Involvement of cocaine- and amphetamine-regulated transcript peptide in the hyperphagic and body weight promoting effects of allopregnanolone in rats

Brain Research

Volumn 1532, Issue , 2013, Pages 44-55

  Nakhate, Kartik T ^a   Subhedar, Nishikant K ^b   Bharne, Ashish P ^c   Singru, Praful S ^d   Kokare, Dadasaheb M ^c  

^a RUNGTA COLLEGE OF PHARMACEUTICAL SCIENCES AND RESEARCH   (India)

^b INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

^c RTM NAGPUR UNIVERSITY   (India)

^d NATIONAL INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

Author keywords

Allopregnanolone; Body weight; CART; Food intake

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; PRASTERONE SULFATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; HYPERPHAGIA; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LATERAL HYPOTHALAMUS; MALE; MEASUREMENT; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT;

RATTUS; RODENTIA;

ALLOPREGNANOLONE; BODY WEIGHT; CART; FOOD INTAKE;

ANIMALS; EATING; HYPERPHAGIA; HYPOTHALAMUS; MALE; NERVE TISSUE PROTEINS; NUCLEUS ACCUMBENS; PREGNANOLONE; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT GAIN;

EID: 84883795751     PISSN: 00068993     EISSN: 18726240     Source Type: Journal    
DOI: 10.1016/j.brainres.2013.07.055     Document Type: Article

References (79)

1. A.A. Arjona, S.X. Zhang, B. Adamson, and R.J. Wurtman An animal model of antipsychotic-induced weight gain Behav. Brain Res. 152 2004 121 127
2. M. Bäckberg, C. Ultenius, J.M. Fritschy, and B. Meister Cellular localization of GABA receptor alpha subunit immunoreactivity in the rat hypothalamus: relationship with neurones containing orexigenic or anorexigenic peptides J. Neuroendocrinol. 16 2004 589 604
3. S.M. Bartell, C.M. Isales, C.A. Baile, M.J. Kuhar, and M.W. Hamrick CART deficiency increases body weight but does not alter bone strength J. Musculoskelet. Neuronal Interact. 8 2008 146 153
4. A. Basta-Kaim, B. Budziszewska, L. Jaworska-Feil, M. Leśkiewicz, M. Tetich, M. Otczyk, M. Kubera, and W. Lasoń Effects of neurosteroids on glucocorticoid receptor-mediated gene transcription in LMCAT cells: a possible interaction with psychotropic drugs Eur. Neuropsychopharmacol. 17 2007 37 45
5. G. Beaudry, H. Zekki, C. Rouillard, and D. Levesque Clozapine and dopamine D3 receptor antisense reduce cocaine- and amphetamine-regulated transcript expression in the rat nucleus accumbens shell Synapse 51 2004 233 240
6. L. Bellocchio, P. Lafenêtre, A. Cannich, D. Cota, N. Puente, P. Grandes, F. Chaouloff, P.V. Piazza, and G. Marsicano Bimodal control of stimulated food intake by the endocannabinoid system Nat. Neurosci. 13 2010 281 283
7. F. Bernardi, C. Salvestroni, E. Casarosa, R.E. Nappi, A. Lanzone, S. Luisi, R.H. Purdy, F. Petraglia, and A.R. Genazzani Aging is associated with changes in allopregnanolone concentrations in brain, endocrine glands and serum in male rats Eur. J. Endocrinol. 138 1998 316 321
8. S.M. Bhisikar, D.M. Kokare, K.T. Nakhate, C.T. Chopde, and N.K. Subhedar Tolerance to ethanol sedation and withdrawal hyper-excitability is mediated by neuropeptide Y Y1 and Y5 receptors Life Sci. 85 2009 765 772
9. C. Blasquez, S. Jegou, M. Feuilloley, A. Rosier, F. Vandesande, and H. Vaudry Visualization of gamma-aminobutyric acid A receptors on proopiomelanocortin-producing neurons in the rat hypothalamus Endocrinology 135 1994 2759 2764
10. K.R. Bruckdorfer, S.S. Kang, I.H. Khan, A.R. Bourne, and J. Yudkin Diurnal changes in the concentrations of plasma lipids, sugars, insulin and corticosterone in rats fed diets containing various carbohydrates Horm. Metab. Res. 6 1974 99 106
11. S.W. Chen, L. Rodriguez, M.F. Davies, and G.H. Loew The hyperphagic effect of 3 alpha-hydroxylated pregnane steroids in male rats Pharmacol. Biochem. Behav. 53 1996 777 782
12. D.L. Cheney, D. Uzunov, E. Costa, and A. Guidotti Gas chromatographic-mass fragmentographic quantitation of 3 alpha-hydroxy-5 alpha-pregnan-20-one (allopregnanolone) and its precursors in blood and brain of adrenalectomized and castrated rats J. Neurosci. 15 1995 4641 4650
13. C. Corpechot, J. Young, M. Calvel, C. Wehrey, J.N. Veltz, G. Touyer, M. Mouren, V.V.K. Prasad, C. Banner, J. Sjovall, E.E. Baulieu, and P. Robel Neurosteroids: 3a-hydroxy-5a-pregnan-20-one and its precursors in the brain, plasma, and steroidogenic glands of male and female rats Endocrinology 133 1993 1003 1009
14. S. Dallvechia-Adams, M.J. Kuhar, and Y. Smith Cocaine- and amphetamine-regulated transcript peptide projections in the ventral midbrain: colocalization with gamma-aminobutyric acid, melanin-concentrating hormone, dynorphin, and synaptic interactions with dopamine neurons J. Comp. Neurol. 448 2002 360 372
15. M.P. Dandekar, K.T. Nakhate, D.M. Kokare, and N.K. Subhedar Effect of nicotine on feeding and body weight in rats: involvement of cocaine- and amphetamine-regulated transcript peptide Behav. Brain Res. 219 2011 31 38
16. M.P. Dandekar, K.T. Nakhate, D.M. Kokare, and N.K. Subhedar Involvement of CART in estradiol induced anorexia Physiol. Behav. 105 2012 460 469
17. 34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family Diabetes 50 2001 2157 2160
18. G.S. Deo, M.P. Dandekar, M.A. Upadhya, D.M. Kokare, and N.K. Subhedar Neuropeptide Y Y1 receptors in the central nucleus of amygdala mediate the anxiolytic-like effect of allopregnanolone in mice: behavioral and immunocytochemical evidences Brain Res. 1318 2010 77 86
19. A.J. Douglas Neuroendocrine mechanisms of change in food intake during pregnancy Handbook of Behavior, Food and Nutrition vol. 5 2011 Springer Press 1969 1983
20. J. Duan, Y.H. Choi, D. Hartzell, M.A. Della-Fera, M. Hamrick, and C.A. Baile Effects of subcutaneous leptin injections on hypothalamic gene profiles in lean and ob/ob mice Obesity (Silver Spring) 15 2007 2624 2633
21. C.F. Elias, C. Lee, J. Kelly, C. Aschkenasi, R.S. Ahima, P.R. Couceyro, M.J. Kuhar, C.B. Saper, and J.K. Elmquist Leptin activates hypothalamic CART neurons projecting to the spinal cord Neuron 21 1998 1375 1385
22. C.F. Elias, C. Aschkenasi, C. Lee, J. Kelly, R.S. Ahima, C. Bjorbaek, J.S. Flier, C.B. Saper, and J.K. Elmquist Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area Neuron 23 1999 775 786
23. P. Fagergren, and Y.L. Hurd Mesolimbic gender differences in peptide CART mRNA expression: effects of cocaine Neuroreport 10 1999 3449 3452
24. C. Fekete, G. Wittmann, Z. Liposits, and R.M. Lechan Origin of cocaine- and amphetamine-regulated transcript (CART)-immunoreactive innervation of the hypothalamic paraventricular nucleus J. Comp. Neurol. 469 2004 340 350
25. V.S. Fenelon, and A.E. Herbison Characterisation of GABAA receptor gamma subunit expression by magnocellular neurones in rat hypothalamus Mol. Brain Res. 34 1995 45 56
26. M.A. Fudge, M. Kavaliers, and K.P. Ossenkopp Allopregnanolone produces hyperphagia by reducing neophobia without altering food palatability Eur. Neuropsychopharmacol. 16 2006 272 280
27. F.A. Giuliani, R. Yunes, C.E. Mohn, M. Laconi, V. Rettori, and R. Cabrera Allopregnanolone induces LHRH and glutamate release through NMDA receptor modulation Endocrine 40 2011 21 26
28. S. Grosso, S. Luisi, R. Mostardini, M. Matera, E.G. Barlocco, E. Casarosa, P. Balestri, and F. Petraglia Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy Neuroendocrinology 93 2011 159 164
29. A. Guérardel, M. Barat-Houari, F. Vasseur, C. Dina, V. Vatin, K. Clément, D. Eberlé, V. Vasseur-Delannoy, C.G. Bell, P. Galan, S. Hercberg, N. Helbecque, N. Potoczna, F.F. Horber, P. Boutin, and P. Froguel Analysis of sequence variability in the CART gene in relation to obesity in a Caucasian population BMC Genet. 6 2005 19
30. S.P. Kalra, M.G. Dube, S. Pu, B. Xu, T.L. Horvath, and P.S. Kalra Interacting appetite-regulating pathways in the hypothalamic regulation of body weight Endocr. Rev. 20 1999 68 100
31. S.P. Kamdi, K.T. Nakhate, M.P. Dandekar, D.M. Kokare, and N.K. Subhedar Participation of corticotropin-releasing factor type 2 receptors in the acute, chronic and withdrawal actions of nicotine associated with feeding behavior in rats Appetite 53 2009 354 362
32. A. Kask, L. Rago, and J. Harro Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y1-selective antagonist BIBP3226 Br. J. Pharmacol. 124 1998 1507 1515
33. R.T. Khisti, C.T. Chopde, and S.P. Jain Antidepressant-like effect of 3α-hydroxy-5α-pregnan-20-one in mice forced swim test Pharmacol. Biochem. Behav. 67 2000 137 143
34. T. Kimura, T. Maji, and K. Ashida Periodicity of food intake and lipogenesis in rats subjected to two different feeding plans J. Nutr. 100 1970 691 697
35. W. Kishimoto, T. Hiroi, M. Shiraishi, M. Osada, S. Imaoka, S. Kominami, T. Igarashi, and Y. Funae Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain Endocrinology 145 2004 699 705
36. D.M. Kokare, G.P. Shelkar, C.D. Borkar, K.T. Nakhate, and N.K. Subhedar A simple and inexpensive method to fabricate a cannula system for intracranial injections in rats and mice J. Pharmacol. Toxicol. Methods 64 2011 246 250
37. P.C. Konturek, J.W. Konturek, M. Cześnikiewicz-Guzik, T. Brzozowski, E. Sito, and S.J. Konturek Neuro-hormonal control of food intake: basic mechanisms and clinical implications J. Physiol. Pharmacol. 56 2005 5 25
38. E.O. Koylu, P.R. Couceyro, P.D. Lambert, N.C. Ling, E.B. DeSouza, and M.J. Kuhar Immunohistochemical localization of novel CART peptides in rat hypothalamus, pituitary and adrenal gland J. Neuroendocrinol. 9 1997 823 833
39. P.R. Kramer, S.F. Kramer, K. Marr, G. Guan, P.J. Wellman, and L.L. Bellinger Nicotine administration effects on feeding and cocaine-amphetamine- regulated transcript (CART) expression in the hypothalamus Regul. Pept. 138 2007 66 73
40. P. Kristensen, M.E. Judge, L. Thim, U. Ribel, K.N. Christjansen, B.S. Wulff, J.T. Clausen, P.B. Jensen, O.D. Madsen, N. Vrang, P.J. Larsen, and S. Hastrup Hypothalamic CART is a new anorectic peptide regulated by leptin Nature 393 1998 72 76
41. P.D. Lambert, P.R. Couceyro, K.M. McGirr, S.E. Dall Vechia, Y. Smith, and M.J. Kuhar CART peptides in the central control of feeding and interactions with neuropeptide Y Synapse 29 1998 293 298
42. J.J. Lambert, D. Belelli, D.R. Peden, A.W. Vardy, and J.A. Peters Neurosteroid modulation of GABAA receptors Prog. Neurobiol. 71 2003 67 80
43. N.C. Lan, and K.W. Gee Neuroactive steroid actions at the GABA-A receptor Horm. Behav. 28 1994 537 544
44. M. Lancel, J. Feulhaber, T. Schiffelholz, E. Romeo, F. di Michele, R. Ruppercht, and F. Holsboer Allopregnanolone affects sleep in a benzodiazepine fashion J. Pharmacol. Exp. Ther. 282 1997 1213 1218
45. M.S. Lee, I.H. Kim, C.T. Kim, and Y. Kim Reduction of body weight by dietary garlic is associated with an increase in uncoupling protein mRNA expression and activation of AMP-activated protein kinase in diet-induced obese mice J. Nutr. 141 2011 1947 1953
46. D. Lonsdale, and W.M. Burnham The anticonvulsant effects of allopregnanolone against amygdala-kindled seizures in female rats Neurosci. Lett. 10 2007 147 151
47. T.A. Lovick GABA in the female brain - oestrous cycle-related changes in GABAergic function in the periaqueductal grey matter Pharmacol. Biochem. Behav. 90 2008 43 50
48. C.E. Marx, G.E. Duncan, J.H. Gilmore, J.A. Lieberman, and A.L. Morrow Olanzapine increases allopregnanolone in the rat cerebral cortex Biol. Psychiatry 47 2000 1000 1004
49. H. Meena, K.T. Nakhate, D.M. Kokare, and N.K. Subhedar GABAA receptors in nucleus accumbens shell mediate the hyperphagia and weight gain following haloperidol treatment in rats Life Sci. 84 2009 156 163
50. R. Menozzi, P. Florio, M. Bondi, S. Luisi, L. Cobellis, A.R. Genazzani, G. Del Rio, and F. Petraglia Increased response of plasma allopregnanolone to corticotropin-releasing hormone in obese patients Neuroendocrinology 75 2002 124 129
51. N. Moragues, P. Ciofi, P. Lafon, G. Tramu, and M. Garret GABAA receptor epsilon subunit expression in identified peptidergic neurons of the rat hypothalamus Brain Res. 967 2003 285 289
52. K.T. Nakhate, M.P. Dandekar, D.M. Kokare, and N.K. Subhedar Involvement of neuropeptide Y Y(1) receptors in the acute, chronic and withdrawal effects of nicotine on feeding and body weight in rats Eur. J. Pharmacol. 609 2009 78 87
53. K.T. Nakhate, D.M. Kokare, P.S. Singru, A.G. Taksande, S.D. Kotwal, and N.K. Subhedar Hypothalamic cocaine- and amphetamine-regulated transcript peptide is reduced and fails to modulate feeding behavior in rats with chemically-induced mammary carcinogenesis Pharmacol. Biochem. Behav. 97 2010 340 349
54. K.T. Nakhate, D.M. Kokare, P.S. Singru, and N.K. Subhedar Central regulation of feeding behavior during social isolation of rat: evidence for the role of endogenous CART system Int. J. Obesity 35 2011 773 784
55. T.A. Obut, S.K. Saryg, M.V. Ovsukova, T.U. Dementeva, E.T. Obut, and T.A. Erdinieva Effect of dehydroepiandrosterone sulfate on aldosterone level during stress exposures: role of μ-opioid receptors. Bull Exp. Biol. Med. 152 2012 696 698
56. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 1998 Academic Press London
57. E. Peyron-Caso, A. Quignard-Boulangé, M. Laromiguière, S. Feing-Kwong-Chan, A. Véronèse, B. Ardouin, G. Slama, and S.W. Rizkalla Dietary fish oil increases lipid mobilization but does not decrease lipid storage-related enzyme activities in adipose tissue of insulin-resistant, sucrose-fed rats J. Nutr. 133 2003 2239 2243
58. R.H. Purdy, A.L. Morrow, P.H. Moore, and S.M. Paul Stress-induced elevations of g-aminobutyric acid type A receptor-active steroids in the rat brain Proc. Natl. Acad. Sci. USA 88 1991 4553 4557
59. R.J. Rangani, M.A. Upadhya, K.T. Nakhate, D.M. Kokare, and N.K. Subhedar Nicotine evoked improvement in learning and memory is mediated through NPY Y1 receptors in rat model of Alzheimer's disease Peptides 33 2012 317 328
60. D.S. Reddy, and S.K. Kulkarni The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice Psychopharmacology 137 1998 391 400
61. D.S. Reddy, and S.K. Kulkarni Sex and estrous cycle-dependent changes in neurosteroid and benzodiazepine effects on food consumption and plus-maze learning behaviors in rats Pharmacol. Biochem. Behav. 62 1999 53 60
62. P. Robel, and E.E. Baulieu Neurosteroids: biosynthesis and function Trends Endocrinol. Metab. 5 1994 1 8
63. P. Robel, and E.E. Baulieu Neurosteroids: biosynthesis and function Crit. Rev. Neurobiol. 9 1995 383 394
64. D.C. Roberts Preclinical evidence for GABAB agonists as a pharmacotherapy for cocaine addiction Physiol. Behav. 86 2005 18 20
65. G. Rogge, D. Jones, G.W. Hubert, Y. Lin, and M.J. Kuhar CART peptides: regulators of body weight, reward and other functions Nat. Rev. Neurosci. 9 2008 747 758
66. S.A. Stanley, C.J. Small, K.G. Murphy, E. Rayes, C.R. Abbott, L.J. Seal, D.G. Morgan, D. Sunter, C.L. Dakin, M.S. Kim, R. Hunter, M. Kuhar, M.A. Ghatei, and S.R. Bloom Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats Brain Res. 893 2001 186 194
67. B.G. Taksande, N.R. Kotagale, K.T. Nakhate, P.D. Mali, D.M. Kokare, K. Hirani, N.K. Subhedar, C.T. Chopde, and R.R. Ugale Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y Br. J. Pharmacol. 164 2011 704 718
68. P. Thomas, and Y. Pang Membrane progesterone receptors (MPRs): evidence for neuroprotective, neurosteroid signaling and neuroendocrine functions in neuronal cells Neuroendocrinology 96 2012 162 171
69. D.R. Tian, X.D. Li, Y.S. Shi, Y. Wan, X.M. Wang, J.K. Chang, J. Yang, and J.S. Han Changes of hypothalamic alpha-MSH and CART peptide expression in diet-induced obese rats Peptides 25 2004 2147 2153
70. M.A. Upadhya, K.T. Nakhate, D.M. Kokare, P.S. Singru, and N.K. Subhedar Cocaine- and amphetamine-regulated transcript peptide increases spatial learning and memory in rats Life Sci. 88 2011 322 334
71. M.A. Upadhya, K.T. Nakhate, D.M. Kokare, U. Singh, P.S. Singru, and N.K. Subhedar CART peptide in the nucleus accumbens shell acts downstream to dopamine and mediates the reward and reinforcement actions of morphine Neuropharmacology 62 2012 1823 1833
72. C. Wang, C.J. Billington, A.S. Levine, and C.M. Kotz Effect of CART in the hypothalamic paraventricular nucleus on feeding and uncoupling protein gene expression Neuroreport 11 2000 3251 3255
73. J.M. Wang, P.B. Johnston, B.G. Ball, and R.D. Brinton The neurosteroid allopregnanolone promotes proliferation of rodent and human neural progenitor cells and regulates cell-cycle gene and protein expression J. Neurosci. 25 2005 4706 4718
74. J.M. Wang, C. Singh, L. Liu, R.W. Irwin, S. Chen, E.J. Chung, R.F. Thompson, and R.D. Brinton Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease Proc. Natl. Acad. Sci. USA 107 2010 6498 6503
75. Y.D. Wang, M.F. Tao, L. Wang, W.W. Cheng, and X.P. Wan Selective regulation of osteoblastic OPG and RANKL by dehydroepiandrosterone through activation of the estrogen receptor β-mediated MAPK signaling pathway Horm. Metab. Res. 44 2012 494 500
76. K.E. Wortley, G.Q. Chang, Z. Davydova, S.K. Fried, and S.F. Leibowitz Cocaine- and amphetamine-regulated transcript in the arcuate nucleus stimulates lipid metabolism to control body fat accrual on a high-fat diet Regul. Pept. 117 2004 89 99
77. S.C. Yang, K.R. Shieh, and H.Y. Li Cocaine- and amphetamine-regulated transcript in the nucleus accumbens participates in the regulation of feeding behavior in rats Neuroscience 133 2005 841 851
78. S.Y. Yoon, D.H. Roh, H.S. Seo, S.Y. Kang, H.J. Han, A.J. Beitz, and J.H. Lee Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: involvement of spinal sigma-1 and GABA receptors Br. J. Pharmacol. 157 2009 666 673
79. H. Zheng, M. Corkern, I. Stoyanova, L.M. Patterson, R. Tian, and H.R. Berthoud Peptides that regulate food intake: appetite-inducing accumbens manipulation activates hypothalamic orexin neurons and inhibits POMC neurons Am. J. Physiol. Regul. Integr. Comp. Physiol. 284 2003 R1436 R1444