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Volumn 54, Issue 10, 2013, Pages 2586-2594

Niacin, an old drug with a new twist

Author keywords

Cardiovascular; Cholesterol; Prostaglandin

Indexed keywords

ACETYLSALICYLIC ACID; CLOFIBRATE; COLESTIPOL; DEXTROTHYROXINE; ESTROGEN; EZETIMIBE; G PROTEIN COUPLED RECEPTOR; HIGH DENSITY LIPOPROTEIN; LAROPIPRANT; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; MEVINOLIN; NICOTINIC ACID; PLACEBO; PROTEIN GPR109A; SIMVASTATIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

EID: 84884153189     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.R040592     Document Type: Review
Times cited : (42)

References (124)
  • 1
    • 22644437126 scopus 로고    scopus 로고
    • Nicotinic acid: The broad-spectrum lipid drug. A 50th anniversary review
    • Carlson, L. A. 2005. Nicotinic acid: the broad-spectrum lipid drug. A 50th anniversary review. J. Intern. Med. 258: 94-114.
    • (2005) J. Intern. Med , vol.258 , pp. 94-114
    • Carlson L., .A.1
  • 2
    • 57349165755 scopus 로고    scopus 로고
    • Niacin for dairy cattle: A review
    • Niehoff, I. D., L. Huther, and P. Lebzien. 2009. Niacin for dairy cattle: a review. Br. J. Nutr. 101: 5-19.
    • (2009) Br. J. Nutr , vol.101 , pp. 5-19
    • Niehoff, I.D.1    Huther, L.2    Lebzien, P.3
  • 3
    • 0000808276 scopus 로고
    • Influence of nicotinic acid on serum cholesterol in man
    • Altschul, R., A. Hoffer, and J. D. Stephen. 1955. Influence of nicotinic acid on serum cholesterol in man. Arch. Biochem. Biophys. 54: 558-559.
    • (1955) Arch. Biochem. Biophys , vol.54 , pp. 558-559
    • Altschul, R.1    Hoffer, A.2    Stephen, J.D.3
  • 5
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • Tunaru, S., J. Kero, A. Schaub, C. Wufka, A. Blaukat, K. Pfeffer, and S. Offermanns. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9: 352-355.
    • (2003) Nat. Med , vol.9 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3    Wufka, C.4    Blaukat, A.5    Pfeffer, K.6    Offermanns, S.7
  • 8
    • 0037352280 scopus 로고    scopus 로고
    • PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
    • Tunaru, S., J. Kero, A. Schaub, C. Wufka, A. Blaukat, K. Pfeffer, and S. Offermanns. 2003. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Nat. Med. 9: 352-355.
    • (2003) Nat. Med , vol.9 , pp. 352-355
    • Tunaru, S.1    Kero, J.2    Schaub, A.3    Wufka, C.4    Blaukat, A.5    Pfeffer, K.6    Offermanns, S.7
  • 10
    • 77955300428 scopus 로고    scopus 로고
    • Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice
    • Hanson, J., A. Gille, S. Zwykiel, M. Lukasova, B. E. Clausen, K. Ahmed, S. Tunaru, A. Wirth, and S. Offermanns. 2010. Nicotinic acid- and monomethyl fumarate-induced flushing involves GPR109A expressed by keratinocytes and COX-2-dependent prostanoid formation in mice. J. Clin. Invest. 120: 2910-2919.
    • (2010) J. Clin. Invest , vol.120 , pp. 2910-2919
    • Hanson, J.1    Gille, A.2    Zwykiel, S.3    Lukasova, M.4    Clausen, B.E.5    Ahmed, K.6    Tunaru, S.7    Wirth, A.8    Offermanns, S.9
  • 12
    • 84877299845 scopus 로고    scopus 로고
    • HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: Trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment
    • HPS2-THRIVE Collaborative Group
    • HPS2-THRIVE Collaborative Group. 2013. HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment. Eur. Heart J. 34: 1279-1291.
    • (2013) Eur. Heart J. , vol.34 , pp. 1279-1291
  • 14
    • 11844296800 scopus 로고    scopus 로고
    • Efficacy and safety of high-density lipoprotein cholesterolincreasing compounds: A meta-analysis of randomized controlled trials
    • Birjmohun, R. S., B. A. Hutten, J. J. Kastelein, and E. S. Stroes. 2005. Efficacy and safety of high-density lipoprotein cholesterolincreasing compounds: a meta-analysis of randomized controlled trials. J. Am. Coll. Cardiol. 45: 185-197.
    • (2005) J. Am. Coll. Cardiol , vol.45 , pp. 185-197
    • Birjmohun, R.S.1    Hutten, B.A.2    Kastelein, J.J.3    Stroes, E.S.4
  • 15
    • 0024466520 scopus 로고
    • Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid
    • Carlson, L. A., A. Hamsten, and A. Asplund. 1989. Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid. J. Intern. Med. 226: 271-276.
    • (1989) J. Intern. Med , vol.226 , pp. 271-276
    • Carlson, L.A.1    Hamsten, A.2    Asplund, A.3
  • 16
    • 10644264549 scopus 로고    scopus 로고
    • Lipoprotein(a): An elusive cardiovascular risk factor
    • Berglund, L., and R. Ramakrishnan. 2004. Lipoprotein(a): an elusive cardiovascular risk factor. Arterioscler. Thromb. Vasc. Biol. 24: 2219-2226.
    • (2004) Arterioscler. Thromb. Vasc. Biol , vol.24 , pp. 2219-2226
    • Berglund, L.1    Ramakrishnan, R.2
  • 17
    • 0000242585 scopus 로고
    • The effect of nicotinic acid on the plasma free fatty acid; Demonstration of a metabolic type of sympathicolysis
    • Carlson, L. A., and L. Oro. 1962. The effect of nicotinic acid on the plasma free fatty acid; demonstration of a metabolic type of sympathicolysis. Acta Med. Scand. 172: 641-645.
    • (1962) Acta Med. Scand , vol.172 , pp. 641-645
    • Carlson, L.A.1    Oro, L.2
  • 18
    • 0001036943 scopus 로고
    • Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro
    • Carlson, L. A. 1963. Studies on the effect of nicotinic acid on catecholamine stimulated lipolysis in adipose tissue in vitro. Acta Med. Scand. 173: 719-722.
    • (1963) Acta Med. Scand , vol.173 , pp. 719-722
    • Carlson L., .A.1
  • 19
    • 0014429489 scopus 로고
    • Effects of lipolytic and antilipolytic substances on adenosine 3 ', 5 ' - Monophosphate levels in isolated fat cells
    • Butcher, R. W., C. E. Baird, and E. W. Sutherland. 1968. Effects of lipolytic and antilipolytic substances on adenosine 3 ', 5 ' - monophosphate levels in isolated fat cells. J. Biol. Chem. 243: 1705-1712.
    • (1968) J. Biol. Chem , vol.243 , pp. 1705-1712
    • Butcher, R.W.1    Baird, C.E.2    Sutherland, E.W.3
  • 20
    • 0014282522 scopus 로고
    • Effect of a single dose of nicotinic acid on plasma lipids in patients with hyperlipoproteinemia
    • Carlson, L. A., L. Oro, and J. Ostman. 1968. Effect of a single dose of nicotinic acid on plasma lipids in patients with hyperlipoproteinemia. Acta Med. Scand. 183: 457-465.
    • (1968) Acta Med. Scand , vol.183 , pp. 457-465
    • Carlson, L.A.1    Oro, L.2    Ostman, J.3
  • 21
    • 33044489571 scopus 로고
    • Persistence of the inhibitory effect of nicotinic acid on catecholamine-stimulated lipid mobilization during prolonged treatment with nicotinic acid
    • Carlson, L. A., and L. Oroe. 1965. Persistence of the inhibitory effect of nicotinic acid on catecholamine-stimulated lipid mobilization during prolonged treatment with nicotinic acid. J. Atheroscler. Res. 5: 436-439.
    • (1965) J. Atheroscler. Res , vol.5 , pp. 436-439
    • Carlson, L.A.1    Oroe, L.2
  • 23
    • 0030798890 scopus 로고    scopus 로고
    • Fatty acid regulation of very low density lipoprotein production
    • Lewis, G. F. 1997. Fatty acid regulation of very low density lipoprotein production. Curr. Opin. Lipidol. 8: 146-153.
    • (1997) Curr. Opin. Lipidol , vol.8 , pp. 146-153
    • Lewis, G.F.1
  • 25
    • 0031442321 scopus 로고    scopus 로고
    • Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G2 cells. Implication for reverse cholesterol transport
    • Jin, F. Y., V. S. Kamanna, and M. L. Kashyap. 1997. Niacin decreases removal of high-density lipoprotein apolipoprotein A-I but not cholesterol ester by Hep G2 cells. Implication for reverse cholesterol transport. Arterioscler. Thromb. Vasc. Biol. 17: 2020-2028.
    • (1997) Arterioscler. Thromb. Vasc. Biol , vol.17 , pp. 2020-2028
    • Jin, F.Y.1    Kamanna, V.S.2    Kashyap, M.L.3
  • 26
    • 16644369497 scopus 로고    scopus 로고
    • Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells
    • Ganji, S. H., S. Tavintharan, D. Zhu, Y. Xing, V. S. Kamanna, and M. L. Kashyap. 2004. Niacin noncompetitively inhibits DGAT2 but not DGAT1 activity in HepG2 cells. J. Lipid Res. 45: 1835-1845.
    • (2004) J. Lipid Res , vol.45 , pp. 1835-1845
    • Ganji, S.H.1    Tavintharan, S.2    Zhu, D.3    Xing, Y.4    Kamanna, V.S.5    Kashyap, M.L.6
  • 27
    • 0035317950 scopus 로고    scopus 로고
    • Pharmacological management of high triglycerides and low high-density lipoprotein cholesterol
    • Szapary, P. O., and D. J. Rader. 2001. Pharmacological management of high triglycerides and low high-density lipoprotein cholesterol. Curr. Opin. Pharmacol. 1: 113-120.
    • (2001) Curr. Opin. Pharmacol , vol.1 , pp. 113-120
    • Szapary, P.O.1    Rader, D.J.2
  • 28
    • 0347948456 scopus 로고    scopus 로고
    • Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia
    • Le Goff, W., M. Guerin, and M. J. Chapman. 2004. Pharmacological modulation of cholesteryl ester transfer protein, a new therapeutic target in atherogenic dyslipidemia. Pharmacol. Ther. 101: 17-38.
    • (2004) Pharmacol. Ther , vol.101 , pp. 17-38
    • Le Goff, W.1    Guerin, M.2    Chapman, M.J.3
  • 30
    • 77957674906 scopus 로고    scopus 로고
    • Regulation of hepatic ApoC3 expression by PGC-1beta mediates hypolipidemic effect of nicotinic acid
    • Hernandez, C., M. Molusky, Y. Li, S. Li, and J. D. Lin. 2010. Regulation of hepatic ApoC3 expression by PGC-1beta mediates hypolipidemic effect of nicotinic acid. Cell Metab. 12: 411-419.
    • (2010) Cell Metab , vol.12 , pp. 411-419
    • Hernandez, C.1    Molusky, M.2    Li, Y.3    Li, S.4    Lin, J.D.5
  • 32
    • 84865341762 scopus 로고    scopus 로고
    • It ain't over 'til the fat lady sings
    • Offermanns, S. 2012. It ain't over 'til the fat lady sings. Sci. Transl. Med. 4: 148fs130.
    • (2012) Sci. Transl. Med , vol.4
    • Offermanns, S.1
  • 34
    • 0018743112 scopus 로고
    • Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism
    • Shepherd, J., C. J. Packard, J. R. Patsch, A. M. Gotto, Jr ., and O. D. Taunton. 1979. Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism. J. Clin. Invest. 63: 858-867.
    • (1979) J. Clin. Invest , vol.63 , pp. 858-867
    • Shepherd, J.1    Packard, C.J.2    Patsch, J.R.3    Gotto Jr., A.M.4    Taunton, O.D.5
  • 37
    • 79952418787 scopus 로고    scopus 로고
    • Lipoprotein(a) and risk of myocardial infarction-genetic epidemiologic evidence of causality
    • Kamstrup, P. R., A. Tybjaerg-Hansen, and B. G. Nordestgaard. 2011. Lipoprotein(a) and risk of myocardial infarction-genetic epidemiologic evidence of causality. Scand. J. Clin. Lab. Invest. 71: 87-93.
    • (2011) Scand. J. Clin. Lab. Invest , vol.71 , pp. 87-93
    • Kamstrup, P.R.1    Tybjaerg-Hansen, A.2    Nordestgaard, B.G.3
  • 38
    • 0034609562 scopus 로고    scopus 로고
    • Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies
    • Danesh, J., R. Collins, and R. Peto. 2000. Lipoprotein(a) and coronary heart disease. Meta-analysis of prospective studies. Circulation. 102: 1082-1085.
    • (2000) Circulation , vol.102 , pp. 1082-1085
    • Danesh, J.1    Collins, R.2    Peto, R.3
  • 39
    • 34249784544 scopus 로고    scopus 로고
    • Lipoprotein (a) and stroke: A meta-analysis of observational studies
    • Smolders, B., R. Lemmens, and V. Thijs. 2007. Lipoprotein (a) and stroke: a meta-analysis of observational studies. Stroke. 38: 1959-1966.
    • (2007) Stroke , vol.38 , pp. 1959-1966
    • Smolders, B.1    Lemmens, R.2    Thijs, V.3
  • 41
    • 0028942016 scopus 로고
    • Diet and drug therapy for lipoprotein (a)
    • Berglund, L. 1995. Diet and drug therapy for lipoprotein (a). Curr. Opin. Lipidol. 6: 48-56.
    • (1995) Curr. Opin. Lipidol , vol.6 , pp. 48-56
    • Berglund, L.1
  • 42
    • 0026079452 scopus 로고
    • A comparison between nicotinic acid and acipimox in hypertriglyceridaemia-effects on serum lipids, lipoproteins, glucose tolerance and tolerability
    • Tornvall, P., and G. Walldius. 1991. A comparison between nicotinic acid and acipimox in hypertriglyceridaemia-effects on serum lipids, lipoproteins, glucose tolerance and tolerability. J. Intern. Med. 230: 415-421.
    • (1991) J. Intern. Med , vol.230 , pp. 415-421
    • Tornvall, P.1    Walldius, G.2
  • 44
    • 34247598542 scopus 로고    scopus 로고
    • Nicotinic acid receptor subtypes and their ligands
    • Soudijn, W., I. van Wijngaarden, and A. P. Ijzerman. 2007. Nicotinic acid receptor subtypes and their ligands. Med. Res. Rev. 27: 417-433.
    • (2007) Med. Res. Rev , vol.27 , pp. 417-433
    • Soudijn, W.1    Van Wijngaarden, I.2    Ijzerman, A.P.3
  • 45
    • 33749671772 scopus 로고    scopus 로고
    • Small-molecule compounds that modulate lipolysis in adipose tissue: Targeting strategies and molecular classes
    • Wang, M., and C. Fotsch. 2006. Small-molecule compounds that modulate lipolysis in adipose tissue: targeting strategies and molecular classes. Chem. Biol. 13: 1019-1027.
    • (2006) Chem. Biol , vol.13 , pp. 1019-1027
    • Wang, M.1    Fotsch, C.2
  • 47
    • 33144455148 scopus 로고    scopus 로고
    • 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b
    • Semple, G., P. J. Skinner, M. C. Cherrier, P. J. Webb, C. R. Sage, S. Y. Tamura, R. Chen, J. G. Richman, and D. T. Connolly. 2006. 1-Alkyl-benzotriazole- 5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J. Med. Chem. 49: 1227-1230.
    • (2006) J. Med. Chem , vol.49 , pp. 1227-1230
    • Semple, G.1    Skinner, P.J.2    Cherrier, M.C.3    Webb, P.J.4    Sage, C.R.5    Tamura, S.Y.6    Chen, R.7    Richman, J.G.8    Connolly, D.T.9
  • 52
    • 84868648516 scopus 로고    scopus 로고
    • The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis?
    • Rader, D. J., and A. R. Tall. 2012. The not-so-simple HDL story: Is it time to revise the HDL cholesterol hypothesis? Nat. Med. 18: 1344-1346.
    • (2012) Nat Med , vol.18 , pp. 1344-1346
    • Rader, D.J.1    Tall, A.R.2
  • 53
    • 77951483195 scopus 로고    scopus 로고
    • Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids
    • Wu, B. J., L. Yan, F. Charlton, P. Witting, P. J. Barter, and K. A. Rye. 2010. Evidence that niacin inhibits acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids. Arterioscler. Thromb. Vasc. Biol. 30: 968-975.
    • (2010) Arterioscler. Thromb. Vasc. Biol , vol.30 , pp. 968-975
    • Wu, B.J.1    Yan, L.2    Charlton, F.3    Witting, P.4    Barter, P.J.5    Rye, K.A.6
  • 54
    • 79952240405 scopus 로고    scopus 로고
    • Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells
    • Lukasova, M., C. Malaval, A. Gille, J. Kero, and S. Offermanns. 2011. Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells. J. Clin. Invest. 121: 1163-1173.
    • (2011) J. Clin. Invest , vol.121 , pp. 1163-1173
    • Lukasova, M.1    Malaval, C.2    Gille, A.3    Kero, J.4    Offermanns, S.5
  • 55
    • 79954995814 scopus 로고    scopus 로고
    • Nicotinic acid has anti-atherogenic and anti-inflammatory properties on advanced atherosclerotic lesions independent of its lipid-modifying capabilities
    • Holzhäuser, E., C. Albrecht, Q. Zhou, A. Buttler, M. R. Preusch, E. Blessing, H. A. Katus, and F. Bea. 2011. Nicotinic acid has anti-atherogenic and anti-inflammatory properties on advanced atherosclerotic lesions independent of its lipid-modifying capabilities. J. Cardiovasc. Pharmacol. 57: 447-454.
    • (2011) J. Cardiovasc. Pharmacol , vol.57 , pp. 447-454
    • Holzhäuser, E.1    Albrecht, C.2    Zhou, Q.3    Buttler, A.4    Preusch, M.R.5    Blessing, E.6    Katus, H.A.7    Bea, F.8
  • 56
    • 34247634533 scopus 로고    scopus 로고
    • Anti-inflammatory effect is an important property of niacin on atherosclerosis beyond its lipidaltering effects
    • Yu, B. L., and S. P. Zhao. 2007. Anti-inflammatory effect is an important property of niacin on atherosclerosis beyond its lipidaltering effects. Med. Hypotheses. 69: 90-94.
    • (2007) Med. Hypotheses , vol.69 , pp. 90-94
    • Yu, B.L.1    Zhao, S.P.2
  • 57
    • 60349109374 scopus 로고    scopus 로고
    • Effects of niacin on cell adhesion and early atherogenesis: Biochemical and functional findings in endothelial cells
    • Tavintharan, S., S. C. Lim, and C. F. Sum. 2009. Effects of niacin on cell adhesion and early atherogenesis: biochemical and functional findings in endothelial cells. Basic Clin. Pharmacol. Toxicol. 104: 206-210.
    • (2009) Basic Clin. Pharmacol. Toxicol , vol.104 , pp. 206-210
    • Tavintharan, S.1    Lim, S.C.2    Sum, C.F.3
  • 58
    • 31044441703 scopus 로고    scopus 로고
    • Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways
    • Knowles, H. J., R. H. te Poele, P. Workman, and A. L. Harris. 2006. Niacin induces PPARgamma expression and transcriptional activation in macrophages via HM74 and HM74a-mediated induction of prostaglandin synthesis pathways. Biochem. Pharmacol. 71: 646-656.
    • (2006) Biochem. Pharmacol , vol.71 , pp. 646-656
    • Knowles, H.J.1    Te Poele, R.H.2    Workman, P.3    Harris, A.L.4
  • 59
    • 33646096454 scopus 로고    scopus 로고
    • Erratum
    • [Erratum. 2006. Biochem. Pharmacol. 71: 1662.]
    • (2006) Biochem. Pharmacol , vol.71 , pp. 1662
  • 60
    • 1242322495 scopus 로고    scopus 로고
    • Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin
    • Rubic, T., M. Trottmann, and R. L. Lorenz. 2004. Stimulation of CD36 and the key effector of reverse cholesterol transport ATP-binding cassette A1 in monocytoid cells by niacin. Biochem. Pharmacol. 67: 411-419.
    • (2004) Biochem. Pharmacol , vol.67 , pp. 411-419
    • Rubic, T.1    Trottmann, M.2    Lorenz, R.L.3
  • 62
    • 40949153934 scopus 로고    scopus 로고
    • Preferential increase in highmolecular weight adiponectin after niacin
    • Westphal, S., and C. Luley. 2008. Preferential increase in highmolecular weight adiponectin after niacin. Atherosclerosis. 198: 179-183.
    • (2008) Atherosclerosis , vol.198 , pp. 179-183
    • Westphal, S.1    Luley, C.2
  • 64
    • 0032977431 scopus 로고    scopus 로고
    • Nicotinic acid and pyridoxine modulate arachidonic acid metabolism in vitro and ex vivo in man
    • Saareks, V., I. Mucha, E. Sievi, and A. Riutta. 1999. Nicotinic acid and pyridoxine modulate arachidonic acid metabolism in vitro and ex vivo in man. Pharmacol. Toxicol. 84: 274-280.
    • (1999) Pharmacol. Toxicol , vol.84 , pp. 274-280
    • Saareks, V.1    Mucha, I.2    Sievi, E.3    Riutta, A.4
  • 65
    • 79955476272 scopus 로고    scopus 로고
    • Novel HDL-directed pharmacotherapeutic strategies
    • Degoma, E. M., and D. J. Rader. 2011. Novel HDL-directed pharmacotherapeutic strategies. Nat. Rev. Cardiol. 8: 266-277.
    • (2011) Nat. Rev. Cardiol , vol.8 , pp. 266-277
    • Degoma, E.M.1    Rader, D.J.2
  • 67
    • 0041662117 scopus 로고    scopus 로고
    • Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo
    • Zhang, Y., I. Zanotti, M. P. Reilly, J. M. Glick, G. H. Rothblat, and D. J. Rader. 2003. Overexpression of apolipoprotein A-I promotes reverse transport of cholesterol from macrophages to feces in vivo. Circulation. 108: 661-663.
    • (2003) Circulation , vol.108 , pp. 661-663
    • Zhang, Y.1    Zanotti, I.2    Reilly, M.P.3    Glick, J.M.4    Rothblat, G.H.5    Rader, D.J.6
  • 68
    • 0028167663 scopus 로고
    • Apolipoprotein AI transgene corrects apolipoprotein e deficiency- induced atherosclerosis in mice
    • Pászty, C., N. Maeda, J. Verstuyft, and E. M. Rubin. 1994. Apolipoprotein AI transgene corrects apolipoprotein E deficiency- induced atherosclerosis in mice. J. Clin. Invest. 94: 899-903.
    • (1994) J. Clin. Invest , vol.94 , pp. 899-903
    • Pászty, C.1    Maeda, N.2    Verstuyft, J.3    Rubin, E.M.4
  • 69
    • 0029992667 scopus 로고    scopus 로고
    • Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility
    • Weng, W., and J. L. Breslow. 1996. Dramatically decreased high density lipoprotein cholesterol, increased remnant clearance, and insulin hypersensitivity in apolipoprotein A-II knockout mice suggest a complex role for apolipoprotein A-II in atherosclerosis susceptibility. Proc. Natl. Acad. Sci. USA. 93: 14788-14794.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 14788-14794
    • Weng, W.1    Breslow, J.L.2
  • 70
    • 0025322265 scopus 로고
    • Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit
    • Badimon, J. J., L. Badimon, and V. Fuster. 1990. Regression of atherosclerotic lesions by high density lipoprotein plasma fraction in the cholesterol-fed rabbit. J. Clin. Invest. 85: 1234-1241.
    • (1990) J. Clin. Invest , vol.85 , pp. 1234-1241
    • Badimon, J.J.1    Badimon, L.2    Fuster, V.3
  • 71
    • 0024550898 scopus 로고
    • High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits
    • Badimon, J. J., L. Badimon, A. Galvez, R. Dische, and V. Fuster. 1989. High density lipoprotein plasma fractions inhibit aortic fatty streaks in cholesterol-fed rabbits. Lab. Invest. 60: 455-461.
    • (1989) Lab. Invest , vol.60 , pp. 455-461
    • Badimon, J.J.1    Badimon, L.2    Galvez, A.3    Dische, R.4    Fuster, V.5
  • 72
    • 0242577955 scopus 로고    scopus 로고
    • Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: A randomized controlled trial
    • Nissen, S. E., T. Tsunoda, E. M. Tuzcu, P. Schoenhagen, C. J. Cooper, M. Yasin, G. M. Eaton, M. A. Lauer, W. S. Sheldon, C. L. Grines, et al. 2003. Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes: a randomized controlled trial. JAMA. 290: 2292-2300.
    • (2003) JAMA , vol.290 , pp. 2292-2300
    • Nissen, S.E.1    Tsunoda, T.2    Tuzcu, E.M.3    Schoenhagen, P.4    Cooper, C.J.5    Yasin, M.6    Eaton, G.M.7    Lauer, M.A.8    Sheldon, W.S.9    Grines, C.L.10
  • 73
    • 77955302309 scopus 로고    scopus 로고
    • Seeing red: Flushing out instigators of niacin-associated skin toxicity
    • Dunbar, R. L., and J. M. Gelfand. 2010. Seeing red: flushing out instigators of niacin-associated skin toxicity. J. Clin. Invest. 120: 2651-2655.
    • (2010) J. Clin. Invest , vol.120 , pp. 2651-2655
    • Dunbar, R.L.1    Gelfand, J.M.2
  • 74
    • 0024335924 scopus 로고
    • Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid
    • Morrow, J. D., W. G. Parsons 3rd, and L. J. Roberts 2nd. 1989. Release of markedly increased quantities of prostaglandin D2 in vivo in humans following the administration of nicotinic acid. Prostaglandins. 38: 263-274.
    • (1989) Prostaglandins , vol.38 , pp. 263-274
    • Morrow, J.D.1    Parsons III, W.G.2    Roberts II, L.J.3
  • 75
    • 0026508010 scopus 로고
    • Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans
    • Morrow, J. D., J. A. Awad, J. A. Oates, and L. J. Roberts 2nd. 1992. Identification of skin as a major site of prostaglandin D2 release following oral administration of niacin in humans. J. Invest. Dermatol. 98: 812-815.
    • (1992) J. Invest. Dermatol , vol.98 , pp. 812-815
    • Morrow, J.D.1    Awad, J.A.2    Oates, J.A.3    Roberts, I.I.L.J.4
  • 76
    • 71449112676 scopus 로고    scopus 로고
    • Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects
    • Lauring, B., V. Dishy, W. L. Luo, O. Laterza, J. Patterson, J. Cote, A. Chao, P. Larson, M. Gutierrez, J. A. Wagner, et al. 2009. Laropiprant in combination with extended-release niacin does not alter urine 11-dehydrothromboxane B2, a marker of in vivo platelet function, in healthy, hypercholesterolemic, and diabetic subjects. J. Clin. Pharmacol. 49: 1426-1435.
    • (2009) J. Clin. Pharmacol , vol.49 , pp. 1426-1435
    • Lauring, B.1    Dishy, V.2    Luo, W.L.3    Laterza, O.4    Patterson, J.5    Cote, J.6    Chao, A.7    Larson, P.8    Gutierrez, M.9    Wagner, J.A.10
  • 77
    • 70449322511 scopus 로고
    • Effect of aspirin on cutaneous response to the local application of an ester of nicotinic acid
    • Truelove, L. H., and J. J. Duthie. 1959. Effect of aspirin on cutaneous response to the local application of an ester of nicotinic acid. Ann. Rheum. Dis. 18: 137-141.
    • (1959) Ann. Rheum. Dis , vol.18 , pp. 137-141
    • Truelove, L.H.1    Duthie, J.J.2
  • 78
    • 33847421500 scopus 로고    scopus 로고
    • Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation
    • Cefali, E. A., P. D. Simmons, E. J. Stanek, M. E. McGovern, and C. J. Kissling. 2007. Aspirin reduces cutaneous flushing after administration of an optimized extended-release niacin formulation. Int. J. Clin. Pharmacol. Ther. 45: 78-88.
    • (2007) Int. J. Clin. Pharmacol. Ther , vol.45 , pp. 78-88
    • Cefali, E.A.1    Simmons, P.D.2    Stanek, E.J.3    McGovern, M.E.4    Kissling, C.J.5
  • 80
    • 84873428570 scopus 로고    scopus 로고
    • Role of prostaglandin D2 and the autonomic nervous system in niacininduced flushing
    • Parson, H. K., H. Harati, D. Cooper, and A. I. Vinik. 2013. Role of prostaglandin D2 and the autonomic nervous system in niacininduced flushing. J. Diabetes. 5: 59-67.
    • (2013) J. Diabetes , vol.5 , pp. 59-67
    • Parson, H.K.1    Harati, H.2    Cooper, D.3    Vinik, A.I.4
  • 83
    • 67649372666 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease
    • Maccubbin, D., M. J. Koren, M. Davidson, D. Gavish, R. C. Pasternak, G. Macdonell, M. Mallick, C. M. Sisk, J. F. Paolini, and Y. Mitchel. 2009. Flushing profile of extended-release niacin/laropiprant versus gradually titrated niacin extended-release in patients with dyslipidemia with and without ischemic cardiovascular disease. Am. J. Cardiol. 104: 74-81.
    • (2009) Am. J. Cardiol , vol.104 , pp. 74-81
    • MacCubbin, D.1    Koren, M.J.2    Davidson, M.3    Gavish, D.4    Pasternak, R.C.5    MacDonell, G.6    Mallick, M.7    Sisk, C.M.8    Paolini, J.F.9    Mitchel, Y.10
  • 85
    • 67650132974 scopus 로고    scopus 로고
    • Flushing profile of extended-release niacin/laropiprant at initiation of therapy in Asian lipid clinic patients
    • Kush, D., D. Y. Hu, P. Ye, H. S. Kim, E. Chen, W. Sirah, C. McCrary Sisk, J. F. Paolini, and D. Maccubbin. 2009. Flushing profile of extended-release niacin/laropiprant at initiation of therapy in Asian lipid clinic patients. Cardiology. 114: 192-198.
    • (2009) Cardiology , vol.114 , pp. 192-198
    • Kush, D.1    Hu, D.Y.2    Ye, P.3    Kim, H.S.4    Chen, E.5    Sirah, W.6    McCrary Sisk, C.7    Paolini, J.F.8    MacCubbin, D.9
  • 86
    • 53149118030 scopus 로고    scopus 로고
    • Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia
    • Maccubbin, D., H. E. Bays, A. G. Olsson, V. Elinoff, A. Ellis, Y. Mitchel, W. Sirah, A. Betteridge, R. Reyes, Q. Yu, et al. 2008. Lipid-modifying efficacy and tolerability of extended-release niacin/laropiprant in patients with primary hypercholesterolaemia or mixed dyslipidaemia. Int. J. Clin. Pract. 62: 1959-1970.
    • (2008) Int. J. Clin. Pract , vol.62 , pp. 1959-1970
    • MacCubbin, D.1    Bays, H.E.2    Olsson, A.G.3    Elinoff, V.4    Ellis, A.5    Mitchel, Y.6    Sirah, W.7    Betteridge, A.8    Reyes, R.9    Yu, Q.10
  • 87
    • 67049172683 scopus 로고    scopus 로고
    • Lipid-modifying effi- cacy of extended release niacin/laropiprant in Asian patients with primary hypercholesterolemia or mixed hyperlipidemia
    • Kush, D., H. S. Kim, Y. Hu da, J. Liu, W. Sirah, A. Sapre, C. McCrary Sisk, J. F. Paolini, and D. Maccubbin. 2009. Lipid-modifying effi- cacy of extended release niacin/laropiprant in Asian patients with primary hypercholesterolemia or mixed hyperlipidemia. J. Clin. Lipidol. 3: 179-186.
    • (2009) J. Clin. Lipidol , vol.3 , pp. 179-186
    • Kush, D.1    Kim, H.S.2    Hu Da, Y.3    Liu, J.4    Sirah, W.5    Sapre, A.6    McCrary Sisk, C.7    Paolini, J.F.8    MacCubbin, D.9
  • 88
    • 79952745060 scopus 로고    scopus 로고
    • Extended-release niacin/laropiprant lipid-altering consistency across patient subgroups
    • Bays, H., A. Shah, Q. Dong, C. McCrary Sisk, and D. Maccubbin. 2011. Extended-release niacin/laropiprant lipid-altering consistency across patient subgroups. Int. J. Clin. Pract. 65: 436-445.
    • (2011) Int. J. Clin. Pract , vol.65 , pp. 436-445
    • Bays, H.1    Shah, A.2    Dong, Q.3    McCrary Sisk, C.4    MacCubbin, D.5
  • 89
    • 78649641649 scopus 로고    scopus 로고
    • Efficacy and tolerability of extended-release niacin/laropiprant in dyslipidemic patients with metabolic syndrome
    • Bays, H. E., A. Shah, J. Lin, C. McCrary Sisk, J. F. Paolini, and D. Maccubbin. 2010. Efficacy and tolerability of extended-release niacin/laropiprant in dyslipidemic patients with metabolic syndrome. J. Clin. Lipidol. 4: 515-521.
    • (2010) J. Clin. Lipidol , vol.4 , pp. 515-521
    • Bays, H.E.1    Shah, A.2    Lin, J.3    McCrary Sisk, C.4    Paolini, J.F.5    MacCubbin, D.6
  • 90
    • 84861726233 scopus 로고    scopus 로고
    • Effects of coadministered extended-release niacin/laropiprant and simvastatin on lipoprotein subclasses in patients with dyslipidemia
    • Ballantyne, C., G. Gleim, N. Liu, C. M. Sisk, A. O. Johnson-Levonas, and Y. Mitchel. 2012. Effects of coadministered extended-release niacin/laropiprant and simvastatin on lipoprotein subclasses in patients with dyslipidemia. J. Clin. Lipidol. 6: 235-243.
    • (2012) J. Clin. Lipidol , vol.6 , pp. 235-243
    • Ballantyne, C.1    Gleim, G.2    Liu, N.3    Sisk, C.M.4    Johnson-Levonas, A.O.5    Mitchel, Y.6
  • 91
    • 84878602155 scopus 로고    scopus 로고
    • Lipid-altering efficacy and safety profile of co-administered extended release niacin/laropiprant and simvastatin versus atorvastatin in patients with mixed hyperlipidemia
    • Chen, F., D. Maccubbin, L. Yan, W. Sirah, E. Chen, C. M. Sisk, M. Davidson, P. Blomqvist, and J. M. McKenney. 2013. Lipid-altering efficacy and safety profile of co-administered extended release niacin/laropiprant and simvastatin versus atorvastatin in patients with mixed hyperlipidemia. Int. J. Cardiol. 167: 225-231.
    • (2013) Int. J. Cardiol , vol.167 , pp. 225-231
    • Chen, F.1    MacCubbin, D.2    Yan, L.3    Sirah, W.4    Chen, E.5    Sisk, C.M.6    Davidson, M.7    Blomqvist, P.8    McKenney, J.M.9
  • 92
    • 0014581218 scopus 로고
    • Glucose tolerance and plasma insulin in man during acute and chronic administration of nicotinic acid
    • Miettinen, T. A., M. R. Taskinen, R. Pelkonen, and E. A. Nikkila. 1969. Glucose tolerance and plasma insulin in man during acute and chronic administration of nicotinic acid. Acta Med. Scand. 186: 247-253.
    • (1969) Acta Med. Scand , vol.186 , pp. 247-253
    • Miettinen, T.A.1    Taskinen, M.R.2    Pelkonen, R.3    Nikkila, E.A.4
  • 93
    • 0041312408 scopus 로고    scopus 로고
    • Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content
    • Poynten, A. M., S. K. Gan, A. D. Kriketos, A. O'Sullivan, J. J. Kelly, B. A. Ellis, D. J. Chisholm, and L. V. Campbell. 2003. Nicotinic acid-induced insulin resistance is related to increased circulating fatty acids and fat oxidation but not muscle lipid content. Metabolism. 52: 699-704.
    • (2003) Metabolism , vol.52 , pp. 699-704
    • Poynten, A.M.1    Gan, S.K.2    Kriketos, A.D.3    O'Sullivan, A.4    Kelly, J.J.5    Ellis, B.A.6    Chisholm, D.J.7    Campbell, L.V.8
  • 94
    • 11844304073 scopus 로고    scopus 로고
    • Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project)
    • Canner, P. L., C. D. Furberg, M. L. Terrin, and M. E. McGovern. 2005. Benefits of niacin by glycemic status in patients with healed myocardial infarction (from the Coronary Drug Project). Am. J. Cardiol. 95: 254-257.
    • (2005) Am. J. Cardiol , vol.95 , pp. 254-257
    • Canner, P.L.1    Furberg, C.D.2    Terrin, M.L.3    McGovern, M.E.4
  • 97
    • 84868091600 scopus 로고    scopus 로고
    • Statins and risk of new-onset diabetes mellitus
    • Shah, R. V., and A. B. Goldfine. 2012. Statins and risk of new-onset diabetes mellitus. Circulation. 126: e282 - e284.
    • (2012) Circulation , vol.126
    • Shah, R.V.1    Goldfine, A.B.2
  • 98
    • 0015188268 scopus 로고
    • Effect of nicotinic acid on gastric secretion of acid in human subjects and in dogs
    • Andersson, S., L. A. Carlson, L. Oro, and E. A. Richards. 1971. Effect of nicotinic acid on gastric secretion of acid in human subjects and in dogs. Scand. J. Gastroenterol. 6: 693-698.
    • (1971) Scand. J. Gastroenterol , vol.6 , pp. 693-698
    • Andersson, S.1    Carlson, L.A.2    Oro, L.3    Richards, E.A.4
  • 99
    • 0027477243 scopus 로고
    • Transient focal hepatic defects related to sustained-release niacin
    • Lawrence, S. P. 1993. Transient focal hepatic defects related to sustained-release niacin. J. Clin. Gastroenterol. 16: 234-236.
    • (1993) J. Clin. Gastroenterol , vol.16 , pp. 234-236
    • Lawrence, S.P.1
  • 100
    • 0026777781 scopus 로고
    • Hepatotoxicity associated with sustained-release niacin
    • Dalton, T. A., and R. S. Berry. 1992. Hepatotoxicity associated with sustained-release niacin. Am. J. Med. 93: 102-104.
    • (1992) Am. J. Med , vol.93 , pp. 102-104
    • Dalton, T.A.1    Berry, R.S.2
  • 102
    • 1842681535 scopus 로고    scopus 로고
    • New perspectives on the use of niacin in the treatment of lipid disorders
    • McKenney, J. 2004. New perspectives on the use of niacin in the treatment of lipid disorders. Arch. Intern. Med. 164: 697-705.
    • (2004) Arch. Intern. Med , vol.164 , pp. 697-705
    • McKenney, J.1
  • 103
    • 0016250289 scopus 로고
    • Pharmacologic effects of nicotinic acid on human purine metabolism
    • Gershon, S. L., and I. H. Fox. 1974. Pharmacologic effects of nicotinic acid on human purine metabolism. J. Lab. Clin. Med. 84: 179-186.
    • (1974) J. Lab. Clin. Med , vol.84 , pp. 179-186
    • Gershon, S.L.1    Fox, I.H.2
  • 105
    • 0015156391 scopus 로고
    • Oral glucose tolerance, plasma insulin, and uric acid excretion in man during chronic administration of nicotinic acid
    • Gaut, Z. N., R. Pocelinko, H. M. Solomon, and G. B. Thomas. 1971. Oral glucose tolerance, plasma insulin, and uric acid excretion in man during chronic administration of nicotinic acid. Metabolism. 20: 1031-1035.
    • (1971) Metabolism , vol.20 , pp. 1031-1035
    • Gaut, Z.N.1    Pocelinko, R.2    Solomon, H.M.3    Thomas, G.B.4
  • 106
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • 1975. Clofibrate and niacin in coronary heart disease. JAMA. 231: 360-381.
    • (1975) JAMA , vol.231 , pp. 360-381
  • 108
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson, L. A., and G. Rosenhamer. 1988. Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med. Scand. 223: 405-418.
    • (1988) Acta Med. Scand , vol.223 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 111
    • 10044281651 scopus 로고    scopus 로고
    • Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: A double- blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins
    • Taylor, A. J., L. E. Sullenberger, H. J. Lee, J. K. Lee, and K. A. Grace. 2004. Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol (ARBITER) 2: a double- blind, placebo-controlled study of extended-release niacin on atherosclerosis progression in secondary prevention patients treated with statins. Circulation. 110: 3512-3517.
    • (2004) Circulation , vol.110 , pp. 3512-3517
    • Taylor, A.J.1    Sullenberger, L.E.2    Lee, H.J.3    Lee, J.K.4    Grace, K.A.5
  • 112
    • 33751217682 scopus 로고    scopus 로고
    • The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3
    • Taylor, A. J., H. J. Lee, and L. E. Sullenberger. 2006. The effect of 24 months of combination statin and extended-release niacin on carotid intima-media thickness: ARBITER 3. Curr. Med. Res. Opin. 22: 2243-2250.
    • (2006) Curr. Med. Res. Opin , vol.22 , pp. 2243-2250
    • Taylor, A.J.1    Lee, H.J.2    Sullenberger, L.E.3
  • 114
    • 70350516769 scopus 로고    scopus 로고
    • Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: A randomized, placebocontrolled, magnetic resonance imaging study
    • Lee, J. M., M. D. Robson, L. M. Yu, C. C. Shirodaria, C. Cunnington, I. Dylintireas, J. E. Digby, T. Bannister, A. Handa, F. Wiesmann, et al. 2009. Effects of high-dose modified-release nicotinic acid on atherosclerosis and vascular function: a randomized, placebocontrolled, magnetic resonance imaging study. J. Am. Coll. Cardiol. 54: 1787-1794.
    • (2009) J. Am. Coll. Cardiol , vol.54 , pp. 1787-1794
    • Lee, J.M.1    Robson, M.D.2    Yu, L.M.3    Shirodaria, C.C.4    Cunnington, C.5    Dylintireas, I.6    Digby, J.E.7    Bannister, T.8    Handa, A.9    Wiesmann, F.10
  • 115
    • 84861606700 scopus 로고    scopus 로고
    • Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: Reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial with previous surrogate endpoint trials
    • Michos, E. D., C. T. Sibley, J. T. Baer, M. J. Blaha, and R. S. Blumenthal. 2012. Niacin and statin combination therapy for atherosclerosis regression and prevention of cardiovascular disease events: reconciling the AIM-HIGH (Atherothrombosis Intervention in Metabolic Syndrome with Low HDL/High Triglycerides: Impact on Global Health Outcomes) trial with previous surrogate endpoint trials. J. Am. Coll. Cardiol. 59: 2058-2064.
    • (2012) J. Am. Coll. Cardiol , vol.59 , pp. 2058-2064
    • Michos, E.D.1    Sibley, C.T.2    Baer, J.T.3    Blaha, M.J.4    Blumenthal, R.S.5
  • 116
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S)
    • 1994. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet. 344: 1383-1389.
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 117
    • 84876184735 scopus 로고    scopus 로고
    • When clinical trials fail to address treatment gaps: The failure of niacin-laropiprant to reduce cardiovascular events
    • Rosenson, R. S., and A. M. Gotto, Jr. 2013. When clinical trials fail to address treatment gaps: the failure of niacin-laropiprant to reduce cardiovascular events. Curr. Atheroscler. Rep. 15: 332.
    • (2013) Curr. Atheroscler. Rep , vol.15 , pp. 332
    • Rosenson, R.S.1    Gotto Jr., A.M.2
  • 118
    • 0037414218 scopus 로고    scopus 로고
    • Statinassociated myopathy
    • Thompson, P. D., P. Clarkson, and R. H. Karas. 2003. Statinassociated myopathy. JAMA. 289: 1681-1690.
    • (2003) JAMA , vol.289 , pp. 1681-1690
    • Thompson, P.D.1    Clarkson, P.2    Karas, R.H.3
  • 121
    • 0029122754 scopus 로고
    • Attenuation of the synthesis of plasminogen activator inhibitor type 1 by niacin. A potential link between lipid lowering and fibrinolysis
    • Brown, S. L., B. E. Sobel, and S. Fujii. 1995. Attenuation of the synthesis of plasminogen activator inhibitor type 1 by niacin. A potential link between lipid lowering and fibrinolysis. Circulation. 92: 767-772.
    • (1995) Circulation , vol.92 , pp. 767-772
    • Brown, S.L.1    Sobel, B.E.2    Fujii, S.3
  • 122
    • 0033809508 scopus 로고    scopus 로고
    • Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT)
    • Chesney, C. M., M. B. Elam, J. A. Herd, K. B. Davis, R. Garg, D. Hunninghake, J. W. Kennedy, and W. B. Applegate. 2000. Effect of niacin, warfarin, and antioxidant therapy on coagulation parameters in patients with peripheral arterial disease in the Arterial Disease Multiple Intervention Trial (ADMIT). Am. Heart J. 140: 631-636.
    • (2000) Am. Heart J. , vol.140 , pp. 631-636
    • Chesney, C.M.1    Elam, M.B.2    Herd, J.A.3    Davis, K.B.4    Garg, R.5    Hunninghake, D.6    Kennedy, J.W.7    Applegate, W.B.8
  • 123
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A metaanalysis of data from 170,000 participants in 26 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration
    • Cholesterol Treatment Trialists' (CTT) Collaboration; Baigent, C., L. Blackwell, J. Emberson, L. E. Holland, C. Reith, N. Bhala, R. Peto, E. H. Barnes, A. Keech, J. Simes, et al. 2010. Efficacy and safety of more intensive lowering of LDL cholesterol: a metaanalysis of data from 170,000 participants in 26 randomised trials. Lancet. 376: 1670-1681.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2    Emberson, J.3    Holland, L.E.4    Reith, C.5    Bhala, N.6    Peto, R.7    Barnes, E.H.8    Keech, A.9    Simes, J.10


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