Candidate serum biomarkers for early intestinal cancer using 15N metabolic labeling and quantitative proteomics in the ApcMin/+ mouse

Journal of Proteome Research

Volumn 12, Issue 9, 2013, Pages 4152-4166

  Ivancic, Melanie M ^a   Huttlin, Edward L ^a,c   Chen, Xiaodi ^b   Pleiman, Jennifer K ^a,b   Irving, Amy A ^a,b   Hegeman, Adrian D ^a,d   Dove, William F ^a,b   Sussman, Michael R ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

14N 15N metabolic labeling; Apc Min + mouse; blood protein biomarkers; colon cancer; intestinal cancer; mRNA microarray; selected reaction monitoring mass spectrometry; tandem mass spectrometry

Indexed keywords

ALPHA 1 ANTITRYPSIN; ALPHA GLUCOSIDASE; ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; APOLIPOPROTEIN C1; BIOLOGICAL MARKER; BLOOD CLOTTING FACTOR 5; C REACTIVE PROTEIN; CATHEPSIN B; CATHEPSIN E; COLLAGEN ALPHA1 CHAIN; COLLAGEN TYPE 1; COMPLEMENT FACTOR I; EPIDERMAL GROWTH FACTOR RECEPTOR; EXTRACELLULAR SUPEROXIDE DISMUTASE; GLYCOPROTEIN IB ALPHA; HEMOPEXIN; HEPARIN COFACTOR II; INTER ALPHA TRYPSIN INHIBITOR; LIPOPOLYSACCHARIDE BINDING PROTEIN; MESSENGER RNA; NITROGEN; NITROGEN 15; PLASMA PROTEIN; PYRUVATE KINASE; SERINE PROTEINASE INHIBITOR; SERINE PROTEINASE INHIBITOR A3N; SERUM AMYLOID P; THIOL OXIDASE; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; VITRONECTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER SCREENING; COLON POLYPOSIS; CONTROLLED STUDY; DOWN REGULATION; FEMALE; INTESTINE CANCER; INTESTINE TUMOR; MALE; MASS SPECTROMETRY; METABOLIC LABELING; MOUSE; MULTIPLE INTESTINAL NEOPLASIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEOMICS; QUANTITATIVE PROTEOMICS; SPIRULINA; UPREGULATION; WILD TYPE;

ANIMALS; COLORECTAL NEOPLASMS; EARLY DETECTION OF CANCER; FEMALE; GENES, APC; HUMANS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NITROGEN ISOTOPES; PROTEIN INTERACTION MAPS; PROTEOMICS; STAINING AND LABELING; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84883794641     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr400467c     Document Type: Article

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