A novel method to evaluate protein solubility using a high throughput screening approach

Chemical Engineering Science

Volumn 64, Issue 17, 2009, Pages 3778-3788

  Wiendahl, Matthias ^a,b   Völker, Christiane ^b   Husemann, Ilka ^b   Krarup, Janus ^a   Staby, Arne ^a   Scholl, Stephan ^c   Hubbuch, Jürgen ^b,d  

^a NOVO NORDISK A S   (Denmark)

^b FORSCHUNGSZENTRUM JÜLICH   (Germany)

^c TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

^d UNIVERSITY OF KARLSRUHE   (Germany)

Author keywords

Evaporation; High throughput screening; Insulin; Precipitation; Process development; Protein solubility

Indexed keywords

CONCENTRATION OF; DOWNSTREAM-PROCESSING; HIGH THROUGHPUT; HIGH THROUGHPUT SCREENING; KEY PARAMETERS; KINETIC EFFECT; LIQUID HANDLING; NOVEL METHODS; PRECIPITATION; PROCESS DEVELOPMENT; PROTEIN CRYSTAL; PROTEIN SOLUBILITY; SAMPLE CONCENTRATION; SOLUBILITY CURVE; SOLUBILITY LIMITS; STATE ANALYSIS; TIME FRAME; TURBIDITY MEASUREMENTS;

EVAPORATION; INSULIN; PHASE DIAGRAMS; SOLUBILITY; THROUGHPUT; TURBIDITY; VAPORS;

TERNARY SYSTEMS;

EID: 67650729377     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2009.05.029     Document Type: Article

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