Type I collagen promotes epithelial-mesenchymal transition through ILK-dependent activation of NF-κB and LEF-1

Matrix Biology

Volumn 29, Issue 3, 2010, Pages 161-165

  Medici, Damian ^a   Nawshad, Ali ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Collagen I; EMT; Epithelial mesenchymal transition; ILK; LEF 1; NF B

Indexed keywords

COLLAGEN TYPE 1; GLYCOGEN SYNTHASE KINASE 3BETA; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTEGRIN LINKED KINASE; LYMPHOID ENHANCER FACTOR 1; PROTEIN KINASE B; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN; VIMENTIN;

ARTICLE; CELL DIFFERENTIATION; CELL MIGRATION; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; MESENCHYME CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

CELL LINE, TUMOR; CELL MOVEMENT; COLLAGEN TYPE I; EPITHELIAL CELLS; EXTRACELLULAR MATRIX; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; LYMPHOID ENHANCER-BINDING FACTOR 1; MESODERM; NF-KAPPA B; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS;

GASTROPODA;

EID: 77950860363     PISSN: 0945053X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.matbio.2009.12.003     Document Type: Article

References (28)

1. Akhurst R.J., Derynck R. TGF-beta signaling in cancer - a double-edged sword. Trends Cell Biol. 2001, 11:S44-S51.
2. Bachelder R.E., Yoon S.O., Franci C., de Herreros A.G., Mercurio A.M. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J. Cell Biol. 2005, 168:29-33.
3. Docherty N.G., O'Sullivan O.E., Healy D.A., Murphy M., O'Neill A.J., Fitzpatrick J.M., Watson R.W.G. TGF-β1-induced EMT can occur independently of its proapoptotic effects and is aided by EGF receptor activation. Am. J. Physiol. Renal Physiol. 2005, 290:F1202-F1212.
4. Gilles C., Polette M., Seiki M., Birembaut P., Thompson E.W. Implication of collagen type I-induced membrane-type 1-matrix metalloproteinase expression and matrix metalloproteinase-2 activation in the metastatic progression of breast carcinoma. Lab. Invest. 1997, 76:651-660.
5. Hay E.D. An overview of epithelio-mesenchymal transformation. Acta Anat. 1995, 154:8-20.
6. Hay E.D., Zuk A. Transformation between epithelium and mesenchyme: normal, pathological, and experimentally induced. Am. J. Kidney Dis. 1995, 26:678-690.
7. Hannigan G., Troussard A.A., Dedhar S. Integrin-linked kinase: a cancer therapeutic target unique among its ILK. Nat. Rev. Cancer 2005, 5:51-63.
8. Imamichi Y., Konig A., Gress T., Menke A. Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer. Oncogene 2007, 26:2381-2385.
9. Jamora C., DasGupta R., Kocieniewski P., Fuchs E. Links between signal transduction, transcription and adhesion in epithelial bud development. Nature 2003, 422:317-322.
10. Kalluri R., Neilson E.G. Epithelial-mesenchymal transition and its implication for fibrosis. J. Clin. Invest. 2003, 112:1776-1784.
11. Kim K., Lu Z., Hay E.D. Direct evidence for a role of beta-catenin/LEF-1 signalling pathway in the induction of EMT. Cell Biol. Int. 2002, 26:463-476.
12. Koenig A., Mueller C., Hasel C., Adler G., Menke A. Collagen type I induces disruption of E-cadherin-mediated cell-cell contacts and promotes proliferation of pancreatic carcinoma cells. Cancer Res. 2006, 66:4662-4671.
13. Lavrin I.O., McLean W., Seegmiller R.E., Olsen B.R., Hay E.D. The mechanism of palatal clefting in the Col1a1 mutant mouse. Arch. Oral Biol. 2001, 46:865-869.
14. Li Y., Yang J., Dai C., Wu C., Liu Y. Role of integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis. J. Clin. Invest. 2003, 112:503-516.
15. Lustig B., Behrens J. The Wnt signaling pathway and its role in tumor development. J. Cancer Res. Clin. Oncol. 2003, 129:199-221.
16. Medici D., Hay E.D., Goodenough D.A. Cooperation between snail and LEF-1 transcription factors is essential for TGF-beta1-induced epithelial-mesenchymal transition. Mol. Biol. Cell 2006, 17:1871-1879.
17. Medici D., Hay E.D., Olsen B.R. Snail and Slug promote epithelial-mesenchymal transition through β-catenin-TCF-4-dependent expression of TGF-β3. Mol. Biol. Cell 2008, 19:4875-4887.
18. Menke A., Philippi C., Vogelmann R., Seidel B., Lutz M.P., Adler G., Wedlich D. Down-regulation of E-Cadherin gene expression by collagen type I and type III in pancreatic cancer cell lines. Cancer Res. 2001, 61:3508-3517.
19. Nawshad A., Hay E.D. TGF[beta]3 signaling activates transcription of the LEF1 gene to induce epithelial-mesenchymal transformation during mouse palate development. J. Cell Biol. 2003, 163:1291-1301.
20. Nawshad A., Medici D., Liu C.C., Hay E.D. TGFbeta3 inhibits E-cadherin gene expression in palate medial-edge epithelial cells through a Smad2-Smad4-LEF-1 transcription complex. J. Cell Sci. 2007, 120:1646-1653.
21. Peinado H., Portillo F., Cano A. Transcriptional regulation of cadherins during development and carcinogenesis. Int. J. Dev. Biol. 2004, 48:365-375.
22. Shintani Y., Maeda M., Chaika N., Johnson K.R., Wheelock M.J. Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor-β signaling. Am. J. Respir. Cell Mol. Biol. 2008, 38:95-104.
23. Thiery J.P. Epithelial-mesenchymal transitions in tumor progression. Nat. Rev. Cancer 2002, 2:442-454.
24. Thiery J.P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol. 2003, 15:740-746.
25. Valles A.M., Boyer B., Tarone G., Thiery J.P. Alpha 2 beta 1 integrin is required for the collagen and FGF-1 induced cell dispersion in a rat bladder carcinoma cell line. Cell Adhes. Commun. 1996, 4:187-199.
26. Van Kempen L.C., Ruiter D.J., van Muijen G.N., Coussens L.M. The tumor microenvironment: a critical determinant of neoplastic evolution. Eur. Cell Biol. 2003, 82:539-548.
27. Zavadil J., Bottinger E.P. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24:5764-5774.
28. Zhou B.P., Deng J., Xia W., Xu J., Li Y.M., Gunduz M., Hung M.C. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 2004, 6:931-940.