eggerickx D, Denef JF, Labbe O, Hayashi Y, Refetoff S, et al. (1995) Molecular cloning of an orphan G-protein-coupled receptor that constitutively activates adenylate cyclase. Biochem J 309 (Pt 3): 837-843.
18. Hinckley M, Vaccari S, Horner K, Chen R, Conti M, (2005) The G-protein-coupled receptors GPR3 and GPR12 are involved in cAMP signaling and maintenance of meiotic arrest in rodent oocytes. Dev Biol 287: 249-261.
19. Benovic JL, Kuhn H, Weyand I, Codina J, Caron MG, et al. (1987) Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein). Proc Natl Acad Sci U S A 84: 8879-8882.
20. Freedman NJ, Lefkowitz RJ (1996) Desensitization of G protein-coupled receptors. Recent Prog Horm Res 51: 319-351; discussion 352-313.
21. Premont RT, Gainetdinov RR, (2007) Physiological roles of G protein-coupled receptor kinases and arrestins. Annu Rev Physiol 69: 511-534.
22. Goodman OB Jr, Krupnick JG, Santini F, Gurevich VV, Penn RB, et al. (1996) Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor. Nature 383: 447-450.
23. Laporte SA, Oakley RH, Zhang J, Holt JA, Ferguson SS, et al. (1999) The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. Proc Natl Acad Sci U S A 96: 3712-3717.
24. DeWire SM, Ahn S, Lefkowitz RJ, Shenoy SK, (2007) Beta-arrestins and cell signaling. Annu Rev Physiol 69: 483-510.
25. Lefkowitz RJ, Shenoy SK, (2005) Transduction of receptor signals by beta-arrestins. Science 308: 512-517.
26. Lefkowitz RJ, Whalen EJ, (2004) beta-arrestins: traffic cops of cell signaling. Curr Opin Cell Biol 16: 162-168.
27. Guan XM, Kobilka TS, Kobilka BK, (1992) Enhancement of membrane insertion and function in a type IIIb membrane protein following introduction of a cleavable signal peptide. J Biol Chem 267: 21995-21998.
28. Ahn S, Nelson CD, Garrison TR, Miller WE, Lefkowitz RJ, (2003) Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Proc Natl Acad Sci U S A 100: 1740-1744.
29. Seeburg DP, Sheng M, (2008) Activity-induced Polo-like kinase 2 is required for homeostatic plasticity of hippocampal neurons during epileptiform activity. J Neurosci 28: 6583-6591.
30. Luttrell LM, Ferguson SS, Daaka Y, Miller WE, Maudsley S, et al. (1999) Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes. Science 283: 655-661.
31. Acharya S, Karnik SS, (1996) Modulation of GDP release from transducin by the conserved Glu134-Arg135 sequence in rhodopsin. J Biol Chem 271: 25406-25411.
32. Greasley PJ, Fanelli F, Scheer A, Abuin L, Nenniger-Tosato M, et al. (2001) Mutational and computational analysis of the alpha(1b)-adrenergic receptor. Involvement of basic and hydrophobic residues in receptor activation and G protein coupling. J Biol Chem 276: 46485-46494.
33. Scheer A, Costa T, Fanelli F, De Benedetti PG, Mhaouty-Kodja S, et al. (2000) Mutational analysis of the highly conserved arginine within the Glu/Asp-Arg-Tyr motif of the alpha(1b)-adrenergic receptor: effects on receptor isomerization and activation. Mol Pharmacol 57: 219-231.
34. Wei H, Ahn S, Shenoy SK, Karnik SS, Hunyady L, et al. (2003) Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2. Proc Natl Acad Sci U S A 100: 10782-10787.
35. Lefkowitz RJ, Inglese J, Koch WJ, Pitcher J, Attramadal H, et al. (1992) G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins. Cold Spring Harb Symp Quant Biol 57: 127-133.
36. Thathiah A, Horre K, Snellinx A, Vandewyer E, Huang Y, et al. (2013) beta-arrestin 2 regulates Abeta generation and gamma-secretase activity in Alzheimer's disease. Nat Med 19: 43-49.
37. Pooler AM, Arjona AA, Lee RK, Wurtman RJ, (2004) Prostaglandin E2 regulates amyloid precursor protein expression via the EP2 receptor in cultured rat microglia. Neurosci Lett 362: 127-130.
38. Nitsch RM, Deng M, Growdon JH, Wurtman RJ, (1996) Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion. J Biol Chem 271: 4188-4194.
39. Page RM, Munch A, Horn T, Kuhn PH, Colombo A, et al. (2012) Loss of PAFAH1B2 reduces amyloid-beta generation by promoting the degradation of amyloid precursor protein C-terminal fragments. J Neurosci 32: 18204-18214.
40. Shenoy SK, Lefkowitz RJ, (2003) Trafficking patterns of beta-arrestin and G protein-coupled receptors determined by the kinetics of beta-arrestin deubiquitination. J Biol Chem 278: 14498-14506.
41. Ni Y, Zhao X, Bao G, Zou L, Teng L, et al. (2006) Activation of beta2-adrenergic receptor stimulates gamma-secretase activity and accelerates amyloid plaque formation. Nat Med 12: 1390-1396.
42. Teng L, Zhao J, Wang F, Ma L, Pei G, (2010) A GPCR/secretase complex regulates beta- and gamma-secretase specificity for Abeta production and contributes to AD pathogenesis. Cell Res 20: 138-153.
43. Konvicka K, F Campagne, H Weinstein, (2000) Iterative construction of residue-based diagrams of proteins: the RbDe web service. Protein Engineering 13(6): 395-6.