Nicotinic acid and pyridoxine modulate arachidonic acid metabolism in vitro and ex vivo in man

Pharmacology and Toxicology

Volumn 84, Issue 6, 1999, Pages 274-280

  Saareks, Virpi ^a,c   Mucha, István ^b   Sievi, Eeva ^d   Riutta, Asko ^a  

^a TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^b Institute of Isotopes   (Hungary)

^c TAMPERE UNIVERSITY HOSPITAL   (Finland)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CALCIMYCIN; LEUKOTRIENE E4; NICOTINIC ACID; PROSTAGLANDIN E2; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE; THROMBOXANE B2;

ADULT; ARACHIDONIC ACID METABOLISM; ARTICLE; BLOOD; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; HUMAN; HUMAN TISSUE; MALE; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0032977431     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1999.tb01494.x     Document Type: Article

References (37)

1. Alanko, J., A. Riutta, I. Mucha, T. Kerttula, S. Kaukinen, H. Vapaatalo, T. Metsä-Ketelä & E. Seppälä: Adrenaline stimulates thromboxane and inhibits leukotriene synthesis in man. Eicosanoids 1992, 5, 169-175.
2. Arm, J. P. & T. H. Lee: Sulphidopeptide leukotrienes in asthma. Clin. Sci. 1993, 84, 501-510.
3. 2 is a potent contractile agonist of human and guinea pig airways. J. Clin. Invest. 1987, 79, 978-983.
4. 2 mechanism. J. Immunol. 1993, 151, 2096-2104.
5. Driskell, J. A.: Vitamin B-6 requirements of humans. Nutr. Res. 1994, 14, 293-324.
6. Dworski, R., J. R. Sheller, N. E. Wickersham, J. A. Oates, K. L. Brigham, L. J. Roberts II & G. A. Fitzgerald: Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Amer. Rev. Respir. Dis. 1989, 139, 46-51.
7. 6 metabolism in man. Clin. Chim. Acta 1990, 190, 67-80.
8. 2 biosynthesis in human disease. Fed. Proc. 1987, 46, 154-158.
9. 4. J. Biol. Chem. 1984, 259, 11403-11407.
10. Fujimoto, Y., K. Nishioka, N. Ohtani, M. Aihara & T. Fujita: Effect of pyridoxine on prostaglandin synthesis in rabbit kidney medulla slices. J. Pharm. Pharmacol. 1987, 39, 314-315.
11. Goerig, M., V. Ullrich, G. Schettler, C. Foltis & A. Habenicht: A new role for nicotine: selective inhibition of thromboxane formation by direct interaction with thromboxane synthase in human promyelocytic leukaemia cells differentiating into macrophages. Clin. Invest. 1992, 70, 239-243.
12. Henriksson, P., G. Rasmanis, O. Edhag, O. Vesterqvist & K. Green: Thromboxane synthase inhibition: "endoperoxide shunt phenomenon" does not occur in healthy humans in vivo. Prostaglandins 1990, 39, 99-107.
13. Kaijser, L. & Ā. Wennmalm: Nicotinic acid stimulates prostaglandin synthesis in the rabbit heart without releasing noradrenaline. Acta physiol. scand. 1978, 102, 246-247.
14. 4 by human platelets. J. Biol. Chem. 1988, 263, 174-180.
15. 2 in the rat. Prostaglandins Leukotr. Essent. Fatty Acids 1993, 49, 531-536.
16. 2 release following oral administration of niacin in humans. J. Invest. Dermatol. 1992, 98, 812-815.
17. 2 in vivo in humans following the administration of nicotinic acid. Prostaglandins 1989, 38, 263-274.
18. 4 by human polymorphonuclear leukocytes. Brit. J. Pharmacol. 1989, 96, 186-192.
19. 2 in human urine and plasma by gas chromatography-mass spectrometry. J. Chromat. B. 1994, 655, 173-178.
20. Olsson, A. G., L. A. Carlson, E. Ånggard & G. Ciabattoni: Prostacyclin production augmented in the short term by nicotinic acid. Lancet 1983, 2, 565-566.
21. Olszewski, A. J., W. B. Szostak, M. Bialkowska, S. Rudnicki & K. S. McCully: Reduction of plasma lipid and homocysteine levels by pyridoxine, folate, cobalamin, choline, riboflavin and troxerutin in atherosclerosis. Atherosclerosis 1989, 75, 1-6.
22. 2 synthase activity in platelet free human monocytes. Biochim. Biophys. Acta 1994, 1215, 285-290.
23. Patrignani, P., D. Volpi, R. Ferrario, L. Romanzini, M. Di Somma & C. Patrono: Effects of racemic. S-and R-indobufen on cyclooxygenase and lipoxygenase activities in human whole blood. Eur. J. Pharmacol. 1990, 191, 83-88.
24. 1α in human whole blood in vitro. Res. Comm. Chem. Path. Pharm. 1987, 55, 423-426.
25. Reynolds, R. D. & C. L. Natta: Depressed plasma pyridoxal phosphate concentrations in adult asthmatics. Amer. J. Clin. Nutr. 1985, 41, 684-688.
26. Riutta, A., V. Saareks, I. Mucha, J. Alanko, M. Parviainen & H. Vapaatalo: Smoking cessation and nicotine substitution modulate eicosanoid synthesis ex vivo in man. Naunyn-Schmiedeberg's Arch. Pharmacol. 1995, 352, 102-107.
27. Saareks, V., A. Riutta, I. Mucha, J. Alanko & H. Vapaatalo: Nicotine and cotinine modulate cicosanoid production in human leukocytes and platelet rich plasma. Eur. J. Pharmacol. 1993, 248, 345-349.
28. 4 synthesis in whole blood. Eur. J. Pharmacol. 1998, 353, 87-92.
29. Sahin, I., M. Tuncer, F. G. Ayanoglu & S. O. Kayaalp: Effects of pyridine and some of its derivatives on prostaglandin synthesis. Arch. Int. Pharmacodyn. 1984, 270, 324-329.
30. Schaumburg, H., J. Kaplan, A. Windebank, N. Vick, S. Rasmus, D. Pleasure & M. J. Brown: Sensory neuropathy from pyridoxine abuse, a new megavitamin syndrome. New. Engl. J. Med. 1983, 309, 445-448.
31. Sirois, P., P. Borgeat, M. Lauziere, L. Dube, P. Rubin & J. Kesterson: Effect of Zileuton (A-64077) on the 5-lipoxygenase activity of human whole blood ex vivo. Agents und Actions 1991, 34, 117-120.
32. Spaethe, S. M., D. W. Snyder, P. A. Pechous, T. Clarke & E. L. Vanalstyne: Guinea pig whole blood 5-lipoxygenase assay: utility in the assessment of potential 5-lipoxygenase inhibitors. Biochem. pharmacol. 1992, 43, 377-382.
33. Subbarao, K., J. Kuchibhotla & V. V. Kakkar: Pyridoxal-5′-phosphate a new physiological inhibitor of blood coagulation and platelet function. Biochem. Pharmacol. 1979, 28, 531-534.
34. Surette, M. E., A. Odeimat, R. Palmantier, S. Marleau, P.E. Poubelle & P. Borgeat: Reverse-phase high-performance liquid chromatography analysis of arachidonic acid metabolites in plasma after stimulation of whole blood ex vivo. Anal. Biochem. 1994, 216, 392-400.
35. van Wyk, V., H. G. Luus & A. du P. Heyns: The in vivo effect in humans of pyridoxal-5′-phosphate on platelet function and blood coagulation. Thromb. Res. 1992, 66, 657-668.
36. Vincent, J. E. & F.J. Zijlstra: Nicotinic acid inhibits thromboxane synthesis in platelets. Prostaglandins 1978, 15, 629-636.
37. Zakrzewski, J. T., A. P. Sampson, J. M. Evans, N. C. Barnes, P. J. Piper & J. F. Costello: The biotransformation in vitro of cysteinyl leukotrienes in blood of normal and asthmatic subjects. Prostaglandins 1989, 37, 425-444.