Model-integrated process development demonstrated on the optimization of a robotic cation exchange step

Chemical Engineering Science

Volumn 76, Issue , 2012, Pages 129-139

  Osberghaus, A ^a   Drechsel, K ^a   Hansen, S ^a   Hepbildikler, S K ^b   Nath, S ^b   Haindl, M ^b   von Lieres, E ^c   Hubbuch, J ^a  

^a KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^b ROCHE DIAGNOSTICS GMBH   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

Author keywords

Chromatography; Downstream processing; Mathematical modeling; Optimization; Scale up; Simulation

Indexed keywords

CATION EXCHANGES; CYTOCHROME C; DESIGNED EXPERIMENTS; DOWNSTREAM-PROCESSING; ELUTION GRADIENT; HIGH PRECISION; HIGH-THROUGHPUT SCREENING; MATHEMATICAL MODELING; MECHANISTIC MODELING; MULTI-COMPONENT SEPARATION; OPTIMAL SETTING; PEAK RESOLUTION; PERFORMANCE VARIABLES; PH CONDITION; PROCESS DEVELOPMENT; RETENTION TIME; RIBONUCLEASE A; ROBUSTNESS ANALYSIS; SCALE-UP; SIMULATION;

CHROMATOGRAPHY; FORECASTING; GEL PERMEATION CHROMATOGRAPHY; SEPARATION;

OPTIMIZATION;

EID: 84860534665     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2012.04.004     Document Type: Article

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