Involvement of CART in estradiol-induced anorexia

Physiology and Behavior

Volumn 105, Issue 2, 2012, Pages 460-469

  Dandekar, Manoj P ^a   Nakhate, Kartik T ^a   Kokare, Dadasaheb M ^a   Subhedar, Nishikant K ^b  

^a RTM NAGPUR UNIVERSITY   (India)

^b INDIAN INSTITUTE OF SCIENCE EDUCATION AND RESEARCH   (India)

Author keywords

CART; Estradiol; Food intake; Immunocytochemistry; Ovariectomy; Tamoxifen

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; ESTRADIOL; TAMOXIFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARCUATE NUCLEUS; ARTICLE; CONTROLLED STUDY; ESTRUS; FEMALE; FOOD INTAKE; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOREACTIVITY; NONHUMAN; OVARIECTOMY; PARAVENTRICULAR THALAMIC NUCLEUS; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANOREXIA; ANTIBODIES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION ROUTES; DRUG INTERACTIONS; EATING; ESTRADIOL; ESTROGEN ANTAGONISTS; ESTROGENS; FEMALE; HYPOTHALAMUS; NERVE TISSUE PROTEINS; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; TAMOXIFEN;

EID: 80053342011     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.09.001     Document Type: Article

References (63)

1. Douglass J., McKinzie A.A., Couceyro P. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. J Neurosci 1995, 15:2471-2481.
2. Couceyro P.R., Koylu E.O., Kuhar M.J. Further studies on the anatomical distribution of CART by in situ hybridization. J Chem Neuroanat 1997, 12:229-241.
3. Vrang N. Anatomy of hypothalamic CART neurons. Peptides 2006, 27:1970-1980.
4. Kalra S.P., Dube M.G., Pu S., Xu B., Horvath T.L., Kalra P.S. Interacting appetite-regulating pathways in the hypothalamic regulation of body weight. Endocr Rev 1999, 20:68-100.
5. Broberger C. Hypothalamic cocaine- and amphetamine-regulated transcript (CART) neurons: histochemical relationship to thyrotropin-releasing hormone, melanin-concentrating hormone, orexin/hypocretin and neuropeptide Y. Brain Res 1999, 848:101-113.
6. Dhillo W.S., Small C.J., Stanley S.A., Jethwa P.H., Seal L.J., Murphy K.G., et al. Hypothalamic interactions between neuropeptide Y, agouti-related protein, cocaine-and amphetamine-regulated transcript and alpha-melanocyte-stimulating hormone in vitro in male rats. J Neuroendocrinol 2002, 14:725-730.
7. Kristensen P., Judge M.E., Thim L., Ribel U., Christjansen K.N., Wulff B.S., et al. Hypothalamic CART is a new anorectic peptide regulated by leptin. Nature 1998, 393:72-76.
8. Nedungadi T.P., Briski K.P. Effects of estradiol on acute and recurrent insulin-induced hypoglycemia-associated patterns of arcuate neuropeptide Y, proopiomelanocortin, and cocaine- and amphetamine-related transcript gene expression in the ovariectomized rat. Neuroendocrinology 2007, 86:270-276.
9. Smith G.P. The direct and indirect controls of meal size. Neurosci Biobehav Rev 1996, 20:41-46.
10. Eckel L.A. Estradiol: an indirect control of meal size. Physiol Behav 2004, 82:35-41.
11. Yu Z., Geary N., Corwin R.L. Ovarian hormones inhibit fat intake under binge-type conditions in ovariectomized rats. Physiol Behav 2008, 95:501-507.
12. Rivera H.M., Oberbeck D.R., Kwon B., Houpt T.A., Eckel L.A. Estradiol increases Pet-1 and serotonin transporter mRNA in the midbrain raphe nuclei of ovariectomized rats. Brain Res 2009, 1259:51-58.
13. Gorodeski G.I. Update on cardiovascular disease in post-menopausal women. Best Pract Res Clin Obstet Gynaecol 2002, 16:329-355.
14. Ren J. Cardiac health and diabetes mellitus in women: problems and prospects. Minerva Cardioangiol 2006, 54:289-309.
15. McElroy J.F., Wade G.N. Short- and long-term effects of ovariectomy on food intake, body weight, carcass composition, and brown adipose tissue in rats. Physiol Behav 1987, 39:361-365.
16. Wager-Srdar S.A., Gannon M., Levine A.S. The effect of cholecystokinin on food intake in gonadectomized and intact rats: the influence of sex hormones. Physiol Behav 1987, 40:25-28.
17. Butera P.C. Estradiol and the control of food intake. Physiol Behav 2010, 99:175-180.
18. Asarian L., Geary N. Cyclic estradiol treatment normalizes body weight and restores physiological patterns of spontaneous feeding and sexual receptivity in ovariectomized rats. Horm Behav 2002, 42:461-471.
19. Roepke T.A. Oestrogen modulates hypothalamic control of energy homeostasis through multiple mechanisms. J Neuroendocrinol 2009, 21:141-150.
20. Geary N., Trace D., McEwen B., Smith G.P. Cyclic estradiol replacement increases the satiety effect of CCK-8 in ovariectomized rats. Physiol Behav 1994, 56:281-289.
21. Messina M.M., Boersma G., Overton J.M., Eckel L.A. Estradiol decreases the orexigenic effect of melanin-concentrating hormone in ovariectomized rats. Physiol Behav 2006, 88:523-528.
22. Clegg D.J., Brown L.M., Zigman J.M., Kemp C.J., Strader A.D., Benoit S.C., et al. Estradiol-dependent decrease in the orexigenic potency of ghrelin in female rats. Diabetes 2007, 56:1051-1058.
23. Santollo J., Eckel L.A. Estradiol decreases the orexigenic effect of neuropeptide Y, but not agouti-related protein, in ovariectomized rats. Behav Brain Res 2008, 191:173-177.
24. Shughrue P.J., Lane M.V., Merchenthaler I. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J Comp Neurol 1997, 388:507-525.
25. Shughrue P.J., Merchenthaler I. Distribution of estrogen receptor β immunoreactivity in the rat central nervous system. J Comp Neurol 2001, 436:64-81.
26. Jones J.E., Wade G.N. Acute fasting decreases sexual receptivity and neural estrogen receptor-alpha in female rats. Physiol Behav 2002, 77:19-25.
27. Leite C.M., Szawka R.E., Anselmo-Franci J.A. Alpha-oestrogen and progestin receptor expression in the hypothalamus and preoptic area dopaminergic neurones during oestrous in cycling rats. J Neuroendocrinol 2008, 20:110-119.
28. Lima F.B., Henderson J.A., Reddy A.P., Tokuyama Y., Hubert G.W., Kuhar M.J., et al. Unique responses of midbrain CART neurons in macaques to ovarian steroids. Brain Res 2008, 1227:76-88.
29. Leslie R.A., Sanders S.J., Anderson S.I., Schuhler S., Horan T.L., Ebling F.J. Appositions between cocaine- and amphetamine-related transcript- and gonadotropin releasing hormone-immunoreactive neurons in the hypothalamus of the Siberian hamster. Neurosci Lett 2001, 314:111-114.
30. Rondini T.A., Baddini S.P., Sousa L.F., Bittencourt J.C., Elias C.F. Hypothalamic cocaine- and amphetamine-regulated transcript neurons project to areas expressing gonadotropin releasing hormone immunoreactivity and to the anteroventral periventricular nucleus in male and female rats. Neuroscience 2004, 125:735-748.
31. Silva L.E., Castro M., Amaral F.C., Antunes-Rodrigues J., Elias L.L. Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides. Braz J Med Biol Res 2010, 43:759-766.
32. Krause E.G., Curtis K.S., Davis L.M., Stowe J.R., Contreras R.J. Estrogen influences stimulated water intake by ovariectomized female rats. Physiol Behav 2003, 79:267-274.
33. Flanagan-Cato L.M., Grigson P.S., King J.L. Estrogen-induced suppression of intake is not mediated by taste aversion in female rats. Physiol Behav 2001, 72:549-558.
34. McCarthy M.M., Coirini H., Schumaker M., Pfaff D.W., McEwen B.S., Schwartz-Giblin S. Ovarian steroid modulation of [3H] muscimol binding in the spinal cord of the rat. Brain Res 1991, 556:321-323.
35. Schumacher M., Coirini H., Pfaff D.W., McEwen B.S. Light-dark differences in behavioral sensitivity to oxytocin. Behav Neurol 1991, 105:487-492.
36. Dandekar M.P., Singru P.S., Kokare D.M., Lechan R.M., Thim L., Clausen J.T., et al. Importance of cocaine- and amphetamine-regulated transcript peptide in the central nucleus of amygdala in anxiogenic responses induced by ethanol withdrawal. Neuropsychopharmacology 2008, 33:1127-1136.
37. Dandekar M.P., Singru P.S., Kokare D.M., Subhedar N.K. Cocaine- and amphetamine-regulated transcript peptide plays a role in the manifestation of depression: social isolation and olfactory bulbectomy models reveal unifying principles. Neuropsychopharmacology 2009, 34:1288-1300.
38. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, London.
39. Kimura T., Maji T., Ashida K. Periodicity of food intake and lipogenesis in rats subjected to two different feeding plans. J Nutr 1970, 100:691-697.
40. Kask A., Schioth H.B., Mutulis F., Wikberg J.E.S., Rago L. Anorexigenic cocaine- and amphetamine-regulated transcript peptide intensifies fear reactions in rats. Brain Res 2000, 857:283-285.
41. Lambert P.D., Couceyro P.R., McGirr K.M., Dall Vechia S.E., Smith Y., Kuhar M.J. CART peptides in the central control of feeding and interactions with neuropeptide Y. Synapse 1998, 29:293-298.
42. Dandekar M.P., Nakhate K.T., Kokare D.M., Subhedar N.K. Effect of nicotine on feeding and body weight in rats: involvement of cocaine-and amphetamine-regulated transcript peptide. Behav Brain Res 2011, 219:31-38.
43. Taksande B.G., Kotagale N.R., Nakhate K.T., Mali P.D., Kokare D.M., Hirani K., et al. Agmatine in the hypothalamic paraventricular nucleus stimulates feeding in rats: involvement of neuropeptide Y. Br J Pharmacol 2011, 164:704-718.
44. Thim L., Nielsen P.F., Judge M.E., Andersen A.S., Diers I., Egel-Mitani M., et al. Purification and characterization of a new hypothalamic satiety peptide, cocaine and amphetamine regulated transcript (CART), produced in yeast. FEBS Lett 1998, 428:263-268.
45. Wingkar K.C. Alterations in feeding and sexual behaviour during reproductive cycle in female rats. Ind J Physiol Pharmacol 1992, 36:174-176.
46. Xu Y., Zhang W., Klaus J., Young J., Koerner I., Sheldahl L.C., et al. Role of cocaine- and amphetamine-regulated transcript in estradiol-mediated neuroprotection. Proc Natl Acad Sci U S A 2006, 103:14489-14494.
47. Shieh K.R., Yang S.C. Effects of estradiol on the stimulation of dopamine turnover in mesolimbic and nigrostriatal systems by cocaine- and amphetamine-regulated transcript peptide in female rats. Neuroscience 2008, 154:1589-1597.
48. Nakhate K.T., Kokare D.M., Singru P.S., Taksande A.G., Kotwal S.D., Subhedar N.K. Hypothalamic cocaine- and amphetamine-regulated transcript peptide is reduced and fails to modulate feeding behavior in rats with chemically-induced mammary carcinogenesis. Pharmacol Biochem Behav 2010, 97:340-349.
49. Nakhate K.T., Kokare D.M., Singru P.S., Subhedar N.K. Central regulation of feeding behavior during social isolation of rat: evidence for the role of endogenous CART system. Int J Obes 2011, 35:773-784.
50. Scruggs P., Dun S.L., Dun N.J. Cocaine- and amphetamine-regulated transcript peptide attenuates phenylephrine-induced bradycardia in anesthetized rats. Am J Physiol Regul Integr Comp Physiol 2003, 285:1496-1503.
51. Butera P.C., Bradway D.M., Cataldo N.J. Modulation of the satiety effect of cholecystokinin by estradiol. Physiol Behav 1993, 53:1235-1238.
52. Geary N., Asarian L. Estradiol increases glucagon's satiating potency in ovariectomized rats. Am J Physiol 2001, 281:R1290-R1294.
53. Rivera H.M., Eckel L.A. The anorectic effect of fenfluramine is increased by estradiol treatment in ovariectomized rats. Physiol Behav 2005, 86:331-337.
54. Wade G.N., Heller H.W. Tamoxifen mimics the effects of estradiol on food intake, body weight, and body composition in rats. Am J Physiol 1993, 264:1219-1223.
55. Kalu D.N., Salerno E., Liu C.C., Echon R., Ray M., Garza-Zapata M., et al. A comparative study of the actions of tamoxifen, estrogen and progesterone in the ovariectomized rat. Bone Miner 1991, 15:109-123.
56. Wade G.N., Powers J.B. Tamoxifen antagonizes the effects of estradiol on energy balance and estrous behavior in Syrian hamsters. Am J Physiol 1993, 265:559-562.
57. Walf A.A., Frye C.A. ER β-selective estrogen receptor modulators produce antianxiety behavior when administered systemically to ovariectomized rats. Neuropsychopharmacology 2005, 30:1598-1609.
58. Versini A., Ramoz N., Le Strat Y., Scherag S., Ehrlich S., Boni C., et al. Estrogen receptor 1 gene (ESR1) is associated with restrictive anorexia nervosa. Neuropsychopharmacology 2010, 35:1818-1825.
59. Kennedy G.C. Interactions between feeding behavior and hormones during growth. Ann N Y Acad Sci 1969, 157:1049-1061.
60. Frisch R.E., McArthur J.W. Menstrual cycles: fatness as a determinant of minimum weight for height necessary for their maintenance or onset. Science 1974, 185:949-951.
61. Otukonyong E.E., Okutani F., Takahashi S., Murata T., Morioka N., Kaba H., et al. Effect of food deprivation and leptin repletion on the plasma levels of estrogen (E2) and NADPH-d reactivity in the ventromedial and arcuate nuclei of the hypothalamus in the female rats. Brain Res 2000, 887:70-79.
62. Kotsuji F., Goto K., Aso T., Tominaga T. The influence of weight loss on the reproductive function of the female rat: changes in the estrous cycle and hypothalamo-pituitary-ovarian function during feed restriction and subsequent refeeding period. Nippon Sanka Fujinka Gakkai Zasshi 1986, 38:1713-1721.
63. Germano C.M., de Castro M., Rorato R., Laguna M.T., Antunes-Rodrigues J., Elias C.F., et al. Time course effects of adrenalectomy and food intake on cocaine- and amphetamine-regulated transcript expression in the hypothalamus. Brain Res 2007, 1166:55-64.