Stable isotope metabolic labeling with a novel 15N-enriched bacteria diet for improved proteomic analyses of mouse models for psychopathologies

PLoS ONE

Volumn 4, Issue 11, 2009, Pages

  Frank, Elisabeth ^a,b   Kessler, Melanie S ^a,c   Filiou, Michaela D ^a   Zhang, Yaoyang ^a   Maccarone, Giusseppina ^a   Reckow, Stefan ^a   Bunck, Mirjam ^a,d   Heumann, Hermann ^e,f   Turck, Christoph W ^a   Landgraf, Rainer ^a   Hambsch, Boris ^a  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d Affectis Pharmaceutical AG   (Germany)

^e MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^f Silantes GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 2; LACTOYLGLUTATHIONE LYASE; NITROGEN 15; NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG; HISTIDINE; NITROGEN; PROTEOME;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; CUPRIAVIDUS NECATOR; DIETARY INTAKE; EXPERIMENTAL MODEL; ISOTOPE LABELING; MASS SPECTROMETRY; MOUSE; NEUROPATHOLOGY; NONHUMAN; PHENOTYPE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE STUDY; ANIMAL; ANXIETY; BIOSYNTHESIS; CHEMISTRY; DEPRESSION; DISEASE MODEL; GENETICS; MAZE TEST; METABOLISM; METHODOLOGY;

ANIMALIA; CUPRIAVIDUS NECATOR; MUS;

ANIMALS; ANXIETY; CUPRIAVIDUS NECATOR; DEPRESSION; DISEASE MODELS, ANIMAL; HISTIDINE; LACTOYLGLUTATHIONE LYASE; MASS SPECTROMETRY; MAZE LEARNING; MICE; NITROGEN ISOTOPES; PHENOTYPE; PROTEOME; PROTEOMICS;

EID: 70649093033     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0007821     Document Type: Article

References (21)

1. Hernandez M, Simon O, Bergner H (1981) [A new method for testing the quality of food proteins for maintenance metabolism. 3. Methodological studies of 15N-labeled adult rats]. Arch Tierernahr 31: 651-60.
2. Ong SE, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, et al. (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1: 376-86.
3. Gruhler S, Kratchmarova I (2008) Stable isotope labeling by amino acids in cell culture (SILAC). Methods Mol Biol 424: 101-11.
4. Bindschedler LV, Palmblad M, Cramer R (2008) Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Phytochemistry 69: 1962-72.
5. Nelson CJ, Huttlin EL, Hegeman AD, Harms AC, Sussman MR (2007) Implications of 15N-metabolic labeling for automated peptide identification in Arabidopsis thaliana. Proteomics 7: 1279-92.
6. Schaff JE, Mbeunkui F, Blackburn K, Bird DM, Goshe MB (2008) SILIP: a novel stable isotope labeling method for in planta quantitative proteomic analysis. Plant J 56: 840-54.
7. Krijgsveld J, Ketting RF, Mahmoudi T, Johansen J, Artal-Sanz M, et al. (2003) Metabolic labeling of C. elegans and D. melanogaster for quantitative proteomics. Nat Biotechnol 21: 927-31.
8. Wu CC, MacCoss MJ, Howell KE, Matthews DE, Yates JR 3rd (2004) Metabolic labeling of mammalian organisms with stable isotopes for quantitative proteomic analysis. Anal Chem 76: 4951-59.
9. McClatchy DB, Dong MQ, Wu CC, Venable JD, Yates JR 3rd (2007) (15)N Metabolic Labeling of Mammalian Tissue with Slow Protein Turnover. J Proteome Res 6(5): 2005-10.
10. McClatchy DB, Liao L, Park SK, Venable JD, Yates JR (2007) Quantification of the synaptosomal proteome of the rat cerebellum during post-natal development. Genome Res 17: 1378-88.
11. Liao L, McClatchy DB, Park SK, Xu T, Lu B, et al. (2008) Quantitative Analysis of Brain Nuclear Phosphoproteins Identifies Developmentally Regulated Phosphorylation Events. J Proteome Res 7(11): 4743-55.
12. Kromer SA, Kessler MS, Milfay D, Birg IN, Bunck M, et al. (2005) Identification of glyoxalase-I as a protein marker in a mouse model of extremes in trait anxiety. J Neurosci 25: 4375-84.
13. Landgraf R, Kessler MS, Bunck M, Murgatroyd C, Spengler D, et al. (2007) Candidate genes of anxiety-related behavior in HAB/LAB rats and mice: focus on vasopressin and glyoxalase-I. Neurosci Biobehav Rev 31: 89-102.
14. Ditzen C, Varadarajulu J, Czibere L, Gonik M, Targosz BS, et al. (2009) Proteomic-based genotyping in a mouse model of trait anxiety exposes disease-relevant pathways. Mol Psychiatry Jan 13 [Epub ahead of print].
15. Bunck M, Czibere L, Horvath C, Graf C, Frank E, et al. (2009) A hypomorphic vasopressin allele prevents anxiety-related behavior. PLoS ONE 4: e5129.
16. Ditzen C, Jastorff AM, Kessler MS, Bunck M, Teplytska L, et al. (2006) Protein biomarkers in a mouse model of extremes in trait anxiety. Mol Cell Proteomics 5(10): 1914-20.
17. Kessler MS, Murgatroyd C, Bunck M, Czibere L, Frank E, et al. (2007) Diabetes insipidus and, partially, low anxiety-related behaviour are linked to a SNP-associated vasopressin deficit in LAB mice. Eur J Neurosci 26: 2857-64.
18. Lenglet S, Antigny F, Vetterli L, Dufour JF, Rossier MF (2008) Hint2 is expressed in the mitochondria of H295R cells and is involved in steroidogenesis. Endocrinology 149: 5461-69.
19. Pellow S, Chopin P, File SE, Briley M (1985) Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14: 149-67.
20. Steru L, Chermat R, Thierry B, Simon P (1985) The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology (Berl) 85: 367-70.
21. Haegler K, Mueller NS, Maccarrone G, Hunyadi-Gulyas E, Webhofer C, et al. (2009) QuantiSpec-Quantitative mass spectrometry data analysis of (15)N-metabolically labeled proteins. J Proteomics 71: 601-08.