High throughput screening for the design and optimization of chromatographic processes - Miniaturization, automation and parallelization of breakthrough and elution studies

Chemical Engineering and Technology

Volumn 31, Issue 6, 2008, Pages 893-903

  Wiendahl, Matthias ^a   Wierling, Pierre Schulze ^b   Nielsen, Jacob ^a   Fomsgaard, Dorthe ^a   Krarup, Christensen Janus ^a   Staby, Arne ^a   Hubbuch, Jürgen ^c  

^a NOVO NORDISK A S   (Denmark)

^b BAYER AG   (Germany)

^c UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Chromatography; Human growth hormone; Insulin analogue; Process development; Proteins

Indexed keywords

BODY FLUIDS; CHROMATOGRAPHIC ANALYSIS; EXPERIMENTS; GEL PERMEATION CHROMATOGRAPHY; ION EXCHANGE; ION EXCHANGE RESINS; RESINS; THROUGHPUT;

CHROMATOGRAPHIC PROCESSES; CHROMATOGRAPHY; DESIGN AND OPTIMIZATION; ELUTION CURVES; ELUTION EXPERIMENTS; FRONTAL ANALYSIS; HIGH THROUGHPUT SCREENING; HUMAN GROWTH HORMONE; INSULIN ANALOGUE; LIPOLASE; LIQUID HANDLING; PARALLELIZATION; PROCESS DEVELOPMENT; PROTEIN MIXTURES; PROTEINS; REFERENCE DATA; SEPHAROSE; STATION ARY PHASES;

ELECTRON BEAM LITHOGRAPHY;

EID: 46049105929     PISSN: 09307516     EISSN: 15214125     Source Type: Journal    
DOI: 10.1002/ceat.200800167     Document Type: Article

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