메뉴 건너뛰기




Volumn 10, Issue 1, 2013, Pages

Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes

(22)  Mann, Jaclyn K a   Byakwaga, Helen b,c   Kuang, Xiaomei T d   Le, Anh Q d   Brumme, Chanson J e   Mwimanzi, Philip d   Omarjee, Saleha a   Martin, Eric d,e   Lee, Guinevere Q e   Baraki, Bemuluyigza d   Danroth, Ryan d   McCloskey, Rosemary d,e   Muzoora, Conrad b   Bangsberg, David R f   Hunt, Peter W c   Goulder, Philip J R g   Walker, Bruce D f,h,i   Harrigan, P R e   Martin, Jeff N c   Ndung'u, Thumbi a,h,j   more..


Author keywords

CD4; HIV AIDS; HLA class I; Nef; Pathogenesis; Viral diversity

Indexed keywords

CD4 ANTIGEN; HLA ANTIGEN CLASS 1; NEF PROTEIN;

EID: 84883810916     PISSN: None     EISSN: 17424690     Source Type: Journal    
DOI: 10.1186/1742-4690-10-100     Document Type: Article
Times cited : (67)

References (64)
  • 1
    • 79957465296 scopus 로고    scopus 로고
    • Mechanisms of HIV-1 Nef Function and Intracellular Signaling
    • 10.1007/s11481-011-9262-y, 3777542, 21336563
    • Foster JL, Denial SJ, Temple BRS, Garcia JV. Mechanisms of HIV-1 Nef Function and Intracellular Signaling. J Neuroimmune Pharmacol 2011, 6:230-246. 10.1007/s11481-011-9262-y, 3777542, 21336563.
    • (2011) J Neuroimmune Pharmacol , vol.6 , pp. 230-246
    • Foster, J.L.1    Denial, S.J.2    Temple, B.R.S.3    Garcia, J.V.4
  • 2
    • 0034894379 scopus 로고    scopus 로고
    • Structure-function relationships in HIV-1 Nef
    • Geyer M, Fackler OT, Peterlin BM. Structure-function relationships in HIV-1 Nef. EMBO reports 2001, 21(7):580-585.
    • (2001) EMBO reports , vol.21 , Issue.7 , pp. 580-585
    • Geyer, M.1    Fackler, O.T.2    Peterlin, B.M.3
  • 3
    • 84867015737 scopus 로고    scopus 로고
    • Human leukocyte antigen (HLA) class I downregulation by human immunodeficiency virus type I negative factor (HIV-1 Nef): what might we learn from natural sequence variants?
    • 10.3390/v4091711, 3499827, 23170180
    • Mwimanzi P, Markle TJ, Ueno T, Brockman MA. Human leukocyte antigen (HLA) class I downregulation by human immunodeficiency virus type I negative factor (HIV-1 Nef): what might we learn from natural sequence variants?. Viruses 2012, 4:1711-1730. 10.3390/v4091711, 3499827, 23170180.
    • (2012) Viruses , vol.4 , pp. 1711-1730
    • Mwimanzi, P.1    Markle, T.J.2    Ueno, T.3    Brockman, M.A.4
  • 4
    • 53549119688 scopus 로고    scopus 로고
    • HIV-1 Nef: at the crossroads
    • doi: 10.1186/1742-4690-1185-1184, 10.1186/1742-4690-5-84, 2563024, 18808677
    • Foster JL, Garcia JV. HIV-1 Nef: at the crossroads. Retrovirology 2008, 5:84. doi: 10.1186/1742-4690-1185-1184, 10.1186/1742-4690-5-84, 2563024, 18808677.
    • (2008) Retrovirology , vol.5 , pp. 84
    • Foster, J.L.1    Garcia, J.V.2
  • 5
    • 0033578016 scopus 로고    scopus 로고
    • Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein
    • 10.1016/S0960-9822(99)80283-8, 10375525
    • Ross TM, Oran AE, Cullen BR. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr Biol 1999, 9:613-621. 10.1016/S0960-9822(99)80283-8, 10375525.
    • (1999) Curr Biol , vol.9 , pp. 613-621
    • Ross, T.M.1    Oran, A.E.2    Cullen, B.R.3
  • 6
    • 0036231461 scopus 로고    scopus 로고
    • Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes
    • 10.1128/JVI.76.9.4625-4633.2002, 155097, 11932428
    • Lundquist CA, Tobiume M, Zhou J, Unutmaz D, Aiken C. Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes. J Virol 2002, 76(9):4625-4633. 10.1128/JVI.76.9.4625-4633.2002, 155097, 11932428.
    • (2002) J Virol , vol.76 , Issue.9 , pp. 4625-4633
    • Lundquist, C.A.1    Tobiume, M.2    Zhou, J.3    Unutmaz, D.4    Aiken, C.5
  • 7
    • 0141780822 scopus 로고    scopus 로고
    • Enhanced CD4 downmodulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
    • 10.1074/jbc.M303679200, 12816953
    • Argañaraz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J. Enhanced CD4 downmodulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication. J Biol Chem 2003, 278(36):33912-33919. 10.1074/jbc.M303679200, 12816953.
    • (2003) J Biol Chem , vol.278 , Issue.36 , pp. 33912-33919
    • Argañaraz, E.R.1    Schindler, M.2    Kirchhoff, F.3    Cortes, M.J.4    Lama, J.5
  • 8
    • 0033151621 scopus 로고    scopus 로고
    • The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells
    • 10.1016/S1074-7613(00)80065-5, 10403641
    • Cohen GB, Gandhi RT, Davis DM, Mandelboim O, Chen BK, Strominger JL, Baltimore D. The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity 1999, 10(6):661-671. 10.1016/S1074-7613(00)80065-5, 10403641.
    • (1999) Immunity , vol.10 , Issue.6 , pp. 661-671
    • Cohen, G.B.1    Gandhi, R.T.2    Davis, D.M.3    Mandelboim, O.4    Chen, B.K.5    Strominger, J.L.6    Baltimore, D.7
  • 9
    • 0025743306 scopus 로고
    • Importance of the nef gene for maintenance of high virus loads and for development of AIDS
    • 10.1016/0092-8674(91)90097-I, 2032289
    • Kestler HW, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD, Desrosiers RC. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 1991, 65(4):651-662. 10.1016/0092-8674(91)90097-I, 2032289.
    • (1991) Cell , vol.65 , Issue.4 , pp. 651-662
    • Kestler, H.W.1    Ringler, D.J.2    Mori, K.3    Panicali, D.L.4    Sehgal, P.K.5    Daniel, M.D.6    Desrosiers, R.C.7
  • 11
    • 0028835788 scopus 로고
    • Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection
    • 10.1056/NEJM199501263320405, 7808489
    • Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC. Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection. N Engl J Med 1995, 332(4):228-232. 10.1056/NEJM199501263320405, 7808489.
    • (1995) N Engl J Med , vol.332 , Issue.4 , pp. 228-232
    • Kirchhoff, F.1    Greenough, T.C.2    Brettler, D.B.3    Sullivan, J.L.4    Desrosiers, R.C.5
  • 12
    • 50149101954 scopus 로고    scopus 로고
    • Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes
    • 10.1128/JVI.00535-08, 2519665, 18562530
    • Miura T, Brockman MA, Brumme CJ, Brumme ZL, Carlson JM, Pereyra F, Trocha A, Addo MM, Block BL, Rothchild AC, et al. Genetic characterization of human immunodeficiency virus type 1 in elite controllers: lack of gross genetic defects or common amino acid changes. J Virol 2008, 82(17):8422-8430. 10.1128/JVI.00535-08, 2519665, 18562530.
    • (2008) J Virol , vol.82 , Issue.17 , pp. 8422-8430
    • Miura, T.1    Brockman, M.A.2    Brumme, C.J.3    Brumme, Z.L.4    Carlson, J.M.5    Pereyra, F.6    Trocha, A.7    Addo, M.M.8    Block, B.L.9    Rothchild, A.C.10
  • 13
    • 84866993309 scopus 로고    scopus 로고
    • Genetic and functional analysis of HIV type 1 nef gene derived from long-term nonprogressor children: association of attenuated variants with slow progression to pediatric AIDS
    • 10.1089/aid.2012.0020, 22583022
    • Corró G, Rocco CA, De Candia C, Catano G, Turk G, Mangano A, Aulicino PC, Bologna R, Sen L. Genetic and functional analysis of HIV type 1 nef gene derived from long-term nonprogressor children: association of attenuated variants with slow progression to pediatric AIDS. AIDS Res Hum Retroviruses 2012, 28(12):1617-1626. 10.1089/aid.2012.0020, 22583022.
    • (2012) AIDS Res Hum Retroviruses , vol.28 , Issue.12 , pp. 1617-1626
    • Corró, G.1    Rocco, C.A.2    De Candia, C.3    Catano, G.4    Turk, G.5    Mangano, A.6    Aulicino, P.C.7    Bologna, R.8    Sen, L.9
  • 14
    • 0028908766 scopus 로고
    • Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection
    • 188552, 7983771
    • Huang Y, Zhang L, Ho DD. Characterization of nef sequences in long-term survivors of human immunodeficiency virus type 1 infection. J Virol 1995, 69:93-100. 188552, 7983771.
    • (1995) J Virol , vol.69 , pp. 93-100
    • Huang, Y.1    Zhang, L.2    Ho, D.D.3
  • 18
    • 0034816492 scopus 로고    scopus 로고
    • Differential effects of primary human immunodeficiency virus type 1 nef sequences on downregulation of CD4 and MHC class I
    • 10.1006/bbrc.2001.5026, 11396948
    • Yoon K, Jeong JG, Yoon H, Lee JS, Kim S. Differential effects of primary human immunodeficiency virus type 1 nef sequences on downregulation of CD4 and MHC class I. Biochem Biophys Res Commun 2001, 284(3):638-642. 10.1006/bbrc.2001.5026, 11396948.
    • (2001) Biochem Biophys Res Commun , vol.284 , Issue.3 , pp. 638-642
    • Yoon, K.1    Jeong, J.G.2    Yoon, H.3    Lee, J.S.4    Kim, S.5
  • 19
    • 65449123927 scopus 로고    scopus 로고
    • Single Nef proteins from HIV type 1 subtypes C and F fail to upregulate invariant chain cell surface expression but are active for other functions
    • 10.1089/aid.2008.0132, 19327048
    • Turk G, Gundlach S, Carobene M, Schindler M, Salomon H, Benaroch P. Single Nef proteins from HIV type 1 subtypes C and F fail to upregulate invariant chain cell surface expression but are active for other functions. AIDS Res Hum Retroviruses 2009, 25(3):285-296. 10.1089/aid.2008.0132, 19327048.
    • (2009) AIDS Res Hum Retroviruses , vol.25 , Issue.3 , pp. 285-296
    • Turk, G.1    Gundlach, S.2    Carobene, M.3    Schindler, M.4    Salomon, H.5    Benaroch, P.6
  • 20
    • 84860201476 scopus 로고    scopus 로고
    • Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function
    • 10.1186/1742-4690-9-34, 3476393, 22537596
    • Meuwissen PJ, Stolp B, Iannucci V, Vermeire J, Naessens E, Saksela K, Geyer M, Vanham G, Arien KK, Fackler OT, et al. Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function. Retrovirology 2012, 9:34. 10.1186/1742-4690-9-34, 3476393, 22537596.
    • (2012) Retrovirology , vol.9 , pp. 34
    • Meuwissen, P.J.1    Stolp, B.2    Iannucci, V.3    Vermeire, J.4    Naessens, E.5    Saksela, K.6    Geyer, M.7    Vanham, G.8    Arien, K.K.9    Fackler, O.T.10
  • 21
    • 66149154716 scopus 로고    scopus 로고
    • CCR5- and CXCR4-tropic subtype C HIV-1 isolates have lower pathogenic fitness as compared to the other dominant group M subtypes: Implications for the epidemic
    • 10.1128/JVI.02051-08, 2681953, 19297481
    • Abraha A, Nankya IL, Gibson R, Demers K, Tebit DM, Johnston E, Katzenstein D, Siddiqui A, Herrera C, Fischetti L, et al. CCR5- and CXCR4-tropic subtype C HIV-1 isolates have lower pathogenic fitness as compared to the other dominant group M subtypes: Implications for the epidemic. J Virol 2009, 83(11):5592-5605. 10.1128/JVI.02051-08, 2681953, 19297481.
    • (2009) J Virol , vol.83 , Issue.11 , pp. 5592-5605
    • Abraha, A.1    Nankya, I.L.2    Gibson, R.3    Demers, K.4    Tebit, D.M.5    Johnston, E.6    Katzenstein, D.7    Siddiqui, A.8    Herrera, C.9    Fischetti, L.10
  • 22
    • 42049086982 scopus 로고    scopus 로고
    • The challenge of HIV-1 subtype diversity
    • 10.1056/NEJMra0706737, 2614444, 18403767
    • Taylor BS, Sobieszczyk ME, McCutchan FE, Hammer SM. The challenge of HIV-1 subtype diversity. N Engl J Med 2008, 358(15):1590-1602. 10.1056/NEJMra0706737, 2614444, 18403767.
    • (2008) N Engl J Med , vol.358 , Issue.15 , pp. 1590-1602
    • Taylor, B.S.1    Sobieszczyk, M.E.2    McCutchan, F.E.3    Hammer, S.M.4
  • 24
    • 4143100219 scopus 로고    scopus 로고
    • Preferential in-utero transmission of HIV-1 subtype C as compared to HIV-1 subtype A or D
    • 10.1097/01.aids.0000131392.68597.34, 15280773, Tanzanian Vitamin and HIV Study Group
    • Renjifo B, Gilbert P, Chaplin B, Msamanga G, Mwakagile D, Fawzi W, Essex M, . Tanzanian Vitamin and HIV Study Group Preferential in-utero transmission of HIV-1 subtype C as compared to HIV-1 subtype A or D. AIDS 2004, 18(12):1629-1636. 10.1097/01.aids.0000131392.68597.34, 15280773, Tanzanian Vitamin and HIV Study Group.
    • (2004) AIDS , vol.18 , Issue.12 , pp. 1629-1636
    • Renjifo, B.1    Gilbert, P.2    Chaplin, B.3    Msamanga, G.4    Mwakagile, D.5    Fawzi, W.6    Essex, M.7
  • 25
    • 0037223706 scopus 로고    scopus 로고
    • Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C
    • 10.1128/JVI.77.2.1021-1038.2003, 140829, 12502818
    • Ball SC, Abraha A, Collins KR, Marozsan AJ, Baird H, Quiñones-Mateu ME, Penn-Nicholson A, Murray M, Richard N, Lobritz M, et al. Comparing the ex vivo fitness of CCR5-tropic human immunodeficiency virus type 1 isolates of subtypes B and C. J Virol 2003, 77(2):1021-1038. 10.1128/JVI.77.2.1021-1038.2003, 140829, 12502818.
    • (2003) J Virol , vol.77 , Issue.2 , pp. 1021-1038
    • Ball, S.C.1    Abraha, A.2    Collins, K.R.3    Marozsan, A.J.4    Baird, H.5    Quiñones-Mateu, M.E.6    Penn-Nicholson, A.7    Murray, M.8    Richard, N.9    Lobritz, M.10
  • 26
    • 0035933060 scopus 로고    scopus 로고
    • Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes
    • 10.1073/pnas.111152698, 33422, 11353856
    • Velazquez-Campoy A, Todd MJ, Vega S, Freire E. Catalytic efficiency and vitality of HIV-1 proteases from African viral subtypes. Proc Natl Acad Sci USA 2001, 98(11):6062-6067. 10.1073/pnas.111152698, 33422, 11353856.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.11 , pp. 6062-6067
    • Velazquez-Campoy, A.1    Todd, M.J.2    Vega, S.3    Freire, E.4
  • 27
    • 77957744675 scopus 로고    scopus 로고
    • Subtype-associated differences in HIV-1 reverse transcription affect viral replication
    • 10.1186/1742-4690-7-85, 2964588, 20939905
    • Iordanskiy S, Waltke M, Feng Y, Wood C. Subtype-associated differences in HIV-1 reverse transcription affect viral replication. Retrovirology 2010, 7:85. 10.1186/1742-4690-7-85, 2964588, 20939905.
    • (2010) Retrovirology , vol.7 , pp. 85
    • Iordanskiy, S.1    Waltke, M.2    Feng, Y.3    Wood, C.4
  • 28
    • 78149246959 scopus 로고    scopus 로고
    • Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes
    • 10.1074/jbc.M110.173286, 2975159, 20833716
    • Iwabu Y, Kinomoto M, Tatsumi M, Fujita H, Shimura M, Tanaka Y, Ishizaka Y, Nolan D, Mallal S, Sata T, et al. Differential anti-APOBEC3G activity of HIV-1 Vif proteins derived from different subtypes. J Biol Chem 2010, 285(46):35350-35358. 10.1074/jbc.M110.173286, 2975159, 20833716.
    • (2010) J Biol Chem , vol.285 , Issue.46 , pp. 35350-35358
    • Iwabu, Y.1    Kinomoto, M.2    Tatsumi, M.3    Fujita, H.4    Shimura, M.5    Tanaka, Y.6    Ishizaka, Y.7    Nolan, D.8    Mallal, S.9    Sata, T.10
  • 29
    • 0034030611 scopus 로고    scopus 로고
    • Functional differences between the long terminal repeat transcriptional promoters of human immunodeficiency virus type 1 subtypes A through G
    • 10.1128/JVI.74.8.3740-3751.2000, 111883, 10729149
    • Jeeninga RE, Hoogenkamp M, Armand-Ugon M, de Baar M, Verhoef K, Berkhout B. Functional differences between the long terminal repeat transcriptional promoters of human immunodeficiency virus type 1 subtypes A through G. J Virol 2000, 74(8):3740-3751. 10.1128/JVI.74.8.3740-3751.2000, 111883, 10729149.
    • (2000) J Virol , vol.74 , Issue.8 , pp. 3740-3751
    • Jeeninga, R.E.1    Hoogenkamp, M.2    Armand-Ugon, M.3    de Baar, M.4    Verhoef, K.5    Berkhout, B.6
  • 30
    • 0032055774 scopus 로고    scopus 로고
    • Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules
    • 10.1016/S1074-7613(00)80553-1, 9586638
    • Le Gall S, Erdtmann L, Benichou S, Berlioz-Torrent C, Liu L, Benarous R, Heard JM, Schwartz O. Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules. Immunity 1998, 8(4):483-495. 10.1016/S1074-7613(00)80553-1, 9586638.
    • (1998) Immunity , vol.8 , Issue.4 , pp. 483-495
    • Le Gall, S.1    Erdtmann, L.2    Benichou, S.3    Berlioz-Torrent, C.4    Liu, L.5    Benarous, R.6    Heard, J.M.7    Schwartz, O.8
  • 31
    • 84865159572 scopus 로고    scopus 로고
    • HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated downregulation
    • 10.1073/pnas.1204199109, 3421200, 22826228
    • Rajapaksa US, Li D, Peng YC, McMichael AJ, Dong T, Xu XN. HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated downregulation. Proc Natl Acad Sci USA 2012, 109(33):13353-13358. 10.1073/pnas.1204199109, 3421200, 22826228.
    • (2012) Proc Natl Acad Sci USA , vol.109 , Issue.33 , pp. 13353-13358
    • Rajapaksa, U.S.1    Li, D.2    Peng, Y.C.3    McMichael, A.J.4    Dong, T.5    Xu, X.N.6
  • 33
    • 0035082266 scopus 로고    scopus 로고
    • Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS
    • 10.1128/JVI.75.8.3657-3665.2001, 114857, 11264355
    • Carl S, Greenough TC, Krumbiegel M, Greenberg M, Skowronski J, Sullivan JL, Kirchhoff F. Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS. J Virol 2001, 75(8):3657-3665. 10.1128/JVI.75.8.3657-3665.2001, 114857, 11264355.
    • (2001) J Virol , vol.75 , Issue.8 , pp. 3657-3665
    • Carl, S.1    Greenough, T.C.2    Krumbiegel, M.3    Greenberg, M.4    Skowronski, J.5    Sullivan, J.L.6    Kirchhoff, F.7
  • 34
    • 0037326239 scopus 로고    scopus 로고
    • Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance
    • 10.1093/jac/dkg079, 12562686
    • Spira S, Wainberg MA, Loemba H, Turner D, Brenner BG. Impact of clade diversity on HIV-1 virulence, antiretroviral drug sensitivity and drug resistance. J Antimicrob Chemother 2003, 51:229-240. 10.1093/jac/dkg079, 12562686.
    • (2003) J Antimicrob Chemother , vol.51 , pp. 229-240
    • Spira, S.1    Wainberg, M.A.2    Loemba, H.3    Turner, D.4    Brenner, B.G.5
  • 35
    • 50849129910 scopus 로고    scopus 로고
    • HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells
    • 10.1371/journal.ppat.1000131, 2515349, 18725938
    • Schaefer MR, Wonderlich ER, Roeth JF, Leonard JA, Collins KL. HIV-1 Nef targets MHC-I and CD4 for degradation via a final common beta-COP-dependent pathway in T cells. PLoS Pathog 2008, 4(8):e1000131. 10.1371/journal.ppat.1000131, 2515349, 18725938.
    • (2008) PLoS Pathog , vol.4 , Issue.8
    • Schaefer, M.R.1    Wonderlich, E.R.2    Roeth, J.F.3    Leonard, J.A.4    Collins, K.L.5
  • 36
    • 0033013962 scopus 로고    scopus 로고
    • Nef-induced CD4 and major histocompatibility complex class I (MHC-I) downregulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking
    • 104438, 9971776
    • Mangasarian A, Piguet V, Wang JK, Chen YL, Trono D. Nef-induced CD4 and major histocompatibility complex class I (MHC-I) downregulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking. J Virol 1999, 73(3):1964-1973. 104438, 9971776.
    • (1999) J Virol , vol.73 , Issue.3 , pp. 1964-1973
    • Mangasarian, A.1    Piguet, V.2    Wang, J.K.3    Chen, Y.L.4    Trono, D.5
  • 37
    • 84864133984 scopus 로고    scopus 로고
    • Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo
    • 10.1128/JVI.00878-12, 3416312, 22553319
    • Lewis MJ, Lee P, Ng HL, Yang OO. Immune selection in vitro reveals human immunodeficiency virus type 1 Nef sequence motifs important for its immune evasion function in vivo. J Virol 2012, 86(13):7126-7135. 10.1128/JVI.00878-12, 3416312, 22553319.
    • (2012) J Virol , vol.86 , Issue.13 , pp. 7126-7135
    • Lewis, M.J.1    Lee, P.2    Ng, H.L.3    Yang, O.O.4
  • 38
    • 0037223712 scopus 로고    scopus 로고
    • Proline 78 is crucial for human immunodeficiency virus type 1 Nef to downregulate class I human leukocyte antigen
    • 10.1128/JVI.77.2.1589-1594.2003, 140770, 12502873
    • Yamada T, Kaji N, Odawara T, Chiba J, Iwamoto A, Kitamura Y. Proline 78 is crucial for human immunodeficiency virus type 1 Nef to downregulate class I human leukocyte antigen. J Virol 2003, 77(2):1589-1594. 10.1128/JVI.77.2.1589-1594.2003, 140770, 12502873.
    • (2003) J Virol , vol.77 , Issue.2 , pp. 1589-1594
    • Yamada, T.1    Kaji, N.2    Odawara, T.3    Chiba, J.4    Iwamoto, A.5    Kitamura, Y.6
  • 39
    • 84863674566 scopus 로고    scopus 로고
    • Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef
    • 10.1038/nsmb.2328, 3407041, 22705789
    • Jia X, Singh R, Homann S, Yang H, Guatelli J, Xiong Y. Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef. Nat Struct Mol Biol 2012, 19(7):701-706. 10.1038/nsmb.2328, 3407041, 22705789.
    • (2012) Nat Struct Mol Biol , vol.19 , Issue.7 , pp. 701-706
    • Jia, X.1    Singh, R.2    Homann, S.3    Yang, H.4    Guatelli, J.5    Xiong, Y.6
  • 41
    • 0032530773 scopus 로고    scopus 로고
    • Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 downregulation and optimal viral infectivity
    • 10.1073/pnas.95.19.11229, 21624, 9736718
    • Craig HM, Pandori MW, Guatelli JC. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 downregulation and optimal viral infectivity. Proc Natl Acad Sci USA 1998, 95(19):11229-11234. 10.1073/pnas.95.19.11229, 21624, 9736718.
    • (1998) Proc Natl Acad Sci USA , vol.95 , Issue.19 , pp. 11229-11234
    • Craig, H.M.1    Pandori, M.W.2    Guatelli, J.C.3
  • 42
    • 0034001233 scopus 로고    scopus 로고
    • Nef-induced major histocompatibility complex class I downregulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 downregulation
    • 10.1128/JVI.74.6.2907-2912.2000, 111784, 10684310
    • Akari H, Arold S, Fukumori T, Okazaki T, Strebel K, Adachi A. Nef-induced major histocompatibility complex class I downregulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 downregulation. J Virol 2000, 74(6):2907-2912. 10.1128/JVI.74.6.2907-2912.2000, 111784, 10684310.
    • (2000) J Virol , vol.74 , Issue.6 , pp. 2907-2912
    • Akari, H.1    Arold, S.2    Fukumori, T.3    Okazaki, T.4    Strebel, K.5    Adachi, A.6
  • 43
    • 84861627468 scopus 로고    scopus 로고
    • Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    • 10.1186/1742-4690-9-47, 3464899, 22651890
    • Kuo LS, Baugh LL, Denial SJ, Watkins RL, Liu M, Garcia JV, Foster JL. Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix. Retrovirology 2012, 9:47. 10.1186/1742-4690-9-47, 3464899, 22651890.
    • (2012) Retrovirology , vol.9 , pp. 47
    • Kuo, L.S.1    Baugh, L.L.2    Denial, S.J.3    Watkins, R.L.4    Liu, M.5    Garcia, J.V.6    Foster, J.L.7
  • 45
    • 40949116993 scopus 로고    scopus 로고
    • Calculation for the chi-square test: An interactive calculation tool for chi-square tests of goodness of fit and independence [Computer software]
    • Available from
    • Preacher KJ. Calculation for the chi-square test: An interactive calculation tool for chi-square tests of goodness of fit and independence [Computer software]. 2001, Available from http://quantpsy.org.
    • (2001)
    • Preacher, K.J.1
  • 47
    • 84883173982 scopus 로고    scopus 로고
    • No evidence for selection of HIV-1 with enhanced Gag-Protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial
    • 10.1371/journal.pone.0071758, 3756015, 24015191
    • Chopera DR, Mann JK, Mwimanzi P, Omarjee S, Kuang XT, Ndabambi N, Goodier S, Martin E, Naranbhai V, Abdool-Karim S, et al. No evidence for selection of HIV-1 with enhanced Gag-Protease or Nef function among breakthrough infections in the CAPRISA 004 tenofovir microbicide trial. PLoS One 2013, 8(8):e71758. 10.1371/journal.pone.0071758, 3756015, 24015191.
    • (2013) PLoS One , vol.8 , Issue.8
    • Chopera, D.R.1    Mann, J.K.2    Mwimanzi, P.3    Omarjee, S.4    Kuang, X.T.5    Ndabambi, N.6    Goodier, S.7    Martin, E.8    Naranbhai, V.9    Abdool-Karim, S.10
  • 49
    • 78650235515 scopus 로고    scopus 로고
    • Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease
    • 10.1016/S1473-3099(10)70186-9, 21126914
    • Tebit DM, Arts EJ. Tracking a century of global expansion and evolution of HIV to drive understanding and to combat disease. Lancet Infect Dis 2011, 11:45-56. 10.1016/S1473-3099(10)70186-9, 21126914.
    • (2011) Lancet Infect Dis , vol.11 , pp. 45-56
    • Tebit, D.M.1    Arts, E.J.2
  • 52
    • 34047207715 scopus 로고    scopus 로고
    • HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
    • 10.1086/512682, 17357054
    • Baeten JM, Chohan B, Lavreys L, Chohan V, McClelland RS, Certain L, Mandaliya K, Jaoko W, Overbaugh J. HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads. J Infect Dis 2007, 195(8):1177-1180. 10.1086/512682, 17357054.
    • (2007) J Infect Dis , vol.195 , Issue.8 , pp. 1177-1180
    • Baeten, J.M.1    Chohan, B.2    Lavreys, L.3    Chohan, V.4    McClelland, R.S.5    Certain, L.6    Mandaliya, K.7    Jaoko, W.8    Overbaugh, J.9
  • 53
    • 0032967672 scopus 로고    scopus 로고
    • Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D
    • 10.1097/00002030-199905280-00005, 10371170
    • Alaeus A, Lidman K, Björkman A, Giesecke J, Albert J. Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D. AIDS 1999, 13(8):901-907. 10.1097/00002030-199905280-00005, 10371170.
    • (1999) AIDS , vol.13 , Issue.8 , pp. 901-907
    • Alaeus, A.1    Lidman, K.2    Björkman, A.3    Giesecke, J.4    Albert, J.5
  • 54
    • 85027958165 scopus 로고    scopus 로고
    • Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection
    • 10.1097/QAD.0b013e3283471eb2, 3544358, 21505307
    • Novitsky V, Ndung'u T, Wang R, Bussmann H, Chonco F, Makhema J, Degruttola V, Walker BD, Essex M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS 2011, 25(12):1515-1522. 10.1097/QAD.0b013e3283471eb2, 3544358, 21505307.
    • (2011) AIDS , vol.25 , Issue.12 , pp. 1515-1522
    • Novitsky, V.1    Ndung'u, T.2    Wang, R.3    Bussmann, H.4    Chonco, F.5    Makhema, J.6    Degruttola, V.7    Walker, B.D.8    Essex, M.9
  • 55
    • 0033775488 scopus 로고    scopus 로고
    • Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo
    • 10.1128/JVI.74.21.9836-9844.2000, 102020, 11024110
    • Iafrate AJ, Carl S, Bronson S, Stahl-Hennig C, Swigut T, Skowronski J, Kirchhoff F. Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo. J Virol 2000, 74(21):9836-9844. 10.1128/JVI.74.21.9836-9844.2000, 102020, 11024110.
    • (2000) J Virol , vol.74 , Issue.21 , pp. 9836-9844
    • Iafrate, A.J.1    Carl, S.2    Bronson, S.3    Stahl-Hennig, C.4    Swigut, T.5    Skowronski, J.6    Kirchhoff, F.7
  • 56
    • 8644289282 scopus 로고    scopus 로고
    • Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus
    • 10.1128/JVI.78.23.13335-13344.2004, 525019, 15542684
    • Swigut T, Alexander L, Morgan J, Lifson J, Mansfield KG, Lang S, Johnson RP, Skowronski J, Desrosiers R. Impact of Nef-mediated downregulation of major histocompatibility complex class I on immune response to simian immunodeficiency virus. J Virol 2004, 78(23):13335-13344. 10.1128/JVI.78.23.13335-13344.2004, 525019, 15542684.
    • (2004) J Virol , vol.78 , Issue.23 , pp. 13335-13344
    • Swigut, T.1    Alexander, L.2    Morgan, J.3    Lifson, J.4    Mansfield, K.G.5    Lang, S.6    Johnson, R.P.7    Skowronski, J.8    Desrosiers, R.9
  • 57
    • 79959343221 scopus 로고    scopus 로고
    • Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages
    • 10.1186/1742-4690-8-50, 3131245, 21696586
    • Mwimanzi P, Hasan Z, Hassan R, Suzu S, Takiguchi M, Ueno T. Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages. Retrovirology 2011, 8:50. 10.1186/1742-4690-8-50, 3131245, 21696586.
    • (2011) Retrovirology , vol.8 , pp. 50
    • Mwimanzi, P.1    Hasan, Z.2    Hassan, R.3    Suzu, S.4    Takiguchi, M.5    Ueno, T.6
  • 58
    • 3342913622 scopus 로고    scopus 로고
    • Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting
    • 10.1097/00126334-200408150-00014, 15247564
    • Oyugi JH, Byakika-Tusiime J, Charlebois ED, Kityo C, Mugerwa R, Mugyenyi P, Bangsberg DR. Multiple validated measures of adherence indicate high levels of adherence to generic HIV antiretroviral therapy in a resource-limited setting. J Acquir Immune Defic Syndr 2004, 36(5):1100-1102. 10.1097/00126334-200408150-00014, 15247564.
    • (2004) J Acquir Immune Defic Syndr , vol.36 , Issue.5 , pp. 1100-1102
    • Oyugi, J.H.1    Byakika-Tusiime, J.2    Charlebois, E.D.3    Kityo, C.4    Mugerwa, R.5    Mugyenyi, P.6    Bangsberg, D.R.7
  • 59
    • 80055049890 scopus 로고    scopus 로고
    • Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy
    • 10.1097/QAD.0b013e32834c4ac1, 3480326, 21881481
    • Hunt PW, Cao HL, Muzoora C, Ssewanyana I, Bennett J, Emenyonu N, Kembabazi A, Neilands TB, Bangsberg DR, Deeks SG, et al. Impact of CD8+ T-cell activation on CD4+ T-cell recovery and mortality in HIV-infected Ugandans initiating antiretroviral therapy. AIDS 2011, 25(17):2123-2131. 10.1097/QAD.0b013e32834c4ac1, 3480326, 21881481.
    • (2011) AIDS , vol.25 , Issue.17 , pp. 2123-2131
    • Hunt, P.W.1    Cao, H.L.2    Muzoora, C.3    Ssewanyana, I.4    Bennett, J.5    Emenyonu, N.6    Kembabazi, A.7    Neilands, T.B.8    Bangsberg, D.R.9    Deeks, S.G.10
  • 61
    • 77957194223 scopus 로고    scopus 로고
    • Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters
    • 10.1128/JVI.01084-10, 2950592, 20702636
    • Wright JK, Brumme ZL, Carlson JM, Heckerman D, Kadie CM, Brumme CJ, Wang B, Losina E, Miura T, Chonco F, et al. Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters. J Virol 2010, 84(20):10820-10831. 10.1128/JVI.01084-10, 2950592, 20702636.
    • (2010) J Virol , vol.84 , Issue.20 , pp. 10820-10831
    • Wright, J.K.1    Brumme, Z.L.2    Carlson, J.M.3    Heckerman, D.4    Kadie, C.M.5    Brumme, C.J.6    Wang, B.7    Losina, E.8    Miura, T.9    Chonco, F.10
  • 62
    • 15844406550 scopus 로고    scopus 로고
    • HyPhy: hypothesis testing using phylogenies
    • 10.1093/bioinformatics/bti079, 15509596
    • Kosakovsky Pond SL, Frost SD, Muse SV. HyPhy: hypothesis testing using phylogenies. Bioinformatics 2005, 21(5):676-679. 10.1093/bioinformatics/bti079, 15509596.
    • (2005) Bioinformatics , vol.21 , Issue.5 , pp. 676-679
    • Kosakovsky Pond, S.L.1    Frost, S.D.2    Muse, S.V.3
  • 63
    • 0242578620 scopus 로고    scopus 로고
    • A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood
    • 10.1080/10635150390235520, 14530136
    • Guindon S, Gascuel O. A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol 2003, 52(5):696-704. 10.1080/10635150390235520, 14530136.
    • (2003) Syst Biol , vol.52 , Issue.5 , pp. 696-704
    • Guindon, S.1    Gascuel, O.2
  • 64
    • 0042424602 scopus 로고    scopus 로고
    • Statistical significance for genomewide studies
    • 10.1073/pnas.1530509100, 170937, 12883005
    • Storey JD, Tibshirani R. Statistical significance for genomewide studies. Proc Natl Acad Sci USA 2003, 100:9440-9445. 10.1073/pnas.1530509100, 170937, 12883005.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 9440-9445
    • Storey, J.D.1    Tibshirani, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.