Intrathecal injection of the neurosteroid, DHEAS, produces mechanical allodynia in mice: Involvement of spinal sigma-1 and GABA A receptors

British Journal of Pharmacology

Volumn 157, Issue 4, 2009, Pages 666-673

  Yoon, Seo Yeon ^c   Roh, Dae Hyun ^c   Seo, Hyoung Sig ^c   Kang, Suk Yun ^c   Han, Ho Jae ^a   Beitz, Alvin J ^b   Lee, Jang Hern ^c  

^a Chonnam National University   (South Korea)

^b UNIVERSITY OF MINNESOTA   (United States)

^c Seoul National University   (South Korea)

Author keywords

Dehydroepiandrosterone; Dehydroepiandrosterone sulphate; GABA a receptor; Mechanical allodynia; Sigma 1 receptor

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; MUSCIMOL; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; NEUROSTEROID; SIGMA 1 OPIATE RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; ANALGESIC AGENT; ETHYLENEDIAMINE DERIVATIVE; PRASTERONE; PRASTERONE SULFATE; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL MOUSE; MALE; MECHANICAL STIMULATION; MOUSE; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; ANIMAL; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG INTERACTION; DRUG POTENTIATION; INSTITUTE FOR CANCER RESEARCH MOUSE; INTRASPINAL DRUG ADMINISTRATION; PHYSIOLOGY; SPINAL CORD;

ANALGESICS; ANIMALS; BICUCULLINE; DEHYDROEPIANDROSTERONE; DEHYDROEPIANDROSTERONE SULFATE; DRUG INTERACTIONS; ETHYLENEDIAMINES; GABA AGONISTS; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED ICR; MUSCIMOL; PAIN THRESHOLD; RECEPTORS, GABA-A; RECEPTORS, SIGMA; SPINAL CORD;

EID: 70349916139     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00197.x     Document Type: Article

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