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Volumn 6, Issue 287, 2013, Pages

Interference with akt signaling protects against myocardial infarction and death by limiting the consequences of oxidative stress

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; CD36 ANTIGEN; CHOLESTEROL; PROTEIN AKT1; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SCAVENGER RECEPTOR BI; UNCLASSIFIED DRUG; AKT1 PROTEIN, MOUSE; SCARB1 PROTEIN, HUMAN; SCAVENGER RECEPTOR B;

EID: 84884149973     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2003948     Document Type: Article
Times cited : (31)

References (65)
  • 4
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis-An inflammatory disease
    • R. Ross, Atherosclerosis-An inflammatory disease. N. Engl. J. Med. 340, 115-126 (1999).
    • (1999) N. Engl. J. Med. , vol.340 , pp. 115-126
    • Ross, R.1
  • 5
    • 0141988913 scopus 로고    scopus 로고
    • Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis
    • B. L. Trigatti, M. Krieger, A. Rigotti, Influence of the HDL receptor SR-BI on lipoprotein metabolism and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 23, 1732-1738 (2003).
    • (2003) Arterioscler. Thromb. Vasc. Biol. , vol.23 , pp. 1732-1738
    • Trigatti, B.L.1    Krieger, M.2    Rigotti, A.3
  • 6
    • 0037155049 scopus 로고    scopus 로고
    • Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-Deficient mice
    • A. Braun, B. L. Trigatti, M. J. Post, K. Sato, M. Simons, J. M. Edelberg, R. D. Rosenberg, M. Schrenzel, M. Krieger, Loss of SR-BI expression leads to the early onset of occlusive atherosclerotic coronary artery disease, spontaneous myocardial infarctions, severe cardiac dysfunction, and premature death in apolipoprotein E-Deficient mice. Circ. Res. 90, 270-276 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 270-276
    • Braun, A.1    Trigatti, B.L.2    Post, M.J.3    Sato, K.4    Simons, M.5    Edelberg, J.M.6    Rosenberg, R.D.7    Schrenzel, M.8    Krieger, M.9
  • 14
    • 79956286435 scopus 로고    scopus 로고
    • Significance of thymosin b4 and implication of PINCH-1-ILK-A-Parvin (PIP) complex in human dilated cardiomyopathy
    • N. Sopko, Y. Qin, A. Finan, A. Dadabayev, S. Chigurupati, J. Qin, M. S. Penn, S. Gupta, Significance of thymosin b4 and implication of PINCH-1-ILK-A-Parvin (PIP) complex in human dilated cardiomyopathy. PLoS One 6, e20184 (2011).
    • (2011) PLoS One , vol.6
    • Sopko, N.1    Qin, Y.2    Finan, A.3    Dadabayev, A.4    Chigurupati, S.5    Qin, J.6    Penn, M.S.7    Gupta, S.8
  • 16
    • 0034845958 scopus 로고    scopus 로고
    • PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
    • M. A. Lawlor, D. R. Alessi, PKB/Akt: A key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114, 2903-2910 (2001).
    • (2001) J Cell Sci. , vol.114 , pp. 2903-2910
    • Lawlor, M.A.1    Alessi, D.R.2
  • 19
    • 23644439061 scopus 로고    scopus 로고
    • Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure
    • I. Shiojima, K. Sato, Y. Izumiya, S. Schiekofer, M. Ito, R. Liao, W. S. Colucci, K. Walsh, Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J. Clin. Invest. 115, 2108-2118 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2108-2118
    • Shiojima, I.1    Sato, K.2    Izumiya, Y.3    Schiekofer, S.4    Ito, M.5    Liao, R.6    Colucci, W.S.7    Walsh, K.8
  • 21
    • 66449118214 scopus 로고    scopus 로고
    • Switching Akt: From survival signaling to deadly response
    • M. Los, S. Maddika, B. Erb, K. Schulze-Osthoff, Switching Akt: From survival signaling to deadly response. Bioessays 31, 492-495 (2009).
    • (2009) Bioessays , vol.31 , pp. 492-495
    • Los, M.1    Maddika, S.2    Erb, B.3    Schulze-Osthoff, K.4
  • 22
    • 56849086301 scopus 로고    scopus 로고
    • AKT and oxidative stress team up to kill cancer cells
    • I. Dolado, A. R. Nebreda, AKT and oxidative stress team up to kill cancer cells. Cancer Cell 14, 427-429 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 427-429
    • Dolado, I.1    Nebreda, A.R.2
  • 25
    • 56849118516 scopus 로고    scopus 로고
    • Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis
    • V. Nogueira, Y. Park, C. C. Chen, P. Z. Xu, M. L. Chen, I. Tonic, T. Unterman, N. Hay, Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis. Cancer Cell 14, 458-470 (2008).
    • (2008) Cancer Cell , vol.14 , pp. 458-470
    • Nogueira, V.1    Park, Y.2    Chen, C.C.3    Xu, P.Z.4    Chen, M.L.5    Tonic, I.6    Unterman, T.7    Hay, N.8
  • 26
    • 23644446462 scopus 로고    scopus 로고
    • Akt1 in the cardiovascular system: Friend or foe?
    • B. T. O?Neill, E. D. Abel, Akt1 in the cardiovascular system: Friend or foe? J. Clin. Invest. 115, 2059-2064 (2005).
    • (2005) J. Clin. Invest. , vol.115 , pp. 2059-2064
    • Oneill, B.T.1    Abel, E.D.2
  • 28
    • 48749114949 scopus 로고    scopus 로고
    • Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing
    • P. R. Somanath, J. Chen, T. V. Byzova, Akt1 is necessary for the vascular maturation and angiogenesis during cutaneous wound healing. Angiogenesis 11, 277-288 (2008).
    • (2008) Angiogenesis , vol.11 , pp. 277-288
    • Somanath, P.R.1    Chen, J.2    Byzova, T.V.3
  • 29
    • 34547932097 scopus 로고    scopus 로고
    • Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly
    • P. R. Somanath, E. S. Kandel, N. Hay, T. V. Byzova, Akt1 signaling regulates integrin activation, matrix recognition, and fibronectin assembly. J. Biol. Chem. 282, 22964-22976 (2007).
    • (2007) J. Biol. Chem. , vol.282 , pp. 22964-22976
    • Somanath, P.R.1    Kandel, E.S.2    Hay, N.3    Byzova, T.V.4
  • 30
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • P. Libby, Inflammation in atherosclerosis. Nature 420, 868-874 (2002).
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 31
    • 0025896795 scopus 로고
    • Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis
    • M. I. Cybulsky, M. A. Gimbrone Jr., Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science 251, 788-791 (1991).
    • (1991) Science , vol.251 , pp. 788-791
    • Cybulsky, M.I.1    Gimbrone Jr., M.A.2
  • 32
    • 0037470077 scopus 로고    scopus 로고
    • Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-D-NF-kB and PKC-z-GATA signaling pathways
    • T. Minami, M. R. Abid, J. Zhang, G. King, T. Kodama, W. C. Aird, Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-D-NF-kB and PKC-z-GATA signaling pathways. J. Biol. Chem. 278, 6976-6984 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 6976-6984
    • Minami, T.1    Abid, M.R.2    Zhang, J.3    King, G.4    Kodama, T.5    Aird, W.C.6
  • 33
    • 16844365642 scopus 로고    scopus 로고
    • Nitric oxide hypoxia and superoxide: The good the bad and the ugly
    • R. A. Dweik, Nitric oxide, hypoxia, and superoxide: The good, the bad, and the ugly! Thorax 60, 265-267 (2005).
    • (2005) Thorax , vol.60 , pp. 265-267
    • Dweik, R.A.1
  • 35
    • 0031816705 scopus 로고    scopus 로고
    • The NF-kB activation pathway: Its regulation and role in inflammation and cell survival
    • M. Karin, The NF-kB activation pathway: Its regulation and role in inflammation and cell survival. Cancer J. Sci. Am. 4 (Suppl. 1), S92-S99 (1998).
    • (1998) Cancer J. Sci. Am. , vol.4 , Issue.SUPPL. 1
    • Karin, M.1
  • 36
    • 0033517190 scopus 로고    scopus 로고
    • NF-kB is a target of AKT in anti-Apoptotic PDGF signalling
    • J. A. Romashkova, S. S. Makarov, NF-kB is a target of AKT in anti-Apoptotic PDGF signalling. Nature 401, 86-90 (1999).
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 38
    • 43749102073 scopus 로고    scopus 로고
    • Mapping and characterization of the binding site for specific oxidized phospholipids and oxidized low density lipoprotein of scavenger receptor CD36
    • N. S. Kar, M. Z. Ashraf, M. Valiyaveettil, E. A. Podrez, Mapping and characterization of the binding site for specific oxidized phospholipids and oxidized low density lipoprotein of scavenger receptor CD36. J. Biol. Chem. 283, 8765-8771 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 8765-8771
    • Kar, N.S.1    Ashraf, M.Z.2    Valiyaveettil, M.3    Podrez, E.A.4
  • 39
    • 79955391768 scopus 로고    scopus 로고
    • Mitochondrial adaptations to physiological vs pathological cardiac hypertrophy
    • E. D. Abel, T. Doenst, Mitochondrial adaptations to physiological vs. pathological cardiac hypertrophy. Cardiovasc. Res. 90, 234-242 (2011).
    • (2011) Cardiovasc. Res. , vol.90 , pp. 234-242
    • Abel, E.D.1    Doenst, T.2
  • 40
    • 0037192815 scopus 로고    scopus 로고
    • High density lipoprotein binding to scavenger receptor, class B, type i activates endothelial nitric-Oxide synthase in a ceramide-Dependent manner
    • X. A. Li,W. B. Titlow, B. A. Jackson, N. Giltiay, M. Nikolova- Karakashian, A. Uittenbogaard, E. J. Smart, High density lipoprotein binding to scavenger receptor, class B, type I activates endothelial nitric-Oxide synthase in a ceramide-Dependent manner. J. Biol. Chem. 277, 11058-11063 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 11058-11063
    • Liw. B Titlow, X.A.1    Jackson, B.A.2    Giltiay, N.3    Nikolova-Karakashian, M.4    Uittenbogaard, A.5    Smart, E.J.6
  • 41
    • 0030667160 scopus 로고    scopus 로고
    • Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkBa
    • M. Spiecker, H. B. Peng, J. K. Liao, Inhibition of endothelial vascular cell adhesion molecule-1 expression by nitric oxide involves the induction and nuclear translocation of IkBa. J. Biol. Chem. 272, 30969-30974 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 30969-30974
    • Spiecker, M.1    Peng, H.B.2    Liao, J.K.3
  • 42
    • 63249119308 scopus 로고    scopus 로고
    • Protein kinase C-D and phosphatidylinositol 3-kinase/Akt activatemammalian target of rapamycin to modulate NF-kB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells
    • M. Minhajuddin, K. M. Bijli, F. Fazal, A. Sassano, K. I. Nakayama, N. Hay, L. C. Platanias, A. Rahman, Protein kinase C-D and phosphatidylinositol 3-kinase/Akt activatemammalian target of rapamycin to modulate NF-kB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. J. Biol. Chem. 284, 4052-4061 (2009).
    • (2009) J. Biol. Chem. , vol.284 , pp. 4052-4061
    • Minhajuddin, M.1    Bijli, K.M.2    Fazal, F.3    Sassano, A.4    Nakayama, K.I.5    Hay, N.6    Platanias, L.C.7    Rahman, A.8
  • 43
    • 4444269330 scopus 로고    scopus 로고
    • Impaired platelet responses to thrombin and collagen in AKT-1-Deficient mice
    • J. Chen, S. De, D. S. Damron, W. S. Chen, N. Hay, T. V. Byzova, Impaired platelet responses to thrombin and collagen in AKT-1-Deficient mice. Blood 104, 1703-1710 (2004).
    • (2004) Blood , vol.104 , pp. 1703-1710
    • Chen, J.1    De, S.2    Damron, D.S.3    Chen, W.S.4    Hay, N.5    Byzova, T.V.6
  • 44
    • 38349188189 scopus 로고    scopus 로고
    • The role of Akt in the signaling pathway of the glycoprotein Ib-IX-Induced platelet activation
    • H. Yin, A. Stojanovic, N. Hay, X. Du, The role of Akt in the signaling pathway of the glycoprotein Ib-IX-Induced platelet activation. Blood 111, 658-665 (2008).
    • (2008) Blood , vol.111 , pp. 658-665
    • Yin, H.1    Stojanovic, A.2    Hay, N.3    Du, X.4
  • 48
    • 0037192473 scopus 로고    scopus 로고
    • Redox regulation of forkhead proteins through a p66shcdependent signaling pathway
    • S. Nemoto, T. Finkel, Redox regulation of forkhead proteins through a p66shcdependent signaling pathway. Science 295, 2450-2452 (2002).
    • (2002) Science , vol.295 , pp. 2450-2452
    • Nemoto, S.1    Finkel, T.2
  • 49
    • 70349633673 scopus 로고    scopus 로고
    • Activation of the AMPK-FOXO3 pathway reduces fatty acid-Induced increase in intracellular reactive oxygen species by upregulating thioredoxin
    • X. N. Li, J. Song, L. Zhang, S. A. LeMaire, X. Hou, C. Zhang, J. S. Coselli, L. Chen, X. L. Wang, Y. Zhang, Y. H. Shen, Activation of the AMPK-FOXO3 pathway reduces fatty acid-Induced increase in intracellular reactive oxygen species by upregulating thioredoxin. Diabetes 58, 2246-2257 (2009).
    • (2009) Diabetes , vol.58 , pp. 2246-2257
    • Li, X.N.1    Song, J.2    Zhang, L.3    Le Maire, S.A.4    Hou, X.5    Zhang, C.6    Coselli, J.S.7    Chen, L.8    Wang, X.L.9    Zhang, Y.10    Shen, Y.H.11
  • 52
  • 53
    • 0033847712 scopus 로고    scopus 로고
    • Oxidized LDL-Induced NF-kB activation and subsequent expression of proinflammatory genes are defective in monocyte-Derived macrophages from CD36-Deficient patients
    • M. Janabi, S. Yamashita, K. Hirano, N. Sakai, H. Hiraoka, K. Matsumoto, Z. Zhang, S. Nozaki, Y. Matsuzawa, Oxidized LDL-Induced NF-kB activation and subsequent expression of proinflammatory genes are defective in monocyte-Derived macrophages from CD36-Deficient patients. Arterioscler. Thromb. Vasc. Biol. 20, 1953-1960 (2000).
    • (2000) Arterioscler. Thromb. Vasc. Biol. , vol.20 , pp. 1953-1960
    • Janabi, M.1    Yamashita, S.2    Hirano, K.3    Sakai, N.4    Hiraoka, H.5    Matsumoto, K.6    Zhang, Z.7    Nozaki, S.8    Matsuzawa, Y.9
  • 54
    • 3042690158 scopus 로고    scopus 로고
    • Regulation of macrophage foam cell formation by aVb3 integrin: Potential role in human atherosclerosis
    • A. S. Antonov, F. D. Kolodgie, D. H. Munn, R. G. Gerrity, Regulation of macrophage foam cell formation by aVb3 integrin: Potential role in human atherosclerosis. Am. J. Pathol. 165, 247-258 (2004).
    • (2004) Am. J. Pathol. , vol.165 , pp. 247-258
    • Antonov, A.S.1    Kolodgie, F.D.2    Munn, D.H.3    Gerrity, R.G.4
  • 55
    • 0035723447 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-OH kinase-Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell line
    • W. Ming Cao, K. Murao, H. Imachi, M. Sato, T. Nakano, T. Kodama, Y. Sasaguri, N. C. Wong, J. Takahara, T. Ishida, Phosphatidylinositol 3-OH kinase-Akt/protein kinase B pathway mediates Gas6 induction of scavenger receptor a in immortalized human vascular smooth muscle cell line. Arterioscler. Thromb. Vasc. Biol. 21, 1592-1597 (2001).
    • (2001) Arterioscler. Thromb. Vasc. Biol. , vol.21 , pp. 1592-1597
    • Ming Cao, W.1    Murao, K.2    Imachi, H.3    Sato, M.4    Nakano, T.5    Kodama, T.6    Sasaguri, Y.7    Wong, N.C.8    Takahara, J.9    Ishida, T.10
  • 56
    • 73349125092 scopus 로고    scopus 로고
    • Calcium-Independent phospholipase A2b-Akt signaling is involved in lipopolysaccharide-Induced NADPH oxidase 1 expression and foam cell formation
    • S. H. Lee, D. W. Park, S. C. Park, Y. K. Park, S. Y. Hong, J. R. Kim, C. H. Lee, S. H. Baek, Calcium-Independent phospholipase A2b-Akt signaling is involved in lipopolysaccharide-Induced NADPH oxidase 1 expression and foam cell formation. J. Immunol. 183, 7497-7504 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 7497-7504
    • Lee, S.H.1    Park, D.W.2    Park, S.C.3    Park, Y.K.4    Hong, S.Y.5    Kim, J.R.6    Lee, C.H.7    Baek, S.H.8
  • 59
    • 34547857777 scopus 로고    scopus 로고
    • Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling
    • D. K. Singla, G. E. Lyons, T. J. Kamp, Transplanted embryonic stem cells following mouse myocardial infarction inhibit apoptosis and cardiac remodeling. Am. J. Physiol. Heart Circ. Physiol. 293, H1308-H1314 (2007).
    • (2007) Am. J. Physiol. Heart Circ. Physiol. , vol.293
    • Singla, D.K.1    Lyons, G.E.2    Kamp, T.J.3
  • 60
    • 34250316051 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development
    • S. Agrawal, M. Febbraio, E. Podrez, M. K. Cathcart, G. R. Stark, G. M. Chisolm, Signal transducer and activator of transcription 1 is required for optimal foam cell formation and atherosclerotic lesion development. Circulation 115, 2939-2947 (2007).
    • (2007) Circulation , vol.115 , pp. 2939-2947
    • Agrawal, S.1    Febbraio, M.2    Podrez, E.3    Cathcart, M.K.4    Stark, G.R.5    Chisolm, G.M.6
  • 62
    • 0033597952 scopus 로고    scopus 로고
    • Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation
    • K. Iiyama, L. Hajra, M. Iiyama, H. Li, M. DiChiara, B. D. Medoff, M. I. Cybulsky, Patterns of vascular cell adhesion molecule-1 and intercellular adhesion molecule-1 expression in rabbit and mouse atherosclerotic lesions and at sites predisposed to lesion formation. Circ. Res. 85, 199-207 (1999).
    • (1999) Circ. Res. , vol.85 , pp. 199-207
    • Iiyama, K.1    Hajra, L.2    Iiyama, M.3    Li, H.4    Dichiara, M.5    Medoff, B.D.6    Cybulsky, M.I.7
  • 63
    • 0344043305 scopus 로고    scopus 로고
    • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
    • F. J. Miller Jr., D. D. Gutterman, C. D. Rios, D. D. Heistad, B. L. Davidson, Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ. Res. 82, 1298-1305 (1998).
    • (1998) Circ. Res. , vol.82 , pp. 1298-1305
    • Miller Jr., F.J.1    Gutterman, D.D.2    Rios, C.D.3    Heistad, D.D.4    Davidson, B.L.5
  • 65
    • 57349164418 scopus 로고    scopus 로고
    • Ischemic preconditioning-Induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency
    • Z. P. Cai, Z. Shen, L. Van Kaer, L. C. Becker, Ischemic preconditioning-Induced cardioprotection is lost in mice with immunoproteasome subunit low molecular mass polypeptide-2 deficiency. FASEB J. 22, 4248-4257 (2008).
    • (2008) FASEB J. , vol.22 , pp. 4248-4257
    • Cai, Z.P.1    Shen, Z.2    Van Kaer, L.3    Becker, L.C.4


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