메뉴 건너뛰기




Volumn 305, Issue 5, 2013, Pages

Dysfunctional mitochondrial bioenergetics and oxidative stress in Akita+/Ins2-derived β-cells

Author keywords

cell; Diabetes mellitus; Endoplasmic reticulum stress; Mitochondrial quality control; Mitochondrial respiration

Indexed keywords

MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN;

EID: 84883792140     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00093.2013     Document Type: Article
Times cited : (41)

References (62)
  • 3
    • 0242609973 scopus 로고    scopus 로고
    • Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus
    • Araki E, Oyadomari S, Mori M. Impact of endoplasmic reticulum stress pathway on pancreatic beta-cells and diabetes mellitus. Exp Biol Med (Maywood) 228: 1213-1217, 2003.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 1213-1217
    • Araki, E.1    Oyadomari, S.2    Mori, M.3
  • 4
    • 0026550830 scopus 로고
    • Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines
    • Asfari M, Janjic D, Meda P, Li G, Halban PA, Wollheim CB. Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines. Endocrinology 130: 167-178, 1992.
    • (1992) Endocrinology , vol.130 , pp. 167-178
    • Asfari, M.1    Janjic, D.2    Meda, P.3    Li, G.4    Halban, P.A.5    Wollheim, C.B.6
  • 6
    • 84870873590 scopus 로고    scopus 로고
    • Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death
    • Bartolome A, Guillen C, Benito M. Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death. Autophagy 8: 1757-1768, 2012.
    • (2012) Autophagy , vol.8 , pp. 1757-1768
    • Bartolome, A.1    Guillen, C.2    Benito, M.3
  • 8
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 54: 1615-1625, 2005.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 10
    • 33644749322 scopus 로고    scopus 로고
    • Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
    • Cnop M, Welsh N, Jonas JC, Jörns A, Lenzen S, Eizirik DL. Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54, Suppl 2: S97-S107, 2005.
    • (2005) Diabetes , vol.54 , Issue.SUPPL. 2
    • Cnop, M.1    Welsh, N.2    Jonas, J.C.3    Jörns, A.4    Lenzen, S.5    Eizirik, D.L.6
  • 12
    • 35448960851 scopus 로고    scopus 로고
    • Functions and dysfunctions of mitochondrial dynamics
    • Detmer SA, Chan DC. Functions and dysfunctions of mitochondrial dynamics. Nat Rev Mol Cell Biol 8: 870-879, 2007.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 870-879
    • Detmer, S.A.1    Chan, D.C.2
  • 14
    • 77249126523 scopus 로고    scopus 로고
    • Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species
    • Dranka BP, Hill BG, Darley-Usmar VM. Mitochondrial reserve capacity in endothelial cells: The impact of nitric oxide and reactive oxygen species. Free Radic Biol Med 48: 905-914, 2010.
    • (2010) Free Radic Biol Med , vol.48 , pp. 905-914
    • Dranka, B.P.1    Hill, B.G.2    Darley-Usmar, V.M.3
  • 15
    • 42449134450 scopus 로고    scopus 로고
    • Insulin mutation screening in 1,044 patients with diabetes: Mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood
    • Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S
    • Edghill EL, Flanagan SE, Patch AM, Boustred C, Parrish A, Shields B, Shepherd MH, Hussain K, Kapoor RR, Malecki M, MacDonald MJ, Støy J, Steiner DF, Philipson LH, Bell GI; Neonatal Diabetes International Collaborative Group, Hattersley AT, Ellard S. Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood. Diabetes 57: 1034-1042, 2008.
    • (2008) Diabetes , vol.57 , pp. 1034-1042
    • Edghill, E.L.1    Flanagan, S.E.2    Patch, A.M.3    Boustred, C.4    Parrish, A.5    Shields, B.6    Shepherd, M.H.7    Hussain, K.8    Kapoor, R.R.9    Malecki, M.10    McDonald, M.J.11    Støy, J.12    Steiner, D.F.13    Philipson, L.H.14    Bell, G.I.15
  • 16
    • 39149104320 scopus 로고    scopus 로고
    • The role for endoplasmic reticulum stress in diabetes mellitus
    • Eizirik DL, Cardozo AK, Cnop M. The role for endoplasmic reticulum stress in diabetes mellitus. Endocr Rev 29: 42-61, 2008.
    • (2008) Endocr Rev , vol.29 , pp. 42-61
    • Eizirik, D.L.1    Cardozo, A.K.2    Cnop, M.3
  • 17
    • 77953799916 scopus 로고    scopus 로고
    • Autophagy in health and disease. 4. The role of pancreatic β-cell autophagy in health and diabetes
    • Fujitani Y, Ueno T, Watada H. Autophagy in health and disease. 4. The role of pancreatic β-cell autophagy in health and diabetes. Am J Physiol Cell Physiol 299: C1-C6, 2010.
    • (2010) Am J Physiol Cell Physiol , vol.299
    • Fujitani, Y.1    Ueno, T.2    Watada, H.3
  • 18
    • 79959346132 scopus 로고    scopus 로고
    • Distinct autophagosomallysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest
    • Ganley IG, Wong PM, Gammoh N, Jiang X. Distinct autophagosomallysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell 42: 731-743, 2011.
    • (2011) Mol Cell , vol.42 , pp. 731-743
    • Ganley, I.G.1    Wong, P.M.2    Gammoh, N.3    Jiang, X.4
  • 19
    • 34248187585 scopus 로고    scopus 로고
    • Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice
    • Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R. Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice. Diabetes 56: 1268-1276, 2007.
    • (2007) Diabetes , vol.56 , pp. 1268-1276
    • Herbach, N.1    Rathkolb, B.2    Kemter, E.3    Pichl, L.4    Klaften, M.5    de Angelis, M.H.6    Halban, P.A.7    Wolf, E.8    Aigner, B.9    Wanke, R.10
  • 22
    • 68349131632 scopus 로고    scopus 로고
    • Methods for the determination and quantification of the reactive thiol proteome
    • Hill BG, Reily C, Oh JY, Johnson MS, Landar A. Methods for the determination and quantification of the reactive thiol proteome. Free Radic Biol Med 47: 675-683, 2009.
    • (2009) Free Radic Biol Med , vol.47 , pp. 675-683
    • Hill, B.G.1    Reily, C.2    Oh, J.Y.3    Johnson, M.S.4    Landar, A.5
  • 23
    • 55149107716 scopus 로고    scopus 로고
    • Radical-free biology of oxidative stress
    • Jones DP. Radical-free biology of oxidative stress. Am J Physiol Cell Physiol 295: C849-C868, 2008.
    • (2008) Am J Physiol Cell Physiol , vol.295
    • Jones, D.P.1
  • 24
    • 2342517248 scopus 로고    scopus 로고
    • Role of oxidative stress in pancreatic beta-cell dysfunction
    • Kajimoto Y, Kaneto H. Role of oxidative stress in pancreatic beta-cell dysfunction. Ann NY Acad Sci 1011: 168-176, 2004.
    • (2004) Ann NY Acad Sci , vol.1011 , pp. 168-176
    • Kajimoto, Y.1    Kaneto, H.2
  • 25
    • 34047179973 scopus 로고    scopus 로고
    • Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy
    • Kaniuk NA, Kiraly M, Bates H, Vranic M, Volchuk A, Brumell JH. Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 56: 930-939, 2007.
    • (2007) Diabetes , vol.56 , pp. 930-939
    • Kaniuk, N.A.1    Kiraly, M.2    Bates, H.3    Vranic, M.4    Volchuk, A.5    Brumell, J.H.6
  • 26
    • 77957294848 scopus 로고    scopus 로고
    • Autophagic pathways and metabolic stress
    • Kaushik S, Singh R, Cuervo AM. Autophagic pathways and metabolic stress. Diabetes Obes Metab 12, Suppl 2: 4-14, 2010.
    • (2010) Diabetes Obes Metab , vol.12 , Issue.SUPPL. 4 , pp. 4-14
    • Kaushik, S.1    Singh, R.2    Cuervo, A.M.3
  • 27
    • 84870663099 scopus 로고    scopus 로고
    • Monogenic models: What have the single gene disorders taught us?
    • Klupa T, Skupien J, Malecki MT. Monogenic models: what have the single gene disorders taught us? Curr Diab Rep 12: 659-666, 2012.
    • (2012) Curr Diab Rep , vol.12 , pp. 659-666
    • Klupa, T.1    Skupien, J.2    Malecki, M.T.3
  • 28
    • 84555195856 scopus 로고    scopus 로고
    • Autophagy, mitochondria and oxidative stress: Cross-talk and redox signalling
    • Lee J, Giordano S, Zhang J. Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling. Biochem J 441: 523-540, 2012.
    • (2012) Biochem J , vol.441 , pp. 523-540
    • Lee, J.1    Giordano, S.2    Zhang, J.3
  • 29
    • 84876231278 scopus 로고    scopus 로고
    • Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy
    • Lei X, Bone RN, Ali T, Wohltmann M, Gai Y, Goodwin KJ, Bohrer AE, Turk J, Ramanadham S. Genetic modulation of islet β-cell iPLA(2)β expression provides evidence for its impact on β-cell apoptosis and autophagy. Islets 5: 29-44, 2013.
    • (2013) Islets , vol.5 , pp. 29-44
    • Lei, X.1    Bone, R.N.2    Ali, T.3    Wohltmann, M.4    Gai, Y.5    Goodwin, K.J.6    Bohrer, A.E.7    Turk, J.8    Ramanadham, S.9
  • 30
    • 77949899139 scopus 로고    scopus 로고
    • Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: A role for regulation by SREBP-1
    • Lei X, Zhang S, Barbour SE, Bohrer A, Ford EL, Koizumi A, Papa FR, Ramanadham S. Spontaneous development of endoplasmic reticulum stress that can lead to diabetes mellitus is associated with higher calcium-independent phospholipase A2 expression: a role for regulation by SREBP-1. J Biol Chem 285: 6693-6705, 2010.
    • (2010) J Biol Chem , vol.285 , pp. 6693-6705
    • Lei, X.1    Zhang, S.2    Barbour, S.E.3    Bohrer, A.4    Ford, E.L.5    Koizumi, A.6    Papa, F.R.7    Ramanadham, S.8
  • 31
    • 34548522699 scopus 로고    scopus 로고
    • The group VIA calcium-independent phospholipase A2 participates in ER stressinduced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase
    • Lei X, Zhang S, Bohrer A, Bao S, Song H, Ramanadham S. The group VIA calcium-independent phospholipase A2 participates in ER stressinduced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Biochemistry 46: 10170-10185, 2007.
    • (2007) Biochemistry , vol.46 , pp. 10170-10185
    • Lei, X.1    Zhang, S.2    Bohrer, A.3    Bao, S.4    Song, H.5    Ramanadham, S.6
  • 32
    • 78650853311 scopus 로고    scopus 로고
    • Two tales of antioxidant enzymes on β cells and diabetes
    • Lei XG, Vatamaniuk MZ. Two tales of antioxidant enzymes on β cells and diabetes. Antioxid Redox Signal 14: 489-503, 2011.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 489-503
    • Lei, X.G.1    Vatamaniuk, M.Z.2
  • 33
    • 84875906572 scopus 로고    scopus 로고
    • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure
    • Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab 17: 491-506, 2013.
    • (2013) Cell Metab , vol.17 , pp. 491-506
    • Liesa, M.1    Shirihai, O.S.2
  • 34
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: New model of diabetes mellitus
    • Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 193: 415-417, 1976.
    • (1976) Science , vol.193 , pp. 415-417
    • Like, A.A.1    Rossini, A.A.2
  • 35
    • 0033150608 scopus 로고    scopus 로고
    • Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite
    • MacMillan-Crow LA, Thompson JA. Tyrosine modifications and inactivation of active site manganese superoxide dismutase mutant (Y34F) by peroxynitrite. Arch Biochem Biophys 366: 82-88, 1999.
    • (1999) Arch Biochem Biophys , vol.366 , pp. 82-88
    • McMillan-Crow, L.A.1    Thompson, J.A.2
  • 37
    • 0014691242 scopus 로고
    • Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
    • McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244: 6049-6055, 1969.
    • (1969) J Biol Chem , vol.244 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.2
  • 38
    • 84873197455 scopus 로고    scopus 로고
    • Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: Implications for mitochondrial therapeutics
    • Mitchell T, Chacko B, Ballinger SW, Bailey SM, Zhang J, Darley-Usmar V. Convergent mechanisms for dysregulation of mitochondrial quality control in metabolic disease: implications for mitochondrial therapeutics. Biochem Soc Trans 41: 127-133, 2013.
    • (2013) Biochem Soc Trans , vol.41 , pp. 127-133
    • Mitchell, T.1    Chacko, B.2    Ballinger, S.W.3    Bailey, S.M.4    Zhang, J.5    Darley-Usmar, V.6
  • 39
    • 0025281303 scopus 로고
    • Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms
    • Miyazaki J, Araki K, Yamato E, Ikegami H, Asano T, Shibasaki Y, Oka Y, Yamamura K. Establishment of a pancreatic beta cell line that retains glucose-inducible insulin secretion: special reference to expression of glucose transporter isoforms. Endocrinology 127: 126-132, 1990.
    • (1990) Endocrinology , vol.127 , pp. 126-132
    • Miyazaki, J.1    Araki, K.2    Yamato, E.3    Ikegami, H.4    Asano, T.5    Shibasaki, Y.6    Oka, Y.7    Yamamura, K.8
  • 40
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 417: 1-13, 2009.
    • (2009) Biochem J , vol.417 , pp. 1-13
    • Murphy, M.P.1
  • 41
    • 1642413540 scopus 로고    scopus 로고
    • The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells
    • Nozaki J, Kubota H, Yoshida H, Naitoh M, Goji J, Yoshinaga T, Mori K, Koizumi A, Nagata K. The endoplasmic reticulum stress response is stimulated through the continuous activation of transcription factors ATF6 and XBP1 in Ins2+/Akita pancreatic beta cells. Genes Cells 9: 261-270, 2004.
    • (2004) Genes Cells , vol.9 , pp. 261-270
    • Nozaki, J.1    Kubota, H.2    Yoshida, H.3    Naitoh, M.4    Goji, J.5    Yoshinaga, T.6    Mori, K.7    Koizumi, A.8    Nagata, K.9
  • 43
    • 73949154312 scopus 로고    scopus 로고
    • Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted
    • Park SY, Ye H, Steiner DF, Bell GI. Mutant proinsulin proteins associated with neonatal diabetes are retained in the endoplasmic reticulum and not efficiently secreted. Biochem Biophys Res Commun 391: 1449-1454, 2010.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1449-1454
    • Park, S.Y.1    Ye, H.2    Steiner, D.F.3    Bell, G.I.4
  • 44
    • 84871955083 scopus 로고    scopus 로고
    • Effect of S-nitrosoglutathione on renal mitochondrial function: A new mechanism for reversible regulation of manganese superoxide dismutase activity?
    • Patil NK, Saba H, MacMillan-Crow LA. Effect of S-nitrosoglutathione on renal mitochondrial function: a new mechanism for reversible regulation of manganese superoxide dismutase activity? Free Radic Biol Med 56: 54-63, 2013.
    • (2013) Free Radic Biol Med , vol.56 , pp. 54-63
    • Patil, N.K.1    Saba, H.2    McMillan-Crow, L.A.3
  • 45
    • 77952555680 scopus 로고    scopus 로고
    • Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor
    • Perez J, Hill BG, Benavides GA, Dranka BP, Darley-Usmar VM. Role of cellular bioenergetics in smooth muscle cell proliferation induced by platelet-derived growth factor. Biochem J 428: 255-267, 2010.
    • (2010) Biochem J , vol.428 , pp. 255-267
    • Perez, J.1    Hill, B.G.2    Benavides, G.A.3    Dranka, B.P.4    Darley-Usmar, V.M.5
  • 46
    • 42449102605 scopus 로고    scopus 로고
    • Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: A report from the French ND (Neonatal Diabetes) Study Group
    • (Neonatal Diabetes) Study Group
    • Polak M, Dechaume A, Cavé H, Nimri R, Crosnier H, Sulmont V, de Kerdanet M, Scharfmann R, Lebenthal Y, Froguel P, Vaxillaire M; French ND (Neonatal Diabetes) Study Group. Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group. Diabetes 57: 1115-1119, 2008.
    • (2008) Diabetes , vol.57 , pp. 1115-1119
    • Polak, M.1    Dechaume, A.2    Cavé, H.3    Nimri, R.4    Crosnier, H.5    Sulmont, V.6    de Kerdanet, M.7    Scharfmann, R.8    Lebenthal, Y.9    Froguel, P.10    Vaxillaire, M.11    French, N.D.12
  • 47
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD, White E. Autophagy and metabolism. Science 330: 1344-1348, 2010.
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 49
    • 3042731121 scopus 로고    scopus 로고
    • The pathogenesis of diabetes in the NOD mouse
    • Solomon M, Sarvetnick N. The pathogenesis of diabetes in the NOD mouse. Adv Immunol 84: 239-264, 2004.
    • (2004) Adv Immunol , vol.84 , pp. 239-264
    • Solomon, M.1    Sarvetnick, N.2
  • 53
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues
    • Tietze F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27: 502-522, 1969.
    • (1969) Anal Biochem , vol.27 , pp. 502-522
    • Tietze, F.1
  • 54
    • 0032918044 scopus 로고    scopus 로고
    • A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse
    • Wang J, Takeuchi T, Tanaka S, Kubo SK, Kayo T, Lu D, Takata K, Koizumi A, Izumi T. A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse. J Clin Invest 103: 27-37, 1999.
    • (1999) J Clin Invest , vol.103 , pp. 27-37
    • Wang, J.1    Takeuchi, T.2    Tanaka, S.3    Kubo, S.K.4    Kayo, T.5    Lu, D.6    Takata, K.7    Koizumi, A.8    Izumi, T.9
  • 55
    • 77956342084 scopus 로고    scopus 로고
    • Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates
    • Westbrook DG, Anderson PG, Pinkerton KE, Ballinger SW. Perinatal tobacco smoke exposure increases vascular oxidative stress and mitochondrial damage in non-human primates. Cardiovasc Toxicol 10: 216-226, 2010.
    • (2010) Cardiovasc Toxicol , vol.10 , pp. 216-226
    • Westbrook, D.G.1    Anderson, P.G.2    Pinkerton, K.E.3    Ballinger, S.W.4
  • 58
    • 26444442450 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Cell life and death decisions
    • Xu C, Bailly-Maitre B, Reed JC. Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 2656-2664
    • Xu, C.1    Bailly-Maitre, B.2    Reed, J.C.3
  • 59
    • 33744900639 scopus 로고    scopus 로고
    • Lessons on autoimmune diabetes from animal models
    • Yang Y, Santamaria P. Lessons on autoimmune diabetes from animal models. Clin Sci (Lond) 110: 627-639, 2006.
    • (2006) Clin Sci (Lond) , vol.110 , pp. 627-639
    • Yang, Y.1    Santamaria, P.2
  • 60
    • 0030907296 scopus 로고    scopus 로고
    • A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
    • Yoshioka M, Kayo T, Ikeda T, Koizumi A. A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes 46: 887-894, 1997.
    • (1997) Diabetes , vol.46 , pp. 887-894
    • Yoshioka, M.1    Kayo, T.2    Ikeda, T.3    Koizumi, A.4
  • 61
    • 84859258784 scopus 로고    scopus 로고
    • Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells
    • Yuan Q, Tang W, Zhang X, Hinson JA, Liu C, Osei K, Wang J. Proinsulin atypical maturation and disposal induces extensive defects in mouse Ins2+/Akita β-cells. PLoS One 7: e35098, 2012.
    • (2012) PLoS One , vol.7
    • Yuan, Q.1    Tang, W.2    Zhang, X.3    Hinson, J.A.4    Liu, C.5    Osei, K.6    Wang, J.7
  • 62
    • 69249099667 scopus 로고    scopus 로고
    • S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function
    • Zmijewski JW, Banerjee S, Abraham E. S-glutathionylation of the Rpn2 regulatory subunit inhibits 26 S proteasomal function. J Biol Chem 284: 22213-22221, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 22213-22221
    • Zmijewski, J.W.1    Banerjee, S.2    Abraham, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.