Nucleocytoplasmic shuttling of the aryl hydrocarbon receptor

Journal of Biochemistry

Volumn 127, Issue 3, 2000, Pages 503-509

  Ikuta, Togo ^c   Tachibana, Taro ^a   Watanabe, Junko ^c   Yoshida, Minoru ^b   Yoneda, Yoshihiro ^a   Kawajiri, Kaname ^c  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c NONE

Author keywords

AhR nuclear translocator (ARNT); Aryl hydrocarbon (TCDD) receptor; CYP1A1; Leptomycin B.; Nucleocytoplasmic shuttling

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CELL PROTEIN; GLUTATHIONE TRANSFERASE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LEPTOMYCIN B;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; HUMAN; HUMAN CELL; INTRACELLULAR TRANSPORT; NONHUMAN; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; TRANSCRIPTION REGULATION; TRANSPORT KINETICS;

ANIMALIA; NES;

EID: 0034070135     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a022633     Document Type: Article

References (40)

1. Poland, A. and Knutson, J.C. (1982) 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554
2. Safe, S.H. (1986) Comparative toxicology and mechanism of action of polychlorinated dibenzo-p-dioxins and dibenzofurans. Annu. Rev. Pharmacol. Toxicol. 26, 371-399
3. Schmidt, J.V. and Bradfield, C.A. (1996) Ah receptor signaling pathways. Annu. Rev. Cell Dev. Biol. 12, 55-89
4. Fernandez-Salguero, P.M., Hilbert, D.M., Rudikoff, S., Ward, J.M., and Gonzalez, F.J. (1996) Aryl hydrocarbon receptor-deficient mice are resistant to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced toxicity. Toxicol. Appl. Pharmacol. 140, 173-179
5. Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T.N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., and Fujii-Kuriyama, Y. (1997) Loss of tetragenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking Ah(dioxin) receptor. Genes Cell 2, 645-654
6. Matsushita, N., Sogawa, K., Ema, M., Yoshida, A., and Fujii-Kuriyama, Y. (1993) A factor binding to the xenobiotic responsive element (XRE) of P-450 1A1 gene consists of at least two helix-loop-helix proteins, Ah receptor and ARNT. J. Biol. Chem. 268, 21002-21006
7. Ikuta, T., Eguchi, H., Tachibana, T., Yoneda, Y., and Kawajiri, K. (1998) Nuclear localization and export signals of the human aryl hydrocarbon receptor. J. Biol. Chem. 273, 2895-2904
8. Perdew, G. H. (1988) Association of the Ah receptor with the 90-kDa heat shock protein. J. Biol. Chem. 263, 13802-13805
9. Pongratz, I., Mason, G.G.F., and Poellinger, L. (1992) Dual roles of the 90-kDa heat shock protein hsp90 in modulating functional activities of the dioxin receptor. J. Biol. Chem. 267, 13728-13734
10. Carver, L.A. and Bradfield, C.A. (1997) Ligand-dependent interaction of the arylhydrocarbon receptor with a novel immunophilin homolog in vivo. J. Biol. Chem. 272, 11452-11456
11. Pollenz, R.S., Sattler, C.A., and Poland, A. (1994) The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localization in Hepa 1c1c7 cell by immunofluorescence microscopy. Mol. Pharmacol. 45, 428-438
12. Lees, M.J. and Whitelaw, M.L. (1999) Multiple roles of ligand in transforming the dioxin receptor to an active basic helix-loop-helix/PAS transcription factor complex with the nuclear protein ARNT. Mol. Cell. Biol. 19, 5811-5822
13. Bacsi, S.G. and Hankinson, O. (1996) Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions. J. Biol. Chem. 271, 8843-8850
14. Dong, L., Ma, Q., and Whitlock, J.P. (1996) DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced CYP1A1 transcription in vivo. J. Biol. Chem. 271, 7942-7948
15. Eguchi, H., Ikuta, T., Tachibana, T., Yoneda, Y., and Kawajiri, K. (1997) A nuclear localization signal of human ARNT/HIF-1β is a novel bipartite type recognized by the two components of nuclear pore-targeting complex. J. Biol. Chem. 272, 17640-17647
16. Swanson, H.I., Chan, W., and Bradfield, C.A. (1995) DNA binding and pairing rules of the Ah receptor, ARNT. and SIM proteins. J. Biol. Chem. 270, 26292-26302
17. Wen, W., Meinkoth, J.L., Tsien, R.Y., and Taylor, S.S. (1995) Identification of a signal for rapid export of proteins from the nucleus. Cell 82, 463-473
18. Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I.W. (1997) CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90, 1051-1060
19. Fukuda, M., Asano, S., Nakamura, T., Adachi, M., Yoshida, M., Yanagida, M., and Nishida, E. (1997) CRM1 is responsible for intracellular transport mediated by the nuclear export signal. Nature 390, 308-311
20. Ossareh-Nazari, B., Bachelerie, F., and Dargemont, C. (1997) Evidence for a role of CRM1 in signal-mediated nuclear protein export. Science 278, 141-144
21. Tachibana, T., Imamoto, N., Seino, H., Nishimoto, T., and Yoneda, Y. (1994) Loss of RCC1 leads to suppression of nuclear protein import in living cells. J. Biol Chem. 269, 24542-24545
22. Kudo, N., Khochbin, S., Nishi, K., Kitano, K., Yanagida, M., Yoshida, M., and Horinouchi, S. (1997) Molecular cloning and cell cycle-dependent expression of mammalian CRM1, a protein involved in nuclear export of proteins. J. Biol. Chem. 272, 29742-29751
23. Kawajiri, K., Watanabe, J., Gotoh, O., Tagashira, Y., Sogawa, K., and Fujii-Kuriyama, Y. (1986) Structure and drug inducibility of the human cytochrome P450c gene. Eur. J. Biochem. 159, 219-225
24. Watanabe, J., Hayashi, S-I., and Kawajiri, K. (1994) Different regulation and expression of the human CYP2E1 gene due to the Rsal polymorphism in the 5′-flanking region. J. Biochem. 116, 321-326
25. Nigg, E.A. (1997) Nucleocytoplasmic transport: signals, mechanisms and regulation. Nature 386, 779-787
26. Kudo, N., Wolff, B., Sekimoto, T., Schreiner, E.P., Yoneda, Y., Yanagida, M., Horinouchi, S., and Yoshida, M. (1998) Leptomycin B inhibition of signal-mediated nuclear export by direct binding to CRM1. Exp. Cell Res. 242, 540-547
27. Zhu, J. and McKeon, F. (1999) NF-AT activation requires suppression of Crm1-dependent export by calcineurin. Nature 398, 256-260
28. Burhach, K.M., Poland, A., and Bradfield, C.A. (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc. Natl. Acad. Sci. USA 89, 8185-8189
29. Ema, M., Sogawa, K., Watanabe, N., Chujo, Y., Matsusita, N., Gotoh, O., Funae, Y., and Fujii-Kuriyama, Y. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem. Biophys. Res. Commun. 184, 246-253
30. Freedman, D.A. and Levine, A.J. (1998) Nuclear export is required for degradation of endogenous p53 by MDM2 and human papilloma virus E6. Mol. Cell. Biol. 18, 7288-7293
31. Rodoriguez, M.S., Thompson, J., Hay. R.T., and Dargemont, C. (1999) Nuclear retention of IκBα protects it from signal-induced degradation and inhibits nuclear factor κB transcriptional activation. J. Biol Chem. 274, 9108-9115
32. Kudo, N., Taoka, H., Toda, T., Yoshida, M., and Horinouchi, S. (1999) A novel nuclear export signal sensitive to oxidative stress in the fission yeast transcription factor pap1. J. Biol. Chem. 274, 15151-15158
33. Chang, C. and Puga, A. (1998) Constitutive activation of the aromatic hydrocarbon receptor. Mol. Cell. Biol. 18, 525-535
34. Stommel, J.M., Marchenko, N.D., Jimenez, G.S., Moll, U.M., Hope, T.J., and Wahl, G.M. (1999) A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J. 18, 1660-1672
35. Fukunaga, B.N., Probst, M.R., Reisz-Porszasz, S., and Hankin-son, O. (1995) Identification of functional domains of the aryl hydrocarbon receptor. J. Biol Chem. 270, 29270-29278
36. Mimura, J., Ema, M., Sogawa, K., and Fujii-Kuriyama, Y. (1999) Identification of a novel mechanism of regulation of Ah (dioxin) receptor function. Genes Dev. 13, 20-25
37. Abbott, B.D., Birnbaum, L.S., and Perdew, G.H. (1995) Developmental expression of two members of a new class of transcription factors: I. Expression of aryl hydrocarbon receptor in the C57BL/6N mouse embryo. Dev. Dynamics 204, 133-143
38. Hayashi, S-I., Okabe-Kado, J., Honma, Y., and Kawajiri, K. (1995) Expression of Ah receptor (TCDD receptor) during human monocytic differentiation. Carcinogenesis 16, 1403-1409
39. Fernandez-Salguero, P., Pineau, T., Hilbert, D.M., McPhail, T., Lee, S.S.T., Kimura, S., Nebert, D.W., Rudikoff, S., Ward, J.M., and Gonzalez, F.J. (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268, 722-726
40. FitzGerald, C.T., Fernandez-Salguero, P., Gonzalez, F.J., Nebert, D.W., and Puga, A. (1996) Differential regulation of mouse Ah receptor gene expression in cell lines of different tissue origins. Arch. Biochem. Biophys. 333, 170-178