Noninvasive molecular biomarkers for the detection of colorectal cancer

Journal of Biochemistry and Molecular Biology

Volumn 41, Issue 10, 2008, Pages 685-692

  Kim, Hye Jung ^a   Yu, Myeong Hee ^a   Kim, Hoguen ^b   Byun, Jonghoe ^c   Lee, Cheolju ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c Dankook University   (South Korea)

Author keywords

Biomarker; Colorectal cancer; Early detection; Fecal occult blood test; Noninvasive marker; Proteomics

Indexed keywords

EID: 55249090218     PISSN: 12258687     EISSN: 02191024     Source Type: Journal    
DOI: 10.5483/bmbrep.2008.41.10.685     Document Type: Short Survey

References (68)

1. Bingham, S. and Riboli, E. (2004) Diet and cancer - the European Prospective Investigation into Cancer and Nutrition. Nat. Rev. Cancer 4, 206-215.
2. Sung, J. J., Lau, J. Y., Goh, K. L., Leung, W. K. and Asia Pacific Working Group on Colorectal Cancer (2005) Increasing incidence of colorectal cancer in Asia: implications for screening. Lancet Oncol. 6, 871-876.
3. Hardcastle, J. D., Chamberlain, J. O., Robinson, M. H., Moss, S. M., Amar, S. S., Balfour, T. W., James, P. D. and Mangham, C. M. (1996) Randomised controlled trial of faecal-occult-blood screening for colorectal cancer. Lancet 348, 1472-1477.
4. Kronborg, O., Fenger, C., Olsen, J., Jorgensen, O. D. and Sondergaard, O. (1996) Randomised study of screening for colorectal cancer with faecal-occult-blood test. Lancet 348, 1467-1471.
5. Rubenstein, K. (2007) Disease-related biomarkers: their potential in patient screening, prognosis, and stratification, Insight Pharma Reports, Needham, MA, USA
6. Geenen, J. E., Schmitt, M. G., Jr., Wu, W. C. and Hogan, W. J. (1975) Major complications of coloscopy: bleeding and perforation. Am. J. Dig. Dis. 20, 231-235.
7. Winawer, S., Fletcher, R., Rex, D., Bond, J., Burt, R., Ferrucci, J., Ganiats, T., Levin, T., Woolf, S., Johnson, D., Kirk, L., Litin, S. and Simmang, C. (2003) Colorectal cancer screening and surveillance: clinical guidelines and rationale-Update based on new evidence. Gastroenterology 124, 544-560.
8. Booth, R. A. (2007) Minimally invasive biomarkers for detection and staging of colorectal cancer. Cancer Lett. 249, 87-96.
9. Duffy, M. J., van Dalen, A., Haglund, C., Hansson, L., Klapdor, R., Lamerz, R., Nilsson, O., Sturgeon, C. and Topolcan, O. (2003) Clinical utility of biochemical markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines. Eur. J. Cancer 39, 718-727.
10. Habermann, J. K., Bader, F. G., Franke, C., Zimmermann, K., Gemoll, T., Fritzsche, B., Ried, T., Auer, G., Bruch, H. P. and Roblick, U. J. (2008) From the genome to the proteome-biomarkers in colorectal cancer. Langenbecks Arch. Surg. 393, 93-104.
11. Kim, S. Y. and Hahn, W. C. (2007) Cancer genomics: integrating form and function. Carcinogenesis 28, 1387-1392.
12. Faca, V., Krasnoselsky, A. and Hanash, S. (2007) Innovative proteomic approaches for cancer biomarker discovery. BioTechniques 43, 279, 281-273, 285.
13. Duffy, M. J., van Dalen, A., Haglund, C., Hansson, L., Holinski-Feder, E., Klapdor, R., Lamerz, R., Peltomaki, P., Sturgeon, C. and Topolcan, O. (2007) Tumour markers in colorectal cancer: European Group on Tumour Markers (EGTM) guidelines for clinical use. Eur. J. Cancer 43, 1348-1360.
14. Huang, C. S., Lal, S. K. and Farraye, F. A. (2005) Colorectal cancer screening in average risk individuals. Cancer Causes Control 16, 171-188.
15. Mandel, J. S., Bond, J. H., Church, T. R., Snover, D. C., Bradley, G. M., Schuman, L. M. and Ederer, F. (1993) Reducing mortality from colorectal cancer by screening for fecal occult blood. Minnesota Colon Cancer Control Study. N. Engl. J. Med. 328, 1365-1371.
16. Loktionov, A., O'Neill, I. K., Silvester, K. R., Cummings, J. H., Middleton, S. J. and Miller, R. (1998) Quantitation of DNA from exfoliated colonocytes isolated from human stool surface as a novel noninvasive screening test for colorectal cancer. Clin. Cancer Res. 4, 337-342.
17. Shaw, R. J. and Cantley, L. C. (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441, 424-430.
18. Fearon, E. R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell 61, 759-767.
19. Losi, L., Roncucci, L., di Gregorio, C., de Leon, M. P. and Benhattar, J. (1996) K-ras and p53 mutations in human colorectal aberrant crypt foci. J. Pathol. 178, 259-263.
20. Shivapurkar, N., Huang, L., Ruggeri, B., Swalsky, P. A., Bakker, A., Finkelstein, S., Frost, A. and Silverberg, S. (1997) K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients. Cancer Lett. 115, 39-46.
21. Smith, A. J., Stern, H. S., Penner, M., Hay, K., Mitri, A., Bapat, B. V. and Gallinger, S. (1994) Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons. Cancer Res. 54, 5527-5530.
22. Mills, A. A. (2005) p53: link to the past, bridge to the future. Genes Dev. 19, 2091-2099.
23. Iacopetta, B. (2003) TP53 mutation in colorectal cancer. Hum. Mutat. 21, 271-276.
24. Hart, M. J., de los Santos, R., Albert, I. N., Rubinfeld, B. and Polakis, P. (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr. Biol. 8, 573-581.
25. Srivastava, S., Verma, M. and Henson, D. E. (2001) Biomarkers for early detection of colon cancer. Clin. Cancer Res. 7, 1118-1126.
26. Ahlquist, D. A., Skoletsky, J. E., Boynton, K. A., Harrington, J. J., Mahoney, D. W., Pierceall, W. E., Thibodeau, S. N. and Shuber, A. P. (2000) Colorectal cancer screening by detection of altered human DNA in stool: feasibility of a multitarget assay panel. Gastroenterology 119, 1219-1227.
27. Dietmaier, W., Wallinger, S., Bocker, T., Kullmann, F., Fishel, R. and Ruschoff, J. (1997) Diagnostic microsatellite instability: definition and correlation with mismatch repair protein expression. Cancer Res. 57, 4749-4756.
28. Ribic, C. M., Sargent, D. J., Moore, M. J., Thibodeau, S. N., French, A. J., Goldberg, R. M., Hamilton, S. R., Laurent-Puig, P., Gryfe, R., Shepherd, L. E., Tu, D., Redston, M. and Gallinger, S. (2003) Tumor microsatellite- instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N. Engl. J. Med. 349, 247-257.
29. Esteller, M., Levine, R., Baylin, S. B., Ellenson, L. H. and Herman, J. G. (1998) MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas. Oncogene 17, 2413-2417.
30. Albaugh, G. P., Iyengar, V., Lohani, A., Malayeri, M., Bala, S. and Nair, P. P. (1992) Isolation of exfoliated colonic epithelial cells, a novel, non-invasive approach to the study of cellular markers. Int. J. Cancer 52, 347-350.
31. Boynton, K. A., Summerhayes, I. C., Ahlquist, D. A. and Shuber, A. P. (2003) DNA integrity as a potential marker for stool-based detection of colorectal cancer. Clin. Chem. 49, 1058-1065.
32. Imperiale, T. F., Ransohoff, D. F., Itzkowitz, S. H., Turnbull, B. A. and Ross, M. E. (2004) Fecal DNA versus fecal occult blood for colorectal-cancer screening in an average-risk population. N. Engl. J. Med. 351, 2704-2714.
33. Bates, J. (2008) Cancer biomarkers: adoption is driving growth, Insight Pharma Reports, Needham, MA, USA
34. Duffy, M. J. (2001) Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin. Chem. 47, 624-630.
35. Magnani, J. L., Nilsson, B., Brockhaus, M., Zopf, D., Steplewski, Z., Koprowski, H. and Ginsburg, V. (1982) A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. J. Biol. Chem. 257, 14365-14369.
36. Duffy, M. J. (1998) CA 19-9 as a marker for gastrointestinal cancers: a review. Ann. Clin. Biochem. 35 (Pt 3), 364-370.
37. Hundt, S., Haug, U. and Brenner, H. (2007) Blood markers for early detection of colorectal cancer: a systematic review. Cancer Epidemiol. Biomarkers Prev. 16, 1935-1953.
38. Holten-Andersen, M. N., Murphy, G., Nielsen, H. J., Pedersen, A. N., Christensen, I. J., Hoyer-Hansen, G., Brunner, N. and Stephens, R. W. (1999) Quantitation of TIMP-1 in plasma of healthy blood donors and patients with advanced cancer. Br. J. Cancer 80, 495-503.
39. Sorensen, N. M., Schrohl, A. S., Jensen, V., Christensen, I. J., Nielsen, H. J. and Brunner, N. (2008) Comparative studies of tissue inhibitor of metalloproteinases-1 in plasma, serum and tumour tissue extracts from patients with primary colorectal cancer. Scand. J. Gastroenterol. 43, 186-191.
40. Holten-Andersen, M. N., Fenger, C., Nielsen, H. J., Rasmussen, A. S., Christensen, I. J., Brunner, N. and Kronborg, O. (2004) Plasma TIMP-1 in patients with colorectal adenomas: a prospective study. Eur. J. Cancer 40, 2159-2164.
41. Holten-Andersen, M., Christensen, I. J., Nilbert, M., Bendahl, P. O., Nielsen, H. J., Brunner, N. and Fernebro, E. (2004) Association between preoperative plasma levels of tissue inhibitor of metalloproteinases 1 and rectal cancer patient survival. a validation study. Eur. J. Cancer 40, 64-72.
42. Holten-Andersen, M. N., Stephens, R. W., Nielsen, H. J., Murphy, G., Christensen, I. J., Stetler-Stevenson, W. and Brunner, N. (2000) High preoperative plasma tissue inhibitor of metalloproteinase-1 levels are associated with short survival of patients with colorectal cancer. Clin. Cancer Res. 6, 4292-4299.
43. diaDexus Inc. (2007) Clinical application of diaDexus diagnostics in colorectal cancer http://www.diadexus.com/products/research/oncoogy_diagnostics. php
44. Roessler, M., Rollinger, W., Palme, S., Hagmann, M. L., Berndt, P., Engel, A. M., Schneidinger, B., Pfeffer, M., Andres, H., Karl, J., Bodenmuller, H., Ruschoff, J., Henkel, T., Rohr, G., Rossol, S., Rosch, W., Langen, H., Zolg, W. and Tacke, M. (2005) Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin. Cancer Res. 11, 6550-6557.
45. Roessler, M., Rollinger, W., Mantovani-Endl, L., Hagmann, M. L., Palme, S., Berndt, P., Engel, A. M., Pfeffer, M., Karl, J., Bodenmuller, H., Ruschoff, J., Henkel, T., Rohr, G., Rossol, S., Rosch, W., Langen, H., Zolg, W. and Tacke, M. (2006) Identification of PSME3 as a novel serum tumor marker for colorectal cancer by combining two-dimensional polyacrylamide gel electrophoresis with a strictly mass spectrometry-based approach for data analysis. Mol. Cell. Proteomics 5, 2092-2101.
46. Volmer, M. W., Stuhler, K., Zapatka, M., Schoneck, A., Klein-Scory, S., Schmiegel, W., Meyer, H. E. and Schwarte-Waldhoff, I. (2005) Differential proteome analysis of conditioned media to detect Smad4 regulated secreted biomarkers in colon cancer. Proteomics 5, 2587-2601.
47. Chang, J. W., Kang, U.-B., Kim, D. H., Yi, J. K., Lee, J. W., Noh, D.-Y., Lee, C. and Yu, M.-H. (2008) Identification of circulating endorepellin LG3 fragment: Potential use as a serological biomarker for breast cancer. Proteomics Clin. Appl. 2, 23-32.
48. Wu, C. C., Chen, H. C., Chen, S. J., Liu, H. P., Hsieh, Y. Y., Yu, C. J., Tang, R., Hsieh, L. L., Yu, J. S. and Chang, Y. S. (2008) Identification of collapsin response mediator protein-2 as a potential marker of colorectal carcinoma by comparative analysis of cancer cell secretomes. Proteomics 8, 316-332.
49. Engwegen, J. Y., Gast, M. C., Schellens, J. H. and Beijnen, J. H. (2006) Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry. Trends Pharmacol. Sci. 27, 251-259.
50. Ward, D. G., Suggett, N., Cheng, Y., Wei, W., Johnson, H., Billingham, L. J., Ismail, T., Wakelam, M. J., Johnson, P. J. and Martin, A. (2006) Identification of serum biomarkers for colon cancer by proteomic analysis. Br. J. Cancer 94, 1898-1905.
51. Habermann, J. K., Roblick, U. J., Luke, B. T., Prieto, D. A., Finlay, W. J., Podust, V. N., Roman, J. M., Oevermann, E., Schiedeck, T., Homann, N., Duchrow, M., Conrads, T. P., Veenstra, T. D., Burt, S. K., Bruch, H. P., Auer, G. and Ried, T. (2006) Increased serum levels of complement C3a anaphylatoxin indicate the presence of colorectal tumors. Gastroenterology 131, 1020-1029; quiz 1284.
52. Albrethsen, J., Bogebo, R., Gammeltoft, S., Olsen, J., Winther, B. and Raskov, H. (2005) Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1-3) in colon cancer serum and tumours: a biomarker study. BMC Cancer 5, 8.
53. Melle, C., Ernst, G., Schimmel, B., Bleul, A., Thieme, H., Kaufmann, R., Mothes, H., Settmacher, U., Claussen, U., Halbhuber, K. J. and Von Eggeling, F. (2005) Discovery and identification of alpha-defensins as low abundant, tumor-derived serum markers in colorectal cancer. Gastroenterology 129, 66-73.
54. Lee, H., Rhee, H., Kang, H. J., Kim, H. S., Min, B. S., Kim, N. K. and Kim, H. (2008) Macrophage migration inhibitory factor may be used as an early diagnostic marker in colorectal carcinomas. Am. J. Clin. Pathol. 129, 772-779.
55. Mroczko, B., Groblewska, M., Wereszczynska-Siemiatkowska, U., Okulczyk, B., Kedra, B., Laszewicz, W., Dabrowski, A. and Szmitkowski, M. (2007) Serum macrophage-colony stimulating factor levels in colorectal cancer patients correlate with lymph node metastasis and poor prognosis. Clin. Chim. Acta 380, 208-212.
56. Mroczko, B., Groblewska, M., Wereszczynska-Siemiatkowska, U., Kedra, B., Konopko, M. and Szmitkowski, M. (2006) The diagnostic value of G-CSF measurement in the sera of colorectal cancer and adenoma patients. Clin. Chim. Acta 371, 143-147.
57. Soroush, A. R., Zadeh, H. M., Moemeni, M., Shakiba, B. and Elmi, S. (2004) Plasma prolactin in patients with colorectal cancer. BMC Cancer 4, 97.
58. Schneider, J., Bitterlich, N. and Schulze, G. (2005) Improved sensitivity in the diagnosis of gastro-intestinal tumors by fuzzy logic-based tumor marker profiles including the tumor M2-PK. Anticancer Res. 25, 1507-1515.
59. Zhang, B., Chen, J. Y., Chen, D. D., Wang, G. B. and Shen, P. (2004) Tumor type M2 pyruvate kinase expression in gastric cancer, colorectal cancer and controls. World J. Gastroenterol. 10, 1643-1646.
60. Zhu, J. and Yao, X. (2007) Use of DNA methylation for cancer detection and molecular classification. J. Biochem. Mol. Biol. 40, 135-141.
61. Lofton-Day, C., Model, F., Devos, T., Tetzner, R., Distler, J., Schuster, M., Song, X., Lesche, R., Liebenberg, V., Ebert, M., Molnar, B., Grutzmann, R., Pilarsky, C. and Sledziewski, A. (2008) DNA methylation biomarkers for blood-based colorectal cancer screening. Clin. Chem. 54, 414-423.
62. Liew, C. C., Ma, J., Tang, H. C., Zheng, R. and Dempsey, A. A. (2006) The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J. Lab. Clin. Med. 147, 126-132.
63. Han, M., Liew, C. T., Zhang, H. W., Chao, S., Zheng, R., Yip, K. T., Song, Z. Y., Li, H. M., Geng, X. P., Zhu, L. X., Lin, J. J., Marshall, K. W. and Liew, C. C. (2008) Novel blood-based, five-gene biomarker set for the detection of colorectal cancer. Clin. Cancer Res. 14, 455-460.
64. Brunagel, G., Vietmeier, B. N., Bauer, A. J., Schoen, R. E. and Getzenberg, R. H. (2002) Identification of nuclear matrix protein alterations associated with human colon cancer. Cancer Res. 62, 2437-2442.
65. Leman, E. S., Schoen, R. E., Magheli, A., Sokoll, L. J., Chan, D. W. and Getzenberg, R. H. (2008) Evaluation of colon cancer-specific antigen 2 as a potential serum marker for colorectal cancer. Clin. Cancer Res. 14, 1349-1354.
66. Hurst, N. G., Stocken, D. D., Wilson, S., Keh, C., Wakelam, M. J. and Ismail, T. (2007) Elevated serum matrix metalloproteinase 9 (MMP-9) concentration predicts the presence of colorectal neoplasia in symptomatic patients. Br. J. Cancer 97, 971-977.
67. Maurel, J., Nadal, C., Garcia-Albeniz, X., Gallego, R., Carcereny, E., Almendro, V., Marmol, M., Gallardo, E., Maria Auge, J., Longaron, R., Martinez-Fernandez, A., Molina, R., Castells, A. and Gascon, P. (2007) Serum matrix metalloproteinase 7 levels identifies poor prognosis advanced colorectal cancer patients. Int. J. Cancer 121, 1066-1071.
68. Saito, N. and Kameoka, S. (2005) Serum laminin is an independent prognostic factor in colorectal cancer. Int. J. Colorectal Dis. 20, 238-244.