Knockout of the aryl hydrocarbon receptor results in distinct hepatic and renal phenotypes in rats and mice

Toxicology and Applied Pharmacology

Volumn 272, Issue 2, 2013, Pages 503-518

  Harrill, Joshua A ^a   Hukkanen, Renee R ^b   Lawson, Marie ^b   Martin, Greg ^b   Gilger, Brian ^c   Soldatow, Valerie ^d   LeCluyse, Edward L ^a   Budinsky, Robert A ^b   Rowlands, J Craig ^b   Thomas, Russell S ^a  

^a RTP   (United States)

^b DOW CHEMICAL COMPANY   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Aryl hydrocarbon receptor knockout mouse; Aryl hydrocarbon receptor knockout rat; Comparison; Kidney; Liver; Tissue phenotypes

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 1B1; ZINC FINGER NUCLEASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DUCTUS VENOSUS; EXON; FEMALE; GENE MUTATION; HYDRONEPHROSIS; HYDROURETER; LIVER FUNCTION; LIVER WEIGHT; MALE; MOUSE; NONHUMAN; PHENOTYPE; PROTEIN EXPRESSION; RAT; URINARY TRACT;

Γ-GLUTAMYL TRANSPEPTIDASE; 2,3,7,8-TETRACHOLORODIBENZO-P-DIOXIN; 90-KDA HEAT SHOCK PROTEIN; AHR; AHR-KO; AHRR; AIP; ALANINE AMINOTRANSFERASE; ALB; ALKALINE PHOSPHATASE; ALP; ALT; ARNT; ARYL HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN; ARYL HYDROCARBON RECEPTOR KNOCKOUT; ARYL HYDROCARBON RECEPTOR KNOCKOUT MOUSE; ARYL HYDROCARBON RECEPTOR KNOCKOUT RAT; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; ARYL HYDROCARBON RECEPTOR REPRESSOR; ASPARTATE AMINOTRANSFERASE; AST; BAS; BASOPHILS; BILI; BLO; BLOOD UREA NITROGEN; BUN; CA; CALCIUM; CALCIUM OXALATE CRYSTALS; CAOX; CBC; CHLORIDE; CHOL; CHOLESTEROL; CL; COMPARISON; COMPLETE BLOOD COUNT; CREA; CREATININE; CYP1A1; CYP1A2; CYP1B1; CYTOCHROME P450, FAMILY 1, SUBFAMILY A, POLYPEPTIDE 1; CYTOCHROME P450, FAMILY 1, SUBFAMILY A, POLYPEPTIDE 2; CYTOCHROME P450, FAMILY 1, SUBFAMILY B, POLYPEPTIDE 1; DIOXIN-RESPONSE ELEMENT; DRE; EOS; EOSINOPHILS; EPI; GGT; GLOB; GLUC; HANK'S BALANCED SALT SOLUTION; HB; HBSS; HCT; HEMATOCRIT; HEMOGLOBIN; HSP90; K; KET; KIDNEY; LD(50); LEUC; LEUKOCYTES; LIVER; LYM; LYMPHOCYTES; MCH; MCHC; MCV; MEAN CORPUSCULAR HEMOGLOBIN; MEAN CORPUSCULAR HEMOGLOBIN CONCENTRATION; MEAN CORPUSCULAR VOLUME; MEDIAN LETHAL DOSE; MON; MONOCYTES; NA; NEU; NEUTROPHILS; PHOS; PHOSPHORUS; PLATELETS; PLT; POTASSIUM; RBC; RED BLOOD CELLS; SERUM ALBUMIN; SERUM GLOBULIN; SERUM GLUCOSE; SG; SODIUM; TBA; TBIL; TCDD; TISSUE PHENOTYPES; TOTAL BILE ACID; TOTAL BILIRUBIN; TOTAL SERUM PROTEIN; TOTAL WHITE BLOOD CELLS; TP; TPHO; TRIG; TRIGLYCERIDES; TRIPLE PHOSPHATE CRYSTALS; UBIL; UGLU; ULEUC; UPRO; URBC; URINE BILINOGEN; URINE BILIRUBIN; URINE EPITHELIAL CELLS; URINE GLUCOSE; URINE KETONES; URINE LEUKOCYTES; URINE OCCULT BLOOD; URINE PROTEIN; URINE RED BLOOD CELLS; URINE SPECIFIC GRAVITY; UWBC; WILD-TYPE; WT; ZFN; ZINC FINGER NUCLEASE;

ANIMALS; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; KIDNEY; LIVER; MICE; MICE, KNOCKOUT; ORGAN SIZE; PHENOTYPE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ARYL HYDROCARBON; SPECIES SPECIFICITY; TETRACHLORODIBENZODIOXIN;

EID: 84884144343     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.06.024     Document Type: Article

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