Glycyrrhizic acid confers neuroprotection after subarachnoid hemorrhage via inhibition of high mobility group box-1 protein: A hypothesis for novel therapy of subarachnoid hemorrhage

Medical Hypotheses

Volumn 81, Issue 4, 2013, Pages 681-685

  Sun, Qing ^a   Wang, Fan ^b   Li, Wei ^a   Li, Weide ^c   Hu, Yang chun ^a   Li, Song ^c   Zhu, Jian hong ^a   Zhou, Mengliang ^a   Hang, Chun hua ^a  

^a NANJING UNIVERSITY   (China)

^b GUIZHOU MEDICAL UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN VASOSPASM; CELL DEATH; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLIA CELL; GLYCYRRHIZA; HYPOTHESIS; INFLAMMATION; NERVE CELL; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; SUBARACHNOID HEMORRHAGE;

GLYCYRRHIZIC ACID; HMGB1 PROTEIN; HUMANS; MODELS, BIOLOGICAL; NEUROPROTECTIVE AGENTS; SUBARACHNOID HEMORRHAGE;

EID: 84883777568     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2013.07.026     Document Type: Article

References (45)

1. Schuette A.J., Barrow D.L. Epidemiology and Long-Term Mortality in Subarachnoid Hemorrhage. World Neurosurg 2012.
2. Kolias A.G., Sen J., Belli A. Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches. J Neurosci Res 2009, 87:1-11.
3. Zhou M.L., Shi J.X., Hang C.H., Cheng H.L., Qi X.P., Mao L., et al. Potential contribution of nuclear factor-kappaB to cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits. J Cereb Blood Flow Metab 2007, 27:1583-1592.
4. Pradilla G., Chaichana K.L., Hoang S., Huang J., Tamargo R.J. Inflammation and cerebral vasospasm after subarachnoid hemorrhage. Neurosurg Clin N Am 2010, 21:365-379.
5. Cahill J., Calvert J.W., Zhang J.H. Mechanisms of early brain injury after subarachnoid hemorrhage. J Cereb Blood Flow Metab 2006, 26:1341-1353.
6. Sehba F.A., Pluta R.M., Zhang J.H. Metamorphosis of subarachnoid hemorrhage research: from delayed vasospasm to early brain injury. Mol Neurobiol 2011, 43:27-40.
7. Zhou M.L., Shi J.X., Hang C.H., Zhang F.F., Gao J., Yin H.X. Expression of Toll-like receptor 4 in the brain in a rabbit experimental subarachnoid haemorrhage model. Inflamm Res 2007, 56:93-97.
8. Sozen T., Tsuchiyama R., Hasegawa Y., Suzuki H., Jadhav V., Nishizawa S., et al. Role of interleukin-1beta in early brain injury after subarachnoid hemorrhage in mice. Stroke 2009, 40:2519-2525.
9. Zhou M.L., Wu W., Ding Y.S., Zhang F.F., Hang C.H., Wang H.D., et al. Expression of Toll-like receptor 4 in the basilar artery after experimental subarachnoid hemorrhage in rabbits: a preliminary study. Brain Res 2007, 1173:110-116.
10. Larysz-Brysz M., Lewin-Kowalik J., Czuba Z., Kotulska K., Olakowska E., Marcol W., et al. Interleukin-1beta increases release of endothelin-1 and tumor necrosis factor as well as reactive oxygen species by peripheral leukocytes during experimental subarachnoid hemorrhage. Curr Neurovasc Res 2012, 9:159-166.
11. Greenhalgh A.D., Brough D., Robinson E.M., Girard S., Rothwell N.J., Allan S.M. Interleukin-1 receptor antagonist is beneficial after subarachnoid haemorrhage in rat by blocking haem-driven inflammatory pathology. Dis Model Mech 2012, 5:823-833.
12. C.J. McMahon, S. Hopkins, A. Vail, A.T. King, D. Smith and K.J. Illingworth, et al., Inflammation as a predictor for delayed cerebral ischemia after aneurysmal subarachnoid haemorrhage, J Neurointerv Surg (2012).
13. Wu Y., Tang K., Huang R.Q., Zhuang Z., Cheng H.L., Yin H.X., et al. Therapeutic potential of peroxisome proliferator-activated receptor gamma agonist rosiglitazone in cerebral vasospasm after a rat experimental subarachnoid hemorrhage model. J Neurol Sci 2011, 305:85-91.
14. Andersson U., Tracey K.J. HMGB1 is a therapeutic target for sterile inflammation and infection. Annu Rev Immunol 2011, 29:139-162.
15. Evankovich J., Cho S.W., Zhang R., Cardinal J., Dhupar R., Zhang L., et al. High mobility group box 1 release from hepatocytes during ischemia and reperfusion injury is mediated by decreased histone deacetylase activity. J Biol Chem 2010, 285:39888-39897.
16. van Beijnum J.R., Buurman W.A., Griffioen A.W. Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1). Angiogenesis 2008, 11:91-99.
17. Kim J.B., Sig C.J., Yu Y.M., Nam K., Piao C.S., Kim S.W., et al. HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci 2006, 26:6413-6421.
18. Murakami K., Koide M., Dumont T.M., Russell S.R., Tranmer B.I., Wellman G.C. Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein. Transl Stroke Res 2011, 2:72-79.
19. Nakahara T., Tsuruta R., Kaneko T., Yamashita S., Fujita M., Kasaoka S., et al. High-mobility group box 1 protein in CSF of patients with subarachnoid hemorrhage. Neurocrit Care 2009, 11:362-368.
20. Zhu X.D., Chen J.S., Zhou F., Liu Q.C., Chen G., Zhang J.M. Relationship between plasma high mobility group box-1 protein levels and clinical outcomes of aneurysmal subarachnoid hemorrhage. J Neuroinflamm 2012, 9:194.
21. Su X., Wang H., Zhao J., Pan H., Mao L. Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-kappaB pathway after traumatic brain injury in the rat. Mediators Inflamm 2011, 2011:807142.
22. Gong G., Yuan L.B., Hu L., Wu W., Yin L., Hou J.L., et al. Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1. Acta Pharmacol Sin 2012, 33:11-18.
23. Kim S.W., Jin Y., Shin J.H., Kim I.D., Lee H.K., Park S., et al. Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion. Neurobiol Dis 2012, 46:147-156.
24. Li W., Ling H.P., You W.C., Ji X.J., Tang Y., Zhao J.B., et al. Recombinant high-mobility group box 1 protein (HMGB-1) promotes myeloid differentiation primary response protein 88 (Myd88) upregulation in mouse primary cortical neurons. Neurol Sci 2013, 34:847-853.
25. Mollica L., De Marchis F., Spitaleri A., Dallacosta C., Pennacchini D., Zamai M., et al. Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities. Chem Biol 2007, 14:431-441.
26. Arase Y., Ikeda K., Murashima N., Chayama K., Tsubota A., Koida I., et al. The long term efficacy of glycyrrhizin in chronic hepatitis C patients. Cancer 1997, 79:1494-1500.
27. Girard J.P. A direct inhibitor of HMGB1 cytokine. Chem Biol 2007, 14:345-347.
28. Mathiesen T., Edner G., Ulfarsson E., Andersson B. Cerebrospinal fluid interleukin-1 receptor antagonist and tumor necrosis factor-alpha following subarachnoid hemorrhage. J Neurosurg 1997, 87:215-220.
29. Gaetani P., Tartara F., Pignatti P., Tancioni F., Rodriguez Y.B.R., De Benedetti F. Cisternal CSF levels of cytokines after subarachnoid hemorrhage. Neurol Res 1998, 20:337-342.
30. Pisetsky D. Cell death in the pathogenesis of immune-mediated diseases: the role of HMGB1 and DAMP-PAMP complexes. Swiss Med Wkly 2011, 141:w13256.
31. Bianchi M.E., Manfredi A.A. Immunology. Dangers in and out. Science 2009, 323:1683-1684.
32. Macdonald R.L., Weir B.K. A review of hemoglobin and the pathogenesis of cerebral vasospasm. Stroke 1991, 22:971-982.
33. Friedrich V., Flores R., Sehba F.A. Cell death starts early after subarachnoid hemorrhage. Neurosci Lett 2012, 512:6-11.
34. Qiu J., Xu J., Zheng Y., Wei Y., Zhu X., Lo E.H., et al. High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke 2010, 41:2077-2082.
35. McGirt M.J., Mavropoulos J.C., McGirt L.Y., Alexander M.J., Friedman A.H., Laskowitz D.T., et al. Leukocytosis as an independent risk factor for cerebral vasospasm following aneurysmal subarachnoid hemorrhage. J Neurosurg 2003, 98:1222-1226.
36. Maiuri F., Gallicchio B., Donati P., Carandente M. The blood leukocyte count and its prognostic significance in subarachnoid hemorrhage. J Neurosurg Sci 1987, 31:45-48.
37. Nissen J.J., Mantle D., Blackburn A., Barnes J., Wooldridge T., Gregson B., et al. The selectin superfamily: the role of selectin adhesion molecules in delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage. Acta Neurochir Suppl 2000, 76:55-60.
38. Polin R.S., Bavbek M., Shaffrey M.E., Billups K., Bogaev C.A., Kassell N.F., et al. Detection of soluble E-selectin, ICAM-1, VCAM-1, and L-selectin in the cerebrospinal fluid of patients after subarachnoid hemorrhage. J Neurosurg 1998, 89:559-567.
39. Lin C.L., Dumont A.S., Calisaneller T., Kwan A.L., Hwong S.L., Lee K.S. Monoclonal antibody against E selectin attenuates subarachnoid hemorrhage-induced cerebral vasospasm. Surg Neurol 2005, 64. 201-205, 205-206.
40. Nishizawa S., Peterson J.W., Shimoyama I., Iwasaki K., Uemura K. Therapeutic effect of a new immunosuppressant, FK-506, on vasospasm after subarachnoid hemorrhage. Neurosurgery 1993, 32. 986-991, 991-992.
41. Qiu J., Nishimura M., Wang Y., Sims J.R., Qiu S., Savitz S.I., et al. Early release of HMGB-1 from neurons after the onset of brain ischemia. J Cereb Blood Flow Metab 2008, 28:927-938.
42. Jeon H., Ai J., Sabri M., Tariq A., Macdonald R.L. Learning deficits after experimental subarachnoid hemorrhage in rats. Neuroscience 2010, 169:1805-1814.
43. Ulloa L., Ochani M., Yang H., Tanovic M., Halperin D., Yang R., et al. Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. Proc Natl Acad Sci U S A 2002, 99:12351-12356.
44. Wang H., Liao H., Ochani M., Justiniani M., Lin X., Yang L., et al. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat Med 2004, 10:1216-1221.
45. Fink M.P. Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis. Am J Pathol 2008, 172:1171-1173.