Allopregnanolone produces hyperphagia by reducing neophobia without altering food palatability

European Neuropsychopharmacology

Volumn 16, Issue 4, 2006, Pages 272-280

  Fudge, Melissa A ^a   Kavaliers, Martin ^a   Ossenkopp, Klaus Peter ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Anxiety; Appetitive behaviors; Consummatory behaviors; Drinking behavior; Hyperphagia; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; QUININE; SUCROSE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FOOD; HYPERPHAGIA; LICKING; MALE; MONITORING; NEOPHOBIA; NONHUMAN; PALATABILITY; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE;

ANALYSIS OF VARIANCE; ANESTHETICS; ANIMALS; BEHAVIOR, ANIMAL; EATING; FEEDING BEHAVIOR; FOOD PREFERENCES; HYPERPHAGIA; MALE; PHOBIC DISORDERS; PREGNANOLONE; RATS; RATS, LONG-EVANS; REINFORCEMENT (PSYCHOLOGY); TIME FACTORS;

EID: 33646005166     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2005.08.002     Document Type: Article

References (44)

1. Benke D., Michel C., and Mohler H. GABA(A) receptors containing the alpha4-subunit: prevalence, distribution, pharmacology, and subunit architecture in situ. J. Neurochem. 69 (1997) 804-814
2. Berridge K.C., and Treit D. Chlordiazepoxide directly enhances positive ingestive reactions in rats. Pharmacol. Biochem. Behav. 24 2 (1986) 217-221
3. Brooks-Kayal A.R., Shumate M.D., Jin H., Rikhter T.Y., and Coulter D.A. Selective changes in single cell GABA(A) receptor subunit expression and function in temporal lobe epilepsy. Nat. Med. 4 10 (1998) 1166-1172
4. Chen S.-W., Rodriguez E., Davies M.F., and Loew G.H. The hyperphagic effect of 3α-hydroxylated pregnane steroids in male rats. Pharmacol. Biochem. Behav. 53 4 (1996) 777-782
5. Clarke S.N.D.A., and Ossenkopp K.-P. Taste reactivity responses in rats: influence of sex and the estrous cycle. Am. J. Physiol. 274 3 Pt 2 (1998) R718-R724
6. Cooper S.J. Benzodiazepines as appetite-enhancing compounds. Appetite 1 (1980) 7-19
7. Cooper S.J. Palatability-dependent appetite and benzodiazepines: new directions from the pharmacology of GABA(A) receptor subtypes. Appetite 44 2 (2005) 133-150
8. Craig W. Appetites and aversions as constituents of instincts. Biol. Bull. 34 (1918) 91-107
9. Cross-Mellor S.K., Roberts S., Kavaliers M., and Ossenkopp K.-P. Activation of the immune system in rats with lipopolysaccharide reduces voluntary sucrose intake but not intraoral intake. Pharmacol. Biochem. Behav. 76 1 (2003) 153-159
10. Cross-Mellor S.K., Kavaliers M., and Ossenkopp K.-P. Comparing immune activation (lipopolysaccharide) and toxin (lithium chloride)-induced gustatory conditioning: lipopolysaccharide produces conditioned taste avoidance but not aversion. Behav. Brain Res. 148 1-2 (2004) 11-19
11. Davis J.D. Microstructural analysis of the ingestive behavior of the rat ingesting polycose. Physiol. Behav. 60 6 (1996) 1557-1563
12. Davis J.D., and Breslin P.A.S. A behavioral analysis of the ingestion of glucose, maltose and maltooligosaccharide by rats. Physiol. Behav. 69 4-5 (2000) 477-485
13. Davis J.D., and Smith G.P. Analysis of the microstructure of the rhythmic tongue movements of rats ingesting maltose and sucrose solutions. Behav. Neurosci. 106 1 (1992) 217-228
14. Frostholm A., Evans J.E., Cummings S.L., and Rotter A. Harmaline-induced changes in gamma aminobutyric acid(A) receptor subunit mRNA expression in murine olivocerebellar nuclei. Brain Res. Mol. Brain Res. 85 1-2 (2000) 200-208
15. Garcia J., Lasiter P.S., Bermudez-Rattoni F., and Deems D.A. A general theory of aversion learning. Ann. N.Y. Acad. Sci. 443 (1985) 8-21
16. Glendinning J.I. Is the bitter rejection response always adaptive?. Physiol. Behav. 56 6 (1994) 1217-1227
17. Grill H.J., and Norgren R. The taste reactivity test. I. Mimetic responses to gustatory stimuli in neurologically normal rats. Brain Res. 143 2 (1978) 263-279
18. Gulinello M., and Smith S.S. Anxiogenic effects of neurosteroid exposure: sex differences and altered GABAA receptor pharmacology in adult rats. J. Pharmacol. Exp. Ther. 305 2 (2003) 541-548
19. Gulinello M., Gong Q.H., Li X., and Smith S.S. Short-term exposure to a neuroactive steroid increases alpha4 GABA(A) receptor subunit levels in association with increased anxiety in the female rat. Brain Res. 910 1-2 (2001) 55-66
20. Gulinello M., Gong Q.H., and Smith S.S. Progesterone withdrawal increases the α4 subunit of the GABAA receptor in male rats in association with anxiety and altered pharmacology-a comparison with female rats. Neuropharmacology 43 4 (2003) 701-714
21. Hatcher R.A. The mechanism of vomiting. Physiol. Rev. 4 (1924) 479-504
22. Higgs S., and Cooper S.J. Antineophobic effect of the neuroactive steroid 3α-hydroxy-5β-pregnan-20-one in males rats. Pharmacol. Biochem. Behav. 60 1 (1998) 125-131
23. Korpi E.R., Gründer G., and Lüddens H. Drugs interactions at GABAA receptors. Prog. Neurobiol. 67 2 (2002) 113-159
24. Lüddens H., Pritchett D.B., Kohler M., Killisch M., Keinmanen K., Monyer H., Sprengel R., and Seeburg P.H. Cerebellar GABA-A receptor selective for a behavioral alcohol antagonist. Nature 346 6285 (1990) 648-651
25. McBurney D.H., and Gent J.F. On the nature of taste qualities. Psychol. Bull. 86 1 (1979) 151-167
26. Mehta A.K., and Ticku M.K. An update on GABA-A receptors. Brain Res. Brain Res. Rev. 29 2-3 (1999) 196-217
27. Ossenkopp K.-P., and Eckel L.A. Toxin-induced conditioned changes in taste reactivity and the role of the chemosensitive area postrema. Neurosci. Biobehav. Rev. 19 1 (1995) 99-108
28. Parker L.A. Conditioned suppression of drinking: a measure of the CR elicited by a lithium conditioned flavor. Learn. Motiv. 11 (1980) 538-559
29. Parker L.A. Chlordiazepoxide nonspecifically enhances consumption of saccharin solution. Pharmacol. Biochem. Behav. 38 2 (1991) 375-377
30. Parker L.A. Chlordiazepoxide enhances the palatability of lithium-, amphetamine-, and saline-paired saccharin solution. Pharmacol. Biochem. Behav. 50 3 (1995) 345-349
31. Reddy D.S., and Kulkarni S.K. Differential anxiolytic effects of neurosteroids in the mirrored chamber behavior test in mice. Brain Res. 752 1-2 (1997) 61-71
32. Reddy D.S., and Kulkarni S.K. The role of GABA-A and mitochondrial diazepam-binding inhibitor receptors on the effects of neurosteroids on food intake in mice. Psychopharmacology (Berl) 137 4 (1998) 391-400
33. Reddy D.S., and Kulkarni S.K. Sex and estrous cycle-dependent changes in neurosteroid and benzodiazepine effects on food consumption and plus-maze learning behaviors in rats. Pharmacol. Biochem. Behav. 62 1 (1999) 53-60
34. Rodgers R.J., and Johnson N.J.T. Behaviorally selective effects of neurosteroids on plus-maze anxiety in mice. Pharmacol. Biochem. Behav. 59 1 (1998) 221-232
35. Rozin P. Preference and affect in food selection. In: Kroeze J.H.A. (Ed). Preference Behavior and Chemoreception (1979), Information Retrieval Limited, London 289-297
36. Rupprecht R. Neuroactive steroids: mechanisms of action and neuropharmacological properties. Neuroendocrinology 28 2 (2003) 139-168
37. Sinnott R.S., Phillips T.J., and Fin D.A. Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology (Berl) 162 4 (2002) 438-447
38. Smith S. Novel effects of neuroactive steroids in the central nervous system. In: Pfaff D., Arnold A.P., Etgen A., Fahrbach S.E.M., and Rubin R.T. (Eds). Hormones, Brain and Behaviour vol. 3 (2002), Academic Press, Elsevier 759-765
39. Smith S.S., Gong Q.H., Li X., Moran M.H., Bitran D., Frye C.A., and Hsu F.C. Withdrawal from 3alpha-OH-5alpha-pregnan-20-one using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety. J. Neurosci. 18 14 (1998) 2584-5275
40. Treit D., Berridge K.C., and Schultz C.E. The direct enhancement of positive palatability by chlordiazepoxide is antagonized by Ro 15-1788 and CGS 8216. Pharmacol. Biochem. Behav. 26 4 (1987) 709-714
41. Wieland S., Lan N.C., Mirasedegi S., and Gee K.W. Anxiolytic activity of the progesterone metabolite 5α-hydroxy-pregnan-3α-ol-20-one. Brain Res. 565 2 (1991) 263-268
42. Wieland S., Belluzzi J.D., Stein L., and Lan N.C. Comparative behavioral characterization of the neuroactive steroids 3α-OH,5α-pregnan-20-one and 3α-OH,5β-pregnan-20-one in rodents. Psychopharmacology (Berl) 118 1 (1995) 65-71
43. Wingrove P.B., Sato P., Wheat L., Thompson S.A., Watford K.A., and Whiting P.J. Mechanisms of α-subunit selectivity of benzodiazepines pharmacology at γ-aminobutyric acid type A receptors. Eur. J. Pharmacol. 437 1-2 (2002) 31-39
44. Wohlfarth K.M., Bianchi M.T., and Macdonald R.I. Enhanced neurosteroid potentiation of ternary GABA-A receptors containing the δ subunit. J. Neurosci. 22 5 (2002) 1541-1549